Antaxon - description of the drug, instructions for use, reviews

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Manufacturers: Zambon Laboratorios Farmaceuticos Ltda

Active ingredients

  • Naltrexone

Disease class

  • Mental and behavioral disorders caused by alcohol consumption - dependence syndrome
  • Mental and behavioral disorders caused by opioid use

Clinical and pharmacological group

  • Not indicated. See instructions

Pharmacological action

  • Opiate receptor blocker

Pharmacological group

  • Opioid non-narcotic analgesics
  • Detoxifying agents, including antidotes

Contraindications

According to the annotation for the drug, the use of Antaxon is contraindicated:

  • People taking narcotic analgesics;
  • If the urine test is positive for the presence of opiates or opioids;
  • Without conducting a preliminary provocative test with naloxone;
  • Patients with acute hepatitis;
  • With opioid withdrawal syndrome;
  • Patients with liver failure;
  • If you have hypersensitivity to naltrexone or any auxiliary component of the medication.

Antaxon is prescribed, but with great caution and under special medical supervision to patients who have impaired liver/kidney function.

It is not recommended to prescribe the drug to children and adolescents under 18 years of age, pregnant and breastfeeding women, because There is insufficient data on the effectiveness and safety of its use in this category of patients.

Guide to the boss Zi'ex Dealer in The Other Side

Zi'ex Dealer: Tips and Tricks

Thrash for the Xy'exa dealer is mostly simple and can be suppressed by AoE.

  • Weald Shimmermoth throws the sleep aid Shimmerdust which forces you to keep jumping or you'll fall asleep.
  • Mythresh, Sky's Talons will periodically fear players within 8 yards when casting Wailing Grief.

Dealer Xy'exa Boss Tips and strategy on the other side

Dealer Xi'ex has very few abilities, but they can be lethal if used incorrectly.

Its main mechanic is related to the displacement trap.

  • They are like portals on earth.
  • Stepping into one will teleport you high into the air before landing and taking fall damage.
  • These portals are used to evade Dealer Xi'exa's various mechanics.

The Xi'ex Dealer will periodically cast Localized Explosive Device, planting a bomb on a random player.

  • This player will be marked with a standard bomb timer icon above their head.
  • A couple of seconds before the bomb explodes, this player must fall into the displacement trap.
  • This will cause a bomb to explode above each player's head.

Dealer Xi'exa also periodically uses Explosive Device.

  • After a long cast, it will cause a lot of damage to anyone still on the ground.
  • About 2-3 seconds before the cast ends, all players
    must jump into the displacement trap to avoid the attack.

Directions for use and dosage

The first stage of Antaxon treatment for heroin addiction is the administration phase.

Therapy begins at least 7 days after the last use of the drug (as determined by urine analysis), provided that all symptoms of withdrawal syndrome are absent.

Next, a so-called provocative test is necessarily carried out with intravenous administration of 500 mcg of naloxone (if there is a need to repeat the test, a 24-hour interval is observed).

As soon as the provocative test shows a negative result, the patient is given the first dose of Antaxon in the amount of 20 mg. After one hour, provided that the patient does not show signs of withdrawal syndrome, another 30 mg is given - the remainder of the daily dose.

The second stage of treatment with Antaxon is maintenance therapy. It is carried out according to one of the following schemes:

  • 50 mg of naltrexone (1 capsule) once a day;
  • 50 mg during the first five days, 100 mg on day 6, then repeat;
  • 100 mg every two days or 150 mg every three days and repeat again.

Patients with a long-term deprivation of narcotic substances are recommended to adhere to the following treatment regimen: on the first and second days of maintenance therapy - 100 mg, then on the fifth day - 150 mg, etc.

Note: one capsule of Antaxon (50 mg of naltrexone) is enough to block the effect of 25 mg of heroin administered intravenously.

The minimum recommended course of maintenance therapy is 6 months, the minimum acceptable is 3 months.

For chronic alcoholism, Antaxon, according to the instructions, is prescribed after a naloxone test, in the absence of signs of withdrawal syndrome: 1 capsule once a day for at least 3 months.

Release form and composition

Antaxone is produced in the form of hard gelatin capsules with a blue cap and an opaque body, which are filled with white powder inside, with the inscription “Antaxone® 50” on the cap and the company’s trademark on the body, 10 pieces each. in blisters.

One capsule contains 50 mg of naltrexone hydrochloride and excipients - magnesium stearate, indigo carmine, lactose monohydrate, gelatin and titanium dioxide.

