Effervescent tablets Antigrippin - at what age can they be given to children?

Pharmacological authorities

Pharmacodynamics.

Combination drug. Paracetamol has an analgesic and antipyretic effect, relieves headaches and other types of pain, and reduces elevated temperature.

Ascorbic acid (vitamin C) plays a role in regulating oxide-based processes, carbohydrate metabolism, and promotes the body's strength.

Chlorphenamine - a blocker of H1-histamine receptors - has a protiallergic effect, relieves nasal breathing, reduces nasal congestion, coughing, lacrimation, itching and burning of the eyes.

Pharmacokinetics.

The drug is well absorbed in the scolio-intestinal tract, at which the maximum concentration of paracetamol in blood plasma is 30-60 minutes. The inhibition of the elimination of paracetamol and its metabolites is avoided in case of impaired liver function and in patients with chronic liver disease.

Contraindications

It is necessary to stop using Antigrippin if:

• The child has previously had an allergic reaction to any of the components of the medicine;
• Acute forms of gastrointestinal diseases were diagnosed;
• There are signs of renal and liver failure;
• A closed form of glaucoma was discovered.

Antigrippin is not compatible with drugs containing paracetamol .

Side effects are extremely rare. Unlike medicinal syrups, Antigrippin does not cause allergic reactions. Manufacturers use natural food additives and flavors.

Contraindicated

Increased sensitivity to the components of the drug or to other antihistamines, severely impaired liver function or low function, congenital hyperbilirubinemia, deficiency of glucose-6-phosphate dehydrogenase, alcoholism, blood disease, severe anemia, leukopenia, severe arterial hypertension, unstable angina; severe damage to cardiac conduction, acute period of myocardial infarction, severe atherosclerosis, uncompensated heart failure, hyperthyroidism, acute blockage of the section with hypertrophy of the anterior amycholar gland, obstruction cervical mikhur, pyloroduodenal obstruction, vulcanis and duodenum at the stage of constipation, closed cuta glaucoma, thrombosis, thrombophlebitis , severe forms of diabetes, epilepsy. Do not use MAO inhibitors at the same time and for two days after the completion of the MAO inhibitors. Contraindicated for patients taking tricyclic antidepressants or beta blockers. Sechokamyan ailment – ​​for the reason that ascorbic acid is absorbed into the body at a dose of over 1 g per dose. Fructose intolerance. Children up to 3 years of age.

Is it possible for children

Is it possible to give children medicine in the form of effervescent tablets? This is a common question among parents. The fizzy drink will not harm the child. The substances that form carbon dioxide bubbles are easily soluble in water. There are no traces of carbonates left in the finished solution; they are quenched with ascorbic acid. Conventional food baking powders work on the same principle.

Effervescent tablets dissolved in water are considered safer than conventional syrups and powders.

Gas bubbles accelerate the dissolution of the medicine, and flavorings and sweeteners make Antigrippin similar to soda. Children take it willingly and love to watch the dissolution process. Treatment becomes a game.

In the form of a solution, the drug is absorbed faster. The main disadvantage of dry medicines, which, once in the stomach, dissolve slowly, is eliminated. Sweet mixtures and syrups, although liquid in structure, are also inferior in speed to Antigrippin. They need time to release drugs.

Parents need to ensure that the tablets are stored out of the reach of children. The tablets have a pleasant taste and color, so you’re tempted to try them. This cannot be allowed. An overdose of the drug is extremely dangerous and leads to liver damage.

Interactions with other medicinal drugs and other types of interactions

Unnecessary combinations.

Due to the presence of chlorphenamine maleate, which is a sedative, it can be avoided by means of transport or other mechanisms. During the hour of bathing, the infusion of alcoholic drinks and the stagnation of medicinal preparations, which remove ethyl alcohol, and ethanol fragments, promote the sedative effect of H1-blockers.

Combinations that should be taken to your esteem.

Due to the presence of chlorphenamine maleate, other sedatives can cause suppression of the central nervous system, such as drugs such as morphine-like drugs (analgesics, cough suppressants, and replacement therapy), antipsychotics , barbiturates, benzodiazepines, anxiolytics, other lower benzodiazepines (for example meprobamate ), Snodіinі Zasobi, sedative antideparests (Amiriplin, Doxepin, Minserarin, Miretazin, Tramіpramin), sedative n1-blocker, antigerentziv bibs of the central di, Talofen.

