Cycloferon, 5 pcs., 2 ml, 125 mg/ml, solution for intravenous and intramuscular administration

Composition and pharmacokinetics

The composition of the injection solution of Cycloferon includes:

• active substance - meglumine acridone acetate (acridone acetic acid) - a low molecular weight interferon inducer with a wide spectrum of bioactivity;
• excipient - water for injection.

The main cells producing interferon after administration of Cycloferon are T- and B-lymphocytes, macrophages. Depending on the type of infection, one or another part of the immune system begins to predominate.

In addition, the drug stimulates the formation of granulocytes, activating bone marrow stem cells.

Cycloferon is highly effective against influenza viruses, herpes, papilloma, hepatitis, tick-borne encephalitis, human immunodeficiency virus, cytomegalovirus and others.

The use of medication for acute viral hepatitis prevents the disease from becoming chronic.

In case of HIV infection at the stage of primary manifestations, immunity indicators stabilize.

The effectiveness of Cycloferon as an immunotherapy in the complex treatment of acute and chronic bacterial infections - chlamydia, urogenital infections, bronchitis, pneumonia, neuroinfections, chlamydia, postoperative complications has been clinically confirmed.

In the case of rheumatic and systemic connective tissue diseases, the drug suppresses autoimmune reactions and has an anti-inflammatory and analgesic effect.

1.5-2 hours after the injection, the maximum level of the drug in the blood is observed. After a day, the substance is already contained in trace quantities.

Cycloferon is characterized by low toxicity and does not cause mutations or allergic reactions. The drug quickly dissolves in the tissues of the body and is excreted from the body naturally (through the kidneys) without consequences. With long-term therapy, the substance also does not accumulate in organic tissues.

The half-life of Cycloferon from the body is 4-5 hours.

Cycloferon solution for IV and IM administration 125 mg/ml 2ml No. 5 39156

Description

Transparent yellow liquid. Low molecular weight interferon inducer with a wide spectrum of biological activity (antiviral, immunomodulatory, anti-inflammatory, etc.). The main interferon-producing cells after the administration of Cycloferon® are macrophages, T- and B-lymphocytes. Depending on the type of infection, the activity of one or another part of the immune system predominates. The drug induces high titers of interferon in organs and tissues containing lymphoid elements (spleen, liver, lungs), activates bone marrow stem cells, stimulating the formation of granulocytes. Activates T-lymphocytes and natural killer cells, normalizes the balance between subpopulations of T-helpers and T-suppressors. The BBB passes. Cycloferon® is effective against tick-borne encephalitis viruses, influenza, hepatitis, herpes, CMV, HIV, papilloma virus and other viruses. The drug has been found to be highly effective in the complex treatment of acute and chronic bacterial infections (neuroinfections, chlamydia, bronchitis, pneumonia, postoperative complications, urogenital infections, peptic ulcers) as a component of immunotherapy. It is highly effective in treating rheumatic and systemic connective tissue diseases, suppressing autoimmune reactions and providing anti-inflammatory and analgesic effects. Freezing the solution during transportation at subzero temperatures does not lead to changes in the properties of the drug. Thawed at room temperature, the drug retains its biological and physicochemical properties. If the color of the solution changes and a precipitate forms, the use of the drug is unacceptable.

Compound

Solution for intravenous and intramuscular administration 125 mg/ml 1 ml meglumine acridone acetate in terms of acridoneacetic acid 125 mg excipients: water for injection in ampoules of 2 ml, in one-sided blister pack of 5 ampoules, blister pack open or heat-sealed with a cover sheet aluminum film or foil; 1 contour blister package along with instructions for use and a knife for opening ampoules or an ampoule scarifier (if there is no point or break line on the ampoule) in a cardboard box.