Antaxon is also produced in the form of a transparent yellowish solution with a characteristic odor, 10 and 20 ml in bottles.

10 ml of the product contains 50 mg of naltrexone hydrochloride and such excipients as:

  • Aromatic bitterness No. 1631;
  • Sorbitol 70%;
  • Methyl parahydroxybenzoate;
  • Propyl parahydroxybenzoate;
  • Saccharin;
  • Purified water.

Side effects

According to numerous reviews, when the doctor-recommended dosages of Antaxon are followed, serious adverse reactions do not occur in patients who do not have opioids in their bodies.

However, in some cases the drug has side effects:

  • In more than 10% of cases, the following are observed: nausea, weakness, pain in the abdomen, muscles and joints, increased irritability, vomiting, anxiety, sleep disturbances;
  • Less than 10% of patients experience: dizziness, diarrhea, loss of appetite, constipation, skin rashes, psychomotor agitation, delayed ejaculation and/or decreased sexual potency;
  • In individual cases, photophobia, hallucinations, increased fatigue, cough, depression, confusion, and nightmares are possible.

When conducting laboratory tests, lymphocytosis and increased transaminase activity are sometimes observed.

It is important to note that all the described negative reactions of the body were observed in patients both during the use of Antaxon and before the start of therapy, and therefore these symptoms cannot be unambiguously considered as side effects of the drug.

Dungeon Mining That Side

Armor and weapons

Hakkar the Soul Slayer
TypeParagraphStatistics
KeychainBlood Spattered ScalesAGI-STR
Leg fabricMoccasins WindscaleINT-STA, Crete / Version
Leather LegsSoul Feather PantsAGI-INT, Acceleration/Mast
Postal handsHakkari Ghost GripsAGI-INT, Crit/Speed
Plate WaistSoul Slayer GirdleSTR-INT, Speed ​​/ Version
1H swordBloodspillerAGI, Crit/Vers
2H swordZin'has, Blade of the Fallen GodSTR
Manastorm
TypeParagraphStatistics
KeychainCrystal of Suppressive PowerSTR
Cloth chestMagnificent Threads of ManastormINT, Crete / Ver
Leather HandsRocket chicken handlersAGI-INT, Crete / Mast
Postal feetTechno-Spiral GaitersAGI-INT, Acceleration/Mast
Foot plateDynamo DoomstompersSTR-INT, crit/speed
StaffWhizblast caneINT, Vers/Mast
1H MaceSuper colliderSTR, Crete / Mast
Dealer Xy'exa
TypeParagraphStatistics
KeychainAn Incomprehensible Quantum DeviceAGI/INT/STR
CloakTrader Xi'exa's CapeAGI / INT / STR, Vers / Mast
Fabric WaistSash of Exquisite AcquisitionsINT, Vers/Mast
Leather ShouldersFarstrider's ShoulderpadsAGI-INT, Crit/Vers
Mail ShouldersWanderers of the Dimensional RiftAGI-INT, Crit/Speed
Plate ChestBreastplate of Fatal InventionsSTR-INT, crit/speed
StaffCollector's Pulse StaffAGI, Haste/Vers
CrossbowXy Cartel CrossbowAGI, Crete / Mast
Mueh'zala
TypeParagraphStatistics
RingRing of the God of DeathSTA Haste/Mast
KeychainShadow Grasp TotemA.G.I.
Fabric LegsMueh'zala's wavy sarongINT Acceleration/Mast
Leather LegsLegguards of the Primordial SoulAGI-INT Crit/Mast
MailboxHarness of Perverted Whims[td] AGI-INT Crit/Haste
Plate WristsReality-Breaking BracersSTR-INT Crit/Vers

Pipelines

Hakkar the Soul Slayer
ClassParagraphSpell ID
Druid GuideDark intensityDark intensity
Monk GuideNourishing QiNourishing Qi
Rogue GuideWell placed steelWell placed steel
Shamanic GuideRestless windsRestless winds
Manastorm
ClassParagraphSpell ID
Magic ConductorArcane MiracleArcane Miracle
Warlock GuideBorne of BloodBorne of Blood
Dealer Xy'exa
ClassParagraphSpell ID
Hunting guideFlask of FlameFlask of Flame
Rogue GuideSleight of handSleight of hand
Warrior GuideShow of forceShow of force
Mueh'zala
ClassParagraphSpell ID
Druid GuideFlower processingFlower processing
Monk GuideInner RageInner Rage
Paladin GuideDetermined DefenderDetermined Defender (Stamina)
Priest GuideMind FlayerMind Flayer
Shamanic GuideShowerShower
Warlock GuideRolling agonyRolling agony