Due to the presence of chlorphenamine maleate, medicinal methods can be used to perform atropine-like treatment, such as: imipramine antidepressants, most atropine H1-blockers, anticholinergics, antiparkinsonians. drugs, atropine antispasmodics, disopramide, phenothiazine antipsychotics and clozapine may cause undesirable atropine effects, such as diarrhea, constipation dry mouth.

When taken simultaneously with oral anticoagulants, there is a risk of increased action and increased risk of bleeding when taking paracetamol at maximum doses (4 g/dose) for at least 4 days. The team regularly checks the INR (International Normalized Relations). If necessary, the dose of the oral anticoagulant can be adjusted before taking paracetamol and after taking paracetamol.

Taking paracetamol may interfere with blood glucose measurements using the glucose oxidase-peroxidase method with abnormally high concentrations.

Taking paracetamol can affect the results of blood tests using the phosphotungstic acid method.

The liquidity of soaked paracetamol can increase through one-hour infusion with metoclopramide and domperidone and change through infusion with cholestyramine. Barbiturates alter the antipyretic effect of paracetamol.

Anti-drug drugs (including phenytoin, barbiturates, carbamazepine), which stimulate the activity of microsomal enzymes in the liver, can cause the toxic infusion of paracetamol on the liver due to the advanced stage of drug conversion to hepatotoxicity and metabolites. With one-hour infusion of paracetamol with isoniazid, there is a risk of developing hepatotoxic syndrome. Paracetamol reduces the effectiveness of diuretics.

Don't hang out with alcohol all at once.

Ascorbic acid promotes digestion in the intestines, promotes the addition of ethinylestradiol, penicillins, tetracyclines; reduces the level of antipsychotic drugs, phenothiazine-like drugs in the blood. Glucocorticosteroids change the reserves of ascorbic acid. One-time use of ascorbic acid and deferoxamine promotes tissue toxicity of the tissue, especially in heart meat, which can lead to decompensation of the blood circulation system. It can be stopped only 2 years after injecting deferoxamine. Large doses of ascorbic acid alter the effectiveness of tricyclic antidepressants. Absorption of ascorbic acid decreases with one-hour infusion of oral contraceptives, fruit or vegetable juices, and water drinks.

