Zoely, 2.5 mg+1.5 mg, set of tablets, film-coated tablets, 28 pcs.

Compound

1 tablet - 2.5 mg of nomegestrol acetate and 1.55 mg of estradiol hemihydrate (respectively 1.5 mg of estradiol ) - active substances.
Auxiliary ingredients:

• 0.7 mg - talc;
• 14 mg - microcrystalline cellulose;
• 0.7 mg - magnesium stearate;
• 2.4 mg - crospovidone;
• 57.71 mg - lactose monohydrate;
• 0.44 mg - colloidal silicon dioxide.

Shell:

• 1.6 mg - opadry II white.

Placebo tablets :

• 0.7 mg - talc;
• 14 mg - microcrystalline cellulose;
• 0.7 mg - magnesium stearate;
• 2.4 mg - crospovidone;
• 61.76 mg - lactose monohydrate;
• 0.44 mg - colloidal silicon dioxide.

Shell:

• 2.4 mg - opadry II yellow.

What are Zoely birth control pills?

Hormonal contraceptives Zoely are available in tablet format containing nomegestrol and estradiol. The drug is produced by the Irish pharmaceutical company Organon. By combining two complex components, the contraceptive suppresses ovulation, causing the woman’s ovaries to stop functioning . This protects against unplanned pregnancy.

Active ingredients

The contraceptive drug Zoely is intended for oral use. Its active components are microdoses of hormones. The peculiarity of the composition of the product is that it contains the estrogen hormone 17 beta-estradiol, which is 99% close to the natural substance. The second active component is ethinyl estradiol and the progestogen nomegesterol acetate. It is a derivative of natural glucocorticoid hormone and is a highly selective protestogen.

Nomegestrol acetate is related to human endogenous progesterone, has antigonadotropic and antiestrogenic activity, and a moderate antiandrogenic effect. When using COCs (combined oral contraceptives) Zoely, the average concentrations of E2 do not differ from those in the initial follicular phase and late luteal phase of the corpus luteum.

Composition of the drug and release form

Monophasic oral contraceptive Zoely is available in tablet format - there are two types of them in a pack. Differences in composition:

Pharmacodynamics and pharmacokinetics

Zoely is a hormonal combined contraceptive drug consisting, in addition to additional substances, of the active components: estradiol (17β) and nomegestrol.

Estradiol is a naturally occurring estrogen identical to human endogenous 17β-estradiol (E2) . The main difference from ethinyl estradiol , which is part of the structure of other COCs (combined oral contraceptives), is the absence of an ethynyl group in the 17α-position. Taking Zoely's medication causes average concentrations of E2 , which correspond to those in the initial follicular phase and the final luteal phase of the menstrual cycle.

A derivative of natural progesterone, nomegestrol , is similar to it in structure and is a highly selective progestogen . Having a pronounced affinity for the progesterone (human), it exhibits high antigonadotropic and moderate antiandrogenic activity, without having androgenic, glucocorticoid, estrogenic and mineralocorticoid effects.

The contraceptive effect of Zoely is a combination of several effects, the most significant of which are changes in the secretion of the cervical and suppression of ovulation . E2 increases the effects of progestogen , and nomegestrol is involved in the process of suppressing ovulation. After stopping taking Zoely, normal ovulation , in most women, is restored quite quickly.

The serum folic acid content does not change while taking Zoely and remains at the baseline level for six months of sequential use.

Clinical studies have established a Pearl index of 0.66 for the age category of women 18-50 years old and 0.75 for women 18-35 years old, with a corresponding upper limit of the 95% confidence interval of 1.07/1.23.

Studies have shown that taking Zoely does not lead to significant changes in lipid metabolism and does not affect insulin glucose tolerance and hemostasis . The drug increased the amount of proteins that transport CSG (corticosteroid-binding) and TSH (thyroxine-binding) globulins , but to a much lesser extent than the combination of ethinyl estradiol and levonorgestrel . Also, the content of free and total testosterone, dehydroepiandrosterone, and androstenedione globulin increased slightly . When conducting a histological examination of the endometrium , after using Zoely for 13 cycles, no pathological changes were observed.

Nomegestrol, when taken internally, is rapidly absorbed and detects Cmax (7 ng/ml) in plasma after 2 hours. When taken once, the absolute bioavailability, regardless of food intake, is 63%.

