The drug "Erinit": indications for use and rules of administration

pharmachologic effect

Venous vasodilator, has an antianginal effect. Stimulates the formation of nitric oxide in the vascular wall, which is an endothelial relaxing factor. Reduces preload (dilatation of peripheral veins and reduction of blood flow to the right atrium) and afterload, total peripheral vascular resistance (TPVR) on the heart; reduces myocardial oxygen demand.

Restores blood flow through small endocardial vessels, improves blood flow in the epicardial coronary arteries, increases exercise tolerance in patients with coronary heart disease (CHD), angina pectoris.

In heart failure, it helps to unload the myocardium by reducing preload. Reduces pressure in the pulmonary circulation.

Compared to nitroglycerin, it has a slower but longer-lasting effect (up to 10 hours). When taken orally, the onset of effect is after 30 - 45 minutes (with sublingual administration - after 15 - 20 minutes), duration - 4 - 5 hours.

Compound

Erinite is a vasodilator. It helps improve blood flow to tissues and organs. The active ingredient of the drug is pentaerythrityl tetranitrate. Auxiliary components of the composition:

• glucose;
• potato starch;
• white crumbly talc;
• octadecanoic acid;
• sucrose.

The drug stimulates the entry of nitric oxide into the vascular walls, which is a relaxant. When using Erinite, blood flow into the right atrium decreases, superficial veins dilate, and the heart's need for oxygen decreases.

Erinitis is able to redistribute blood flow in places where there is a lack of blood supply (ischemia).

Contraindications

Hypersensitivity, severe arterial hypotension (systolic blood pressure below 90 mm Hg, diastolic blood pressure below 60 mm Hg), collapse, shock, acute myocardial infarction occurring with hypotension, hemorrhagic stroke, traumatic brain injury, angle closure glaucoma, severe liver failure (risk of developing methemoglobinemia), severe renal failure, severe anemia, hypertrophic obstructive cardiomyopathy, constrictive pericarditis, cardiac tamponade, severe aortic and/or mitral valve stenosis, hyperthyroidism, primary pulmonary hypertension (hyperemia of insufficiently ventilated alveolar zones can lead to to hypoxia), chronic heart failure with low left ventricular filling pressure, simultaneous use of phosphodiesterase-5 inhibitors (including sildenafil, vardenafil, tadalafil), lactose and sucrose intolerance, deficiency of sucrase-isomaltase, lactase or glucose-galactose malabsorption, hypersensitivity to the drug and its components, other organic nitrates, age under 18 years (efficacy and safety have not been established).

Carefully

Used for patients prone to arterial hypotension in elderly and dehydrated patients; with a history of orthostatic hypotension.

Use during pregnancy and breastfeeding

The use of the drug during pregnancy and lactation is contraindicated.

Erinite price

Before purchasing Erinit tablets, it is important to consult a doctor, study the main aspects of use and recommendations written in the instructions. It is convenient to buy cardiovascular pills in a regular pharmacy kiosk in Moscow with a prescription. Online pharmacies do not deliver prescription drugs; only self-pickup is available upon presentation of a prescription. Below is the price of the drug for 50 pcs. The cost varies depending on the place of sale and the manufacturer - Farmapol-Volga, Tatkhimfarmpreparaty and Pharmstandard-Leksredstva:

special instructions

When taken, the risk of developing arterial hypotension increases in elderly patients and dehydrated patients.

It is necessary to exclude alcohol consumption during treatment.

With prolonged use, the therapeutic effect may decrease (due to the development of tolerance). To reduce the risk of developing tolerance, it is recommended to observe a “nitrate-free” period (8 - 12 hours).

When using the drug once a day in combination with other antianginal drugs, the risk of developing tolerance is less.

The drug is not used to relieve angina attacks. Do not suddenly interrupt treatment with the drug.

Due to the fact that when using the drug, side effects such as dizziness, drowsiness and blurred vision may occur, it is therefore necessary to refrain from driving vehicles and engaging in potentially hazardous activities that require increased concentration and rapid mental and motor reactions.

Reviews about the drug

Many patients take Erinit. Its price is low: a package of 50 tablets costs about 70 rubles. Therefore, any person has access to a full course of treatment with the drug. And since it is usually well tolerated, doctors often prescribe Erinit. Reviews about it are mostly positive. Patients note an improvement in their condition and a decrease in the frequency of angina attacks. If they happen, they are not so intense.

Doctors also like to prescribe Erinit.” Indications for use allow the drug to be used for any form of coronary heart disease. It is especially effective in combination with other antianginal agents. By choosing the right combination of medications, you can achieve almost complete cessation of attacks.

Directions for use and doses

Erinit is taken orally (1 hour before meals) in the form of tablets of 10 - 20 mg (1 - 2 tablets) 3 - 4 times a day, if necessary - up to 40 mg 4 times a day, it is acceptable to prescribe 80 mg 2 times a day day.

To prevent nocturnal attacks of angina pectoris, 20 mg is prescribed before bedtime. The course of treatment usually lasts 2 - 4 weeks. A repeated course is prescribed with breaks, the duration of which depends on the course of the disease.

