pharmachologic effect
The active component has antispasmodic, myotropic, vasodilating and short-term hypotonic effects. The active substance affects the smooth muscles of the blood vessels of internal organs, affects venules and arterioles. The drug is able to reduce the tone of blood vessels, lowering blood pressure and increasing blood flow to those areas of the myocardium that suffer from ischemia and hypoxia , which is observed in coronary artery disease .
Bendazole is able to stimulate synaptic interneuron transmission in the spinal cord, which allows the drug to be used in neurological practice. The active component also has an immunomodulatory effect , because similar to Levamisole , which belongs to a group of medications that stimulate immune processes. The immunostimulating effect of the drug is explained by the ability of bendazole to enhance the production of the endogenous form of interferon .
Indications for use of Dibazol
Bendazole- based drugs are prescribed to patients who suffer from spasms of vascular smooth muscle tissue. The medication can be used to relieve a hypertensive crisis . When there is spasm of the smooth muscles of internal organs ( intestinal colic , peptic ulcer , pancreatitis , cholecystitis ), the severity of the pain syndrome decreases due to muscle relaxation.
Indications for the use of Dibazol in neurology:
- flaccid paralysis syndrome;
- facial paralysis;
- treatment of residual effects of polio .
What do Dibazol tablets help with?
The tablet form has found wide application in medical practice: cardiology, neurology, therapy, gastroenterology.
The medication helps reduce blood pressure, relieve spasms and reduce the severity of pain that occurs due to spasms of smooth muscle tissue.
Reviews about the drug
Due to the fact that Dibazol only rarely produces side effects, reviews of it from patients are mostly positive. The medicine is not used on an ongoing basis, but only as an emergency measure to urgently reduce high blood pressure.
Dibazol has been used in various branches of medicine for more than half a century; it is especially popular as a prophylactic agent during influenza epidemics to generally strengthen the immune system. But those who have developed stable arterial hypertension call Dibazol for blood pressure ineffective because of its short action.
What is most attractive about the drug is its affordable price and the ability to purchase without a prescription. Before starting to use Dibazol, it is better to consult a qualified specialist.
Contraindications
Dibazol UBF is not prescribed for individual hypersensitivity to bendazole. In pediatric practice, tablets with a dosage of 20 mg of the active substance are not used.
It is not recommended to prescribe the medication to patients who suffer from arterial hypotension , peptic ulcer of the digestive tract with bleeding , or pathology of the renal system. It is unacceptable to prescribe bendazole to persons suffering from diabetes mellitus , heart failure (severe), or with reduced muscle tone.
Relative contraindications include old age (especially with long-term use). Prescribed with caution to persons whose work requires increased attention and concentration, because Possible loss of coordination and dizziness during treatment.
Useful tips
It is not recommended to discontinue Dibazol on your own immediately after the painful symptoms of any pathology have subsided. When prescribing it, the doctor often relies on the immunostimulating properties of the drug. Only after the end of the treatment course determined by him, the use of tablets or injection solution is completed.
In combination with alcoholic beverages, Dibazol may lose some of its pharmacological properties. Under the influence of ethyl alcohol, the absorption of the active substance slows down, it is eliminated from the body without showing any therapeutic effects. The risk of distortion of the antispasmodic effect of Dibazol also increases. Therefore, during treatment it is necessary to avoid drinking alcoholic beverages.
The use of Dibazol in tablets and solution for parenteral administration can have a negative effect on the functioning of the autonomic and central nervous systems. Therefore, during treatment, especially coursework, it is undesirable to drive vehicles, as well as perform work that requires special concentration and speed of reactions. It is necessary to discuss such nuances of therapy with your doctor immediately after prescribing a peripheral vasodilator.
Instructions for use of Dibazol (Method and dosage)
Dibazol tablets, instructions for use
20-50 mg 2-3 times a day for 3-4 weeks. Children are prescribed 1-5 mg once a day, the dosage varies depending on age.
Instructions for the use of Dibazol UBF in neurological practice
5 mg per day every other day, course 5-10 days. Treatment is repeated after 3-4 weeks. Further courses can be carried out every 1-2 months.
To relieve hypertensive crisis
Dibazol is used in ampoules at a dose of 30-40 mg. Injections can be given intramuscularly or intravenously. With a significant increase in blood pressure and exacerbation of arterial hypertension, 20-30 mg of bendazole is administered intramuscularly 2-3 times a day. The course lasts 8-14 days.
