GENFERON suppositories vaginal/rectal 1 million IU No. 10
GENFERON is a combination drug, the effect of which is determined by the components included in its composition. Has local and systemic effects.
The drug Genferon includes recombinant human interferon alpha-2b, produced by a strain of the bacterium Escherichia coli, into which the human interferon alpha-2b gene has been introduced using genetic engineering methods.
Interferon alpha-2b has antiviral, immunomodulatory, antiproliferative and antibacterial effects. The antiviral effect is mediated by the activation of a number of intracellular enzymes that inhibit viral replication. The immunomodulatory effect is manifested, first of all, by enhancing cell-mediated reactions of the immune system, which increases the effectiveness of the immune response against viruses, intracellular parasites and cells that have undergone tumor transformation. This is achieved through the activation of CD8+ T killer cells, NK cells (natural killer cells), increased differentiation of B lymphocytes and their production of antibodies, activation of the monocyte-macrophage system and phagocytosis, as well as increased expression of molecules of the major histocompatibility complex type I, which increases the likelihood recognition of infected cells by cells of the immune system. Activation of leukocytes contained in all layers of the mucous membrane under the influence of interferon ensures their active participation in the elimination of pathological foci; in addition, due to the influence of interferon, the production of secretory immunoglobulin A is restored. The antibacterial effect is mediated by reactions of the immune system, enhanced under the influence of interferon.
Taurine helps normalize metabolic processes and tissue regeneration, has membrane-stabilizing and immunomodulatory effects. Being a strong antioxidant, taurine directly interacts with reactive oxygen species, the excessive accumulation of which contributes to the development of pathological processes. Taurine helps maintain the biological activity of interferon, enhancing the therapeutic effect of the drug.
Benzocaine (anesthetic) is a local anesthetic. Reduces the permeability of the cell membrane to sodium ions, displaces calcium ions from receptors located on the inner surface of the membrane, and blocks the conduction of nerve impulses. Prevents the occurrence of pain impulses at the endings of sensory nerves and their conduction along nerve fibers. It has an exclusively local effect, without being absorbed into the systemic circulation.
Genferon suppositories 1000000IU No. 10
A country
Russia
The country of production may vary depending on the batch of goods. Please check with the operator for detailed information when confirming your order.
Active substance
Interferon alpha-2b + Taurine + Benzocaine
Compound
Active ingredients: recombinant human interferon alpha-2, taurine, anesthesin.
pharmachologic effect
Genferon is a combination drug, the effect of which is determined by the components included in its composition. Has local and systemic effects. Interferon alpha-2 has antiviral, antimicrobial and immunomodulatory effects. Under the influence of interferon alpha-2, the activity of natural killer cells, T-helper cells, phagocytes, as well as the intensity of differentiation of B-lymphocytes in the body increases. Activation of leukocytes contained in all layers of the mucous membrane ensures their active participation in the elimination of primary pathological foci and ensures the restoration of the production of secretory immunoglobulin A. Interferon alpha-2 also directly inhibits the replication and transcription of viruses, chlamydia. Taurine, which is part of the drug, has regenerative properties , reparative, membrane- and hepatoprotective, antioxidant, anti-inflammatory properties. Anesthesin is a local anesthetic. Reduces the permeability of the cell membrane to sodium ions, displaces calcium ions from receptors located on the inner surface of the membrane, and blocks the conduction of nerve impulses. Prevents the occurrence of pain impulses in the endings of sensory nerves and their conduction along nerve fibers. When administered vaginally or rectally, interferon alpha-2 is absorbed through the mucous membrane, enters the surrounding tissues, and enters the lymphatic system, providing a systemic effect. Also, due to partial fixation on the cells of the mucous membrane, it has a local effect.
Indications for use
As part of complex therapy for infectious and inflammatory diseases of the urogenital tract: genital herpes, chlamydia, ureaplasmosis, mycoplasmosis, recurrent vaginal candidiasis, gardnerellosis, trichomoniasis, human papillomavirus infections, bacterial vaginosis, cervical erosion, cervicitis, vulvovaginitis, bartholinitis, adnexitis, prostate it, urethritis , balanitis, balanoposthitis.
Mode of application
Infectious and inflammatory diseases of the urogenital tract in women. 1 suppository (250,000 IU or 500,000 IU depending on the severity of the disease) vaginally 2 times a day every day for 10 days. In severe forms, 1 suppository 3 times a week every other day for 1-3 months. Infectious and inflammatory diseases in men. Rectally, 1 suppository (500,000 IU or 1,000,000 IU depending on the severity of the disease) 2 times a day for 10 days.
Interaction
Genferon is most effective in combination with medications (including antibiotics and other antimicrobials) used to treat urogenital diseases. It is recommended to simultaneously use vitamins E and C, which enhance the effect of interferon. Non-narcotic analgesics and anticholinesterase drugs enhance the effect of anesthesin. Anestezin reduces the antibacterial activity of sulfonamides.
Side effect
Allergic reactions, namely skin rashes and itching. These phenomena are reversible and disappear 72 hours after stopping the administration or reducing the dose. Phenomena that occur with the use of all types of interferon alfa-2, such as chills, fever, fatigue, loss of appetite, muscle and headaches, joint pain may also be observed , sweating, as well as leuko- and thrombocytopenia, but they are more common when a dose of over 10 million IU is administered daily.
Contraindications
Individual intolerance to interferon and other substances included in the drug. Use with caution during exacerbation of allergic and autoimmune diseases. Use in the second half of pregnancy is allowed if the benefit of the therapy outweighs the possible risk to the fetus.
Overdose
No cases of overdose with Genferon have been reported.
special instructions
No data.
