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Manufacturers: Zambon Laboratorios Farmaceuticos Ltda
Active ingredients
- Naltrexone
Disease class
- Mental and behavioral disorders caused by alcohol consumption - dependence syndrome
- Mental and behavioral disorders caused by opioid use
Clinical and pharmacological group
- Not indicated. See instructions
Pharmacological action
- Opiate receptor blocker
Pharmacological group
- Opioid non-narcotic analgesics
- Detoxifying agents, including antidotes
Contraindications
According to the annotation for the drug, the use of Antaxon is contraindicated:
- People taking narcotic analgesics;
- If the urine test is positive for the presence of opiates or opioids;
- Without conducting a preliminary provocative test with naloxone;
- Patients with acute hepatitis;
- With opioid withdrawal syndrome;
- Patients with liver failure;
- If you have hypersensitivity to naltrexone or any auxiliary component of the medication.
Antaxon is prescribed, but with great caution and under special medical supervision to patients who have impaired liver/kidney function.
It is not recommended to prescribe the drug to children and adolescents under 18 years of age, pregnant and breastfeeding women, because There is insufficient data on the effectiveness and safety of its use in this category of patients.
Guide to the boss Zi'ex Dealer in The Other Side
Zi'ex Dealer: Tips and Tricks
Thrash for the Xy'exa dealer is mostly simple and can be suppressed by AoE.
- Weald Shimmermoth throws the sleep aid Shimmerdust which forces you to keep jumping or you'll fall asleep.
- Mythresh, Sky's Talons will periodically fear players within 8 yards when casting Wailing Grief.
Dealer Xy'exa Boss Tips and strategy on the other side
Dealer Xi'ex has very few abilities, but they can be lethal if used incorrectly.
Its main mechanic is related to the displacement trap.
- They are like portals on earth.
- Stepping into one will teleport you high into the air before landing and taking fall damage.
- These portals are used to evade Dealer Xi'exa's various mechanics.
The Xi'ex Dealer will periodically cast Localized Explosive Device, planting a bomb on a random player.
- This player will be marked with a standard bomb timer icon above their head.
- A couple of seconds before the bomb explodes, this player must fall into the displacement trap.
- This will cause a bomb to explode above each player's head.
Dealer Xi'exa also periodically uses Explosive Device.
- After a long cast, it will cause a lot of damage to anyone still on the ground.
- About 2-3 seconds before the cast ends, all players
must jump into the displacement trap to avoid the attack.
Directions for use and dosage
The first stage of Antaxon treatment for heroin addiction is the administration phase.
Therapy begins at least 7 days after the last use of the drug (as determined by urine analysis), provided that all symptoms of withdrawal syndrome are absent.
Next, a so-called provocative test is necessarily carried out with intravenous administration of 500 mcg of naloxone (if there is a need to repeat the test, a 24-hour interval is observed).
As soon as the provocative test shows a negative result, the patient is given the first dose of Antaxon in the amount of 20 mg. After one hour, provided that the patient does not show signs of withdrawal syndrome, another 30 mg is given - the remainder of the daily dose.
The second stage of treatment with Antaxon is maintenance therapy. It is carried out according to one of the following schemes:
- 50 mg of naltrexone (1 capsule) once a day;
- 50 mg during the first five days, 100 mg on day 6, then repeat;
- 100 mg every two days or 150 mg every three days and repeat again.
Patients with a long-term deprivation of narcotic substances are recommended to adhere to the following treatment regimen: on the first and second days of maintenance therapy - 100 mg, then on the fifth day - 150 mg, etc.
Note: one capsule of Antaxon (50 mg of naltrexone) is enough to block the effect of 25 mg of heroin administered intravenously.
The minimum recommended course of maintenance therapy is 6 months, the minimum acceptable is 3 months.
For chronic alcoholism, Antaxon, according to the instructions, is prescribed after a naloxone test, in the absence of signs of withdrawal syndrome: 1 capsule once a day for at least 3 months.
Release form and composition
Antaxone is produced in the form of hard gelatin capsules with a blue cap and an opaque body, which are filled with white powder inside, with the inscription “Antaxone® 50” on the cap and the company’s trademark on the body, 10 pieces each. in blisters.
One capsule contains 50 mg of naltrexone hydrochloride and excipients - magnesium stearate, indigo carmine, lactose monohydrate, gelatin and titanium dioxide.
Antaxon is also produced in the form of a transparent yellowish solution with a characteristic odor, 10 and 20 ml in bottles.
10 ml of the product contains 50 mg of naltrexone hydrochloride and such excipients as:
- Aromatic bitterness No. 1631;
- Sorbitol 70%;
- Methyl parahydroxybenzoate;
- Propyl parahydroxybenzoate;
- Saccharin;
- Purified water.
