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Valerian tablets are produced by different pharmaceutical companies, and, accordingly, the rules for using different preparations differ, sometimes significantly. That is why before you start taking them, you must carefully study the instructions. Tablets may have different dosages, additional active ingredients and excipients. If some drugs can be taken 2 tablets 3 times a day, then for others 3 tablets per day is the maximum allowable dose.
Valerian in tablets is considered safer than in tincture form, and therefore is used in more cases.
Very often, mistakes are made in the use of valerian, wanting to get a quick sedative or hypnotic effect. Having taken 1-2 tablets and not feeling better, the person decides to take the drug a second and third time. This still does not provide the desired result, but can lead to an overdose of the drug, which, in turn, can cause deterioration in well-being.
It is important to remember that valerian is effective for long-term treatment, while a single dose of tablets has a subtle effect that may go unnoticed. The drug can provide only slight relaxation, promoting calm and falling asleep. It does not have a “tranquilizing” or strong sedative effect.
Valerian provides not only sedative and hypnotic effects, but also antispasmodic, hypotensive and others, due to which it is used for various diseases of internal organs. To know in what cases a drug can be effective and how to use it correctly, you need to read the instructions specifically for the drug you decide to take. However, different valerian-based products have general instructions for use.
pharmachologic effect
The drug is of plant origin. Wikipedia indicates that valerian officinalis is a herbaceous, perennial plant.
Its other name is cat grass , since it is well known how valerian affects cats. Cat grass, as valerian is sometimes called differently, causes a pronounced arousal reaction in felines.
The characteristics of the plant can be seen in the photo of valerian officinalis.
Valerian extract has a moderate sedative effect on the body. This effect is noted due to the presence in its composition of essential oil, the main content of which is an ester of isovaleric acid and borneol.
valerine and hotenin also have a sedative effect . As a result, a slow but stable sedative effect is observed.
Under the influence of the drug, inhibition processes in the cerebral cortex are enhanced. The synthesis and secretion of GABA at the synapses of cortical neurons also increases. This effect occurs only in the case of the total effect of substances that are part of valerian.
The extract helps facilitate the onset of natural sleep. Valeric acid and valepotriates have a weak antispasmodic effect. Also, the active substances of valerian provide a choleretic effect , activates the secretory activity of the gastrointestinal mucosa, slows the heart rate and dilates the coronary vessels.
The therapeutic effect is observed if treatment is carried out systematically and over a long period of time.
Valerian extract, due to the presence of actinidin , has an unusual effect on felines.
Answering the question why cats love valerian, experts note that the smell of actinidin is reminiscent of the smell of certain substances contained in the urine of cats.
Release form and composition
Dosage form – film-coated tablets: biconvex round, yellow with a greenish tint; the core in cross section is from light to gray-brown in color with a greenish tint (in a cardboard pack there are 1–5 contour strip packs of 10, 25 or 50 pcs., or 1 jar, bottle or polymer container of 30, 40, 50 or 100 PC.)
Composition of 1 tablet:
- active substance: thick valerian extract – 20 mg (the sum of carboxylic acid esters in terms of valeric acid ethyl ester – 1.8%);
- auxiliary components: lactose monohydrate – 43.11 mg; Magnesium hydroxycarbonate – 20 mg; sucrose – 5 mg; potato starch – 10.84 mg; polysorbate 80 – 0.05 mg; calcium stearate monohydrate – 1 mg;
- shell: Opadry II yellow – 7 mg.
Indications for use
The use of valerian tablets is indicated in the following cases:
- high degree of nervous excitement;
- insomnia and problems falling asleep;
- migraine;
- vegetative-vascular dystonia;
- functional disorders of the cardiovascular system (as part of complex treatment);
- spasms of the gastrointestinal tract (as part of complex treatment).
Before taking valerian tablets for blood pressure or stress (before an exam, etc.), you must consult a doctor who will tell you how to take the tablets, how much to drink, and whether you should do it.
Notes
- For the convention of indicating the class of dicotyledons as a superior taxon for the group of plants described in this article, see the section “APG Systems” of the article “Dicotyledons”.
- ↑ 1 2 3 4 5 Burmistrov A. N., Nikitina V. A.
Honey plants and their pollen: Handbook. - M.: Rosagropromizdat, 1990. - P. 29. - 192 p. — ISBN 5-260-00145-1. - Barabanov E.I.
