Compound
The drug contains a combined active substance Co-Trimoxazole , which in turn consists of the substances sulfamethoxazole (200 mg for suspension and 100 mg (400 mg) for tablets) and trimethoprim (40 mg for suspension and 20 mg (80 mg) for tablets ).
Additional funds
For suspension: purified water, macrogol, sodium carmellose, propylene glycol, propyl parahydroxybenzoate, aluminum magnesium silicate, sodium saccharin, citric acid monohydrate, maltitol, sodium hydrogen phosphate dodecahydrate, methyl parahydroxybenzoate.
For tablets: propylene glycol, potato starch, methyl parahydroxybenzoate, talc, propyl parahydroxybenzoate, magnesium stearate, polyvinyl alcohol.
Pharmacodynamics and pharmacokinetics
Combined antimicrobial drug. The main active ingredient is Co-Trimoxazole (trimethoprim + sulfamethoxazole). What is it used for? Biseptol has a double blocking effect on bacterial metabolism. Trimethoprim has an inhibitory effect on the enzyme involved in the metabolism of folic acid and converts dihydrofolate to tetrahydroflorate. Sulfamethoxazole has a bacteriostatic effect. In combination, the components of the drug Biseptol block the biosynthesis of purines and nucleic acids, without which the reproduction and growth of bacteria is impossible.
The active substances are actively absorbed from the gastrointestinal tract. They are excreted mainly through the kidneys.
Pharmacological group
Biseptol is a combination drug from the group of sulfonamides. The medicine has a wide spectrum of action and exhibits a high bactericidal and antimicrobial effect. The active components of the drug block the synthesis of folic acid. The drug is effective in the fight against staphylococci, streptococci, pneumococci, typhoid bacilli, E. coli, salmonella and other pathogenic bacteria that often provoke the development of infectious diseases. Biseptol is ineffective against Pseudomonas aeruginosa, the causative agent of tuberculosis, spirochetes and viruses.
Sulfamethoxazole, which is the main component of Biseptol, has a pronounced and persistent long-term bactericidal effect. The component disrupts the synthesis of dihydrofolic acid and enhances the effect of sulfomethoxazole.
The bactericidal effect allows you to stop the metabolic processes of bacteria, disrupt their biosynthesis, and cause death and destruction. The tablets, as well as the suspension, are quickly absorbed from the stomach into the bloodstream, which allows the maximum concentration in the blood to be reached within 1-3 hours after administration.
Indications for use of Biseptol
What are these tablets and suspension for?
In general, the drug is prescribed for infectious lesions of the urinary tract: pyelitis, urethritis , prostatitis , pyelonephritis , gonorrhea , epididymitis, lymphogranuloma venereum, chancroid , inguinal granuloma. Let's look at what Biseptol helps with in different parts of the body.
Indications for the use of Biseptol for gastrointestinal infections: paratyphoid , cholera , typhoid fever , cholangitis, dysentery , gastroenteritis (E. coli), cholangitis, salmonella carriage.
Respiratory tract infections: lobar pneumonia, bronchiectasis, bronchitis (acute and chronic), Pneumocystis pneumonia, bronchopneumonia .
Infections of the ENT organs: tonsillitis , sinusitis , otitis media , scarlet fever , laryngitis .
Infections of soft tissues, skin: furunculosis, acne , wound infections, pyoderma .
In complex therapy it is used to treat toxoplasmosis, malaria, South American blastomycosis, and acute brucellosis.
Biseptol for colds: necessary, contraindicated or useless?
One of the most common misconceptions of Russian patients is blind faith in the powerful power of antibiotics for any disease. It is impossible to connect this confidence with objective reasons. Our citizens stubbornly want to treat influenza, colds and ARVI with antibiotics. The worst thing is that caring mothers often conduct these experiments with their children.
So, let's try to understand this, of course, important issue. Are antibacterial drugs, which include Biseptol, necessary for colds or acute respiratory viral infections?
To do this, first of all, you need to remember that colds, flu, and acute viral diseases - ARVI - are caused by various viruses. And from the instructions for use of Biseptol, we know that this drug, like any other antibacterial agents, does not affect viruses. Absolutely. Thus, using it for a cold, we will not get any effect. Except for the side effects.
A common cold or acute respiratory viral infection usually goes away on its own within a week or a little more. However, in weakened patients, young children, elderly patients - all those who have malfunctions of the immune system - the disease can take a protracted course. This leads to complications of the pathology and additional infection by bacteria. In such cases, an antibacterial drug is usually necessary. And the use of Biseptol tablets will be very appropriate.
