Instructions for use of children's Ingavirin 60, ➄ analogues for replacement

Release form and composition

The drug is produced in the form of capsules of size No. 2, with a white logo on the cap of the capsule in the form of the letter “I” inside the ring, filled with granules and almost white or white powder; Clumping of the filler is allowed, which can be eliminated under mild mechanical stress:

• dosage 30 mg: blue (7 pieces in blister packs, 1 or 2 packs in a pack);
• dosage 60 mg: yellow (7 pieces in blister packs, 1 pack in a pack);
• dosage 90 mg: red (7 pieces in blister packs, 1 pack in a pack).

Composition per 1 capsule:

• active ingredient: vitaglutam (pentanedioic acid imidazolylethanamide) – 30, 60 or 90 mg;
• auxiliary ingredients: lactose monohydrate, potato starch, colloidal silicon dioxide (aerosil), magnesium stearate;
• ink for applying the logo: shellac, titanium dioxide, propylene glycol.

Shell composition:

• 30 mg capsules: gelatin, titanium dioxide, dyes (diamond black, patent blue, crimson - Ponceau 4R, azorubine);
• 60 mg capsules: gelatin, titanium dioxide, yellow iron oxide dye;
• 90 mg capsules: gelatin, titanium dioxide, dyes (azorubine, crimson - Ponceau 4R and quinoline yellow).

Manufacturer, price, release form

Medicines for adults (Ingavirin 90) and children (60)
Manufacturer: Russian pharmaceutical company. The medicine has been commercially available since 2009.

Available in yellow capsules (capsules for adults are red) with white, fine-grained powder inside. The drug has no taste or smell.

Capsules are packaged in blisters of 7 pieces, designed for a weekly course of therapy.

The blisters and detailed instructions for use of Ingavirin 60 for children are packaged in an individual box with factory markings, shelf life and production dates.

INGAVIRIN 60 is sold without a prescription, the average price in the Russian Federation is 450-470 rubles.

Pharmacological properties

Pharmacodynamics

An antiviral drug with proven efficacy in preclinical and clinical studies against influenza viruses type A - A(H1N1), including swine flu A(H1N1) pdm09, A(H5N1), A(M3N2) and type B virus parainfluenza, adenovirus, RSV (respiratory syncytial virus). According to the results of preclinical studies, the drug is also effective against metapneumovirus, coronavirus and enteroviruses, including rhinovirus and Coxsackie virus.

Ingavirin accelerates the elimination of viruses, which helps reduce the duration of the disease and reduces the likelihood of complications. The mechanism of action of vitaglutam is realized at the level of infected cells by stimulating innate immune factors inhibited by viral proteins. During the experiments, it was established, in particular, that pentanedioic acid imidazolylethanamide increases the expression of the type I interferon receptor IFNAR on the surface of epithelial immunocompetent cells. With an increase in the density of interferon receptors, the sensitivity of cells to endogenous interferon signals increases. The process occurs with phosphorylation (activation) of the transmitter protein STAT1, which transmits a signal to the cell nucleus, inducing the activity of antiviral genes. In the presence of infection, the production of the antiviral effector protein M×A is stimulated, which suppresses the intracellular transport of ribonucleoproteins of various viruses, which slows down viral replication.

Vitaglutam increases the level of interferon in the blood to the physiological norm, stimulating and normalizing the reduced α- and γ-interferon producing ability of blood leukocytes. Activates the generation of cytotoxic lymphocytes, increases the content of NK-T cells, which have high killer activity in relation to cells infected with viruses.

The anti-inflammatory effect is achieved by inhibiting the production of key pro-inflammatory cytokines [tumor necrosis factor (TNF-α), interleukins (IL-1β and IL-6)] and reducing myeloperoxidase activity. It has been experimentally proven that the use of Ingavirin together with antibiotics enhances the effectiveness of therapy in the model of bacterial sepsis, including that caused by strains of staphylococcus resistant to penicillin. An experimental study of the toxicological effect of imidazolylethanamide pentanedioic acid showed a low level of toxicity and a high safety profile of the drug. According to the parameters of acute toxicity, Ingavirin belongs to class IV - “Low toxic substances” (lethal doses of the drug when determining LD50 during acute toxicity experiments could not be established).

Pharmacokinetics

When taking vitaglutam in recommended doses, it is not possible to determine its content in the blood plasma using available methods.

In experimental studies using a radioactive label, it was established that vitaglutam enters the blood quickly from the gastrointestinal tract and is distributed evenly throughout the internal organs. It reaches its maximum concentration in the blood and most organs half an hour after administration. The area under the concentration-time pharmacokinetic curve (AUC) of the liver, kidneys and lungs slightly exceeds the blood AUC of 43.77 mcg h/g, and the AUC value of the adrenal glands, spleen, thymus and lymph nodes is lower than the blood AUC. The mean retention time of the drug (MRT) in the blood is 37.2 hours.