97-98% binds to albumin , without binding to CSG or SHBG. Vss - 1.645±576 l.

Metabolized by cytochrome P450 to several hydroxylated inactive metabolites, which in turn, together with nomegestrol , form sulfate and glucuronide conjugates. At steady state, the clearance is 26 l/h.

At steady state, T1/2 is on average 46 hours (from 28 to 83 hours). Nomegestrol is excreted through the kidneys to a lesser extent and through the intestines to a greater extent. Approximately 80% is eliminated within 4 days and almost completely within 10 days.

The linearity of the pharmacokinetics of nomegestrol depends on the dose taken (in the range of 0.625–5 mg).

the pharmacokinetics of nomegestrol . The equilibrium state is observed after 5 days. Average Css is 4 ng/ml. Cmax in plasma is approximately 12 ng/ml and appears 90 minutes after administration.

Nomegestrol does not interact with glycoprotein P and does not have a significant inhibitory or inducing effect on cytochrome P450.

Estradiol , when taken orally, is subject to significant first-pass metabolism. Absolute bioavailability, regardless of food intake, is about 5%.

Actively spreads throughout the body. The highest content is shown in target organs of PG ( sex hormones ). In the blood it binds 37% to SHBG, 61% to albumin . Only 1–2% of estradiol is found in unbound form.

When taken orally, exogenous estradiol is actively biotransformed and, due to its similarity with endogenous estradiol , is quickly converted in the liver and intestines into several metabolites (mainly estrone ). The latter are conjugated, undergoing hepatic-intestinal circulation. Oxidation occurs due to cytochrome P450 isoenzymes.

Cmax in serum is observed after 6 hours and is equal to 90 pg/ml. The average serum concentration is 50 pg/ml.

It is cleared from the blood quickly, T1/2 fluctuates over a wide range and after intravenous administration is 8.4 ± 6.4 hours.

Contraindications

exact data on contraindications for oral contraceptives containing 17β-estradiol . However, it can be assumed that they correspond to those when taking ethinyl estradiol-containing drugs. While taking Zoely, if any of the following conditions occur, you should stop taking it immediately.

• hypersensitivity to any of the components of the tablet;
• pulmonary embolism thrombosis , both current and past;
• arterial thrombosis (pathologies of cerebral circulation, myocardial infarction );
• migraine with focal neurological symptoms, including a history;
• prodromal conditions ( angina pectoris, transient ischemic attack ), including a history of;
• multiple and/or pronounced factors for the occurrence of arterial or venous thrombosis ( severe hypertension, diabetes mellitus with vascular symptoms, severe dyslipoproteinemia );
• pancreatitis with severe hypertriglyceridemia, both currently and in the past;
• acquired or hereditary predisposition of the patient to arterial or venous thrombosis , for example: deficiency of antithrombin III and proteins C and S, protein C resistance, hyperhomocysteinemia and the presence of antiphospholipid antibodies (lupus anticoagulant, antibodies to cardiolipin);
• tumors and severe pathologies of the liver, including a history of it;
• suspected or diagnosed malignant hormone-dependent neoplasms ( tumors of the breast or genital organs );
• breastfeeding period;
• suspected or diagnosed pregnancy ;
• vaginal bleeding of unknown etiology;
• lactose intolerance, lactase deficiency, glucose-galactose malabsorption;
• postmenopause.

With extreme caution:

• severe depression , also in history;
• diabetes mellitus , passing without vascular pathologies;
• systemic lupus erythematosus;
• ulcerative colitis;
• Crohn's disease;
• pathologies of liver function;
• hypertriglyceridemia , currently present or traced in a family history;
• risk factors for ischemic heart disease ( smoking, obesity, arterial hypertension );
• presence in the family history of arterial embolism and venous thrombosis ;
• major surgery and prolonged immobilization.

Side effects

As practice has shown, the Zoely contraceptive is generally well-tolerated, and the safety of use is at the level of other combination drugs with similar effects. Below are possible negative effects that have been observed while taking Zoely.

Metabolism:

• weight gain;
• fluid retention;
• increase or decrease in appetite.

CNS:

• decreased or increased libido ;
• depression;
• migraine;
• attention disorder;
• headache.

Organs of vision:

• dry eyeballs;
• intolerance to wearing contact lenses.

Vascular system:

• tides.

