Ftivazid - description of the drug, instructions for use, reviews

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Manufacturers: Pharmasintez

Active ingredients

• Ftivazid

Disease class

• Not indicated. See instructions

Clinical and pharmacological group

• Not indicated. See instructions

Pharmacological action

• Antituberculosis

Pharmacological group

• Other synthetic antibacterial agents

Pharmacodynamics and pharmacokinetics

These anti-tuberculosis tablets have a bactericidal effect. The drug exhibits a blocking effect on the synthesis of mycolic acid, which ensures the acid resistance of tuberculous mycobacteria, and leads to cell death. In this case, the synthesis of phospholipids is destroyed, resulting in the formation of intra- and extracellular chelate complexes with the presence of divalent ions, inhibiting oxidative processes and the production of deoxy- and ribonucleic acids.

Ftivazid is characterized by high absorption. Reaching the maximum concentration in the blood can be detected after 1–2 hours. Plasma protein binding is up to 10%. The drug is able to penetrate the placental barrier and enter breast milk. metabolic process occurs in the liver. In this case, the main metabolite - isonicotinic acid hydrazide , which undergoes subsequent hydrolysis and acetylation. Excretion occurs mainly through the kidneys and a little through the intestines.

Pharmacological action of Ftivazid

Phtivazid has a pronounced bacteriostatic effect against Mycobacterium tuberculosis. Phtivazid damages the membrane of mycobacteria, inhibits oxidative and metabolic processes, the synthesis of nucleic acids, and has an effect on mycobacteria outside and inside the cell.

Phtivazid is well absorbed from the gastrointestinal tract, distributed evenly and quickly in tissues and organs, creating conditions for the therapeutic effect of the drug in various localizations of lesions.

Phtivazid is close in its properties and action to isoniazid, but has less toxicity in comparison with it, is absorbed and eliminated more slowly, and therefore the therapeutic concentration of Phtivazid is maintained longer in the blood and at a lower level.

As it is less toxic, Phtivazid is more often used in elderly and debilitated patients, in children and in cases of intolerance to streptomycin.

The effect of using Ftivazid occurs quickly. The patient's general condition improves, temperature and appetite normalize, cough decreases, and weight increases.

Contraindications for use

The drug is not prescribed for:

• hypersensitivity;
• angina pectoris;
• chronic heart failure stage 2-3;
• epilepsy;
• organic lesions of the central nervous system;
• liver and kidney diseases;
• alcoholism;
• lactation, pregnancy;
• children under 1 year of age.

Side effects

When treated with Ftivazid, disturbances in the functioning of the nervous system may occur, for example: headache , cardialgia, dizziness, sleep problems, fatigue, depression, psychosis, euphoria , increased frequency of epileptic seizures.

Deviations in the activity of the sensory organs and the digestive system in the form of: peripheral neuritis, nausea, vomiting, decreased appetite , dry mouth, gastralgia, hepatitis and so on are also possible.

Allergic reactions , high bleeding, gynecomastia , etc. are possible

Instructions:

Clinical and pharmacological group

06.051 (Anti-tuberculosis drug)

pharmachologic effect

Antituberculosis agent, a derivative of isonicotinic acid hydrazide. It has high selective activity against Mycobacterium tuberculosis. Causes damage to the mycobacterial membrane, inhibits metabolic and oxidative processes, inhibits the synthesis of nucleic acids, and affects mycobacteria both inside and outside the cell.

Slowly absorbed from the gastrointestinal tract.

Dosage

Taken orally. Adults - 500 mg 2-3 times a day. Children - at the rate of 30-40 mg/kg/day in 3 divided doses. For tuberculous lupus - 250-300 mg 3-4 times a day. Per course - 40-60 g. If necessary, the course of treatment is repeated 2-3 times with a month's break.

Maximum doses: for adults single dose - 1 g, daily dose - 2 g; for children the daily allowance is 1.5 g.

Side effects

From the central nervous system and peripheral nervous system: headache, dizziness, euphoria, poor sleep; in rare cases - psychosis, memory impairment, peripheral neuritis, optic neuritis; in patients with epilepsy, an increase in seizures may occur.

From the digestive system: nausea, vomiting, dry mouth, epigastric pain, drug-induced hepatitis,

From the endocrine system: in men - gynecomastia, in women - menorrhagia.

Allergic reactions: skin manifestations.

