Lomilan - description of the drug, instructions for use, reviews

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Manufacturers: Lek

Active ingredients

• Loratadine

Disease class

• Acute atopic conjunctivitis
• Vasomotor and allergic rhinitis
• Chronic rhinitis, nasopharyngitis and pharyngitis
• Asthma
• Asthma with a predominance of an allergic component
• Atopic dermatitis
• Allergic contact dermatitis
• Itching
• Hives
• Angioedema
• Allergy unspecified

Clinical and pharmacological group

• Not indicated. See instructions

Pharmacological action

• Antipruritic
• Antiallergic
• Antihistamine

Pharmacological group

• H1-antihistamines

Release form and composition

• Tablets: flat, round, chamfered, with a line on one side, almost white or white (10 pcs per blister, 1, 2 or 3 blisters in a cardboard pack; 7 pcs per blister, 1 cardboard pack) blister);
• Suspension for oral administration: homogeneous suspension from almost white to white (120 ml in dark glass bottles, 1 bottle in a cardboard pack, complete with a dosage spoon).

Each pack also contains instructions for using Lomilan.

Composition of 1 tablet:

• Active ingredient: loratadine – 10 mg;
• Additional components: gelatinized starch, corn starch, magnesium stearate, lactose.

Composition of 1 ml oral suspension:

• Active ingredient: loratadine – 1 mg;
• Additional components: citric acid monohydrate, polysorbate 80, sodium benzoate, sodium citrate dihydrate, white crystalline sugar, Avicel RC 591 FMC, concentrated glycerol, propylene glycol, wild cherry aroma, purified water.

Analogs

Other antihistamines can be considered as analogues of the drug Lomilan.

Claritin

The drug Claritin is considered as a medication that provides rapid relief of allergy symptoms. The drug can be used to prevent relapses of chronic diseases. The drug is considered as a histamine receptor blocker. The active substance has no effect on the condition of internal organs and affects only cellular structures. The product is produced in the form of tablets and syrup for oral administration. The syrup is considered as a dosage form intended for use in pediatric practice. The advantage of the medication is that it does not cause drowsiness.

Fenistil

The drug Fenistil is considered as the most popular antiallergic drug intended for the treatment and elimination of allergy symptoms in children. The product effectively and quickly eliminates itching of the skin, therefore it is often used for various viral and dermatological diseases. The product has a high safety indicator and can be used even during the neonatal period.

Kestin

The drug Kestin belongs to the group of antiallergic drugs that are histamine receptor blockers. The product relieves swelling and eliminates spasms of bronchial smooth muscles, and also reduces the degree of production. The drug is often used for various allergic conditions associated with the active release of histamine. The products should not be used during pregnancy and breastfeeding.

Pharmacological properties

Pharmacodynamics

Loratadine, the active substance of Lomilan suspension and tablets, is a histamine H1 receptor blocker for systemic use. It has antiallergic, antipruritic and antiexudative properties.

It has no effect on the central nervous system and is not addictive.

Lomilan helps reduce capillary permeability, prevents the appearance of tissue edema, and relieves spasms of smooth muscles.

The development of the therapeutic effect begins 30 minutes after administration, the maximum effect is observed after 8–12 hours and persists for 24 hours.

Pharmacokinetics

The substance after oral administration is quickly and completely absorbed from the gastrointestinal tract. After a single dose of 10 mg of loratadine, Cmax (maximum concentration of the substance) is reached in 60 minutes. In the presence of food, absorption slows down.

Plasma protein binding is more than 95%. Does not penetrate the blood-brain barrier.

Metabolism occurs in the liver, resulting in the formation of an active metabolite - descarboethoxyloratadine.

T1/2 (half-life) – approximately 8 hours. Excreted in urine and bile.

In chronic alcoholism and in older people, T1/2 increases.

The pharmacokinetic parameters of loratadine during hemodialysis and chronic renal failure remain virtually unchanged.

Overdose

If the dose is significantly exceeded, negative symptoms may occur, which include headache, drowsiness, palpitations, and prolonged deterioration in well-being. The drug does not have a specific antidote. In case of overdose of the drug, it is worth performing a gastric lavage and offering the patient an adsorbent. Lomilan is not excreted from the body by hemodialysis. Currently, no cases of critical deterioration in health have been recorded. After emergency care, the patient should consult a doctor for follow-up.