Digestive system:

• bloating;
• nausea;
• increased activity of liver enzymes;
• dry mouth.

Skin and subcutaneous tissues:

• acne;
• alopecia;
• hyperhidrosis;
• itching;
• seborrhea;
• dry skin;
• hypertrichosis;
• chloasma.

Musculoskeletal system:

• feeling of heaviness.

Genital organs and mammary glands:

• withdrawal bleeding;
• menorrhagia;
• pain in the pelvic area;
• hypomenorrhea;
• engorgement of the mammary glands;
• metrorrhagia;
• galactorrhea;
• premenstrual syndrome;
• uterine spasm;
• lumps in the mammary glands;
• dryness of the vagina and vulva;
• dyspareunia;
• discomfort in the vaginal area;
• unpleasant odor from the vagina.

Are common:

• edema;
• irritability;
• hunger.

Side effects observed with the use of COCs (combined oral contraceptives) that contain ethinyl estradiol:

• increase in blood pressure;
• arterial and venous thromboembolism ;
• chloasma;
• hormone-dependent tumors ( breast cancer, liver tumors ).

The incidence of breast cancer diagnosis in women using COCs is slightly higher than that in women using other methods and means of contraception.

The connection between breast cancer and COC use has not been established.

Instructions for use of Zoely (Method and dosage)

The instructions for Zoely recommend taking the tablets orally at the same time every day, without taking into account food intake. The tablets are taken in the sequence indicated on the blister and washed down with water.

For all women, recommendations for using Zoely are the same. For 28 days you need to take 1 tablet every day in a row. In the first 24 days, take white tablets containing active ingredients, after which, over the next 4 days, take yellow tablets ( placebo ), which do not contain active ingredients.

The initial tablet from each subsequent blister (or package) must be taken the next day after the final tablet from the previous blister. The drug is taken regardless of the absence or presence of withdrawal bleeding , which is usually observed 24-36 hours after consuming the last white tablet and can continue until the next blister is used.

Start of use

For women who have not previously taken hormonal contraceptives, it is best to start taking Zoely on the first day of the menstrual cycle . In this case, additional contraception will not be needed. It is allowed to start using it from the 2nd to 5th day of the cycle, but during the week, it is necessary to use additional contraceptive barrier methods.

When switching from other contraceptives with combined hormonal action (other COCs, patches , vaginal rings ), in the case of using other COCs, it is recommended to start taking Zoely on the next day after the last active tablet ( not placebo ) and no later than the next day after the end of the usual range between cycles or taking placebo . If you have previously used a transdermal patch or vaginal ring , it is advisable to start switching to Zoely tablets on the day of their removal (removal), but no later than during the next recommended application of the patch or insertion of the ring.

With correct and constant use of previous contraceptive methods and guaranteeing the absence of pregnancy, it is possible to switch to Zoely any day. Under no circumstances should you exceed the recommended hormone-free period of the previous contraceptive method.

In case of switching from contraceptives containing one progestogen ( implants , tablets, injections or IUD - intrauterine system ) with previous use of other tablets, you can switch to Zoely on any day, the next day after stopping taking tablets with progestogen. When switching from injection forms, taking Zoely tablets is replaced by the next recommended injection. The IUD or implant is removed on any convenient day, on which Zoely is started. In all of the above cases, it is recommended to use additional barrier contraceptives for a week.

After an abortion in the first trimester , you can begin using Zoely immediately after the end of the procedure, and no additional contraceptive measures are required.

After an abortion in the second trimester or childbirth, you should start using the drug between 21 and 28 days. barrier contraceptives for a week . In case of previous sexual intercourse, it is necessary to exclude possible pregnancy before using it.

If you miss taking pills

If you miss another active (white) tablet, the following recommendations are given.

If the next dose is less than 12 hours late, take the required tablet without adjusting the order and time of taking subsequent tablets.

If you are more than 12 hours late, two rules are followed:

• Active tablets should be taken for at least 7 days in a row;
• The greater the number of active tablets missed and the closer the time of placebo , the higher the possibility of pregnancy.

If you miss the first tablet, take it as soon as possible, even if you take the next 2 tablets at the same time. In the future, continue with the usual regimen of use, without additional measures.

If you miss 2 or more tablets and there is no withdrawal bleeding during the placebo , pregnancy .

