- September 28, 2019
- Dermatology
- Elena Kerra
Ointment "Kanizon" is a medical preparation that has a fungistatic and fungicidal effect on various types of pathogenic microorganisms. Manufactured in India by the pharmaceutical company Agio Pharmaceuticals. What can Canizon ointment help with? How should it be used to get lasting results? What side effects can it cause? Does it have analogues? We offer detailed instructions for the medication that answer all these questions.
Compound
Kanison cream contains the active component clotrimazole , as well as a number of additional substances: monopropylene glycol, cytomacrogol 1000, liquid light paraffin, white paraffin, chlorocresol, cytostearyl alcohol, benzyl alcohol, EDTA disubstituted sodium phosphate dodecahydrate, disodium salt, monosubstituted sodium phosphate dihydrate, water.
Kanizon tablets also contain the active substance clotrimazole ; the tablets also contain magnesium stearate, sodium benzoate, aerosil, lactose, gelatin, starch, and water as additional components.
Kanizon solution contains the active component clotrimazole , additional substances ethanol, propylene glycol, PEG 400.
Release form
The drug is manufactured by Agio Pharmaceuticals Ltd, India. Kanizon is produced in different forms, which allows you to choose a more suitable form for the treatment of pathology, based on the specifics, severity, degree of damage, and localization of the infection.
Cream
Kanison cream 1% is contained in a 20 g tube. Intended for external use. It has a uniform white structure.
Solution
Kanizon solution 1% is applied externally. The drug is transparent, colorless, produced in 20 ml polyethylene bottles.
Pills
Kanizon vaginal tablets are white, oval, biconvex in shape, with beveled edges at one end. The tablets are placed in contour-free packaging of 6 tablets with an applicator included.
Drops
A 1% solution is also used as drops to treat fungal infections of the oral mucosa. Apply the solution using a cotton swab or cotton swab.
Kanizon Plus is also produced, which has antibacterial, antifungal and anti-inflammatory effects. The active components of this type are betamethasone dipropinate, gentamicin sulfate, clotrimazole.
Gentamicin is a broad-spectrum antibiotic classified as an aminoglycoside. The component has a bactericidal effect. Betamethasone is a glucocorticosteroid that has anti-inflammatory, antiallergic, and vasoconstrictor effects. Clotrimazole is an antifungal agent intended for local therapy. Clotrimazole is an imidazole derivative. This type of drug may cause side effects when used systemically, especially in children.
pharmachologic effect
Clotrimazole has a fungicidal and fungistatic dose-dependent effect.
Sensitivity to Kanison is demonstrated by mold fungi , dermatophytes , dimorphic fungi , actinomycetes , and blastomycetes .
The active component of the drug inhibits the synthesis of ergosterol . This is a substance necessary for the formation of fungal cell walls.
If the synthesis of this component is disrupted, the cell walls are eventually destroyed and the intracellular composition changes. As a result, the fungal cell dies.
In addition, clotrimazole acts as a peroxidase inhibitor, enhancing intracellular oxidative processes.
This drug has an antibacterial effect against streptococci, staphylococci, and corynebacteria . The medicine is active against Trichomonas , amoebas .
Interaction with other drugs
"Kanizon" is not combined with all drugs, since it contains clotrimazole, which is an inhibitor of certain chemicals. Here is a list of established interactions:
- With Amphotericin B. Patients develop resistance to this drug if it is used together with medications containing clotrimazole. Combination treatment should be prescribed with caution.
- With Astemizole. Clotrimazole increases the cardiotoxicity of this drug and its biotransformation. Combination treatment is not prescribed.
- Eye drops "Timolol" and "Brinzolamide". Caution must be exercised during combined treatment with these drugs and Canizon, since clotrimazole inhibits the metabolism of eye drops.
- With Diazepam. Clotrimazole can increase the concentration of this drug in the blood.
- With Lovastatin and Simvastatin. The combined use of these drugs and Canizon due to the presence of clotrimazole in it is not allowed.
