Bromhexine Berlin-Chemie solution 4 mg 60 ml price 172 rubles in Moscow, buy Bromhexine Berlin-Chemie solution 4 mg 60 ml inexpensively online from the manufacturer Berlin-Chemie instructions for use, online reviews

June 4, 2020
Pulmonology
Ulyana Romanova

Bromhexine Berlin Hemi syrup is a very common mucolytic agent characterized by an expectorant effect. What does it contain? What are the indications? Are there any side effects from this drug? You will find answers to all important questions regarding this product below.

Composition and price

Bromhexine Berlin Chemie syrup for children and adults is a colorless, transparent, slightly viscous solution with an apricot smell.

100 ml of syrup contains 80 mg of active ingredient. In 5 ml – 4 mg. This substance, as you might guess, is bromhexine hydrochloride.

There are auxiliary elements: purified water, propylene glycol, hydrochloric acid, sorbitol, and aromatic concentrate.

The product is available in bottles of 60 and 100 ml. The set also includes a convenient measuring spoon. The cost is relatively low: a bottle with 60 ml of syrup will cost about 180-190 rubles.

Analogs

Level 4 ATX code matches:
Mukolik

Abrol

Ambrosan

Bronchorus

ACC 100

ACC 200

ACC Long

ACC

Mukolwan

Lazolvan

Bromhexine 8 Berlin-Chemie

Bromhexine

Bronchobos

Impact on the body

By studying the instructions for Bromhexine Berlin Hemi syrup for children and adults, you can understand how it affects the body. As mentioned earlier, it is a mucolytic agent that produces an expectorant effect.

The syrup helps reduce the viscosity of bronchial secretions. How does this happen? Due to the depolarization of acidic polysaccharides contained in sputum. In addition, the medicine stimulates the secretory cells of the bronchial mucosa, which produce it. Sputum is known to contain neutral polysaccharides.

It is assumed that the syrup promotes the formation of surfactant.

Pharmacokinetics

Having understood the composition of Bromhexine Berlin Hemi syrup, we can discuss how this product is absorbed by the body.

It is quickly absorbed from the gastrointestinal tract, after which it undergoes intensive metabolism. The syrup is approximately 20% bioavailable. In people who do not have any special health problems, the maximum concentration of the substance is determined after one hour.

Bromhexine binds well to plasma proteins. The half-life lasts about 12 hours. It is important to know that this substance penetrates the BBB and the placental barrier.

Approximately 85-90% of the active substance, which is widely distributed throughout all tissues of the body, is excreted in the urine. Mainly in the form of metabolites. By the way, the main substance formed during the processing of bromhexine is ambroxol.

It should be recalled that the clearance of the main substance and its metabolites in people with impaired renal and liver function is worse than in all other cases.

Release forms

There are two versions of the medication - with the designation 4 and 8. In the first case, we are talking about tablets, which are small in size and packaged in packaging with cells. The pack contains one blister of 25 units.

Berlin-Chemie number 8 is produced in the form of a sweet syrup with a faint peach flavor.

That is why the composition is often prescribed to children. The package contains a special measuring spoon, which pediatricians use to calculate the dosage of the medicine.

Indications

Continuing the topic, it is worth discussing for what cough Bromhexine Berlin Hemie syrup is prescribed. The instructions indicate that the drug should be taken for bronchopulmonary diseases of the chronic and acute type, if they are accompanied by the formation of very viscous sputum. The list of such pathologies is as follows:

Bronchial asthma.
Pneumoconiosis.
Tracheobronchitis.
Tuberculosis.
Obstructive bronchitis.
Cystic fibrosis.
Pneumonia.
Emphysema.
Bronchiectasis.

However, you must remember that only a doctor has the right to prescribe the drug. Even if a person knows that he has indications for using the syrup, there is no need to self-medicate; there may be contraindications to taking the syrup. There are conditions in which this medicine may cause harm.

Contraindications

Bromhexine Berlin Hemi syrup is prohibited in the following cases:

Fructose intolerance, present in the patient since birth.
Aggravated ulcer.
Lactation period.
Pregnancy in the first trimester.
Hypersensitivity to the components of the syrup.

With caution, a specialist may prescribe this remedy in the following cases:

Age up to 2 years.
Liver or kidney failure.
History of gastric bleeding.
Diseases of the bronchi, the main symptom of which is excessive accumulation of secretions.

For such pathologies, the patient is prescribed Bromhexine Berlin Chemie syrup if the expected benefit outweighs the probable risk.

Side effects of Bromhexine Berlin-Chemie

In patients with hypersensitivity to the components of the drug, an allergic reaction may occur. Liver disease may cause nausea, vomiting and abdominal pain. If the patient has stomach ulcers, blood may be present in the vomit. People with kidney disease may experience anaphylactic reactions. If side effects occur, the medication should be stopped.