If you miss a cycle during the 1st – 7th day, you should take the last missed tablet as soon as possible, even if you take 2 subsequent tablets at the same time. In the future, continue the usual regimen of use, using barrier contraception , during the first week. If you have sexual intercourse at this time, pregnancy .

If you miss during the 8th - 17th day of the cycle, you should take the last missed tablet as soon as possible, even if you take 2 subsequent tablets at the same time. In the future, continue the usual regimen of use, using barrier contraception , during the first week.

If you miss during the 18th - 24th day of the cycle, you should take the last missed tablet as soon as possible, even if you take 2 subsequent tablets at the same time. You cannot take more than 2 active tablets at the same time. During the first week barrier contraception , and the first active tablet from the next blister should be taken after the last active tablet from the previous one, that is, the last phase of taking placebo . With this regimen, withdrawal bleeding most often occurs during the next placebo spotting or breakthrough bleeding may occur during the current cycle

If you are unsure about the number of missed pills, you need to use barrier contraceptives for at least a week of continuous use of the current pills.

placebo pills does not reduce the contraceptive effect.

In case of gastrointestinal painful conditions, such as diarrhea or vomiting, the absorption process of Zoely may be affected, and therefore it is necessary to resort to auxiliary contraceptive measures.

If vomiting within 3–4 hours after swallowing the tablet, this dose is considered to be a missed dose. If this painful condition continues for several days, you should use the recommendations described above. If you do not want to change the typical regimen of use, you can take an additional active tablet or a tablet from another blister.

To delay the moment of menstrual-like bleeding, you need to start taking white tablets from the next blister, immediately after finishing them from the previous blister, that is, exclude taking placebo . The white tablets from the second blister can be taken in full. After taking the placebo from the second blister, resume the usual regimen of taking Zoely. , spotting and/or breakthrough bleeding may occur . To shift the day of onset of menstrual-like bleeding , you can reduce the placebo (by a maximum of 4 days). A shorter break increases the risk of no withdrawal bleeding and the development of spotting and breakthrough bleeding.

What to do if you miss taking a tablet with active ingredients

If you take a pill with hormonal substances less than 12 hours late, the effect of contraception is not reduced. The drug should be taken as soon as possible after the omission is detected. The following daily doses are taken without deviation. If the delay is more than 12 hours, then the effect of the protection is reduced; you need to take white tablets for seven days in a row according to the correction scheme:

• if you miss one dose - take the missed dose as quickly as possible, you can take two pieces, then the dose lasts as standard, no additional protection is needed;
• if you miss two or more doses on days 1-7 of the cycle - if there is no bleeding while taking yellow doses, pregnancy should be ruled out, take the missed dose as soon as possible, and protect yourself with condoms for an additional week;
• missing 2 or more doses on days 8-17 of the cycle - take the missed dose as early as possible, use additional protection for a week;
• missing 2 or more pieces on days 18-24 of the cycle - take the missed dose as early as possible, but you cannot take two tablets at the same time, start the next pack immediately, do not take the yellow elements.

If you are unsure about the number of missed doses or their color, you must additionally protect yourself for seven days of taking the white tablets. If you skip the yellow placebo elements, the contraceptive effect is not reduced. The woman may not take them, but missed doses should be discarded to prevent deliberate prolongation of the phase.

Interaction

In order to completely exclude possible interactions, you should carefully read the instructions for them in the instructions for use of drugs used in parallel.

Interaction of COCs, including Zoely, with other drugs may cause bleeding and/or a decrease in contraceptive effectiveness. Below are generalized interactions of other drugs with COCs.

Hepatic metabolism

Interaction with inducers of microsomal liver enzymes is possible, which can cause an increase in the clearance of PG ( sex hormones). There is definitely an interaction with barbiturates, Phenytoin, Primidone, Rifampicin, Carbamazepine . Interaction with Griseofulvin, Topiramate, Oxcarbazepine, Felbamate and St. John's wort preparations is possible. Also, agents that inhibit HIV proteases ( Ritonavir , etc.) and non-nucleoside reverse transcriptase inhibitors ( Nevirapine , etc.), as well as their combinations, have an effect on hepatic metabolism.

When taking microsomal enzyme inducers , as well as for 28 days after their discontinuation, it is necessary to use barrier contraception. In case of long-term therapy with these drugs, the issue of prescribing another contraceptive method should be considered.