How to notice this line between a viral and an already complicated viral-bacterial infection? For a person far from medicine, this is indeed not so simple. One of the symptoms of a complicated viral disease is a sharp deterioration in the condition. For example, a significant increase in temperature after several days of illness and a period of relative calm. In this case, the fever either does not stop at all, or after taking antipyretic drugs, the temperature drops very slowly and not for long. A complication of the infection may be indicated by the appearance of a severe cough, accompanied by the discharge of sputum. A cold complicated by a bacterial infection should be treated by a doctor, who will select the correct antibacterial drug.
Side effects
Nervous system: dizziness, headaches, rarely depression, aseptic meningitis , tremor, apathy , peripheral neuritis.
Respiratory system: pulmonary infiltrates, bronchospasm.
Digestive system: dyspeptic disorders, cholestasis, diarrhea, vomiting, loss of appetite, glossitis, epigastric pain, gastritis, increased levels of liver transaminases, stomatitis, pseudomembranous enterocolitis, hepatonecrosis, hepatitis.
Hematopoietic organs: megaloblastic anemia, agranulocytosis, neutropenia, leukopenia, thrombocytopenia.
Side effects from the urinary system: crystalluria, interstitial nephritis, polyuria, toxic nephropathy with anuria , oliguria, increased urea levels, hematuria, impaired renal function.
Musculoskeletal system: myalgia, arthralgia. thrombophlebitis , hypoglycemia, allergies .
Precautionary measures
Biseptol, like other medications, has contraindications:
- Functional failure of the liver, kidneys, heart.
- Diseases of the hematopoietic system.
- Allergy to components.
- During pregnancy and lactation.
In addition, the bactericidal drug should not be given to children under 6 weeks of age.
Biseptol rarely provokes disorders:
- nausea, vomiting, bile stagnation, inflammation of the colon and other digestive disorders;
- anemia, erythropenia, leukopenia, thrombocytopenia;
- polyuria (increased urine volume), inflammatory kidney damage, blood in the urine;
- hand tremors, lack of coordination, headaches;
- itching, burning sensation on the skin, angioedema, cough.
If such symptoms occur, stop taking Biseptol and consult your doctor.
Instructions for use of Biseptol (Method and dosage)
The dose of the drug in each case is prescribed by the doctor.
Biseptol tablets, instructions for use
Adults: 960 mg once, or 480 mg in 2 doses. Severe infections: 480 mg three times. Course 1-2 weeks.
For acute brucellosis, the course of treatment is 3-4 weeks, for paratyphoid and typhoid fever - up to 3 months.
Chronic infections: twice 480 mg tablets.
Instructions for use for children
For children, Biseptol is prescribed twice a day, dose from 120 to 480 mg.
At the age of 3-5 years: 2 times 120 mg per 24 hours.
Biseptol suspension, instructions for use
The syrup is used in the same way as the tablets.
Contraindications
Before starting treatment, it is important to familiarize yourself with the contraindications of Biseptol. This drug should not be used for the following diseases and conditions:
- hypersensitivity to individual components of the drug;
- pregnancy;
- breastfeeding period;
- Intramuscular administration is contraindicated for children under 6 years of age;
- age up to 3 months;
- Pneumocystis pneumonia;
- increased level of bilirubin in the child’s body;
- bronchial asthma;
- folic acid deficiency.
The drug should not be taken if the thyroid gland is not functioning properly. The main components of the drug can cause a more severe disorder when there are serious pathologies in the organs of the hematopoietic system.
Overdose
Intestinal colic, dyspeptic disorders, headaches, dizziness, drowsiness, vomiting, confusion, fever, depression, hematuria , fainting, visual impairment, leukopenia, fever, crystalluria . With prolonged overdose, jaundice, megaloblastic anemia, thrombocytopenia, and leukopenia are noted. It is necessary to administer trimethoprim, calcium folinate intramuscularly at a dose of 5-15 mg/day. If necessary, hemodialysis is prescribed. There is no specific antidote.
Interaction
Biseptol enhances the effect of hypoglycemic drugs, indirect anticoagulants, methotrexate. The drug reduces the effectiveness and reliability of oral contraception. The risk of developing megaloblastic anemia increases when taken concomitantly with pyrimethamine (more than 25 mg per week). Thiazides may cause thrombocytopenia. The effectiveness of Biseptol is reduced by procainamide , procaine , and benzocaine . The drug leads to the development of cross-allergy when taken simultaneously with oral hypoglycemic drugs. Lack of folic acid increases with the prescription of barbiturates, phenytoin, PAS . Crystalluria develops when taking hexamethylenetetramine , ascorbic acid.
