Corvalol Phyto is a combined sedative and vasodilator in tablets and drops for oral administration. Developed based on plant components.
Indications for the use of Corvalol Phyto (tablets and drops) are:
- Functional disorders of the cardiovascular system
- Neurotic states with accompanying increased irritability
- Sleep disorders
- Cardiopalmus
- Excited state with vegetative disorders
- Intestinal spasms (as an antispasmodic).
Release form and composition
Corvalol Phyto is available in the following dosage forms:
- drops for oral administration: greenish-brown transparent liquid with a characteristic odor, the presence of a suspension in the form of small particles is allowed, sediment may form during storage (25 ml or 50 ml in glass dropper bottles with screw caps, 1 bottle in a cardboard box and instructions for medical use of the drug);
- tablets: flat-cylindrical, round, light brown in color with darker and lighter inclusions, scored and chamfered, have a slight characteristic odor (10 pcs. in blister packs, in a cardboard pack of 1, 2, 3, 4 or 5 blister packs packages and instructions for use of Corvalol Phyto).
Composition of Corvalol Phyto per 1 ml drops for oral administration:
- active ingredients: ethyl ester of alpha-bromoisovaleric acid (ethyl alpha-bromoisovalerate) – 20 mg; peppermint leaf oil – 1.42 mg; tincture of motherwort herb (to obtain 100 ml of motherwort tincture, use 20 g of motherwort herb and 70% ethyl alcohol in sufficient quantity) – 720 mg;
- auxiliary components: purified water.
Composition of Corvalol Phyto per 1 tablet (0.58 mg + 14 mg + 8.2 mg)/(1.16 mg + 28 mg + 16.4 mg):
- active ingredients: ethyl ester of alpha-bromoisovaleric acid (ethyl alpha-bromoisovalerate) – 8.2/16.4 mg; dry extract of motherwort herb – 14/28 mg; peppermint leaf oil – 0.58/1.16 mg;
- auxiliary components: betadex, magnesium aluminum metasilicate, lactose monohydrate, talc, potato starch, magnesium stearate.
Analogs
The issue of replacing Corvalol Phyto with other sedatives should be dealt with by the treating specialist. Group analogues of the drug are: Sodium bromide, Tincture of evasive peony, Valerian extract, Valerian tincture, Motherwort tincture.
Adonis-bromine
Borisov ZMP (Belarus), Vifitech (RF)
Price: table (20 pcs.) – 53 rub., (25 pcs.) – 55 rub.
A complex product with a sedative and cardiotonic effect, developed on the basis of dry extract of adonis and potassium bromide. The drug is prescribed to eliminate unexpressed neuroses, mild forms of circulatory disorders or chronic heart failure.
The drug is produced in coated tablets. It is recommended to take the drug 1 piece three times a day. During treatment, drowsiness, loss of appetite, heart rhythm disturbances, and nausea may occur.
Pros:
- Contains natural substance
- Helps you calm down.
Flaws:
- Not suitable for long-term use.
Valocordin
Krewel Meuselbach (Germany)
Price 1 bottle-drop: (20 ml) – 138 rub., (50 ml) – 259 rub.
Combined drug with a sedative, antispasmodic and mild hypnotic effect. The medication contains phenobarbital, ethyl α-bromoisovalerate, natural mint and hop oils.
The drug can be used for insufficient functioning of the cardiovascular system, neuroses, poor sleep, and nervous agitation.
The medicine is available in drops, which are recommended to be taken before meals, 15-20 drops. three times a day. During therapy, it is better to avoid activities associated with risks to health and life, since the drug can cause drowsiness and dizziness. The duration of the treatment course is determined individually.
Pros:
- Helps you calm down quickly
- Speeds up falling asleep
- Affordable price.
Flaws:
- Causes drug addiction
- Strong smell
- Can't take it for a long time.
Pharmacological properties
Pharmacodynamics
Corvalol Phyto is a complex herbal preparation that has antispasmodic, sedative, moderate hypotensive and slight cardiotonic effects (increases the force of heart contractions and slows down the heart rate).