Antigrippin effervescent tablets for children No. 30 30137

Description

Antigrippin Latin name Active substance ATC: Pharmacological group Nosological classification (ICD-10) Description of the dosage form Pharmacological action Pharmacodynamics Indications of the drug Antigrippin Contraindications Use during pregnancy and breastfeeding Side effects Interaction Overdose Special instructions Manufacturer Storage conditions of the drug Antigrippin Shelf life of the drug Antigrippin Natur Produkt Europe BV (Nor derlands) effervescent tablets for children 250 mg + 3 mg + 50 mg; contour packaging 10, cardboard pack 1; No. P N015187/02, 2008-08-07 from Natur Produkt Europe BV (Netherlands) Antigrippin Paracetamol* + Chlorphenamine* + Ascorbic acid* (Paracetamolum + Chlorphenaminum + Acidum ascorbinicum) N02BE51 Paracetamol in combination with other drugs, except psycholeptics Anilides in combinations J06 Acute upper respiratory tract infections of multiple and unspecified localization J11 Influenza, virus not identified M25.5 Joint pain M79.1 Myalgia R07.0 Sore throat R50.0 Fever with chills R51 Headache R52.9 Pain, unspecified Powder for preparing an oral solution, honey-lemon: powder of varying degrees of granulation, consisting of particles from white to grayish-beige in color, with a specific odor. Dark brown inclusions are allowed. Chamomile powder for the preparation of a solution for oral administration: powder of varying degrees of granulation, consisting of particles from white to beige and light brown, with a specific odor. Brown inclusions are allowed. Effervescent tablets with raspberry flavor: round, flat, with a beveled edge and a separating line on one side, pink, pinkish-lilac or lilac in color, with lighter and darker inclusions, with a specific fruity odor. Effervescent tablets with grapefruit flavor: round, flat, with a beveled edge and a scoring line on one side, white, almost white or creamy-white in color, with barely noticeable marbling, with a specific citrus odor. Effervescent tablets: round, flat, with a beveled edge and a score line on one side, white or almost white in color, with barely noticeable marbling, with a fruity odor. Effervescent tablets for children: round, flat, with a beveled edge and a separating line on one side, pink in color with lighter and darker inclusions, randomly located, with a fruity smell. Pharmacological action - antiallergic, analgesic, antipyretic. Combined drug. Paracetamol has an analgesic and antipyretic effect, eliminates headaches and other types of pain, and reduces fever. Ascorbic acid (vitamin C) - participates in the regulation of redox processes, carbohydrate metabolism, and increases the body's resistance. Chlorphenamine - a blocker of H1-histamine receptors - has an antiallergic effect, facilitates breathing through the nose, reduces nasal congestion, sneezing, lacrimation, itching and redness of the eyes. Infectious and inflammatory diseases (ARVI, influenza), accompanied by fever, chills, headache, joint and muscle pain, nasal congestion and pain in the throat and sinuses. Common to the four dosage forms: hypersensitivity to paracetamol, ascorbic acid, chlorphenamine or any other component of the drug; erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase); severe renal and/or liver failure; angle-closure glaucoma. For powder for the preparation of a honey-lemon or chamomile solution for oral administration, effervescent tablets with raspberry or grapefruit flavor, effervescent tablets (optional): alcoholism; phenylketonuria; prostatic hyperplasia; children under 15 years of age; pregnancy; lactation period. For effervescent tablets for children (optional) - children under 3 years of age. With caution For four dosage forms: renal and/or liver failure; deficiency of glucose-6-phosphate dehydrogenase; congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes); viral hepatitis. For powder for the preparation of a honey-lemon or chamomile solution for oral administration, effervescent tablets with raspberry or grapefruit flavor, effervescent tablets (optional): alcoholic hepatitis; elderly age; hyperoxalaturia (effervescent tablets with raspberry or grapefruit flavor); progressive malignant diseases (effervescent tablets with raspberry or grapefruit flavor). Contraindicated during pregnancy. Breastfeeding should be stopped during treatment. The drug is well tolerated in recommended doses. In isolated cases, they occur on the part of the central nervous system: headache, feeling of fatigue. From the gastrointestinal tract: nausea, pain in the epigastric region. From the endocrine system: hypoglycemia (up to the development of coma). From the hematopoietic organs: anemia, hemolytic anemia (especially for patients with glucose-6-phosphate dehydrogenase deficiency); extremely rarely - thrombocytopenia. Allergic reactions: skin rash, itching, urticaria, Quincke's edema. Other: hypervitaminosis, metabolic disorders, feeling of heat, dry mouth, accommodation paresis, urinary retention, drowsiness. For powder for the preparation of a solution for oral administration of honey-lemon, effervescent tablets with raspberry or grapefruit flavor (optional): anaphylactoid reactions (including anaphylactic shock), exudative erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome). All side effects of the drug should be reported to your doctor. For four dosage forms, ethanol enhances the sedative effect of antihistamines. Antidepressants, antiparkinsonian drugs, antipsychotic drugs (phenothiazine derivatives): increase the risk of side effects (urinary retention, dry mouth, constipation). GCS: increase the risk of developing glaucoma. With simultaneous use, the positive chronotropic effect of isoprenaline decreases. Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants. Inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants): increase the production of hydroxylated active metabolites, which makes it possible to develop severe intoxications with small overdoses. Ethanol contributes to the development of acute pancreatitis. Inhibitors of microsomal oxidation (including cimetidine): reduce the risk of hepatotoxicity. Simultaneous use of the drug Antigrippin and diflunisal: the concentration in the blood plasma of paracetamol increases by 50%, resulting in increased hepatotoxicity. Simultaneous use of barbiturates reduces the effectiveness of paracetamol and increases the excretion of ascorbic acid in the urine. Paracetamol: reduces the effectiveness of uricosuric drugs. For powder for preparing a solution for oral administration of honey-lemon and chamomile, effervescent tablets with raspberry or grapefruit flavor (optional) Ascorbic acid: increases the concentration of benzylpenicillin and tetracyclines in the blood; improves the absorption of iron preparations in the intestine (converts ferric iron to divalent iron); may increase iron excretion when used concomitantly with deferoxamine; increases the risk of developing crystalluria during treatment with salicylates and short-acting sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs that have an alkaline reaction (including alkaloids), reduces the concentration of oral contraceptives in the blood; increases the overall clearance of ethanol; can both increase and decrease the effect of anticoagulant drugs. Chlorphenamine maleate: enhances the effect of hypnotics. Symptoms: caused by the substances included in the composition. The clinical picture of an acute overdose of paracetamol develops within 6–14 hours after its administration. Symptoms of chronic overdose appear 2–4 days after increasing the dose of the drug. Symptoms of acute paracetamol overdose: diarrhea, loss of appetite, nausea and vomiting, abdominal discomfort and/or abdominal pain, increased sweating. Symptoms of an overdose of chlorphenamine: dizziness, agitation, sleep disturbance, depression, convulsions. Treatment: symptomatic. For four dosage forms If you are taking metoclopramide, domperidone or cholestyramine, you should consult your doctor. With long-term use in doses significantly higher than recommended, the likelihood of liver and kidney dysfunction increases; monitoring of the peripheral blood picture is necessary. Paracetamol and ascorbic acid can distort laboratory tests (quantitative determination of glucose and uric acid in blood plasma, bilirubin, liver transaminase activity, LDH). Prescribing ascorbic acid to patients with rapidly proliferating and intensively metastasizing tumors can aggravate the process. In patients with high iron levels in the body, ascorbic acid should be used in minimal doses. For powder for the preparation of a solution for oral administration of honey-lemon or chamomile, effervescent tablets with raspberry or grapefruit flavor, effervescent tablets (optional) To avoid toxic damage to the liver, paracetamol should not be combined with alcoholic beverages, and should not be taken by persons prone to chronic use alcohol. The risk of developing liver damage increases in patients with alcoholic hepatosis. For powder for preparing a solution for oral administration of honey-lemon or chamomile (optional) One sachet of honey-lemon powder contains 1.793 g of sugar, which corresponds to 0.15 XE. One sachet of chamomile powder contains 2.058 g of sugar, which corresponds to 0.17 XE. Natur Product Europe B.V. (Netherlands), Natur Product Pharma Sp z o.o. (Poland) by order and under the control of Natur Product Europe B.V. (Netherlands) (Antigrippin effervescent tablets, Antigrippin effervescent tablets for children). Natur Product Pharma Sp z o.o. (Poland) by order and under the control of Natur Product Europe B.V. (Netherlands) (Antigrippin effervescent tablets with raspberry, grapefruit flavors, Antigrippin powder for the preparation of a solution for oral administration, honey-lemon, chamomile). At a temperature of 10–30 °C. Keep out of the reach of children. 3 years. 2000-2014. Register of Medicines of Russia The database is intended for healthcare professionals. Commercial use of materials is not permitted.