Alcohol compatibility
During Biseptol therapy, it is prohibited to consume alcohol or protein contained in food. If this rule is not followed, convulsions occur in the lower and upper extremities. The combination of Biseptol and alcohol leads to the following symptoms:
- high blood pressure;
- increase in body temperature;
- state of fever;
- sharp spasms in the bronchi;
- suffocating cough.
Concomitant use with alcoholic beverages provokes the development of a severe allergic reaction. Rash and itching on the body may occur in the future, even in cases where there is no ethanol in the body. The most serious complication is cerebral ischemia. There is a risk of death with this condition.
special instructions
Regular monitoring of the concentration of sulfamethoxazole in the blood is necessary. If the value is more than 150 mcg/ml, then treatment is stopped until the value reaches 120 mcg/ml or lower. If the course of treatment lasts a month or more, then regular monitoring of the blood condition is required. When folic acid , hematological changes are reversible. In patients with AIDS, side effects are more common and more pronounced. Biseptol is not recommended to be prescribed for pharyngitis and tonsillitis caused by beta-hemolytic streptococcus gr. A.
Biseptol - an antibiotic or not? According to the annotation, the drug is not an antibiotic.
The recipe in Latin may look something like this: Rp: “Biseptoli-420” Dtd No. 20 in tab.
There is no description of the drug on Wikipedia.
Is treatment of intestinal infections justified?
The activity of the drug against Escherichia coli allows the use of Biseptol for acute intestinal infections. It is important that the effect of the drug also extends to enterotoxigenic strains of the pathogen. Enterotoxigenic E. coli is responsible for severe bloody diarrhea, which is accompanied by general intoxication of the body. In addition, there is experience in using the drug for salmonellosis.
However, before deciding to use any antibacterial agent for intestinal infections, you should remember one important nuance. All pathogens of these diseases are eliminated on their own within a week. In plain language, a week after infection the disease will stop without any treatment. This also applies to the notorious salmonellosis, the diagnosis of which sometimes leads the patient and his relatives into a state of panic.
Standard protocols for the treatment of acute intestinal infections do not include the use of any antibacterial drugs. The basis of therapy for such diseases is to ensure sufficient fluid intake.
In severe cases (for example, when an infection develops in young children or the elderly, in patients with weakened immune systems), it is still possible to prescribe antibacterial drugs. And again, Biseptol is not the gold standard in such cases - there are many other, safer drugs. For example, drugs from the nitrofuran group are not absorbed into the blood at all. The effectiveness and safety of these drugs is based on the fact that they work only in the intestinal lumen.
Therefore, in the vast majority of cases, treatment of intestinal infections with Biseptol is absolutely unjustified.
Biseptol for children
It is noted that the drug can be used from 3 months of life; naturally, the doses will vary. However, this should be done with caution and only as directed by a doctor. In some countries of the world, Biseptol for children is allowed to be used only from 12 years of age.
Usually they can prescribe a suspension from 3 months, tablets from 2 years.
Instructions for Biseptol for children
At the age of 3 to 6 months, 2.5 ml of syrup is prescribed 2 times a day. The interval between doses should be at least 12 hours. From six months to 3 years, take up to 5 ml of Biseptol suspension for children twice a day.
From 3 to 6 years, the dosage is made equal to 5-10 ml twice, 6-12 years - 10 ml 2 times a day. From 12 years of age, take 20 ml every 12 hours.
How to take pills for children?
At the age of 2-5 years: 2 times 120 mg per 24 hours. From 6 to 12 years, use 480 mg every 12 hours.
The course of treatment is 5-7 days. When using drugs for children, you should drink plenty of water.
Release form
Biseptol is available in the form:
- Round yellowish tablets engraved with “Bs” containing 2 active ingredients – sulfamethoxazole and trimethoprim. 120 and 480 mg, 20 tablets per package;
- Concentrate for the preparation of solution for infusion (Biseptol 480) in ampoules of 5 ml;
- Sugar-free oral suspension with strawberry flavor.
Analogues of Biseptol in terms of active components are Bactrim, Bi-Septin, Brifeseptol, Metosulfabol, Dvaseptol, Co-trimoxazole.
Biseptol's analogue by mechanism of action is Sulfatone in the form of tablets and solution for injection.
Biseptol's analogs
Level 4 ATC code matches:
Biseptol 480
Co-Trimoxazole
Bactrim
Analogues are the following drugs: Bactiseptol , Bactrim , Biseptazol , Biseptrim , Groseptol , Co-Trimoxazole , Oriprim , Raseptol , Solyuseptol , Sumetrolim , Triseptol .