Botany: a textbook for students. higher textbook establishments. - M.: Publishing house. , 2006. - P. 319. - 448 p. — ISBN 5-7695-2656-4. - ↑ 12
Encyclopedic Dictionary of Medicinal, Essential Oil and Poisonous Plants / Comp. G. S. Ogolevets. - M.: Selkhozgiz, 1951. - P. 52-54. — 584 p. - ↑ 1 2 3 4 5 Blinova K. F. et al.
Botanical-pharmacognostic dictionary: Reference. allowance / Under (inaccessible link) ed. K. F. Blinova, G. P. Yakovleva. - M.: Higher. school, 1990. - P. 174-175. — ISBN 5-06-000085-0. Archived copy from April 20, 2014 on the Wayback Machine - Kovaleva N.
G. Treatment with plants: essays on herbal medicine / N. G. Kovaleva. - M.: Medicine, 1972. - P. 201-202. - ↑ 1 2
Search in the drug database, search options: INN -
Valerian medicinal rhizomes with roots
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Circulation of medicines
. Federal State Institution “Scientific Center for Expertise of Medical Products” of Roszdravnadzor of the Russian Federation (May 26, 2009). — A standard clinical and pharmacological article is a by-law and is not protected by copyright in accordance with part four of the Civil Code of the Russian Federation No. 230-FZ of December 18, 2006. Access date: June 28, 2009. Archived September 3, 2011. - Gubanov I.A. et al.
Wild useful plants of the USSR / resp. ed. T. A. Rabotnov. - M.: Mysl, 1976. - P. 16. - 360 p. — (Reference books for geographers and travelers). - ATX code N05CM09 | Valerian roots | ATC classification of medicines 2019
- Clinical pharmacology of valerian preparations and European traditions of their use: the collapse of post-Soviet stereotypes. Review of foreign scientific sources. — Naletov Sergey Vasilievich, Doctor of Medical Sciences, Professor, Head. Department of Clinical Pharmacology, Donetsk State Medical University / Ukrainian Medical Hours, No. 3(71) V-VI 2009
- Donath F. et al.
(2000) Critical Evaluation of the Effect of Valerian Extract on Sleep Structure and Sleep Quality.
// Pharmacopsychiatry
. - No. 33(2). - P. 47-53. PMID10761819 - Abrikosov Kh. N. et al.
Valerian officinalis // Dictionary-reference book for beekeepers / Comp. Fedosov N. F. - M.: Selkhozgiz, 1955. - P. 39. Archival copy dated January 7, 2012 on the Wayback Machine - ↑ 123
All about medicinal plants in your garden beds / Ed. Radelova S. Yu. - St. Petersburg: LLC "SZKEO", 2010. - P. 171. - 224 p. — ISBN 978-5-9603-0124-4. - Valeriana officinalis L. (English). The Plant List (2010).
Version 1. Published on the Internet; https://www.theplantlist.org/ . Royal Botanic Gardens, Kew and Missouri Botanical Garden (2010). Access date: September 19, 2012. Archived October 19, 2012.
Contraindications
Before you start taking this remedy, you should know its medicinal properties and contraindications. You should not take the drug if you have the following conditions and diseases:
- high sensitivity to the components of the drug;
- fructose intolerance;
- lactase deficiency;
- sucrase/isomaltase deficiency;
- glucose-galactose malabsorption;
- first trimester of pregnancy ;
- age up to 3 years.
Pregnant women should take into account the beneficial properties and contraindications and consult a doctor.
Contraindications for valerian and drugs based on it
An absolute contraindication to the use of valerian is the presence of an allergy to it. If it has not been taken before and it is not known how it can affect the body, the first doses should be carried out with a small amount of the product.
Typical signs of allergy upon contact with the product.
Further, valerian is contraindicated for people who are depressed and depressed, as well as people taking other sedatives with similar pharmacological effects.
It is also useful to read: Is it possible to give a cat valerian?
Enterocolitis is also a contraindication, which can be aggravated by the influence of both valerian and the alcohol from its tincture.
This is interesting
Since valerian is included in Corvalol, which is banned in many countries, it is sometimes believed that valerian is banned in Europe, but this is not the case. Valerian is a medicinal product approved in all countries of the world.