Inhibitors of microsomal enzymes , such as ketoconazole , can lead to increased plasma concentrations of PG.

Antibiotics

When used together with antibiotics such as tetracyclines and ampicillin , a decrease in the effectiveness of COCs containing ethinyl estradiol . The mechanism of this interaction is not fully understood. reliable data on the interaction of COCs containing 17β-estradiol and antibiotics. Women who are undergoing antibiotic therapy (except for the use of Griseofulvin and Rifampicin ) should use additional barrier contraceptives throughout the entire period of treatment, as well as 7 days after. If the period of additional barrier contraception covers the end of taking the active pills, it is recommended to skip the placebo and immediately proceed to taking the active pills from another blister.

Other drugs

COCs can affect the metabolism of other drugs, increasing their plasma and tissue concentrations, as in the case of Cyclosporine , or decreasing, as in the case of Lamotrigine .

Indications for use

In what cases should Zoely be used?

Zoely birth control pills are an analogue of the natural hormone estrogen in combination with nomogestrol and additional substances, intended for contraception. The form of administration is oral. One tablet on day 1 of the menstrual cycle. 4 tablets out of 28 are placebo (non-medicinal), taken during the menstrual break.

The main indication for use is protection against unwanted pregnancy 24 hours a day while taking the drug. To achieve the contraceptive effect, it is enough to take 1 tablet daily, preferably at the same time. Please note that there is a violation of the dose of the drug. Zoely is one of those remedies whose active component is quickly eliminated from the body, allowing ovulation to resume. Already on the 4th day after stopping taking the pills, almost 80% of the substances are removed from the body, and on the 6-5th day ovulation resumes, stopping the effect of the contraceptive function.

The tablets are designed for use by women who are at full puberty and who are not pregnant. The recommended age for taking the drug is 18 years.

In addition to the contraceptive function, tablets act as a stabilizer of the menstrual cycle; they can be used to even out or restore it in some cases. Another role of the drug is to control hormonal levels, due to active components that are more than 99% identical to estrogen.

What you need to know about the drug No-shpa. Release form, detailed instructions for use

Due to a wide range of contraindications, the drug is prescribed only after checking the tests with a doctor, after carefully studying the benefits and possible negative consequences for the body. They also pay attention to the presence of the listed diseases in close blood relatives. It is strictly not recommended to take Zoely in case of severe mental condition (depression, post-traumatic shock).

special instructions

The data below were obtained during epidemiological studies of COCs containing ethinyl estradiol . The drug Zoely includes 17β-estradiol , however, the special instructions described apply to it as well.

Vascular disorders

An association has been observed between taking COCs and the risk of thromboembolism , as well as venous and arterial thrombosis ( myocardial infarction, deep vein thrombosis, stroke, pulmonary embolism). Against the general background, these conditions rarely develop, but during the first year of taking COCs, the risk of developing these complications is highest. You should know that 1-2% of cases of embolism and venous thrombosis .

With the development of thrombosis, the following may occur:

• pain and/or swelling of the legs;
• sudden shortness of breath ;
• sharp pain in the chest, with or without rebound, in the left arm;
• unexpected cough ;
• sudden loss of vision (partial or complete), uncharacteristic severe prolonged headaches;
• diplopia;
• dizziness;
• speech disorder;
• collapse (possibly with convulsions);
• weakness;
• movement disorders;
• sudden severe numbness on one side of the body;
• acute abdomen syndrome.

Risk factors for embolism and venous thrombosis :

• advanced age;
• hereditary predisposition (family history of these diseases);
• obesity;
• thrombophlebitis;
• phlebeurysm;
• serious injury;
• major surgery;
• long-term immobilization.

Risk factors for arterial thrombosis :

• smoking;
• advanced age;
• dyslipoproteinemia;
• arterial hypertension;
• obesity;
• migraine;
• atrial fibrillation;
• heart valve disease;
• hereditary predisposition.

It is worth remembering the increased risk of thromboembolic exacerbations in the postpartum period.

For any of these disorders, you should consult your doctor before taking Zoely tablets. In cases of suspected thrombosis or its diagnosis, while using COCs, the tablets should be discontinued. For conditions requiring hospitalization (serious trauma, major surgery, prolonged immobilization), it is better to stop using COCs (one month before a planned operation), with resumption of use 14 days after normal resumption of motor functions.