Reviews of Biseptol
The product is very effective, especially for respiratory diseases. Has an excellent antibacterial effect. Among the disadvantages, it should be noted that there are sometimes side effects. Should not be used without the direction of the attending physician.
Biseptol for children, reviews
It is considered a very effective means of combating microbes. There are generally no negative reviews when treating children with Biseptol syrup.
Reviews of Biseptol for cystitis
The drug is effective against cystitis, but do not forget about the side effects.
For sore throat
Prescribed when it is impossible to take antibiotics. According to research, microorganisms that cause sore throat have begun to lose sensitivity to this drug.
Is the drug an antibiotic?
This question often worries patients, so it is necessary to put everything in its place.
An antibiotic is a medicinal substance of natural (animal, plant or microbial) origin that has an antibacterial effect that completely suppresses the growth and reproduction of bacteria.
Upon careful reading of the instructions for Biseptol, it becomes obvious that the components of the drug have nothing to do with antibiotics. Both substances were synthesized in the laboratory. Sulfamethoxazole belongs to the group of sulfonamide drugs, and trimethoprim is used only to enhance the effect of the main component. So, Biseptol is a medicine that has an antimicrobial effect, but is not an antibiotic. At the same time, it is naive to believe that a drug that is not one of the notorious “harmful” antibiotics is as safe as vitamins. Sulfonamides are serious substances, and medications containing them should only be taken under the supervision of a physician. Otherwise, you may experience unpleasant consequences, including the development of drug-resistant microorganisms.
Biseptol, like antibiotics, is a prescription drug. Don't forget about this.
Biseptol price
The price of Biseptol in 120 mg tablets is 35 rubles for 20 pieces. You can buy 480 mg tablets for 100 rubles per pack of 28 pieces.
The price of Biseptol syrup is approximately 130 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Biseptol Susp.
for internal approx. 240mg/5ml 80mlMedana Pharma Terpol Group Joint Stock Company RUR 105 order - Biseptol tablets 480 mg 28 pcs Adamed Pharma JSC
82 RUR order
- Biseptol tablets 120 mg 20 pcs JSC "Adamed Pharma"
33 rub. order
Pharmacy Dialogue
- Biseptol suspension (vial 240mg/5ml 80ml)Medana
126 rub. order
- Biseptol 480 tablets 480 mg No. 28Polfa
96 RUR order
- Biseptol 120 tablets 120 mg No. 20Polfa
33 rub. order
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Pharmacy24
- Biseptol 480 No. 14 tablets Pub Yanitsky FZ, Polfa A.T., Poland
76 UAH.order - Biseptol 100/20 mg No. 20 tablets Pub Yanitsky FZ, Polfa A.T., Poland
43 UAH order
- Biseptol 480 mg 5 ml N10 Warsaw Federal Plant, Poland
263 UAH order
- Biseptol 480 N20 tablets Pub Yanitsky FZ, Polfa A.T., Poland
88 UAH order
PaniPharmacy
- Biseptol infusion Biseptol solution d/in. 480mg amp. 5ml No. 10 Poland, Warsaw Federal Law
271 UAH order
- Biseptol liquid Biseptol suspension for oral use bottle 80ml Poland, Medana Pharma SA
119 UAH order
- Biseptol tablets Biseptol tablets 480 mg No. 20 Poland, Pabianicki Federal Plant Polfa
96 UAH order
- Biseptol tablets Biseptol tablets 120 mg No. 20 Poland, Pabianicki Federal Plant Polfa
45 UAH order
- Biseptol tablets Biseptol tablets. 480 mg No. 14 Poland, Pabianicki Federal Plant Polfa
75 UAH order
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Features of the use of suspensions
I would like to draw attention to the features of taking Biseptol suspension. Typically, in the instructions for each suspension, the manufacturer tries to warn the patient about the need to shake the bottle before using the medicine. And unfortunately, not everyone complies with this requirement. Why is it so important to read the annotation for Biseptol to the end and remember to shake the bottle of suspension?
Any suspension is a two-fraction system in which the active substance is present in undissolved form. It is evenly distributed only after vigorous shaking. Otherwise, you risk drinking a teaspoon of suspension containing not 240 mg of Biseptol, but much less, and it is not possible to determine the exact mass.
If you bought Biseptol syrup, you can safely give it to your child without prior manipulation of the bottle - the syrup is absolutely homogeneous.
And finally. All children's forms of Biseptol - both syrup and suspension - have a pleasant taste. Children are usually happy to be treated with such “edible” medications, so be careful and keep the drug out of reach.