Due to the limited data available on the use of valerian in pregnant women and nursing mothers, valerian is contraindicated for this population group, except as directed by the attending physician.
Children under 12 years of age are also contraindicated for valerian, however, in certain cases, the pediatrician may prescribe this drug.
Valerian tincture is not recommended for use by people with liver problems due to the alcohol it contains. Any form of release of valerian is contraindicated for persons before driving vehicles or working with dangerous mechanisms that require increased concentration. In general, any activity that requires increased concentration and performance is incompatible with taking valerian in any form of release.
If you plan to drive home, you should drink valerian upon arrival home
Due to the same decrease in concentration, inhaling valerian essential oil is not recommended for people aged 10 to 65 years, as well as for pregnant and lactating women.
Valerian is quite dangerous for people who combine it with alcohol. This combination can have consequences in the form of loss of consciousness and even coma, leading to cardiac arrest, which is explained by the combination of the relaxing and inhibitory effect of alcohol on the brain with the inhibitory and inhibitory effect of valerian on the nervous system as a whole. Taking valerian tincture in alcohol together with alcohol can lead to chronic liver damage.
Side effects
During treatment, the following side effects of the tablets may occur:
- lethargy;
- drowsiness and decreased performance;
- muscle weakness;
- constipation (if long-term use is practiced).
Sometimes side effects may develop in the form of allergic reactions .
Content
- 1 Botanical description
- 2 Distribution
- 3 Chemical composition
- 4 Meaning and application 4.1 Medicinal use 4.1.1 Pharmacodynamics
- 4.1.2 Pharmacotherapeutic group
- 4.1.3 Dosage forms
- 4.1.4 Results of clinical studies
- 7.1 Synonyms
Valerian extract, instructions for use of tablets (Method and dosage)
The instructions for valerian tablets include taking 1-2 tablets three times a day immediately after meals. If necessary, the dose can be increased, but only under the supervision of a specialist. Treatment should last from 2 to 4 weeks.
The instructions for using valerian tablets provide for repeated courses of therapy if necessary. The dose should not be adjusted for people who have impaired liver or kidney function.
How to take other types of medicine (Bulgarian valerian, brown valerian, etc.) should be checked with the doctor who prescribes the treatment.
The doctor prescribing the treatment regimen should tell you how to take valerian tablets for a certain disease.
Drug interactions
Valerian tablets help enhance the effect of other sedatives, antispasmodics, and sleep aids. Before starting to take the drug, doctors require that you inform them about all the drugs that the patient is taking at the same time. If you do not follow the instructions and recommendations of specialists, then harmless valerian can lead to unpredictable consequences: increased activity or, conversely, stupor, semi-fainting.
It is especially dangerous to combine the product with alcohol. While using this medication, it is better to avoid excessive consumption of coffee, strong tea, and energy drinks, as they may negate the desired effect of the drug.
Overdose of Valerian
The consequences of an overdose of valerian tablets are the manifestation of drowsiness , muscle weakness , lethargy and other signs of depression of the central nervous system.
bradycardia and arrhythmia may occur . As a rule, such symptoms appear when taking large doses of the medicine (doses 20 times or more higher than usual).
However, how many tablets cause such phenomena is individual for each person. The instructions do not indicate a lethal dose of the drug. Whether you can die after a severe overdose depends on the person’s health.
In case of overdose, you must immediately stop the drug, perform gastrointestinal lavage, give the patient activated carbon , as well as magnesium sulfate to prevent intestinal absorption of substances and cause a laxative effect.
There is no specific antidote.
What is Valerian tablets
The product is attractive due to its low price and is very popular among Russians. The drug has the international name Valeriana officinalis. It is available in the form of a liquid tincture, tablets, or is included in other medications with a sedative effect. Valerian is a herbal remedy. In addition to the fact that the drug calms the nervous system, it has a positive effect on the gastrointestinal tract and genitourinary system.
special instructions
You should clearly read the instructions before taking the product in order to compare the benefits and harms of taking the product in each specific case.
If the tablets are used over a long period of time, the effect on a person may lead to a decrease in psychomotor reactions. How long it takes for the drug to act in this way depends on the individual characteristics of the body.
When taking the medicine, you should take into account how valerian acts on a person, so you need to carefully drive vehicles, as well as perform other actions that require accurate reactions.
Another name for the plant is cat grass, as it is called because valerian causes a specific effect on animals. Many people are interested in whether valerian is harmful for cats.