Contraindications

Absolute:

• lactose intolerance, lactase deficiency, glucose-galactose malabsorption (tablets);
• fructose intolerance, sucrase/isomaltase deficiency, glucose-galactose malabsorption (suspension);
• pregnancy and lactation;
• age up to 2 or 3 years (suspension and tablets, respectively);
• individual intolerance to the components of the drug.

Relative (Lomilan is prescribed under medical supervision):

• severe renal failure (in patients with creatinine clearance <30 ml/min);
• liver failure.

Indications for use

The list of contraindications to the use of the drug includes:

• seasonal and year-round allergic rhinitis;
• allergic conjunctivitis;
• skin diseases;
• chronic idiopathic urticaria;
• all allergic reactions;
• allergic reactions to insect bites.

for adults

Patients in this age category can use the drug when indications for use appear. The drug is well tolerated by people in this age group. Adverse reactions during use are extremely rare. Most often, the occurrence of adverse reactions during administration is due to the patient’s non-compliance with the norms of use. Elderly patients, as well as people with liver and kidney diseases, can use the drug composition when indications for use are identified.

for children

It is not recommended to use the drug in pediatric practice. Children over 2 years of age can use the drug as prescribed by their doctor. The preferred form of release is a suspension. Tablets should not be used by children under three years of age.

for pregnant women and during lactation

When taken during pregnancy and breastfeeding, the safety of the drug has not been established. The use of the drug is contraindicated. Women can use the medication as prescribed by their doctor after weighing the expected harm against the required benefit. It is worth noting that the active substance Loratadine is excreted from a woman’s body through breast milk. The use of the drug during breastfeeding is possible subject to cessation of lactation.

Lomilan, instructions for use: method and dosage

The drug is taken orally with milk or water. May be taken simultaneously with food. Lomilan tablets can be chewed if necessary.

Dosage regimen:

• tablets: adult patients and children over 12 years old – 1 pc. (10 mg) 1 time per day, children from 3 to 12 years old, whose body weight exceeds 30 kg - 1 pc. (10 mg) 1 time per day, children over 3 years old weighing less than 30 kg – ½ pc. (5 mg) 1 time per day;
• oral suspension: adult patients and children over 12 years of age - 2 dosage spoons (10 ml) 1 time per day, children from 2 to 12 years old, whose body weight exceeds 30 kg - 2 dosage spoons (10 ml) 1 time per day , children over 2 years old weighing less than 30 kg – 1 dosage spoon (5 ml) 1 time per day.

It is preferable for children under 12 years of age to take Lomilan syrup.

Patients with impaired liver function should reduce the daily dose of the drug by prescribing adults and children weighing more than 30 kg 2 dosage spoons of suspension (10 ml) or 1 tablet (10 mg) every other day. The duration of treatment depends on the duration of symptoms of the disease.

In patients with severe renal impairment (creatinine clearance < 30 ml/min), the starting dose is: adults and children from 6 years of age - 2 dosage spoons of suspension (10 ml) or 1 tablet (10 mg) every other day, children from 3 to 6 years - 1 dosage spoon of suspension (5 ml) or ½ tablet (5 mg) every other day.

Patients with moderate to mild renal impairment, as well as elderly patients, do not require dose adjustment of Lomilan.

If there is no improvement within 3 days of therapy, it is necessary to resolve the issue of the effectiveness of the drug with the attending physician.

