pharmachologic effect
What is the medicine for? This is a source of potassium and magnesium. The drug helps restore electrolyte balance , regulates metabolic and metabolic reactions and processes, and has a pronounced antiarrhythmic effect. Potassium takes an active part in synaptic transmission , in the conduction of nerve impulses along fibers, in muscle contractions, and supports the normal functioning of the heart. When potassium metabolism is disturbed, the excitability of muscle tissue and nerves changes. Active ion transport maintains a high potassium gradient across the plasma membrane. Small dosages of potassium contribute to the expansion of the coronary arteries, and in large dosages the microelement narrows their lumen. Potassium has a moderate diuretic effect , negative bathmotropic and chronotropic effects. Magnesium is a cofactor in three hundred enzyme reactions. Magnesium is an essential element during processes and reactions that provide energy intake and expenditure. Magnesium is part of the pentose phosphate structure of DNA, takes part in the process of cell division and growth, the structure of heredity, and RNA synthesis; is a natural BMCA, prevents the release of free fatty acids and catecholamines under stress, and promotes the penetration of potassium ions into the cell. The drug has a stimulating effect on intercellular phosphate synthesis.
INN: potassium and magnesium aspartate.
Pharmacological group: potassium and magnesium preparation.
Health Importance of Potassium
Among all the minerals involved in life processes, potassium is considered one of the most important. It is necessary to maintain water-salt balance and normalize acid-base balance in the body. Potassium is part of the intracellular fluid and helps eliminate excess water and sodium salts. A sufficient level of this microelement prevents the formation of edema and the deposition of salts on the walls of blood vessels. It is its ions that support the normal excitability of heart tissue.
Potassium deficiency causes the development of arrhythmia and tachycardia, as the normal contractility of the heart muscle is disrupted. This condition often triggers a heart attack. In addition, with a lack of potassium, weakness, depression of respiratory function, fluctuations in blood pressure, deterioration of the skin and hair, nausea, and muscle spasms may occur.
Indications for use of Panangin
Panangin tablets - what are they for?
Indications for use of Panangin are as follows. The drug is prescribed for hypomagnesemia, hypokalemia , when taking laxatives and diuretics, glucocorticosteroids, for diarrhea, persistent vomiting, taking saluretics, for myocardial infarction, heart failure , digitalis intoxication, ventricular extrasystole , atrial extrasystole, supraventricular tachycardia, paroxysmal tachycardia.
Example of a recipe in Latin: Rp.: Dragee “Panangin” N. 20
Reception scheme
Since injections need to be given, injections must be carried out by a specially trained person following all the rules of asepsis. It is best to carry out this process in a medical facility. This should be an intravenous injection of the solution at a slow pace. The procedure is carried out with a frequency of 20 drops in 60 seconds. The next dose, if necessary, can be given only after 6 hours.
Carefully! The rapid speed of injection is fraught with the development of facial hyperemia.
The solution is prepared according to the following scheme:
- Take 1 ampoule of the drug and open it.
- Dilute its contents with 5% glucose in a volume of 50 ml.
- Insert into the intravenous drip system.
It is permissible to combine the drug with other drugs.
Contraindications for Panangin
The drug is not used for intolerance to fructose, sorbitol, impaired amino acid metabolism, chronic pathology of the renal system, hemolysis, exicosis, dehydration, arterial hypotension , myasthenia gravis, atrioventricular block, hypermagnesemia, hyperkalemia, metabolic acidosis , Addison's disease. Panangin is used with caution during pregnancy.
Overdose
Episodes of overdose are not visible.
In view of the fact that drugs remove a lot of potassium from the body, increasing the dosage of the drug can lead to hyperkalemia, as this is associated with gastrointestinal tract or manifestations of impaired potassium excretion.
The therapeutic index of magnesium is wide, and in the presence of nitric deficiency, severe side effects are extremely rare.
Symptoms of hyperkalemia/hypermagnesemia may occur with rapid intravenous administration.
In case of overdose, symptoms of hyperkalemia and hypermagnesemia can be avoided.
Symptoms of hyperkalemia: mental weakness, paresthesia, bradycardia, paralysis. Extremely high concentrations of potassium in the plasma can lead to death due to decreased cardiac function, arrhythmia or heart failure.
Symptoms of hypermagnesemia: boredom, vomiting, drowsiness, arterial hypotension, bradycardia, weakness, blurred speech, double vision. At very high plasma concentrations of magnesium, hyporeflexia, paralysis of the muscles, dyspnea and heart failure may develop.
In case of overdose, it is necessary to replace K+-, Mg2+-aspartate and carry out symptomatic treatment (calcium chloride 100 mg/intravenously, dialysis, if necessary).
Side effects
Side effects are the following manifestations: ulceration of the mucous wall of the digestive tract, epigastric pain, diarrhea, bleeding from the organs of the digestive system, drop in blood pressure, bradycardia, paradoxical reaction in the form of an increase in the number of extrasystoles, dry mouth, nausea, flatulence, hyporeflexia, skin itching , dyspnea, thrombosis, phlebitis, paresthesia, dizziness, increased sweating, asthenia , myasthenia. With rapid intravenous infusion, hypermagnesemia and hyperkalemia are observed.
Important information
It is necessary to prescribe Panangin with extreme caution to patients with an increased risk of hyperkalemia. In this case, you will need to constantly monitor the level of potassium ions in the blood.
Before using the medicine, the patient should consult a doctor.
If the drug is injected quickly into a vein, hyperemia of the skin may develop.
Panangin does not affect the ability to drive vehicles or engage in work that requires concentrated concentration and an instant psychomotor reflex.