In case of an overdose of Bromhexine, treatment will be symptomatic. A separate antidote for the drug has not been developed. If symptoms of overdose appear (nausea, diarrhea), it is recommended to induce artificial vomiting and rinse the stomach within 2 hours of taking the medicine. The drug quickly binds to proteins, so it cannot be detected during hemodialysis.

Dosage

The amount of the drug required for use depends on the severity of the patient’s condition and age. Usually the therapeutic regimen is drawn up on an individual basis, but there are some general recommendations:

Everyone over 10 years old: 8 mg 3-4 times a day.
Children under 2 years old: 2 mg three times a day.
Children aged 2 to 6 years: 4 mg three times a day.
Patients from 6 to 10 years: 6-8 mg three times a day.

If the doctor considers it necessary, he may increase the daily dosage to 16 mg. However, if adults can take it 4 times a day, then children can take it only 2 times.

Many also know that this syrup is used for inhalation. In such cases, the dosage is also selected taking into account age and can vary from 1-2 mg to 8 mg (this is the maximum). Inhalations are allowed twice a day.

Bromhexine 8 drops, instructions for use

Instructions for use suggest oral (inside) use of drops, both in pure form and diluted with water.

Unless the doctor has prescribed a different dosage regimen, patients over 14 years of age are recommended to take 8-16 mg of bromhexine (23-46 drops) three times every 24 hours. You can drink a maximum of 138 drops per day.

Patients 12-14 years old or weighing up to 50 kilograms are prescribed three doses of 8 mg of bromhexine (23 drops) per day. You can drink a maximum of 69 drops per day.

Patients with kidney pathologies may require reduced dosages or increased intervals between doses.

During treatment, it is necessary to consume increased volumes of liquids in order to maintain the secretolytic activity of the drug.

If there is no improvement in the painful condition within 4-5 days, or the picture of the disease has worsened, you should inform your doctor about this to review the treatment regimen.

Side effects

Bromhexine Berlin Hemi syrup for children, which is also often taken by adults, is not at all a harmless apricot mixture. This is a serious medicine that, if used incorrectly, can lead to negative reactions. Most often these are:

Diarrhea.
Nausea and vomiting.
Fever.
Skin rash.
Hives.
Quincke's edema.
Itching.
Difficulty breathing.

Rarely the following problems may occur:

Lyell's syndrome.
Anaphylactic reactions, including shock.
Stevens-Johnson syndrome.
Severe skin reactions.

If any alarming symptom occurs, it is important to consult a doctor for qualified help.

Price, where to buy

You can buy Bromhexine 8 drops in a 20 ml bottle for 120-150 rubles.

Online pharmacies in UkraineUkraine
Online pharmacies in KazakhstanKazakhstan

Pharmacy24

Bromhexine 8 No. 25 tablets Berlin Chemi AG, Nimechchina
20 UAH. order

PaniPharmacy

Bromhexine tablets Bromhexine 8 BERLIN-CHEMIE tablets 8 mg No. 25 Germany, Berlin-Chemie
27 UAH order

special instructions

It is very important to ensure fluid intake into the body during therapy. This is necessary to maintain the secretolytic effect.

If a person is diagnosed with impaired bronchial motility or sputum is produced in excessively large quantities (this happens, for example, with malignant cilia syndrome), the syrup should be used with caution. There is always a risk of secretions being retained in the respiratory tract.

In childhood and pregnancy, Bromhexine Berlin Hemi syrup can be taken only under the supervision of a doctor.

Also useful and important information for people with diabetes: 5 ml of solution, which is equal to one measuring spoon, contains 2 g of sorbitol. This corresponds to 0.17 XE.

Drug interactions

The syrup can be used simultaneously with other drugs that are usually prescribed for the treatment of bronchopulmonary pathologies. But there are some nuances.

For example, you cannot combine it with medications that suppress the cough reflex, including those that contain codeine. This combination is fraught with consequences! As a result, the cough reflex is weakened, and there is a danger of congestion: sputum is not removed, which can also lead to trouble.

It is also worth knowing that the syrup under discussion increases the permeability of antibiotics. Especially if it is Amoxicillin, Ampicillin, Cephalexin, Erythromycin or Oxytetracycline. Under the influence of bromhexine, they intensively penetrate into the lung tissue.

Also, this substance is not compatible with medications that contain alkali.

Reviews

Doctors believe that when prescribed adequately, this syrup is safe and effective, and in a fairly wide age range of patients. It is also recognizable and inexpensive, which is also a significant plus.

People who have been treated with Bromhexine Berlin Hemi syrup also have a positive opinion. In reviews, many patients claim that this remedy helps in cases where other medications are powerless.

A pronounced effect develops the very next day after the start of the therapeutic course, and for some it occurs even after a few hours. The syrup helps get rid of stagnant phlegm and significantly alleviate the condition. True, children drink it without much enthusiasm, since it is bitter and without strong sweetness.

Not everyone is satisfied with the expiration date. The syrup can be stored for three years. But after the autopsy - only 3 months. After this period, the drug cannot be used.