Other: pain in the heart area.

Indications

Treatment of active tuberculosis of all forms and localizations in adults and children.

Contraindications

Angina; decompensated heart defects; organic diseases of the central nervous system; kidney diseases of a non-tuberculous nature, as well as with impaired excretory function; hypersensitivity to ftivazid.

special instructions

During the treatment period, periodic examination of the fundus is necessary. To prevent the development of neuritis, vitamins B1 and B6 are prescribed simultaneously.

Phtivazid can be used to treat patients with hypersensitivity to isoniazid.

Maximum effectiveness is manifested in fresh, acute processes. Penetrates the placental barrier and is excreted in breast milk.

Preparations containing FTIVAZIDE

• FTIVAZIDE tab. 500 mg: 10, 50 or 100 pcs. • FTIVAZIDE tab. 500 mg: 10, 50 or 100 pcs. • FTIVAZIDE tab. 300 mg: 50 or 100 pcs. • FTIVAZIDE-AKOS tab. 300 mg: 100 pcs. • FTIVAZIDE tab. 500 mg: 50, 100, 500 or 1000 pcs. • FTIVAZIDE tab. 300 mg: 10, 50 or 100 pcs. • FTIVAZIDE tab. 500 mg: 100 pcs. • FTIVAZIDE tab. 500 mg: 50 pcs. • FTIVAZIDE tab. 100 mg: 10, 50 or 100 pcs. • FTIVAZIDE tab. 100 mg: 100 pcs. • FTIVAZIDE MS tab. 300 mg: 50 or 100 pcs. • FTIVAZIDE-AKOS tab. 500 mg: 100 pcs. • FTIVAZIDE tab. 300 mg: 100 pcs. • FTIVAZIDE tab. 300 mg: 10, 50 or 100 pcs. • FTIVAZIDE MS tab. 500 mg: 25, 30, 50 or 100 pcs. • FTIVAZIDE tab. 500 mg: 50 or 100 pcs. • FTIVAZIDE tab. 100 mg: 10, 50 or 100 pcs. • FTIVAZIDE tab. 500 mg: 10, 20, 40 or 100 pcs. • FTIVAZIDE tab. 500 mg: 100 pcs.

Ftivazid, instructions for use (Method and dosage)

The drug is taken orally: for adult patients the average daily dosage is set at 1-1.5 g for 2-3 times a day, and for children the dose is calculated taking into account their weight, tablets are taken 3 times a day.

The maximum dosage for adult patients is: 1 g per dose, 2 g per day.

When treating tuberculous lupus, 0.2–0.3 g is prescribed 3–4 times a day, with a course dosage of 40–60 g. If necessary, the therapeutic course is repeated 3-4 times a year, taking a break of 1 month.

Ftivazid

Active substance:

Ftivazide*

Pharmgroup:

Other synthetic antibacterial agents

Average price in pharmacies

special instructions

While taking Ftivazid, a fundus examination is required. To prevent the development of neuritis, Thiamine and Pyridoxine along with this drug . When the medicine is prescribed during lactation, feeding the baby with breast milk immediately stops. This drug can be prescribed to patients intolerant to isoniazid.

Side effects

According to reviews, Ftivazid is usually well tolerated by patients, but can sometimes cause side effects.

Digestive system: vomiting, nausea, epigastric pain, dry mouth, drug-induced hepatitis.

Central and peripheral nervous systems: dizziness, headache, sleep deterioration, euphoria, psychosis, peripheral neuritis, memory impairment, optic neuritis, increased frequency of seizures in patients with epilepsy.

Endocrine system: menorrhagia - in women, gynecomastia - in men.

Allergic reactions on the skin.

Heartache.

Reviews of Ftivazid

As reviews of Ftivazid show, this is one of the most effective anti-tuberculosis drugs. It is prescribed to patients of different ages (but not younger than 1 year) at various stages of the disease.

Almost everyone who took this remedy noted a significant improvement, elimination of Koch's bacillus , normalization of general well-being and complete relief from shortness of breath .

The high effectiveness of this drug is confirmed by many experts. At the same time, they remind that this medicine can only be prescribed by the attending physician, since it is important to establish the optimal dosage and take into account the list of contraindications for use.

Only thanks to this approach can you get an excellent result and completely get rid of the disease without causing possible harm to the entire body.

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** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use the drug Ftivazid, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.

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