Ethyl bromizovalerate has a calming and antispasmodic effect. The mechanism of action is due to irritation of receptors (mainly the nasopharynx and oral cavity), increased inhibition in neurons located in the cerebral cortex and subcortical structures, a decrease in reflex excitability in the central nervous system, as well as a direct effect on smooth muscles. The nature of the action of ethyl bromizovalerianate is close to that of valerian-based drugs.
Peppermint oil has antispasmodic, antiseptic, reflex vasodilating and mild choleretic effects. Mint is able to irritate cold receptors located on the mucous membrane of the oral cavity and reflexively dilate blood vessels (mainly the vessels of the brain and heart). In addition, it irritates the receptors of the mucous membranes of the gastrointestinal tract and enhances intestinal motility, thereby reducing increased gas formation (flatulence).
Motherwort has a pronounced sedative effect, exhibits hypotensive activity, and also increases the strength of contractions of the heart muscle and reduces heart rate (heart rate).
Pharmacokinetics
Information on the pharmacokinetic parameters of the drug is not provided.
Contraindications
Absolute:
- severe liver dysfunction;
- exacerbation of erosive and ulcerative lesions of the gastrointestinal tract (for drops);
- severe renal dysfunction;
- children and adolescents up to 18 years of age;
- During pregnancy and breastfeeding;
- lactase enzyme deficiency, glucose-galactose malabsorption syndrome, lactose intolerance (for tablets, since they contain lactose);
- hypersensitivity to the main or auxiliary components of the drug.
Relative (Corvalol Phyto drops and tablets are used with caution, after consulting with your doctor):
- mild to moderate renal dysfunction;
- mild to moderate liver dysfunction;
- brain diseases, traumatic brain injuries, epilepsy, alcoholism (for drops).
Corvalol Phyto, instructions for use: method and dosage
The drug is taken orally, before meals. Corvalol Phyto tablets should be taken with water, and the drops should be pre-dissolved in 30–40 ml of water.
Recommended doses for adults:
- drops for oral administration: 30 drops three times a day;
- tablets 0.58 mg + 14 mg + 8.2 mg: 2 tablets twice a day;
- tablets 1.16 mg + 28 mg + 16.4 mg: 1 tablet twice a day.
In patients with tachycardia, it is possible to increase the single dose of the drug to 3 tablets, while the maximum daily dose should not exceed 6 tablets.
The duration of treatment is 28 days (4 weeks). On the recommendation of a specialist, the duration of the course can be increased.
Is it worth using Corvalol in early and late pregnancy?
The use of all medications during gestation should be approached with caution. Corvalol cannot be an exception in this case. You can take it only after the permission of the doctor, who will indicate the safest method of treatment.
Since one of the components of Corvalol is phenobarbital, its use in the early stages of pregnancy is prohibited . The drug can cause serious developmental disorders: the heart and nervous system of the fetus are especially affected.
In the second and third trimester, one-time use of this remedy is possible on the recommendation of a doctor . Taking Corvalol 2-3 times throughout the entire period in the second half of pregnancy will not cause any particular harm.
Course use of this drug during this period is permissible only under strict indications and under the supervision of doctors.
The use of phenobarbital in the prenatal period can cause breathing problems in the newborn . And the presence of ethyl alcohol can form an alcohol addiction in a child even before he is born.
Peppermint in Kovalol can contribute to the appearance of uterine hypertonicity.
When using Corvalol Phyto, allergies may occur.
Side effects
- digestive system: dyspeptic disorders;
- cardiovascular system: slowing heart rate;
- central nervous system: dizziness, drowsiness, poor concentration, weakness;
- immune system: allergic reactions.
The listed side effects disappear when the dose is reduced or drug therapy is stopped.
With long-term treatment with high doses of Corvalol Phyto, drug dependence may occur. In addition, bromine accumulates in the body and the following signs of bromism may appear: rhinitis, hemorrhagic diathesis, conjunctivitis, apathy, impaired coordination of movements, depressive mood and drug dependence.
If the course of the listed side effects worsens or other adverse reactions not listed in the instructions for the drug occur, you should consult your doctor.
Side effects and overdose
Price: (50 ml) – from 62 rub.
As a rule, the effect of the sedative Corvalol-Phyto is well accepted by most patients, without causing any complaints. But, like any medicine, it can be accompanied by side effects.