Legendary Recipes

Manastorm
ClassParagraphSpell ID
Legendary Demon Hunter RecipeMemories of the Blight BombingFel Bombardment
MageLegendary recipeMemories of an endless mysteryArcane Harmony
Dealer Xy'exa
ClassParagraphSpell ID
Legendary Hunter RecipeMemories of a cluster of forest firesWildfire Cluster
Mueh'zala
ClassParagraphSpell ID
Legendary Monk RecipeMemories of a Deadly TouchDeath Touch
Legendary Priest RecipeMemories of the Prism of Shadow and FireShadow Flame Prism
Legendary shaman recipeMemory of the Great SchismEchoes of the Great Schism

Vanity Items

Mueh'zala
TypeParagraphRestrictions
soulshapeSoul of the LizardNight fairies

special instructions

If the patient is undergoing surgery with the use of opioid analgesics, the last Antaxon capsule should be taken no later than 48 hours before.

Each person receiving treatment with a drug containing naltrexone should carry a prescription card with them, which is required to inform health care providers in cases where they need emergency care. If the patient requires overcoming opioid receptor blockade (for example, during induction of anesthesia or pain relief in an emergency), high doses of short-acting opioid analgesics should be used. This reduces the risk of respiratory depression of the patient and vascular collapse.

When Antaxon is used in doses recommended by the doctor, the drug does not have a negative effect on the speed of psychomotor reactions and visual acuity.

Antaxone capsule

Instructions for medical use of the drug

Description of pharmacological action

Competitively binds to opioid receptors of all types and prevents or eliminates the effect of both endogenous opioids and exogenous opioid drugs - narcotic analgesics and their surrogates.

Indications for use

Opioid addiction (dependence) - with the aim of maintaining a patient’s condition in which opioids cannot have a characteristic effect (as part of complex therapy). The drug is prescribed only after the withdrawal syndrome has stopped. The use of Antaxon begins in specialized drug addiction treatment units 7–10 days after the last use of an opioid drug. In the future, the patient should be under strict medical supervision. The patient must have a positive attitude toward drug addiction treatment. Alcoholism (as part of complex therapy), including with maintenance therapy in the same dosages as for heroin addiction during psychotherapy.

Release form

capsules 50 mg; blister 10, cardboard pack 1.

Pharmacodynamics

It does not have significant pharmacological properties of its own, with the exception of some constriction of the pupil. At a dose of 50 mg, Antaxon blocks the pharmacological effects caused by intravenous administration of 25 mg of heroin for 24 hours. When doubling the dose of the drug, the effect is extended to 48 hours, when tripling it - up to 72 hours. By administering opioids in increased doses, the effect of Antaxon can be weakened or eliminated. Antaxon does not cause addiction or drug dependence.

Pharmacokinetics

It is well absorbed after oral administration and is 95% metabolized in the liver to form pharmacologically active metabolites. The main metabolite, 6-beta-naltrexone, also has the properties of a competitive opioid antagonist. In addition, 2-hydroxy-3-methoxy-6-beta-naltrexone is formed. Cmax of naltrexone and 6-beta-naltrexone in blood plasma is achieved after 1 hour. It penetrates well through histohematic barriers, the volume of distribution is 1350 l. T1/2 for naltrexone is 4 hours, for its metabolite 6-beta-naltrexone is 13 hours, which explains its ability to cumulate. Antaxon and its metabolites undergo enterohepatic recirculation. It is excreted through the kidneys unchanged (about 1%) and metabolized (38% as free and bound 6-beta-naltrexone).

Use during pregnancy

Contraindicated during pregnancy. Breastfeeding should be stopped during treatment.

Contraindications for use

History of hypersensitivity to naltrexone drugs; use of narcotic analgesics or a positive urine test for opioids; lack of data on conducting a provocative test with naloxone (see “Method of administration and dosage”); acute hepatitis or liver failure; age under 18 years (safety of use has not been established); pregnancy, breastfeeding.

Side effects

In therapeutic doses in patients whose bodies do not contain opioids, Antaxon usually does not cause serious side effects. It should be borne in mind that with a frequency of more than 10%, sleep disturbance, anxiety, nervousness, abdominal pain, nausea, vomiting, weakness, headache, pain in muscles and joints are observed; less than 10% - loss of appetite, constipation or diarrhea, psychomotor agitation, dizziness, skin rashes, chills, decreased potency, delayed ejaculation. The noted symptoms occurred with equal frequency both before the start of treatment and during the use of Antaxon. In isolated cases - increased fatigue, confusion, depression, hallucinations and nightmares, photophobia, cough. During laboratory diagnostics, it is possible to increase the level of transaminases in the blood and lymphocytosis. One case of idiopathic thrombocytopenic purpura was described in a patient who may have been sensitized to Antaxon during previous treatment (recovery occurred after discontinuation of the drug and a course of corticosteroid therapy).