Possible product names

• Antigrippin effervescent tablets for children No. 30
• ANTI-GRIPPIN EFFERVANT CHILDREN'S TAB. No. 30
• ANTIGRIPPIN FOR CHILDREN N30 SHIP TABLE
• ANTI-GRIPPIN TABLE. D/CHILDREN SPIKE. X30
• ANTI-GRIPPIN SPIKE. TAB. D/CHILDREN №30
• ANTIGRIPPIN FOR CHILDREN TAB. EFFERVANT X30

Features of good stagnation

If your liver is sick or before taking the drug, you need to see a doctor. Before taking the drug, you should consult with your doctor if the patient is taking warfarin or similar drugs that may have an anticoagulant effect. It is clear that in patients with alcoholic necrotic liver disease, the risk of hepatotoxicity from paracetamol increases. In patients with severe infections, such as sepsis, which are accompanied by a decrease in glutathione levels, when taking paracetamol, the risk of developing metabolic acidosis increases. Symptoms of metabolic acidosis include severe, accelerated or difficult breathing, boredom, vomiting, loss of appetite. It is important to consult a doctor once these symptoms appear.

Do not overestimate the prescribed doses. If you don’t know the symptoms, you have to go to the doctor.

Particular care should be taken in patients with impaired metabolic metabolism (hemosiderosis, hemochromatosis, thalassemia).

Some ascorbic acid has a mild stimulating effect; it is not recommended to take this drug at the end of the day. In connection with the stimulating infusion of ascorbic acid on the release of corticosteroid hormones when ingested in large doses, control of the function of the nerve and arterial pressure is required.

Use the drug with caution in case of increased blood loss.

Particular caution should be taken in patients with a history of nephrolithiasis (risk of hyperoxaluria and oxalate deposition in the urinary tract after taking large doses of ascorbic acid).