Buy Lomilan tablets 10 mg No. 10 in pharmacies

Instructions for use Lomilan tab. 10mg №10

Dosage forms tablets 10 mg Synonyms Clallergin Claridol Clarisens Claritin Clarotadine LauraHexal Loratadine Loratadine Stada Loratadine-Teva Loratadine-Hemofarm Group H1-histamine receptor blockers International nonproprietary name Loratadine Composition Active substance - loratadine. Manufacturers Lek dd. (Slovenia) Pharmacological action Antihistamine, antiallergic, antiexudative, antipruritic. Selectively blocks H1-histamine receptors and prevents the effect of histamine on smooth muscles and blood vessels, reduces capillary permeability, inhibits exudation, reduces itching and erythema. Prevents the development and facilitates the course of allergic reactions. The effect develops after 1-3 hours, reaches its maximum after 8-12 hours and lasts for at least 24 hours. Does not affect the central nervous system and the QT interval on the ECG. Rapidly absorbed after oral administration. The maximum concentration is reached after 1.3 hours, the active metabolite (descarboethoxyloratadine) - after 2.5 hours. The half-life of loratadine is 3-20 hours (average 8.4 hours), the active metabolite is 8.8 to 92 hours (average 28 hours). Excreted in urine (most of it) and feces. Easily passes into breast milk. Side effects Headache, drowsiness, fatigue, impaired concentration, dizziness, nervousness, anxiety, agitation (in children), insomnia, fainting, amnesia, depression, hyperkinesia, tremor, paresthesia, hypoesthesia, dysphonia, blurred vision, changes in lacrimation, conjunctivitis , blepharospasm, pain in the eyes and ears, tinnitus; dry mouth, increased appetite, weight gain, anorexia, nausea, changes in salivation, taste disturbance, toothache, stomatitis, vomiting, gastritis, flatulence, dyspepsia, constipation or diarrhea; very rarely - jaundice, hepatitis, liver necrosis; nasal congestion, sneezing, dry nose, nosebleeds, sinusitis, pharyngitis, laryngitis, cough, hemoptysis, bronchitis, bronchospasm, chest pain, upper respiratory tract infections, dyspnea; change in urine color, painful urge to urinate, dysmenorrhea, menorrhagia, vaginitis, decreased libido, impotence, edema; back pain, arthralgia, myalgia, calf muscle cramps; hyperemia, skin rash, urticaria, dermatitis, itching, angioedema, very rarely - anaphylaxis; hypertension or hypotension, palpitations, tachycardia, supraventricular tachyarrhythmia; dry hair and skin, thirst, asthenia, malaise, fever, chills, photosensitivity, increased sweating, pain in the mammary glands, weight gain, very rarely - alopecia, enlarged chest, erythema multiforme. Indications for use Allergic rhinitis (seasonal and year-round), hay fever, allergic conjunctivitis, chronic idiopathic urticaria, itchy dermatoses (contact allergic dermatitis, chronic eczema), allergic reactions to insect bites, pseudoallergic reactions to histamine liberators, angioedema, bronchial asthma (auxiliary agent) . Contraindications Hypersensitivity, lactation, children under 2 years of age. Use during pregnancy is possible only if the expected benefit to the mother outweighs the potential risk to the fetus and newborn. Method of administration and dosage Orally, adults and children over 12 years of age (body weight more than 30 kg): 10 mg/day, once, i.e. 1 table per day or 2 dosage spoons of suspension (10 ml). Children 2-12 years old (body weight less than 30 kg): - 5 mg/day, once, i.e. 1 dosage spoon (5 ml) or 1/2 tablet. per day. The maximum daily dose is 40 mg. Overdose Symptoms: headache, drowsiness, tachycardia. Treatment: induction of vomiting with ipecac syrup, gastric lavage, administration of activated charcoal; symptomatic and supportive therapy. Interaction Erythromycin and ketoconazole, cimetidine increase the concentration of loratadine and its active metabolite in the blood. Reduces plasma levels of erythromycin. Special instructions It is recommended to discontinue treatment at least 1 week before performing a skin test for allergens. Storage conditions List B. Store in a dry place, protected from light, at room temperature, out of the reach of children.

special instructions

Two days before skin allergy tests, you must stop taking Lomilan, as it can distort test results.

Impact on the ability to drive vehicles and complex mechanisms

There is no data on the effect of Lomilan (when used in recommended doses) on concentration and speed of psychomotor reactions. However, patients should be careful if the dose is exceeded or if unusual reactions occur when engaging in potentially hazardous activities.

Side effects

Adverse reactions may occur during the use of the drug composition. Similar effects include:

• anaphylactic reactions;
• headache;
• drowsiness;
• increased excitability;
• increased fatigue;
• insomnia;
• dizziness;
• tachycardia;
• cardiopalmus;
• arrhythmia;
• increased appetite;
• nausea;
• dry mouth;
• gastritis;
• liver dysfunction;
• allergic reactions;
• alopecia.

In addition to the above effects, sedative reactions may occur.

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** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use the drug Lomilan, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.

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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Lomilan is provided for informational purposes and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!

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