You can find out why cats like this medicine by studying its composition. actinidin in its composition .
As a rule, cats behave in a special way after valerian. But, answering the question whether it is possible to give a dog or whether it is possible to give a cat valerian, it should be noted that sometimes veterinarians even prescribe this drug to cats in small doses in order to increase vitality.
Unlike people, cats are not sedated by this remedy. There have been cases where an overdose led to the death of an animal. Sometimes the lethal dose for a cat is a relatively small amount of the drug, so it is advisable not to keep the tablets in places where animals have access.
If valerian is given in tablets to dogs, the product can provoke allergic reactions .
Does valerian really help?
This question, as a rule, arises among representatives of the new generation, who are accustomed to believing that all effective drugs must certainly be produced abroad and cost more than 500 rubles. Therefore, if you are wondering what valerian tablets help with and whether it has any effect at all, we strongly recommend that you read the information in this section - it will come in handy for you.
What caused the development of doubts around the effectiveness of the drug? Perhaps the fact is that the active substance begins to show activity only 30-40 minutes after ingestion. This is due to the fact that the composition contains essential oils, which resemble dietary supplements. However, it is precisely because of this that valerian does not harm the body and copes with unpleasant symptoms very gently.
Knowing what valerian tablets help with, you can prevent the effects of hysteria or depression. For example, the drug can be taken half an hour before an important exam, so that during the process you can focus on solving an important task and not worry about possible failure. Well, or you can use the pills half an hour before bed to cope with insomnia. So, yes, valerian has an effective effect, but it does so carefully.
Analogs
Level 4 ATC code matches:
Alora
Motherwort Extract
Novo-Passit
Cardiovalen
Liked
Carmolis
Valerian tincture
Lotusonic
Relaxil
Persen Forte
Persen
Phytosed
Sedavit
Motherwort Forte Evalar
Dormiplant
Sondox
Sedafiton
Peony tincture
Menovalen
Bromcamphor
Pharmacies sell a wide variety of valerian-based medications. In particular, these are Valerian P, Himalayan valerian, Bulgarian valerian, etc. There are also a number of drugs with similar indications.
Which is better - Valerian or Motherwort?
When answering the question of which is better - valerian or motherwort, it should be taken into account that the effect of motherwort on the human body is almost the same. However, in the treatment of neuroses and cardiovascular diseases, a more pronounced effect is observed when taking motherwort.
Those who are interested in whether this remedy increases or decreases blood pressure should take into account that when taking motherwort, blood pressure levels decrease.
Botanical description
Botanical illustration from Köhler's Medizinal-Pflanzen
, 1887 Stem with leaves
Valerian officinalis is a perennial herbaceous plant that reaches a height of 1.5 (1.2-1.8[2]) m.
The rhizome is short, thick (up to 4 cm long, up to 3 cm thick), with a loose core, often hollow, with transverse partitions. Numerous thin adventitious roots, sometimes underground shoots - stolons, extend from the rhizome on all sides. The roots are often separated from the rhizome, smooth, brittle, up to 3 cm thick, up to 10-12 cm long. The color of the rhizome and roots on the outside is yellowish-brown, at the break - from yellowish to brown. The smell is strong, aromatic. The taste of the water extract is spicy, sweetish-bitter.
The stem is erect, arched, grooved, and branches closer to the inflorescence. Several stems develop on one bush[2].
Leaves: lower and middle - long-petiolate, upper - sessile, opposite, sometimes alternate or collected in whorls of three or four, pinnately dissected.
The flowers are fragrant, small, up to 4 mm in diameter, bisexual, with a double perianth, white, pale purple or pinkish, collected in large apical and axillary corymbose or paniculate branched inflorescences. The corolla is funnel-shaped, with a five-lobed bend. There are three stamens. It blooms from the second year of life almost all summer[2].
Pollen grains are tricolate, spherical-flattened in shape. The length of the polar axis is 37.4–46.2 µm, the equatorial diameter is 41.8–50.6 µm (without spines). In outline they are rounded-triangular from the pole, and broadly elliptical from the equator. The grooves are 8-12 µm wide, short, the edges are uneven, the ends are blunt; the membrane of the grooves is covered with unevenly granular sculpture. The width of the mesocolpium is 30.8–39.6 µm, the diameter of the apocolpium is 12–18 µm. Exine up to 3 µm thick (without spines), the rod layer is visible. The sculpture is spinous, the spines have a wide base, elongated and finely pointed ends up to 1.5 microns in height. The diameter of the base of the spines is 1–1.2 µm, the distance between them is 1–4 µm. The texture is grainy. The pollen is yellow[2].