Side effects
According to numerous reviews, when the doctor-recommended dosages of Antaxon are followed, serious adverse reactions do not occur in patients who do not have opioids in their bodies.
However, in some cases the drug has side effects:
- In more than 10% of cases, the following are observed: nausea, weakness, pain in the abdomen, muscles and joints, increased irritability, vomiting, anxiety, sleep disturbances;
- Less than 10% of patients experience: dizziness, diarrhea, loss of appetite, constipation, skin rashes, psychomotor agitation, delayed ejaculation and/or decreased sexual potency;
- In individual cases, photophobia, hallucinations, increased fatigue, cough, depression, confusion, and nightmares are possible.
When conducting laboratory tests, lymphocytosis and increased transaminase activity are sometimes observed.
It is important to note that all the described negative reactions of the body were observed in patients both during the use of Antaxon and before the start of therapy, and therefore these symptoms cannot be unambiguously considered as side effects of the drug.
Dungeon Mining That Side
Armor and weapons
Hakkar the Soul Slayer
Type | Paragraph | Statistics |
Keychain | Blood Spattered Scales | AGI-STR |
Leg fabric | Moccasins Windscale | INT-STA, Crete / Version |
Leather Legs | Soul Feather Pants | AGI-INT, Acceleration/Mast |
Postal hands | Hakkari Ghost Grips | AGI-INT, Crit/Speed |
Plate Waist | Soul Slayer Girdle | STR-INT, Speed / Version |
1H sword | Bloodspiller | AGI, Crit/Vers |
2H sword | Zin'has, Blade of the Fallen God | STR |
Manastorm
Type | Paragraph | Statistics |
Keychain | Crystal of Suppressive Power | STR |
Cloth chest | Magnificent Threads of Manastorm | INT, Crete / Ver |
Leather Hands | Rocket chicken handlers | AGI-INT, Crete / Mast |
Postal feet | Techno-Spiral Gaiters | AGI-INT, Acceleration/Mast |
Foot plate | Dynamo Doomstompers | STR-INT, crit/speed |
Staff | Whizblast cane | INT, Vers/Mast |
1H Mace | Super collider | STR, Crete / Mast |
Dealer Xy'exa
Type | Paragraph | Statistics |
Keychain | An Incomprehensible Quantum Device | AGI/INT/STR |
Cloak | Trader Xi'exa's Cape | AGI / INT / STR, Vers / Mast |
Fabric Waist | Sash of Exquisite Acquisitions | INT, Vers/Mast |
Leather Shoulders | Farstrider's Shoulderpads | AGI-INT, Crit/Vers |
Mail Shoulders | Wanderers of the Dimensional Rift | AGI-INT, Crit/Speed |
Plate Chest | Breastplate of Fatal Inventions | STR-INT, crit/speed |
Staff | Collector's Pulse Staff | AGI, Haste/Vers |
Crossbow | Xy Cartel Crossbow | AGI, Crete / Mast |
Mueh'zala
Type | Paragraph | Statistics |
Ring | Ring of the God of Death | STA Haste/Mast |
Keychain | Shadow Grasp Totem | A.G.I. |
Fabric Legs | Mueh'zala's wavy sarong | INT Acceleration/Mast |
Leather Legs | Legguards of the Primordial Soul | AGI-INT Crit/Mast |
Mailbox | Harness of Perverted Whims | [td] AGI-INT Crit/Haste |
Plate Wrists | Reality-Breaking Bracers | STR-INT Crit/Vers |
Pipelines
Hakkar the Soul Slayer
Class | Paragraph | Spell ID |
Druid Guide | Dark intensity | Dark intensity |
Monk Guide | Nourishing Qi | Nourishing Qi |
Rogue Guide | Well placed steel | Well placed steel |
Shamanic Guide | Restless winds | Restless winds |
Manastorm
Class | Paragraph | Spell ID |
Magic Conductor | Arcane Miracle | Arcane Miracle |
Warlock Guide | Borne of Blood | Borne of Blood |
Dealer Xy'exa
Class | Paragraph | Spell ID |
Hunting guide | Flask of Flame | Flask of Flame |
Rogue Guide | Sleight of hand | Sleight of hand |
Warrior Guide | Show of force | Show of force |
Mueh'zala
Class | Paragraph | Spell ID |
Druid Guide | Flower processing | Flower processing |
Monk Guide | Inner Rage | Inner Rage |
Paladin Guide | Determined Defender | Determined Defender (Stamina) |
Priest Guide | Mind Flayer | Mind Flayer |
Shamanic Guide | Shower | Shower |
Warlock Guide | Rolling agony | Rolling agony |
Legendary Recipes
Manastorm
Class | Paragraph | Spell ID |
Legendary Demon Hunter Recipe | Memories of the Blight Bombing | Fel Bombardment |
MageLegendary recipe | Memories of an endless mystery | Arcane Harmony |
Dealer Xy'exa
Class | Paragraph | Spell ID |
Legendary Hunter Recipe | Memories of a cluster of forest fires | Wildfire Cluster |
Mueh'zala
Class | Paragraph | Spell ID |
Legendary Monk Recipe | Memories of a Deadly Touch | Death Touch |
Legendary Priest Recipe | Memories of the Prism of Shadow and Fire | Shadow Flame Prism |
Legendary shaman recipe | Memory of the Great Schism | Echoes of the Great Schism |
Vanity Items
Mueh'zala
Type | Paragraph | Restrictions |
soulshape | Soul of the Lizard | Night fairies |
special instructions
If the patient is undergoing surgery with the use of opioid analgesics, the last Antaxon capsule should be taken no later than 48 hours before.