With a 5-day course of taking capsules orally once a day, imidazolylethanamide pentanedioic acid accumulates in tissues and internal organs. The qualitative indicators of the pharmacokinetic curves after each administration were identical: a rapid increase in drug concentration immediately after administration with a further slow decrease by 24 hours.

Vitaglutam is not metabolized in the body; 77% is excreted unchanged through the intestines and 23% through the kidneys. Within 24 hours, up to 80% of the received dose is excreted: 34.8% - from 0 to 5 hours after administration and 45.2% - from 5 to 24 hours.

Analogues of the drug

There is no absolute analogue of Ingavirin for children, but there are a number of medications with similar effects. The table below allows you to figure out which is better - Ingavirin or Amiksin, Ingavirin or Arbidol, etc.

1

ERGOFERON

ERGOFERON tablets are an antiviral drug with antihistamine and anti-inflammatory effects. The drug is prescribed for the treatment or prevention of respiratory viral infections, herpesvirus diseases, and intestinal dysfunctions of viral etiology. Shows activity in the fight against meningococcal pathogens. Suitable for complex therapy in the treatment of tick-borne encephalitis. 2

ARBIDOL

Prescribed for the treatment and prevention of acute respiratory viral infections. Suitable for complex therapy of intestinal infections of rotovirus etiology. Effective for complex therapy of acute, chronic forms of bronchitis, pneumonia and herpesvirus diseases. Sometimes used in combination with other symptomatic drugs in the postoperative period with infectious complications. 3

KAGOCEL

Used for the treatment and prevention of influenza and other ARV infections in adults and children. Shows activity in the fight against herpes infections. It is recommended to take together with immunomodulators. Kagocel is suitable for complex therapy with antibiotic and antihistamine drugs. To figure out which is better – KAGOCEL or INGAVIRIN in a particular case, you need to consult a doctor. For children, it is recommended to use candles to protect against temperature when it rises. 4

AMIXIN

Prescribed for the treatment of ARV infections in children as a complex therapy for viral hepatitis A, B and C, and herpesvirus diseases. For adults, it is used in conjunction with symptomatic medications for the treatment of respiratory chlamydia, cytomegalovirus infection, and tuberculosis. 5

GRIPPFERON

The drug is used as a prophylactic agent to prevent influenza and other respiratory viral diseases. Prescribed from the first days of life. It is a powerful immunomodulator and has anti-inflammatory properties.

More information about effective antiviral drugs for children aged 1 year and older and a separate review for children aged 3 years and older.

Indications for use

• Ingavirin 30 mg: therapy of influenza virus type A and B, other acute respiratory viral infections (acute respiratory viral infections), including parainfluenza, adenovirus infection, respiratory syncytial infection in adults and children over 13 years of age; prevention of influenza virus types A and B, as well as other acute respiratory viral infections in adult patients;
• Ingavirin 60 mg: therapy for influenza virus types A and B, other acute respiratory viral infections, including parainfluenza, adenovirus infection, respiratory syncytial infection in children 7–17 years old;
• Ingavirin 90 mg: therapy for influenza virus types A and B, other acute respiratory viral infections (acute respiratory viral infections), including parainfluenza, adenovirus infection, respiratory syncytial infection in adults; prevention of influenza virus types A and B, as well as other acute respiratory viral infections in adult patients.

Indications for use and age restrictions

Ingavirin 60 (children) is used for the prevention and treatment of viral diseases from 7 years of age. Use for children aged 3, 4, 5 and 6 years is possible only on the recommendation of a doctor, after a clear identification of possible risks.

Treatment is effective for:

• ARVI;
• flu;
• adenoviruses;
• respiratory syncytial virus;
• parainfluenza;
• other viral diseases.

Thanks to its pronounced anti-inflammatory effect, the drug reduces the intensity of pathological symptoms such as headache, joint pain with temperature, fever, and intoxication. The pharmacological properties of the drug do not apply to bacterial infections .

Therapy will be more effective if you start taking it from the first days (up to 48 hours) of the disease. Even minor symptoms of ARVI are a reason for immediate treatment.

Contraindications

Absolute contraindications common to all forms of release:

• period of pregnancy and lactation (breastfeeding);
• lactose intolerance, lactase deficiency, glucose-galactose malabsorption;
• increased individual sensitivity to the components of the drug.

Capsules in dosages of 30 and 90 mg are contraindicated for use by children under 13 years of age when treating influenza virus types A and B and other acute respiratory viral infections, and by children and adolescents under 18 years of age for the prevention of these diseases.

Capsules at a dosage of 60 mg are contraindicated for use by children under 7 years of age and persons over 18 years of age (due to the inability of the drug in this dosage form to provide the intake of vitaglutam at a dose of 90 mg).

Dosage, method of application

Dosage for children depends on the form of the disease. During the acute form of ARVI, the dose of the drug is 2 capsules daily for the first 3 days. Then the dosage must be reduced to 1 capsule. Course up to 7 days.