Dispensing conditions in pharmacies
On prescription
Genferon
Genferon (recombinant human interferon alpha-2 + taurine_benzocaine) is a complex immunomodulatory drug with an antiviral effect. Interferons are biologically active proteins that are formed in the cell in response to the invasion of viruses, exposure to allergens or mutagens. Today, biotechnology is considered one of the most advanced technologies for obtaining interferon preparations. It does not involve the use of human blood as a raw material, which means there is no need to disinfect synthesized drugs. A Russian biotechnological company created the drug Genferon in the form of vaginal and rectal suppositories. This drug is widely in demand today in the complex treatment of infectious and inflammatory diseases of the urogenital tract, including infections caused by trichomonas, chlamydia, mycoplasmas, ureaplasmas, genital herpes, vaginal candidiasis, bacterial vulvovaginitis, genital warts. The key component of Genferon is interferon-alpha 2b, which has a complex antiviral, antimicrobial, cytostatic and immunomodulatory effect. It comes into play even before immune mechanisms are activated, acting as the first line of defense against invading pathogens. Interferon carries out its action indirectly through two enzymes synthesized with its participation, one of which cleaves viral RNA, the other suppresses the formation of new viral proteins.
The result is a decrease in the number of viral particles by several orders of magnitude. But interferon is valuable not only for its antiviral effect: it is also active against Staphylococcus aureus, Toxoplasma, Chlamydia, Legionella, Cryptococcus, and yeast. Another important component of Interferon is taurine. This amino acid has the ability to restore the structure of affected tissues, which is ensured by the presence of immunomodulatory, antioxidant, membrane-stabilizing and osmoregulatory properties. Taurine neutralizes the destructive effect of free radicals that are massively formed at the site of inflammation, which prevents further destruction of cell membranes and damage to cell DNA. The anti-inflammatory properties of taurine promote rapid epithelization and tissue repair in the inflammatory zone. This amino acid has the ability to potentiate immune reactions, activating the proliferation of cells that carry out the immune response. The third component of Genferon is the anesthetic benzocaine, whose task is to quickly eliminate discomfort (itching, burning, etc.) when administering a suppository. The combination of the neuromodulatory effect of taurine with the analgesic properties of benzocaine ensures that the quality of life of patients taking Genferon is maintained at a consistently high level.
Genferon Light suppositories 125000IU+5mg No. 10
A country
Russia
The country of production may vary depending on the batch of goods. Please check with the operator for detailed information when confirming your order.
Active substance
Interferon alpha-2b + Taurine
Compound
Interferon alpha-2b, taurine.
pharmachologic effect
Has local and systemic effects. The drug contains recombinant human interferon alpha-2b. Interferon alpha-2b has antiviral, immunomodulatory, antiproliferative and antibacterial effects. The immunomodulatory effect is manifested, first of all, by enhancing cell-mediated reactions of the immune system, which increases the effectiveness of the immune response against viruses, intracellular parasites and cells that have undergone tumor transformation. Activation under the influence of interferon of leukocytes contained in all layers of the mucous membrane ensures their active participation in the elimination of pathological foci; in addition, due to the influence of interferon, restoration of the production of secretory immunoglobulin A is achieved. The antibacterial effect is mediated by reactions of the immune system, enhanced under the influence of interferon. Taurine helps to normalize metabolic processes and tissue regeneration, has a membrane-stabilizing and immunomodulatory effect. Taurine helps maintain the biological activity of interferon, enhancing the therapeutic effect of the drug. With rectal administration of the drug, high bioavailability of interferon is observed, and therefore both local and pronounced systemic immunomodulatory effects are achieved; when used intravaginally, due to the high concentration at the site of infection and fixation on the cells of the mucous membrane, a pronounced local antiviral, antiproliferative and antibacterial effect is achieved, while the systemic effect is insignificant due to the low absorption capacity of the vaginal mucosa. The maximum concentration of interferon in the blood serum is achieved 5 hours after administration of the drug. The main route of elimination of α-interferon is renal catabolism. The half-life is 12 hours, which necessitates the use of the drug 2 times a day.
Indications for use
For the treatment of infectious and inflammatory diseases of the urogenital tract in children and women, including pregnant women. As a component of complex therapy - for the treatment of other infectious diseases of viral etiology.
Mode of application
The drug can be used both vaginally and rectally. The method of administration, dosage and course duration depend on age, the specific clinical situation and are determined by the attending physician.
Interaction
The drug is most effective as a component of complex therapy. When combined with antibacterial, fungicidal and antiviral drugs, mutual potentiation of action is observed, which makes it possible to achieve a high total therapeutic effect
Side effect
Local allergic reactions (itching and burning sensation in the vagina). These phenomena are reversible and disappear within 72 hours after cessation of administration. Continuation of treatment is possible after consultation with a doctor. Phenomena that occur when using all types of interferon alfa-2b may be observed, such as chills, fever, fatigue, loss of appetite, muscle and headaches, joint pain, sweating, as well as leukemia and thrombocytopenia. In these cases, it is recommended to consult your doctor to decide whether to discontinue the drug or reduce the dose.
Contraindications
Individual intolerance to interferon and other substances included in the drug. With caution: Exacerbation of allergic and autoimmune diseases. Use during pregnancy and lactation: Clinical studies have proven the effectiveness and safety of the drug in the second and third trimesters of pregnancy. The safety of using the drug in the first trimester of pregnancy has not been studied.
Overdose
If you accidentally administer more suppositories at a time than were prescribed by your doctor, further administration should be suspended for 24 hours, after which treatment can be resumed according to the prescribed regimen.
special instructions
The drug does not affect the performance of potentially hazardous activities that require special attention and quick reactions (driving vehicles, machinery, etc.).