Application

In adults (as part of complex therapy): HIV infection (AIDS, stage 2A–2B); neuroinfections (serous meningitis, encephalitis, Lyme disease); viral hepatitis (A, B, C, D); herpes and CMV infection; secondary immunodeficiency conditions associated with acute and chronic bacterial and fungal infections; rheumatic and other systemic connective tissue diseases (rheumatoid arthritis, systemic lupus erythematosus); degenerative-dystrophic diseases of the joints, incl. deforming osteoarthritis. In children over 4 years of age (as part of complex therapy): viral hepatitis (A, B, C, D); herpes and HIV infection (stage 2A–2B). Allergic reactions. Compatible with other drugs used in the treatment of diseases indicated in the indications (interferons, chemotherapeutic drugs, etc.). Adults IM, IV, 1 time per day according to the basic scheme every other day. The duration of treatment depends on the disease. For herpes and cytomegalovirus infection, the basic regimen is 10 injections of 0.25 g each. The total dose is 2.5 g. Treatment is most effective at the beginning of an exacerbation of the disease. For neuroinfections, the drug is administered according to the basic regimen. The course of treatment is 12 injections of 0.25–0.5 g in combination with etiotropic therapy. Total dose - 3-6 g. Repeated courses - as needed. For chlamydial infection, it is administered according to the basic regimen. Course of treatment - 10 injections of 0.25 g. Total dose - 2.5 g. Repeated course of treatment after 10-14 days. It is advisable to combine Cycloferon® with antibiotics. For acute viral hepatitis A, B, C, D and mixed forms, the drug is administered according to the basic scheme of 10 injections of 0.5 g. The total dose is 5.0 g. If the infection is protracted, the course is repeated after 10–14 days. For chronic viral hepatitis B, C, D and mixed forms, the drug is administered according to a basic regimen of 10 injections of 0.5 g each, then according to a maintenance regimen 3 times a week for 3 months as part of complex therapy. Recommended in combination with interferons and chemotherapy. Repeat the course after 10–14 days. For HIV infection (2A–2B) - according to the basic regimen, 10 injections of 0.5 g each and then according to the maintenance regimen - once every three days for 2.5 months. Repeat the course - after 10 days. For immunodeficiency conditions, the course of treatment is 10 intramuscular injections according to the basic regimen in a single dose of 0.25 g. The total dose is 2.5 g. A repeated course is carried out after 6–12 months. For rheumatic and systemic connective tissue diseases - 4 courses of 5 injections according to the basic regimen of 0.25 g with a break of 10-14 days. Repeated course on doctor's recommendation. For degenerative-dystrophic diseases of the joints - 2 courses of 5 injections of 0.25 g each with a break of 10-14 days according to the basic scheme. Repeated course on doctor's recommendation. Children IM, IV, 1 time per day according to the basic regimen, every other day. The daily therapeutic dose is 6–10 mg/kg. For acute viral hepatitis A, B, C, D and mixed forms, the drug is administered according to the basic scheme of 15 injections. In case of prolonged infection, repeat the course after 10–14 days. For chronic viral hepatitis B, C, D, the drug is administered according to a basic regimen of 10 injections and then according to a maintenance regimen 3 times a week for 3 months as part of complex therapy. Recommended in combination with interferons and chemotherapy. For HIV infection (stages 2A–2B) - a course of 10 injections according to the basic regimen and then according to the maintenance regimen once every 3 days for 3 months. Repeat course after 10 days. For herpes infection - a course of 10 injections according to the basic scheme. If the replicative activity of the virus remains, the course of treatment is continued according to a maintenance regimen with administration once every 3 days for 4 weeks. hypersensitivity; decompensated cirrhosis of the liver; pregnancy; lactation period; children up to 4 years old.

Possible product names

• Cycloferon solution for IV and IM administration 125 mg/ml 2ml No. 5
• CYCLOFERON 12.5% ​​AMP 2 ML No. 5
• (Cycloferon) Cycloferon solution for IV and IM injection 125 mg/ml 2ml No. 5

Indications for use

Possessing a wide range of biological activity (immunomodulatory, antiviral, anti-inflammatory, etc.), Cycloferon solution is effective in treating a number of diseases:

• Leyme disease;
• herpetic infection;
• chlamydial infections;
• HIV infection (stages 2A - 2B);
• flu;
• ARVI;
• secondary immunodeficiency;
• meningitis;
• cytomegalovirus infections;
• encephalitis;
• viral hepatitis A, B, C, D;
• rheumatic and systemic connective tissue diseases (systemic lupus erythematosus, rheumatoid arthritis);
• degenerative-dystrophic diseases of the joints (deforming osteoarthritis, etc.).

Cycloferon and Transfer factor

Usually, in order to complete the necessary course of treatment with Cycloferon, the patient has to take about 80 tablets and pay at least 1,600 rubles for the entire course of treatment. However, no one can guarantee that the treatment will be successful and the desired result will be achieved in a short time. Often you have to repeat treatment with Cycloferon, which, accordingly, will increase the amount of money spent on treatment.

Transfer factor, which performs the same functions as Cycloferon, costs about 2,000 rubles per package containing 90 capsules. But the uniqueness of this drug lies in its absolute harmlessness to the human body. Scientists and doctors recommend that Transfer Factor be used by everyone without restrictions, since this drug can have such a profound effect on the human body that it even manages to correct problems in the DNA structure, eliminating not only the disease itself, but also the reason why it occurs. If taking Cycloferon is the final decision, then Transfer Factor will help neutralize all the side effects of the drug described above.

Directions for use and dosage

Cycloferon solution can be administered into the body through intramuscular and intravenous injections. The ampoule is opened immediately before administration of the drug.

In most cases, injections are given once a day according to the following scheme:

• one injection on the 1st and 2nd day of the course;
• then on days 4, 6 and 8 of treatment;
• then at 11 and 14, 17 and 20, 23 and 26, 29 days.

The duration of therapy directly depends on the disease:

• cytomegalovirus infection - no more than 10 injections, the total dose of which should not exceed 2.5 g of solution.
• neuroinfection - from 10 to 12 injections of 300-450 mg every other day in combination with a course of etiotropic therapy.
• viral hepatitis - up to 10-12 injections of 400 mg for three months.
• rheumatic diseases - 4-5 injections every other day for 3-4 months with a two-week break in the middle of the cycle.

The dosage of Cycloferon solution for children is calculated according to body weight - approximately 6-10 mg of medication per 1 kg of child weight. The specific treatment regimen is determined only by the pediatrician.

If the dosage and injection schedule are not followed, Cycloferon can cause side effects:

• nausea and vomiting;
• panic attacks and insomnia;
• skin rashes;
• general malaise.

Cycloferon: price and sale

This drug is quite well known and is often used in medical practice. In any pharmacy you can buy Cycloferon in ampoules or in the form of liniment, and Cycloferon tablets. The price of the drug averages approximately 200 rubles for 10 tablets. You can also buy Cycloferon using the Internet, but here you need to be careful and make every effort to protect yourself from false purchases, and in the future, from receiving low-quality products. Therefore, when buying Cycloferon in ampoules, price is not the main indicator. The main thing is to make sure that the product has a certificate of conformity.

Cycloferon reviews are quite good, but it also has contraindications and side effects. Therefore, before starting to take the drug, you should consult with your doctor, and under no circumstances prescribe the drug to yourself.