Flower formula: ↑ K 0 or ∞ C ( 5 ) A 3 G ( 3 ¯ ) {\displaystyle \uparrow K_{0\;or\;\infty }\;C_{(5)}\;A_{3}\ ;G_{({\overline {3}})}} [3].
The fruit is an achene, ripens in August - September. The weight of a thousand seeds (fruits) is 0.4-0.5 g[4].
Valerian extract during pregnancy and lactation
Whether pregnant women valerian preparations depends on the period of future pregnancy. Valerian tablets are prohibited during pregnancy if the 1st trimester has passed. For pregnant women in later stages (2nd trimester, 3rd trimester), the drug is approved according to strict indications.
As a rule, valerian during pregnancy is prescribed as a relatively safe sedative, since sudden changes in hormonal levels provoke a state of emotional instability in the expectant mother. During pregnancy, valerian can effectively relieve tension.
However, it should be noted that valerian tablets during pregnancy should be taken strictly in the dosage prescribed by the doctor, since an overdose can negatively affect the developing fetus. The question of whether valerian can be taken by pregnant women should initially be discussed individually with a gynecologist.
Valerian can be used during breastfeeding only after the doctor has approved the use of this drug. It should be borne in mind that during breastfeeding, medications pass into breast milk, so the prescribed dosage must be strictly observed.
It is also important to know that when breastfeeding, a woman or baby may experience allergic reactions as a result of taking the drug, and sleep disturbances may occur in the baby. Therefore, when breastfeeding, you can practice taking the extract only according to indications and after prescription.
Features of the use of different valerian preparations
Nowadays you can find many valerian preparations in the pharmacy. Tablets produced by different pharmaceutical companies may not only look different, but also have different compositions, dosages, indications, contraindications and prices.
Let's look at the features of the most common drugs:
- Valerian, produced in Bulgaria by Sopharma, is available in a dosage of 30 mg. Tablets are used in adults and children over 12 years of age, 1-2 tablets 3-4 times a day;
- Valerian Forte, Ukrainian company Arterium, contains 40 mg of active ingredient in 1 tablet. The drug is contraindicated for children under 6 years of age, but for children under 12 years of age it is permitted as prescribed by a doctor in a dosage of up to 3 tablets per day. For adults, the medicine is recommended 1-2 tablets up to three times a day;
- Valerian extract, also produced by Arterium, contains 20 mg of active substance. It is prescribed 1-2 tablets up to four times a day;
- The dietary supplement “Evening dragee” (popularly called night valerian), produced by the Russian company Parapharma, contains extracts of valerian, hop fruits and peppermint. Its dosage is 200 mg. The dietary supplement is taken 1 tablet with meals 3-4 times a day. Due to its hop content, it is contraindicated during pregnancy and breastfeeding;
- Valerian P phytocapsules, also produced by Parapharma, contain vitamin C. Take 2-3 capsules with meals, two to three times a day. The recommended course of treatment with the drug is 14 days;
- The drug "Valerian P", produced in Belarus by the company Amateg, contains 56 mg of valerian extract and 15 mg of ascorbic acid. The drug is recommended for adults and children over 14 years of age, 1-2 tablets up to 4 times a day;
- Valerian extra, also produced by the Belarusian company Amateg, contains a smaller amount of active ingredients: 10 mg of valerian extract, 5 mg of ascorbic acid and 0.007 mg of colloidal silver. They also take 1-2 tablets up to 4 times a day for a course of treatment of up to 14 days;
- Valerian-Belmed, produced by the Belarusian company Belmedpreparaty, contains 200 mg of active substance in 1 tablet. Tablets are taken only as prescribed by a doctor three times a day, maximum 1 tablet;
- Valerian extra, which is produced by the Russian company Biokor, also contains motherwort along with valerian. Tablets at a dosage of 130 mg are taken 1-2 tablets up to three times a day;
- The drug Valerian plus B6, produced by Vneshtorg Pharma, contains 40 mg of valerian extract and 2 mg of vitamin B6. Take the medicine 1 tablet with meals in the morning and evening for one month;
- Valerian extract tablets from the Russian company Evalar contain 20 mg of valerian extract and 5 mg of glycine. They are taken according to the standard scheme.