Directions for use and doses

Treatment of heroin addiction Introduction phase of Antaxon therapy Treatment can be started no earlier than 7-10 days after the last dose of an opioid analgesic and provided there are no signs of withdrawal syndrome. Abstinence from drug use is determined by urine testing for opioids. Treatment is not started until a provocative test with 0.5 mg naloxone administered intravenously becomes negative. The naloxone test is not performed in patients with signs of withdrawal syndrome or when opioids are detected in the urine. The naloxone test can be repeated after 24 hours. The first dose of Antaxon is usually 20 mg in the form of a solution. If there are no signs of withdrawal syndrome within an hour, the patient is given the remainder (30 mg) of the daily dose of the drug. The doctor should monitor the act of swallowing the drug solution. Maintenance therapy with Antaxon Antaxon is prescribed 50 mg every 24 hours (this dose is sufficient to prevent the effects of IV heroin administered at a dose of 25 mg). Other treatment regimens can be used: 1. 50 mg daily for the first 5 days of the week and 100 mg on Saturday. 2. 100 mg every 2 days or 150 mg every 3 days. 3. 100 mg on Monday, 100 mg on Tuesday and 150 mg on Friday. This regimen is convenient for patients with long-term opioid deprivation. The minimum course is 3 months, the recommended course is 6 months. Treatment of alcoholism Daily - 50 mg, minimum course - 3 months. Treatment is not started until a naloxone test has been performed to rule out the presence of opioids in the body.

Overdose

If poisoning is suspected, symptomatic therapy should be prescribed and contact a specialized medical institution.

Interactions with other drugs

Some drugs containing opioids (antitussives, antidiarrheals, narcotic analgesics) may reduce the effect of Antaxon. In these cases, alternative medications that do not contain opioids should be used. Hepatotoxic drugs increase the risk of liver damage. Cases of incompatibility with other drugs have not been described.

Precautions for use

The drug should be discontinued at least 48 hours before surgery that requires the use of opioid analgesics. The patient must have an Antaxon prescription card with him for the information of other health care workers in case of emergency care. If it is necessary to overcome the blockade of opioid receptors (anesthesia, pain relief in emergency cases), increased doses of short-acting opioid analgesics should be used to reduce the risk of respiratory and circulatory depression.

Special instructions for use

In recommended doses, it does not affect work requiring quick reactions or driving.

Storage conditions

List B: Under normal conditions.

Best before date

24 months

ATX classification:

N Nervous system

N07 Other drugs for the treatment of diseases of the nervous system

N07B Drugs used for psychological or physiological dependence on various substances

N07BB Drugs used for alcohol dependence

N07BB04 Naltrexone

List of all trash creatures and abilities in The Other Side

MobSpelling
Risen CultistDark Lotus
Scribe
Risen Bone Soldierbonestrike
Troll
The rebel commanderReaver
Immortal Fury
Skeletal lizardDecrepit Bite
Talking DeathShadowcore
Explosive Darkness
Embrace of Death
Initiated by Atal'aiDedicated sacrifice
Son of HakkarBlood Nova
Spilled Essence
Zealous
Atal'ai High PriestHit
Resume
Shadow Word: Pain
Heal
Atal'ai hoodoo curserLightning strike
Wave of Healing
Hex
Atal'ai DeathBleeding wound
Bladestorm
Angry SpiritFurious Mask
Fury
Defunct dental drillHaywire
4.RF-4.RFMetal jaws
W-00F
Headless clientDischarge
Rotation up
Additional threads
Volatile memoryUnstable capacitor
LubricatorLubricate
Self-cleaning cycle
Reasonable oilOil splashes
Essential oil
Weald ShimmermothSleeping Powder Shimmer Dust
Sleeping Powder Shimmer Dust
Juvenile Runestag
Runestag StarhornAnima Star Storm
Spriggan Mendbender
Spriggan BarkbinderBark armor
Soothing Mists
Territorial bladebillBeak cut
Mithresh, Claws of the Skyclaw rake
Crying grief
Furious Suffering
Bladebeak MatriarchBeak cut
Evil scream
Enrage
Baby RazorbillFrightened screams

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