Each person receiving treatment with a drug containing naltrexone should carry a prescription card with them, which is required to inform health care providers in cases where they need emergency care. If the patient requires overcoming opioid receptor blockade (for example, during induction of anesthesia or pain relief in an emergency), high doses of short-acting opioid analgesics should be used. This reduces the risk of respiratory depression of the patient and vascular collapse.
When Antaxon is used in doses recommended by the doctor, the drug does not have a negative effect on the speed of psychomotor reactions and visual acuity.
Antaxone capsule
Instructions for medical use of the drug
Description of pharmacological action
Competitively binds to opioid receptors of all types and prevents or eliminates the effect of both endogenous opioids and exogenous opioid drugs - narcotic analgesics and their surrogates.
Indications for use
Opioid addiction (dependence) - with the aim of maintaining a patient’s condition in which opioids cannot have a characteristic effect (as part of complex therapy). The drug is prescribed only after the withdrawal syndrome has stopped. The use of Antaxon begins in specialized drug addiction treatment units 7–10 days after the last use of an opioid drug. In the future, the patient should be under strict medical supervision. The patient must have a positive attitude toward drug addiction treatment. Alcoholism (as part of complex therapy), including with maintenance therapy in the same dosages as for heroin addiction during psychotherapy.
Release form
capsules 50 mg; blister 10, cardboard pack 1.
Pharmacodynamics
It does not have significant pharmacological properties of its own, with the exception of some constriction of the pupil. At a dose of 50 mg, Antaxon blocks the pharmacological effects caused by intravenous administration of 25 mg of heroin for 24 hours. When doubling the dose of the drug, the effect is extended to 48 hours, when tripling it - up to 72 hours. By administering opioids in increased doses, the effect of Antaxon can be weakened or eliminated. Antaxon does not cause addiction or drug dependence.
Pharmacokinetics
It is well absorbed after oral administration and is 95% metabolized in the liver to form pharmacologically active metabolites. The main metabolite, 6-beta-naltrexone, also has the properties of a competitive opioid antagonist. In addition, 2-hydroxy-3-methoxy-6-beta-naltrexone is formed. Cmax of naltrexone and 6-beta-naltrexone in blood plasma is achieved after 1 hour. It penetrates well through histohematic barriers, the volume of distribution is 1350 l. T1/2 for naltrexone is 4 hours, for its metabolite 6-beta-naltrexone is 13 hours, which explains its ability to cumulate. Antaxon and its metabolites undergo enterohepatic recirculation. It is excreted through the kidneys unchanged (about 1%) and metabolized (38% as free and bound 6-beta-naltrexone).
Use during pregnancy
Contraindicated during pregnancy. Breastfeeding should be stopped during treatment.
Contraindications for use
History of hypersensitivity to naltrexone drugs; use of narcotic analgesics or a positive urine test for opioids; lack of data on conducting a provocative test with naloxone (see “Method of administration and dosage”); acute hepatitis or liver failure; age under 18 years (safety of use has not been established); pregnancy, breastfeeding.
Side effects
In therapeutic doses in patients whose bodies do not contain opioids, Antaxon usually does not cause serious side effects. It should be borne in mind that with a frequency of more than 10%, sleep disturbance, anxiety, nervousness, abdominal pain, nausea, vomiting, weakness, headache, pain in muscles and joints are observed; less than 10% - loss of appetite, constipation or diarrhea, psychomotor agitation, dizziness, skin rashes, chills, decreased potency, delayed ejaculation. The noted symptoms occurred with equal frequency both before the start of treatment and during the use of Antaxon. In isolated cases - increased fatigue, confusion, depression, hallucinations and nightmares, photophobia, cough. During laboratory diagnostics, it is possible to increase the level of transaminases in the blood and lymphocytosis. One case of idiopathic thrombocytopenic purpura was described in a patient who may have been sensitized to Antaxon during previous treatment (recovery occurred after discontinuation of the drug and a course of corticosteroid therapy).