Glycine is considered a fairly effective and completely safe sedative, an alternative to valerian.
There are many analogues of valerian preparations. How to use them correctly must be discussed with your doctor and also in the instructions for the specific drug.
On a note
Valerian tablets in Russia can be bought for 7-10 rubles per tablet. The average price is 50-60 rubles per package of 30 tablets. Valerian drops are somewhat cheaper. The price for a bottle of alcohol tincture ranges from 15 to 30 rubles.
Reviews
Reviews of valerian tablets, as a rule, indicate that users consider this drug relatively “safe” and very often take it independently, without prescription. As a rule, valerian extract in tablets has a beneficial effect, helping to overcome insomnia, irritability, and survive stressful situations.
Often patients do not know how many tablets to take and exceed the usual dosage. At the same time, drowsiness and lethargy are noted. Whether valerian extract helps calm people often depends on the person's circumstances and condition.
Doctors in the reviews note that before taking it, it is still advisable to consult a doctor, who needs to ask questions about why valerian extract is prescribed, whether a nursing mother can drink this medicine, how much to drink to calm down, why valerian works this way, etc.
How to use
It is important to remember that during the period of use of this drug, the patient may experience slow reactions, absent-mindedness, and inattention. The instructions on how to take Valerian tablets indicate that a long course of treatment may cause slight inhibition. If there is excessive absent-mindedness, you should stop taking valerian root extract.
You can use the product yourself or give it to a child only after a doctor’s prescription, following the following recommendations:
- The tablets are taken after meals.
- There is no need to chew the pills; they are swallowed whole.
- It is important to take the medicine with clean water.
The duration of use of the drug depends on its effectiveness for a particular patient. Courses can be prescribed for 14-30 days, but no more than one and a half months. Long-term use of tablets leads to the development of heartburn, drowsiness, and decreased performance of the patient. If the result from using the pills is not observed within a week, then you should stop taking it and replace the product with another one.
Price, where to buy
How much this drug costs depends on the number of tablets in the package.
The price of valerian tablets is from 70 rubles for 50 pcs.
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Valerian officinalis - what it is, what it looks like
The rhizomes and roots of valerian, namely they are used as raw materials in the pharmaceutical industry, contain essential oil, acids, tannins, and glycosides. The essential oil has a distinct characteristic odor.
Raw materials are harvested in autumn or early spring.
Valerian is available in several dosage forms:
- Briquettes or filter bags containing small pieces of rhizomes, roots or powder from them. They are used for self-preparation of medicinal tincture;
- An alcohol tincture containing at least 65% ethyl alcohol, a dark reddish liquid with a characteristic taste and smell;
- Tablets – valerian extract.
Literature
- Burmistrov A. N., Nikitina V. A.
Honey plants and their pollen: A reference book. - M.: Rosagropromizdat, 1990. - P. 29. - 192 p. — ISBN 5-260-00145-1. - Herzenstein G. M., Transchel V. A.
Valerian // Encyclopedic Dictionary of Brockhaus and Efron: in 86 volumes (82 volumes and 4 additional). - St. Petersburg, 1890-1907. - All about medicinal plants in your garden beds / Ed. Radelova S. Yu. - St. Petersburg: LLC "SZKEO", 2010. - P. 171. - 224 p. — ISBN 978-5-9603-0124-4.
- Gubanov I. A. et al.
1230.
Valeriana officinalis
L. sl (
V. exsaltata
Mikan fil.) - Valerian officinalis // Illustrated guide to plants of Central Russia. In 3 volumes - M.: Scientific T. ed. KMK, Institute of Technology. research, 2004. - T. 3. Angiosperms (dicotyledonous: dicotyledonous). - P. 269. - ISBN 5-87317-163-7. - Ilyushechkina N.V.
Characteristics of cenopopulations of Valeriana officinalis L. on the territory of the Republic of Mari El // Vestn. Kazansk state agrarian un-ta. — Kazan: Kazansk. state agrarian University, 2009. - T. 13, issue. 3. - pp. 126-130. — ISSN 2073-0462. — full text in PDF format, 1574 kb