Long-term stagnation of large doses of ascorbic acid can accelerate its metabolism, through which paradoxical hypovitaminosis can occur after discontinuation of treatment. Do not exceed the recommended dose.

Do not take other medications at the same time, such as vitamin C.

The absorption of ascorbic acid may be disrupted in case of impaired intestinal motility, enteritis or achylia (suppressed scutaneous secretion).

Please note that vitamin C supplementation in high doses can alter the results of laboratory tests (sechoic acid, creatinine, inorganic phosphates) and influence the results of laboratory tests together with blood. and glucose. The result of examining the presence of collected blood in feces may be negative.

In the event of a high body temperature or fever, the drug should be preserved for 3 days while the drug is infused, or if a sign of superinfection appears, contact the doctor to determine the completeness of further infusion I don't like the drug.

Take care with care if you have diabetes.

Alcohol will enhance the sedative effect of chlorphenamine maleate and the hepatotoxicity of paracetamol.

The risk of significant mental stress appears when the recommended doses are exceeded and during prolonged treatment.

To avoid overdose, check and turn off all medications that include paracetamol.

Zapobizhni come in.

The ingestion of alcoholic drinks or the ingestion of sedatives (especially barbiturates) promotes the sedative effect of chlorphenamine maleate, which then leads to the disappearance of these drugs during the hour of celebration.

Method of congestion and dosage

Stop inside. Children aged 3 to 5 years: ½ tablet 2 times per day; children aged 5 to 10 years: 1 tablet 2 times per day; children aged 10 to 15 years, 1 tablet 2-3 times per day.

Dissolve the surface of the tablet in 1 bottle (200 ml) of warm water (50-60 °C). Otrimaniy rozchin odrazu vipiti. It is best to take the drug between meals. The maximum dosage is 3 tablets. The interval between doses of the drug should be at least 4 years, for patients with impaired liver function or at least 8 years.

The danger of taking the drug without consulting a doctor is: no more than 3 days.

Reviews

Judging by the reviews of mothers who gave Antigrippin to their children, the drug copes well with the symptoms of ARVI. They note a quick effect - after just 30 minutes, the children’s temperature became normal, the chills went away, and the runny nose decreased.

Doctors speak well of effervescent tablets, but remind that the drug only relieves symptoms.

It is impossible to eliminate the cause of the disease with Antigrippin alone. Additionally, targeted drugs are needed - antiviral, when the disease is caused by viruses, or antibacterial, if the body is faced with a bacterial infection.

Overdose

Symptoms of overdose are indicated by numerous words that must be included in the medical department.

Associated with ascorbic acid.

Ascorbic acid is well tolerated. It contains a water-dissolving vitamin, and it has a high amount of excretion. However, with severely stagnated vitamin C in large doses, it is possible to suppress the function of the insular apparatus of the subglottic gland, which is important for the control of the body. Overdosing can lead to changes in nitric excretion of ascorbic and sechoic acids under the hour of acetylation of the section with the risk of precipitating oxalate stones. Taking large doses of ascorbic acid can lead to vomiting, nausea or diarrhea, which occurs after your week.

Bound to chlorphenamine maleate.

Overdose of chlorphenamine maleate can cause confusion, restlessness, sleep disturbances, depression, seizures (especially in children), impaired communication, etc.

Take paracetamol.

Acute intoxication with paracetamol develops over a period of 6-14 years after administration. Symptoms of chronic intoxication last 2-4 days after overdose.

There is a significant risk for the development of intoxication in the summer and especially in young children (episodes of therapeutic overdose and episodes of overdose occur quite often).

Overdose of paracetamol can be fatal.

Symptoms

Nudity, vomiting, anorexia, paleness, excessive sweating, abdominal pain, which apparently lasts for the first 24 years.

Acute tubular necrosis may manifest as severe transverse pain, hematuria, proteinuria, and swelling of the liver in the presence of severe liver disease. Cardiac arrhythmia and pancreatitis were also diagnosed.

When the drug is used in large doses, aplastic anemia, pancytopenia, agranulocytosis, neutropenia, leukopenia, thrombocytopenia may develop in the side of the hematopoietic organs. When taking large doses, side effects of the central nervous system include confusion, psychomotor restlessness and impaired orientation; on the side of the thyroid system - nephrotoxicity (nirconic colic, interstitial nephritis, capillary necrosis); on the side of the etching system - hepatonecrosis.