Release form and composition
The treatment line Dibazol consists of tablets and solution for injection.
They are produced by many domestic pharmaceutical companies. The active substance of the drug is bendazole from the clinical and pharmacological group of peripheral vasodilators. Dibazol is produced in the form of a transparent solution without foreign inclusions, packaged in glass or plastic ampoules. In addition to the main component, the solution contains only water for injection. The tablets are white, round, small. The auxiliary composition of this dosage form of Dibazol is represented by the following ingredients:
- sugar;
- potato starch;
- colloidal silicon dioxide;
- calcium stearate.
The tablets are in plastic bottles, but more often - in paper currency cells. Additional substances act as stabilizers and preservatives, ensuring the rapid release of bendazole and its most complete penetration into the bloodstream. The secondary packaging of the injection solution is a cardboard box with instructions for use inside. Attached to it is a special file for opening glass ampoules.
Overdose
When taking doses exceeding those recommended by the manufacturer, negative symptoms are recorded:
- excessive sweating;
- feeling of heat;
- nausea;
- dizziness;
- drop in blood pressure.
A specific antidote has not been developed, so first aid for poisoning is aimed at reducing the absorption of the active drug from the lumen of the digestive tract by inducing vomiting, gastric lavage and prescribing enterosorbent medications such as Smecta, Activated Carbon, Polysorb and others. If a different clinical picture develops, stage-by-syndromic therapy is carried out.
Side effects
Side effects of Dibazol are observed extremely rarely and mainly from the cardiovascular system. The functional indicator of the ratio of the volume of blood leaving the left ventricle to the volume returning to it changes, but without any pronounced discomfort. Systemic reactions are also manifested by the following symptoms:
- dizziness;
- drop in blood pressure.
Local allergic reactions may develop. They are indicated by soreness and rash, itching, burning, redness and swelling of the skin in certain areas of the body. It is necessary to immediately stop treatment with Dibazol and consult your doctor to eliminate the symptoms.
For children, Dibazol for infants
For older children, tablets with a dosage of 4 mg are produced; for infants, solutions are prepared at specialized points in pharmacies. In pediatric practice, the medication is prescribed for the following conditions:
- Muscular hypotonia , which developed after a difficult birth, as a result of prolonged hypoxia, hereditary pathology of the neuromuscular system, with various chromosomal syndromes.
- Colic and spasms . The medication has a gentle effect on smooth muscles, relieving babies of pain caused by spasms of the smooth muscle tissue of internal organs.
- Stress and fatigue . Dibazol is characterized by an adaptogenic effect , which makes it possible to increase the nonspecific resistance of the child’s body.
- Flu , ARVI , colds . The medication enhances the production of interferon when the virus enters the child’s body.
Dibazol price, where to buy Dibazol tablets
The price of the medicine is relatively low. The average cost of the tablet form in Russia is from 30 rubles. The solution costs a little more - about 40 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
ZdravCity
- Dibazol solution for intravenous and intramuscular administration.
1% 1ml 10 pcs. JSC Dalkhimfarm 31 rub. order - Dibazol-UBF tablets 20 mg 10 pcs. JSC Uralbiopharm
42 RUR order
- Dibazol solution for intravenous and intramuscular administration. 10 mg/ml 5 ml No. 10 JSC Dalkhimfarm
41 rub. order
Pharmacy Dialogue
- Dibazol-UBF (20 mg tablet No. 10) Uralbiopharm
45 rub. order
- Dibazol (20 mg tablet No. 10) MFF
41 rub. order
- Dibazol (amp. 1% 1ml No. 10) DHF JSC
38 rub. order
- Dibazol (amp. 1% 5ml No. 10) DHF JSC
50 rub. order
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Pharmacy24
- Dibazol-Darnitsa 0.02 No. 10 tablets PrAT" Pharmaceutical company "Darnitsa", Ukraine
8 UAH. order - Dibazol-Darnitsa 1% 5 ml No. 10 injection solution PrAT” Pharmaceutical company “Darnitsa”, Ukraine
51 UAH order
- Dibazol-Darnitsa 1% 1 ml No. 10 injection solution PrAT" Pharmaceutical company "Darnitsa", Ukraine
21 UAH order
- Analgin-dibazole-papaverine No. 10 tablets INTERCHEM Partnership with additional coverage, Ukraine
19 UAH order