- With Nystatin and Natamycin. These medications reduce the activity of clotrimazole.
- With Sirolimus and Tacrolimus. Complex treatment with Canizon and these drugs should be carried out with caution, as their concentration in the blood may increase.
- "Tegafur" in combination with "Uracil". These medications should be prescribed with caution when combined with Canizon.
- With Cyproterone. The substance clotrimazole inhibits the metabolism of this medication, so their combined use is not allowed.
Indications for use
The use of Kanison cream is practiced for the following diseases and conditions:
- mycotic lesions of the skin, which are associated with sensitive microflora;
- mycotic ear lesions;
- fungal infection of hairy areas;
- erythrasma;
- pityriasis versicolor and versicolor ;
- mycoses , in which pyoderma .
The use of Kanison tablets is practiced for the following diseases and conditions:
- vaginal superinfections;
- urogenital candidiasis ;
- vulvovaginitis;
- preparation for childbirth (for the purpose of vaginal sanitation).
A pronounced effect of the drug in the treatment of genital infections and urethritis . The use of Kanison ointment is advisable for the treatment of dermatomycosis of skin folds and scalp.
It is used as an additional agent as part of general chemotherapy for the treatment of trichomoniasis .
The doctor will tell you in more detail why Kanizon ointment, as well as tablets, are used.
Pregnancy
Scientists conducted studies on mice to determine the effect of clotrimazole on offspring. Overdoses caused the birth of non-viable mice and a decrease in the survival rate of babies. This allows us to conclude that the substance has an effect on fetal development. Therefore, it is prohibited to use it in the first and second trimesters. In the third trimester, treatment with Canizon should be prescribed by a doctor. Pregnant women should not use it on their own initiative.
Tablets "Kanizon" can be prescribed according to indications before childbirth.
Side effects
When using Kanison drugs, the following side effects may occur:
- redness of the skin;
- sensation of itching, burning, tingling;
- increased vaginal secretion;
- pain in the lower abdomen;
- headache;
- swelling of the mucous membranes;
- irritation of the mucous membrane of the genital organs after sexual intercourse.
Instructions for Kanizon (Method and dosage)
Canizon tablets should be inserted into the vagina using an applicator. The vaginal applicator, into which the tablet was previously inserted, is inserted deeply into the vagina.
After using this device, it should be rinsed thoroughly.
After administration, the patient should lie down until the tablet dissolves.
The drug should be administered 1-2 times a day. If the tablets are administered once a day, it is best to do so in the evening. As a rule, the treatment period is six days, if there is such a need, therapy can be repeated.
If candidal vulvitis or candidal balanitis , it is simultaneously recommended to use a cream that is applied to the affected areas 2-3 times a day.
One dose of Kanison solution is equal to 10-20 drops of solution, which are applied to the mucous membrane or skin.
Kanizon ointment, instructions for use
The ointment is indicated for external use. Every day the patient should apply a thin layer of ointment to the affected area. This should be done 2-3 times a day.
Before applying the ointment, areas of the body affected by the disease must be cleaned and dried. Treatment usually lasts four weeks. For patients with pityriasis versicolor , the remedy is prescribed for 3 weeks; people with mycosis of the feet need to apply the ointment to areas affected by the fungus for two weeks.
The doctor prescribes the duration of treatment individually, but it is not advisable to carry out short courses of treatment, as this may subsequently lead to a relapse of the disease.
Pharmacokinetics
Kanizon ointment is used externally. Clotrimazole is poorly absorbed through mucous membranes and skin. It tends to accumulate in the epidermis (in its stratum corneum). If you apply the drug to your nails, the active substance is found in keratin.
In the blood, maximum concentrations of absorbed clotrimazole last from 48 to 72 hours. In the liver, this substance is transformed to produce inactive metabolides. Excreted in feces.
The carcinogenicity and mutagenicity of clotrimazole has not been proven.
special instructions
Do not use tablets during menstrual bleeding.