Overdose of more than 10 g of paracetamol at one time in adults and 150 mg/kg body weight at one time in children causes hepatic cytolysis, which can lead to repeated and non-reversible necrosis, which leads to hepatocellular failure, metabolic acid dose, encephalopathy, what, your damn, you can lead to a coma and lethal succession.

At the same time, watch out for elevated levels of liver transaminases, lactate dehydrogenase and bilirubin due to elevated levels of prothrombin, which can appear 12-48 years after drying out.

In patients with risk factors (trival treatment with carbamazepine, phenobarbital, phenytoin, primadone, rifampicin, hypericum or other drugs that induce liver enzymes; alcohol abuse; glutate Ion cachexia (poisoning disorders, cystic fibrosis, HIV infection, hunger, cachexia) stagnation 5 Or taking more paracetamol can cause liver damage.

Unusual visits

• Negain hospitalization;
• the significance of the cobalt level of paracetamol in blood plasma;
• negayne vyvedenya zastosovanogo medicinal zasobu by way of washing the shlunka;
• Initial treatment of overdose includes administration of the antidote N-acetylcysteine ​​with internal or oral administration. The antidote must be dried before the yakmoga, preferably for 10 years after overdose;
• methionine as symptomatic therapy.

Analogs and price

In Moscow pharmacies the price of Antigrippin for children is from 280 rubles. If the drug is not available, you can purchase analogues:

• Antiflu Kids - a similar composition with a reduced dosage of active substances, suitable for children from 2 years old, cost 5 sachets - 220 rubles.
• Agri granules - a herbal medicine made from aconite, toxicodendron, bryonia, phytolyacia and other plants, can be given to children from 2 years old, cost - from 100 rubles.
• Theraflu - containing 500 mg of paracetamol, ascorbic acid, phenylephrine and pheniramine, prescribed to children over 12 years old, price for 8 sachets - 400 rubles.
• Coldrex Junior - similar composition, suitable for children from 6 years old, price - from 284 rubles.

Side effects

On the side of the hematopoietic and lymphatic systems:

anemia, sulfhemoglobinemia and methemoglobinemia (cyanosis, shortness of breath, heart pain), hemolytic anemia; thrombosis, hyperprothrombinemia, erythrocytopenia, thrombocytopenia, agranulocytosis, neutrophilic leukocytosis, purpura, leukopenia, syncytosis and bleeding.

On the side of the immune system:

anaphylaxis, anaphylactic shock, skin reactions of hypersensitivity, including itching, sagging on the skin and mucous membranes (cause erythematous, urticaria), angioedema, erythema multiforme (including syndrome Stevens-Johnson), toxic epidermal necrolysis (Lyell's syndrome).

On the side of the dichotomy system:

bronchospasm in patients sensitive to acetylsalicylic acid and other NSAIDs.

On the side of the grass system:

dry mouth, fatigue, baking, vomiting, constipation, pain in the epigastric region, diarrhea, impaired liver function, increased activity of liver enzymes, usually without development of hepatitis, hepatonecrosis (dose-dependent effect).

On the side of the endocrine system:

hypoglycemia right up to hypoglycemic coma.

On the side of the nervous system:

rarely – headache, confusion, sleep disturbance, insomnia, drowsiness, confusion, hallucinations, nervousness, tremors; in other episodes – coma, seizures, dyskinesia, changes in behavior, increased restlessness; loss of confidence and memory, disrespect.

On the side of the cardiovascular system:

in single episodes – tachycardia, myocardial dystrophy (dose-dependent effect in case of chronic constipation), orthostatic hypotension.

On the side I will exchange speeches:

disruption of zinc and copper metabolism.

On the side of the thyroid system:

blockage of the cut and difficult discharge of the cut, aseptic pyuria, nitric colic.

From the side of the skin:

eczema.

From the side of the organs:

dry eyes, mydriasis, impaired accommodation.

With severe congestion in high doses: deterioration of the glomerular apparatus, crystalluria, formation of urate, cystine and/or oxalate concretions in cervical and sechovidal areas; deterioration of the insular apparatus of the subglottic gland (hyperglycemia, glycosuria) and disruption of glycogen synthesis right up to the development of cardiovascular diabetes.

Side reactions of ascorbic acid:

when administered at a dose of more than 1 g to the additional mucous membrane of the herbal tract, nitric deficiency, arterial hypertension.