Directions for use and doses
Treatment of heroin addiction Introduction phase of Antaxon therapy Treatment can be started no earlier than 7-10 days after the last dose of an opioid analgesic and provided there are no signs of withdrawal syndrome. Abstinence from drug use is determined by urine testing for opioids. Treatment is not started until a provocative test with 0.5 mg naloxone administered intravenously becomes negative. The naloxone test is not performed in patients with signs of withdrawal syndrome or when opioids are detected in the urine. The naloxone test can be repeated after 24 hours. The first dose of Antaxon is usually 20 mg in the form of a solution. If there are no signs of withdrawal syndrome within an hour, the patient is given the remainder (30 mg) of the daily dose of the drug. The doctor should monitor the act of swallowing the drug solution. Maintenance therapy with Antaxon Antaxon is prescribed 50 mg every 24 hours (this dose is sufficient to prevent the effects of IV heroin administered at a dose of 25 mg). Other treatment regimens can be used: 1. 50 mg daily for the first 5 days of the week and 100 mg on Saturday. 2. 100 mg every 2 days or 150 mg every 3 days. 3. 100 mg on Monday, 100 mg on Tuesday and 150 mg on Friday. This regimen is convenient for patients with long-term opioid deprivation. The minimum course is 3 months, the recommended course is 6 months. Treatment of alcoholism Daily - 50 mg, minimum course - 3 months. Treatment is not started until a naloxone test has been performed to rule out the presence of opioids in the body.
Overdose
If poisoning is suspected, symptomatic therapy should be prescribed and contact a specialized medical institution.
Interactions with other drugs
Some drugs containing opioids (antitussives, antidiarrheals, narcotic analgesics) may reduce the effect of Antaxon. In these cases, alternative medications that do not contain opioids should be used. Hepatotoxic drugs increase the risk of liver damage. Cases of incompatibility with other drugs have not been described.
Precautions for use
The drug should be discontinued at least 48 hours before surgery that requires the use of opioid analgesics. The patient must have an Antaxon prescription card with him for the information of other health care workers in case of emergency care. If it is necessary to overcome the blockade of opioid receptors (anesthesia, pain relief in emergency cases), increased doses of short-acting opioid analgesics should be used to reduce the risk of respiratory and circulatory depression.
Special instructions for use
In recommended doses, it does not affect work requiring quick reactions or driving.
Storage conditions
List B: Under normal conditions.
Best before date
24 months
ATX classification:
N Nervous system
N07 Other drugs for the treatment of diseases of the nervous system
N07B Drugs used for psychological or physiological dependence on various substances
N07BB Drugs used for alcohol dependence
N07BB04 Naltrexone
List of all trash creatures and abilities in The Other Side
Mob | Spelling |
Risen Cultist | Dark Lotus |
Scribe | |
Risen Bone Soldier | bonestrike |
Troll | |
The rebel commander | Reaver |
Immortal Fury | |
Skeletal lizard | Decrepit Bite |
Talking Death | Shadowcore |
Explosive Darkness | |
Embrace of Death | |
Initiated by Atal'ai | Dedicated sacrifice |
Son of Hakkar | Blood Nova |
Spilled Essence | |
Zealous | |
Atal'ai High Priest | Hit |
Resume | |
Shadow Word: Pain | |
Heal | |
Atal'ai hoodoo curser | Lightning strike |
Wave of Healing | |
Hex | |
Atal'ai Death | Bleeding wound |
Bladestorm | |
Angry Spirit | Furious Mask |
Fury | |
Defunct dental drill | Haywire |
4.RF-4.RF | Metal jaws |
W-00F | |
Headless client | Discharge |
Rotation up | |
Additional threads | |
Volatile memory | Unstable capacitor |
Lubricator | Lubricate |
Self-cleaning cycle | |
Reasonable oil | Oil splashes |
Essential oil | |
Weald Shimmermoth | Sleeping Powder Shimmer Dust |
Sleeping Powder Shimmer Dust | |
Juvenile Runestag | |
Runestag Starhorn | Anima Star Storm |
Spriggan Mendbender | |
Spriggan Barkbinder | Bark armor |
Soothing Mists | |
Territorial bladebill | Beak cut |
Mithresh, Claws of the Sky | claw rake |
Crying grief | |
Furious Suffering | |
Bladebeak Matriarch | Beak cut |
Evil scream | |
Enrage | |
Baby Razorbill | Frightened screams |
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WoW Shadowlands