Also, consultation with a doctor will be required for such diseases as:

• diabetes;
• uremic hemolytic syndrome;
• systemic lupus erythematosus;
• ulcerative colitis;
• Crohn's disease;
• sickle cell anemia.

Increased migraine is an indication for immediate discontinuation of Zoely.

Tumors

Long-term use of ethinyl estradiol-containing COCs , according to research results, increases the risk of developing cervical cancer , however, the question of other exposure factors remains open. It is not fully understood whether COC use, more frequent cervical testing, sexual intercourse (including barrier contraception), or a combination of these leads to an increased risk.

reliable information about the effect of Zoely on the development of ovarian and endometrial .

A slight increase in the relative risk (RR) of breast cancer (RR = 1.24). This risk decreases over 10 years after discontinuation of COCs. This increase is possibly due to earlier detection, the effects of COCs, or a combination of both.

Sometimes, when taking COCs, the development of liver tumors (benign) was detected, and even less often - malignant. In rare cases, these tumors, due to intra-abdominal bleeding, became a threat to the patient’s life. If an enlarged liver, intense abdominal pain, or symptoms of intra-abdominal bleeding are detected, a possible liver tumor should be excluded.

Other states

Taking COCs with hypertriglyceridemia or a family history of it slightly increases the risk of pancreatitis .

increase in blood pressure was often observed , which was rarely clinically significant. The connection between COC use and the formation of arterial hypertension . However, if it develops, it is worth stopping the use of COCs and considering prescribing adequate antihypertensive therapy. When blood pressure is stabilized with the use of antihypertensive drugs, it is possible to resume the use of COCs. According to the results of clinical studies, taking Zoely for up to 12 months did not lead to clinically significant blood pressure disorders.

During the use of COCs and during pregnancy, complications or development were noted: itching and/or jaundice , cholelithiasis, gestational herpes, porphyria, hemolytic uremic syndrome, systemic lupus erythematosus, Sydenham's chorea, angioedema , as well as hearing loss.

Liver pathologies may require discontinuation of COCs until the liver condition is completely normalized.

In case of recurrence of cholestatic jaundice, which was first diagnosed during pregnancy or previous steroids

glucose tolerance and insulin resistance . However, while taking them, it is necessary to conduct careful periodic examinations, especially for women with diabetes .

ulcerative colitis, Crohn's disease and was observed .

chloasma developed , especially when this disease was mentioned in the anamnesis. In this case, it is better to avoid prolonged exposure to the sun, solarium and other exposure to ultraviolet radiation.

Conducting consultations and examinations

Before prescribing a COC, it is necessary to obtain an understanding of the woman’s personal and family history, and also to exclude possible pregnancy. Measure blood pressure and, if indicated, prescribe a physical examination , taking into account all contraindications. The frequency of control examinations in each case is determined separately, but at least twice a year.

Women should receive full information about the action and side effects of COCs, and also be informed that this method of contraception does not prevent HIV infection and other sexually transmitted diseases.

Reduced efficiency

The effectiveness of COCs may be reduced if active tablets are missed, as well as gastrointestinal disorders.

Menses

The use of COCs, especially in the first months, may be accompanied by spotting or breakthrough bleeding . In this regard, it is advisable to conduct a study of these manifestations after the adaptation period (3 months). If these symptoms persist after three cycles of taking COCs, their non-hormonal nature should be assumed and diagnostics should be prescribed to exclude possible tumors or pregnancy . may be performed .

When studying the drug Zoely, bleeding developed rarely and was short-lived, mild and slightly painful. In some cases, the absence of proper withdrawal bleeding was observed when taking placebo, without diagnosing pregnancy, which indicates its low probability even in the absence of withdrawal bleeding. If two bleedings are missed, when taking the drug in accordance with the instructions, a possible pregnancy must be excluded.

Zoely's analogs

Level 4 ATC code matches:
Ovidon

Rigevidon

Non-Ovlon

Mercilon

Yarina Plus

Yarina

Miniziston 20 fem

Novinet

Microgynon

Janine

Lindineth

Cyclo-Proginova

Regulon

Logest

Midiana

Belara

Femoden

Jess Plus

Jess

Analogues of Zoely are represented by the following contraceptive drugs:

• Claira;
• Trisiston;
• Trigestrel;
• Tri-regol;
• Triquilar.