- Immune system: manifestation of an individual allergic reaction
- Central NS: daytime drowsiness, lethargy, general weakness, absent-mindedness, dizziness, deterioration in the ability to concentrate
- Gastrointestinal organs: difficult digestion.
Such undesirable manifestations of the properties of the active ingredients disappear after reducing the dosage or discontinuing the medication.
If Corvalol-Phyto is taken for a long course in a high dosage, then patients may develop drug dependence. In addition, bromine accumulates in the body, which contributes to the occurrence of bromism, a condition of chronic poisoning with the substance. As a result, the nervous system and other organs suffer. Characteristic signs of bromism are:
- Depressive state
- Apathy, persistent drowsiness
- Loss of motor coordination, unsteady gait
- Drug addiction
- Pale skin, compactions on the dermis, hemorrhagic diathesis
- Fast weight loss
- MC disorders, erectile dysfunction
- Memory impairment
- Cognitive impairment
- Presence of blood in stool
- Rhinitis
- Tremor of limbs
- Inflammation of the lymph nodes
- Conjunctivitis.
If these or other unfavorable conditions appear during the course of treatment, the patient should contact his doctor.
Oversaturation of the body with Corvalol Phyto occurs as a result of a long course or too frequent use of high dosages. When regularly taking overdoses, dose-dependent side effects of the drug occur.
An overdose is manifested by general weakness, frequent dizziness, and constant drowsiness. Prolonged oversaturation of the body with medicine leads to drug dependence.
To relieve symptoms of overdose, the patient needs to stop taking Corvalol Phyto and undergo symptomatic therapy.
If intoxication is caused by a single dose of a large amount of the drug, then measures are taken to cleanse the stomach and treatment is prescribed according to the patient’s condition.
special instructions
During treatment with Corvalol Fito, you should avoid drinking alcohol.
The drug is not recommended to be taken for a long time or in large doses, since bromine can accumulate in the body and have a toxic effect.
The ethyl alcohol content in Corvalol Phyto drops is 47.5%. The maximum single dose of the drug contains 0.308 g of ethanol, and the maximum daily dose is 0.923 g.
Impact on the ability to drive vehicles and complex mechanisms
Corvalol Phyto can cause dizziness, drowsiness and reduce concentration, therefore, during treatment with the drug, patients should refrain from driving a car or other machinery, as well as any other work that requires high concentration and quick reaction.
Drug during pregnancy
The instructions indicate that Corvalol tablets and drops are contraindicated for use while pregnant.
The use of the drug in the 1st trimester of pregnancy can negatively affect the development of the fetus, and in the 3rd semester it can provoke a disorder of the respiratory system of the newborn.
If there is an urgent need to take the drug during pregnancy, Corvalol can be used in minimal quantities. However, if possible, it is advisable to stop taking the drug.
Reviews of Corvalol Fito
Reviews about Corvalol Phyto are mostly positive. This applies to both oral drops and tablets. Patients note the effectiveness of the product (calms, helps with heart pain, eliminates tachycardia, has a hypnotic effect, fights nervousness and anxiety), ease of use (different release forms), natural composition, cost. The drug acts mildly and, compared to regular Corvalol, does not contain phenobarbital.
Disadvantages include existing contraindications and possible side effects. Thus, while using the product, users complained of headaches and dyspepsia. Sometimes the drug turned out to be ineffective.
How to calm down without pills
The worries and anxieties that a woman experiences during pregnancy can affect the condition of her baby. Therefore, the expectant mother should know a few simple ways to help her quickly calm down:
- Calm walks in the park, slow and deep breathing help you relax and unwind.
- A light massage and soft music improve your well-being.
- A healthy night's sleep and short afternoon naps provide energy and prevent fatigue.
- Any physical activity is good for relieving accumulated tension. Pregnant women can do special gymnastics, exercises with a fitball, and yoga.
In order to avoid the need to urgently take sedatives in tense situations, it is better to engage in prevention. A good preventive measure is auto-training, regular exercises of which help manage your condition and cope with anxiety. Based on personal experience, I can say that several months of such training give impressive results.