To prevent recurrence of a fungal infection, both sexual partners must undergo full treatment.
This medication should not be taken orally.
After the cream has been applied to the skin, occlusive dressings should not be used.
Avoid contact of the product with the mucous membranes of the eyes.
People who suffer from liver failure should be aware of the need to periodically monitor their liver condition.
of high sensitivity appear , therapy should be stopped immediately.
If there is no positive dynamics within four weeks, you should definitely undergo a repeat examination and confirm the diagnosis.
Contraindications
The drug should be used with caution during pregnancy, especially in the first trimester, also during long-term therapy, use on large areas of the skin, in the presence of injuries and damage to the skin, when using occlusive dressings in children.
The use of Canizon is not allowed for:
- skin tuberculosis;
- skin manifestations of syphilis;
- chicken pox;
- herpes simplex virus;
- skin reactions after vaccination;
- hypersensitivity to the components of the drug.
Canizon should not be used in children under two years of age. When prescribing Canizon to patients with impaired liver function, its condition should be kept under control. It is not allowed to apply the cream and solution to the skin in the eye area and to areas where the integrity of the skin is damaged.
If clinical improvement does not occur within 28 days of treatment, a microbiological study is performed to confirm or exclude another cause of the disease.
According to the instructions, the use of any form of medication is contraindicated during the first trimester of pregnancy. The question of use in the second and third trimesters of pregnancy is decided by a specialist after examining the expectant mother and assessing the potential benefits for her and the expected risk to the fetus.
Analogs
Level 4 ATX code matches:
Gainomax
Sertaconazole
Ornisis
Metrogil Plus
Livarol
Flagyl
Ginofort
Zalain
Ketoconazole
Candide B6
Candide
Gyno-Travogen Ovulum
Metromicon-Neo
Lomexin
Klion-D 100
Neo-Penotran
Gyno-Pevaril
Ginesol
Antifungol
Analogues of this remedy are the following drugs: Candide , Imidil , Antifungol , Candibene, Clotrimazole , Triderm .
But you should not change the medicine yourself. Only a doctor can choose the most optimal drug.
Kanizon price, where to buy
In pharmacies, the price of Kanizon ointment ranges from 70 to 80 rubles per 20 g tube. The price of tablets is from 20 rubles per pack of 6 pieces. The cost of the solution is from 55 rubles for 1 bottle.
- Online pharmacies in RussiaRussia
ZdravCity
- Kanizon plus cream 15g AGIO
415 rub. order - Kanizon (clotrimazole) solution for external use 1% bottle 20mlAGIO
98 RUR order
- Kanizon cream 1% tube 20g NOT DEFINED
75 rub. order
Reviews
Angelina, 38 years old
Last month I began to feel itching in my vagina and strange discharge appeared. After going to the gynecologist and having a smear test, I received a diagnosis of candidal vulvitis. The doctor prescribed me Kanizon tablets, which, like suppositories, need to be inserted deep into the vagina. The course is only six days, at the end of it I got rid of the disease, I hope, forever.
Mark, 29 years old
After unprotected sex with a new partner, irritation and itching appeared on the head of the penis. I was afraid that she had infected me with something, so I went to the pharmacy. I first studied reviews on the Internet and settled on Kanizon cream. I lubricated my skin with it for a week and dealt with the problem. I will be careful about contraception.
Alena, 32 years old
The child was diagnosed with candidiasis in the mouth, small red ulcers formed, and he complained of burning and itching. I bought Kanison solution and began to lubricate the affected areas with a cotton swab. Within a week, the symptoms completely disappeared, but I read in the instructions that the therapy should last another two weeks. That's what I did, only three days left.
Vladimir, 51 years old
A strange spot appeared on my hand, it was itchy, it was constantly irritated and itchy. I went to the doctor who prescribed me Kanison ointment, but it gave me allergies. The spot kept growing, so I asked the doctor to prescribe a more effective drug. This is what regular Clotrimazole has become, I smear it twice a day, rub it in thoroughly and enjoy clear skin.