Zoely or Klaira - which is better?

Despite some differences in the composition of the active ingredients, nomegestrol + estradiol in Zoely and dienogest + estradiol valerate in Qlaira , the mechanism of action of both drugs is almost the same. Both drugs are microdosed, however, Klaira , in each group of tablets (different in color), contains a different mass fraction of active substances, while in Zoely the dosage in each active tablet is the same. These contraceptives practically repeat each other, both in contraindications and side effects. In this regard, it is not possible to give a definite answer which of these drugs is better.

Oral contraceptives of hormonal action are selected individually and the best suitable drug can be prescribed only after undergoing many tests and undergoing some research. We should not forget about chronic diseases, a history of painful conditions (both personal and family) and many other factors that can also affect the choice of contraceptive.

Whenever you choose between Zoely and Claira , you should remember that these drugs, if you strictly follow the recommendations for their use, are highly effective and cause fewer side effects compared to other contraceptives. But the choice of COCs should be purely individual.

Reviews about Zoely

The pharmaceutical industry produces many hormonal contraceptives for oral use. Considering Zoely's birth control pills, reviews from gynecologists, subject to all the rules for taking the pills, are mostly positive. Naturally, any doctor in his practice has encountered many side effects of medications, and Zoely cannot do without them. Although, compared to many other COCs, Zoely tablets exhibit fewer side effects, and those that are detected are less pronounced.

Reviews of Zoely among women using this drug are purely positive, and this suggests that the active and auxiliary composition of the tablets is completely suitable for their body. Negative reviews are found among women who tried this contraceptive and eventually abandoned its use due to various side effects.

Each organism is individual and has its own set of characteristics, therefore, when choosing a contraceptive, you need to rely on the experience of a gynecologist, as well as undergo all the tests recommended by him. In this case, you have a much better chance of choosing exactly “your” contraceptive, which will not only protect you from unwanted pregnancy, discomfort into your life .

Upon admission

During the first month of taking the drug, the girl may have periodic spotting and bloody discharge from the genital tract. Sometimes women note that their periods cannot end from the moment they start taking the pills. There is no need to worry too much about this if the dosage regimen is followed and pregnancy is excluded. This is how the body adapts to artificial hormones. As a rule, in the second month of treatment everything returns to normal.

After such erratic bleeding, menstruation may not occur on time. This is due to the fact that the endometrium does not have time to grow. But if a girl takes Zoely and does not have periods for more than two cycles, she should consult a doctor. Perhaps the drug is not suitable or you need to take a break from taking it.

Many people believe that while taking the pill, periods should begin immediately when switching to placebo. In fact, it is accepted that menstruation occurs within a week of the last active pill. This is the absolute norm.

It should also be borne in mind that any irregularities in intake may cause spotting of varying duration. Especially if the time interval between tablets is more than 12 hours. Their nature will depend on the day of the cycle when there were failures in reception. In any case, you should continue to take the pills after pregnancy has been ruled out.

We recommend reading the article about menstrual irregularities. From it you will learn about the causes of deviations from the norm, diseases that cause cycle disorders, as well as treatment of disorders with the help of medications and promptly.

Zoely price, where to buy

The price of Zoely on the Russian pharmaceutical market ranges from 800 to 1100 rubles.

You can buy Zoely birth control pills in Moscow at an average cost of 850 rubles.

• Online pharmacies in RussiaRussia

ZdravCity

• Zoely tablets p.p.o.
  2.5 mg + 1.5 mg placebo 28 pcs. Delpharm Lille S.A.S./Merck Sharp and Dome B.V./N.V.Organon RUB 1,170 order
• Zoely tab. p.p.o. set 2.5mg+1.5mg/placebo 84 pcs. Delpharm Lille S.A.S./Merck Sharp and Dome B.V./N.V.Organon

  RUB 3,309 order

Terms and conditions of storage

Pay attention to the date of manufacture of the drug on the packaging. Normal conditions for storing the drug are temperatures from 2° to 30°, but not more than three years from the date of manufacture of the blister. Do not store tablets in direct contact with sunlight or in the cold. A common mistake is storing new packaging in the refrigerator. The drug is designed for everyday carry in hand luggage.

Important: do not take COCs under any circumstances if the shelf life of the drug has expired; strictly follow the recommendations in the instructions!