Instructions for use of Panangin (Method and dosage)
Panangin tablets, instructions for use
How to take the medicine? The drug is taken orally three times a day, 2 tablets. Maintenance and preventive therapy: 1 tablet three times a day, course for 3-4 weeks. In some situations, a repetition of the course of therapy is required.
Instructions for intravenous use
Panangin solution is injected intravenously, slowly. The drug is administered at a rate of 20-30 drops per minute, 1-2 times a day, 300 ml. Dosing of the drug Panangin during pregnancy is carried out according to the standard regimen of medication use.
Children can take the medicine from birth.
How to take Panangin for prevention?
If you ask the question of the benefits and harms of Panangin, you should realize that this is a drug that has its own side effects, so you should not use it for prevention. Firstly, in this way you accustom the body to a high content of magnesium and potassium, and secondly, you can provoke an overabundance of these substances, which in turn can cause a lot of negative reactions.
The role of magnesium
This microelement is also one of the vital ones. Its deficiency is felt quite quickly. Magnesium is involved in many metabolic processes, is a stimulator of the production of many different enzymes, and is involved in the synthesis of nucleic acids. It stimulates energy exchange, normalizes the functioning of the digestive organs, kidneys and brain. Without it, normal absorption of vitamins B and C is impossible. In addition, magnesium maintains sufficient levels of calcium in the body, which helps improve the condition of hair, nails and teeth.
This trace element is very important for the normal functioning of the heart muscle. It is even called the mineral of the heart. A sufficient amount of magnesium is necessary to reduce myocardial excitability and normalize smooth muscle tone. This helps reduce the heart's need for oxygen. In addition, magnesium protects heart tissue from destruction and prevents the development of coronary disease.
Interaction
Panagin is able to enhance the negative bathmotropic, dromotropic effects of antiarrhythmic drugs . The medication eliminates hypokalemia, which develops against the background of long-term use of diuretics, glucocorticosteroids, and MCS. NSAIDs, ACE inhibitors, heparin, potassium-sparing diuretics, cyclosporine, beta-blockers increase the risk of hyperkalemia. When using general anesthetics, the inhibitory effect of panangin on the nervous system increases. Succinyl chloride, decamethonium, atracuronium, suxamethonium enhance neuromuscular blockade . The use of enveloping and astringent medications reduces the absorption of potassium and magnesium in the digestive tract. In combination with insulin, dextrose as part of a polarizing mixture, the heart rate is normalized in case of an overdose of cardiac glycosides, in case of ectopic arrhythmias, myocardial infarction. Panangin improves the tolerability of cardiac glycosides and is pharmaceutically compatible with their solutions.
Overdose
In case of an overdose, the patient experiences symptoms of hypermagnesemia and hyperkalemia: arrhythmia develops, sensitivity in the extremities is impaired, diarrhea occurs, repeated vomiting, facial flushing, lethargy, hypotension, convulsions, breathing is depressed, and there is a possibility of cardiac arrest.
If signs of intoxication occur, you should immediately stop taking the drug, rinse the patient’s stomach, provide enterosorbents, prescribe peritoneal dialysis and hemodialysis.
Panangin's analogs
Level 4 ATC code matches:
Magnefar
Asparkam
Magnesium orotate
Magnerot
Substitutes can be considered such analogs of Panangin as Asparkam , Biolectra Magnesium Fortissimum , Potassium and Magnesium Asparaginate.
Substitutes
The following drugs have a similar effect and composition:
- Pamaton.
- Asparkam.
- Aspangin.
It is strictly prohibited to independently replace or adjust the dosage and frequency of administration. It is not recommended to discontinue the administration of the medicine without the consent of the attending physician. If you have any questions or adverse reactions or negative symptoms, seek help and advice from medical personnel.
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Panangina price, where to buy
The price of Panangin in tablets is 130-160 rubles, the price in ampoules is 160 rubles.
How much do tablets cost in St. Petersburg? You can buy them for 125 rubles.
The price of Panangin in Ukraine is 110 and 140 UAH for tablets and solution, respectively.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Panangin conc.d/inf.
10ml n5OJSC Gedeon Richter RUB 149 order - Panangin tab. p/o captivity. No. 50 JSC "Gedeon Richter-RUS"
RUB 143 order
- Panangin tab. p/o captivity. 158 mg + 140 mg No. 100 JSC "Gedeon Richter-RUS" RU
RUB 305 order
- Panangin Forte tablets p.p.o. 316mg+280mg 60 pcs. JSC Gedeon Richter
RUB 316 order
Pharmacy Dialogue
- Panangin (tab.p.pl/rev. No. 50)Gedeon-Richter
RUB 141 order
- Panangin forte (tab.pl/vol. 316mg+280mg No. 60)Gedeon-Richter
RUB 356 order
- Panangin (concentrated solution 10ml No. 5) Gedeon-Richter
RUB 157 order
- Panangin (tab.p.pl/rev. No. 50)Gedeon-Richter/Gedeon-Richter-RUS ZAO
147 RUR order
- Panangin (amp. 10ml No. 5) Gedeon-Richter
RUB 169 order
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Pharmacy24
- Panangin N50 tablets VAT "Gedeon Richter", Ugorshchina
110 UAH. order - Panangin 10 ml No. 5 concentrate for the preparation of solution for infusion VAT "Gedeon Richter", Ugorshchina
142 UAH order
PaniPharmacy
- Panangin solution d/in. 10ml No. 5 Hungary, Gedeon Richter
142 UAH order
- Panangin tablet p/captivity about. No. 50 Hungary, Gedeon Richter
115 UAH order
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