It is not recommended to increase the dosage and duration of the course without proper recommendations from the treating pediatrician. Ingavirin for prevention is prescribed to children 1 capsule for 5 days. Taken regardless of food intake . The protective shell of the capsule prevents negative effects on the microflora of the stomach and intestines at the time of dissolution. The drug must be taken with a sufficient amount of water.

Instructions for use of Ingavirin: method and dosage

Ingavirin is taken orally; the effectiveness of the drug does not depend on food intake. It is necessary to start treatment from the moment the first signs appear, but no later than 2 days from the onset of the disease.

Recommended dosage when taking the drug once a day:

• capsules in dosages of 30 and 90 mg: therapy of influenza and acute respiratory viral infections in adult patients - 90 mg each (1 piece of 90 mg each or 3 pieces of 30 mg each), in children 13-17 years old - 60 mg each (2 pieces of each 30 mg); prevention of influenza and ARVI after contact with infected persons for adults – 90 mg (1 piece of 90 mg or 3 pieces of 30 mg);
• capsules in a dosage of 60 mg: therapy of influenza and acute respiratory viral infections in children 7–17 years old - 60 mg each (1 piece of 60 mg).

The duration of treatment is 5–7 days, depending on the severity of the condition, the duration of administration for preventive purposes is 7 days.

INGAVIRIN (capsules)

pentanedioic acid namide (vitaglutam) and nothing else.
I’m not a chemist, but at one time I studied chemistry well, and even then the first doubts arose. Nevertheless, I came home and took a capsule. And although the instructions say that the drug can be used regardless of food intake, I drank it two hours after eating.

The instructions are long, you'll end up reading them. A cure for all diseases, even the flu and even coxsackie. A real bestseller in medicine.

Well, I drink the medicine, in full confidence that it does everything that is described at so much length in the instructions.

On the third day of treatment, I fell ill with Orvi, and so badly that I wouldn’t wish it on my enemy. It was a shock for me. After all, the instructions even say that it is used after contact with patients, so as not to become infected, but I had no contact, and in general after the illness I avoided communication with patients, did not go to public places and avoided large crowds of people. It would seem that I simply could not get sick. But no.

I continued to take Ingaverin after I got sick, but I only saw worsening. Why? Maybe because it's useless? A dummy? I opened the capsule.

There is something inside, that’s already good. The taste is slightly sour, but not intrusive.

I went to read what kind of pentanedioic acid imidazolylethanamide (vitaglutam) is. And I found interesting information. It turns out that until 2008, this same drug was sold under a different name, “Dicarbamine.” It was prescribed to patients receiving chemotherapy for malignant neoplasms.

The instructions for Dicarbamine also suggested taking the drug daily (albeit 100 mg, not 90 mg, which in principle is not significant) for 5 days before the start of chemotherapy and then throughout the entire course of chemotherapy.

I went to look for documentary works about this medicine and it turned out that despite the fact that the medicine was studied for a long time and carefully, no convincing evidence was obtained of the effectiveness of this remedy.

And then, in 2008, Ingaverin entered the market (based on the works I had read) without full-fledged placebo-controlled studies, and a few months later the swine flu epidemic began, which greatly contributed to its sales.

I was shocked by what I read. I don’t know if I should believe this or not, but I am sure that the effectiveness of ingaverin against the flu has not been officially proven. My confidence was supported by dozens of scientific articles talking about the uselessness of pentanedioic acid imidazolylethanamide (vitaglutam) as a means not only for the treatment and prevention of influenza and ARVI, but also as a means for stimulating leukopoiesis in cancer patients.

Nevertheless, I was able to find positive reviews, where those taking Ingaverin directly swore by the lightning-fast action of the drug and convinced that they got back on their feet in two days.

Here, for my part, I can clearly assure you that the drug did not help me at all, but in general turned out to be absolutely useless, I hope that it is not harmful. Therefore, not only will I not buy it anymore, but I don’t even recommend trying it. Moreover, the product costs about half a thousand, and its entire laudatory history is nothing more than a placebo effect. Although in my case, even the placebo effect did not help (probably I shouldn’t have looked at the composition so that doubts would not creep in, but blindly drink the advertised drug).

special instructions

It is not recommended to take Ingavirin simultaneously with other antiviral drugs.

Impact on the ability to drive vehicles and complex mechanisms

The effect of the drug on the speed of psychomotor reactions and concentration has not been studied. But, taking into account the mechanism of its influence on the body and the profile of side effects, it can be assumed that it does not affect the ability to perform work of increased complexity, including driving.

Reviews about Ingavirin

Reviews about Ingavirin are common and have a wide variety of opinions. The average rating of the drug on medical forums on a 5-point scale is 3.86 points. Some patients talk about the effectiveness and quick action of the drug, but you can also often find negative reviews claiming that taking the drug does not alleviate the condition, but increases the manifestation of the symptoms of the disease.

Experts testify that if Ingavirin is used in accordance with the recommendations, it helps to quickly eliminate the symptoms of the disease and helps the body fight the virus more effectively.