If necessary, sublingual administration of the drug is possible, but not to relieve an attack of angina.

Analogs

Erinit tablets have no analogues for the active substance.

Analogues of the drug group existing on the pharmacological market include:

• Pentral;
• Pentaril;
• Vasocor;
• Quintrate;
• Pentafin.

The decision on the prescription and possible replacement of Erinit with analogues can only be made by the attending physician.

Storage of medicine

Erinit must be stored in a place where children and pets have no access, at a temperature no higher than plus 15 degrees. The selected location should be protected from direct sunlight and high humidity.

If all rules are followed, the shelf life is 3 years from the production date indicated on the packaging. After the expiration date, taking tablets is strictly prohibited.

So, Erinit is an effective vasodilator with a prolonged action that normalizes blood circulation, the functioning of the heart and blood vessels. The medicine has side effects that may occur if the instructions for use are not followed. In this regard, only a doctor should prescribe therapy and set its duration. Self-medication is dangerous to health.

Side effect

Allergic reactions, skin flushing, headache, tinnitus, dizziness, nausea, weakness, tachycardia, increased fatigue, anxiety, increased sweating, decreased blood pressure (BP), orthostatic hypotension; sometimes there is a disorder of intestinal function (diarrhea). When the dose is reduced or after stopping the drug, side effects disappear.

Overdose

When using the drug in large doses, tolerance may develop.

Symptoms: orthostatic hypotension, a feeling of compression of the head, throbbing headache, severe sweating, cold skin, covered with sticky sweat, or hyperemic, palpitations, bradycardia, conduction disturbances (blockade), difficulty breathing, Kussmaul breathing, bloody diarrhea, vomiting, dizziness, confusion, syncope, coma, fever, paralysis, visual impairment.

Treatment: gastric lavage, giving a horizontal position with legs raised, in case of severe arterial hypotension and/or in patients in shock - administration of fluid intravenous drip infusion solutions, monitoring the level of methemoglobin in the blood, if it increases - prescribing ascorbic acid in a dose 1 g orally, methylthioninium chloride (Methylene blue) IV up to 50 ml of 1% solution, toluidine blue - 2 - 4 mg/kg body weight IV quickly, if necessary - again at a dose of 2 mg/kg with an interval of 1 hour , oxygen therapy, hemodialysis, exchange transfusion.

Overdose

In case of overdose, emergency assistance is required. Until the doctor arrives, you should drink a sorbent and perform gastric lavage by drinking a large amount of water. Upon arrival of the medical team, the victim is provided with professional assistance.

In a state of overdose, the following manifestations of mild and severe severity are observed:

• vision problems;
• orthostatic hypotension;
• paralysis;
• pressing and throbbing headaches;
• fever;
• increased sweating;
• fainting;
• increased heart rate;
• shallow breathing;
• cold skin and clammy sweat;
• coma.

Interaction with other drugs

If you are taking this drug with other medications at the same time, consult your doctor.

Under the influence of dihydroergotamine, the antianginal effect of erinitis may be reduced. The combination of these means is considered irrational.

It is possible to enhance the hypotensive effect when used simultaneously with vasodilators and antihypertensive drugs (beta-blockers, calcium channel blockers, etc.), antipsychotics, tricyclic antidepressants, monoamine oxidase inhibitors, procainamide, ethanol, phosphodiesterase-5 inhibitors.

The combination with anaprilin is rational, since the antianginal effect is enhanced.

Erinit tablets

A drug called Erinit has a vasodilating effect and is prescribed to people who need to improve blood circulation in organs and tissues. The drug belongs to the pharmacological group of nitrates and nitrate-like drugs. The medication has a beneficial effect on the heart and blood vessels. The drug Erinit can be used as a primary or additional drug. The instructions for it say that using the tablets on a regular basis prevents angina attacks.

Compound

The active ingredient of Erinit is pentaerythrityl tetranitrate, which is contained in quantities of up to 10 mg. The drug dilates blood vessels and is similar in pharmacological action to the well-known nitroglycerin. The difference between Erinite is its longer action time - about 10 hours. Other auxiliary elements of the medication are:

• talc;
• sucrose;
• dextrose;
• potato starch;
• stearic acid.

Release form

The convenient release form allows you to take the vasodilator drug anywhere. To make the medicine better absorbed, it is pre-crushed, although you can take the whole tablet with plenty of water. Erinite is available in the form of biconvex white tablets with a marbled tint. The medicine contains 0.01 and 0.002 g of the active substance - pentaerythrityl tetranitrate. Erinite is placed in blister packs. A blue cardboard box contains 50 pieces. The shelf life of Erinite is 3 years.

pharmachologic effect

The instructions indicate what Erinit tablets are for: the medication eliminates the symptoms of myocardial ischemia, is effective against angina pectoris and other cardiovascular pathologies. Erinite stimulates the production of nitric oxide on the vascular walls, the molecules of which have a relaxing effect. The drug acts in the bloodstream, spreading blood to areas of low circulation.