A weakened immune system is the root cause of the development of many ailments. This mainly applies to colds. Therefore, to avoid illness, you need to strengthen your immune system and take care of your health. Nowadays, there are a sufficient number of medications that will not only have a healing effect during a cold, but also strengthen the body's defenses. One of the most common immunostimulating drugs is the drug Ismigen. Instructions for use, analogues - all this will be described below.
Release form and composition
The dosage form of Ismigen is sublingual tablets: light cream with brown inclusions, flat-cylindrical, scored, with a weak specific mint aroma (10 pieces in blister packs, 1 or 3 packs in a cardboard pack).
Composition of 1 tablet:
- active substance: lysates of bacteria, including Streptococcus viridans, Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae (types - TY3/EQ14, TY1/EQ11, TY2/EQ22, TY8/EQ23, TY5/EQ15, TY47/EQ24), Klebsiella ozaenae, Klebsiella pneumoniae, Neisseria catarrhalis, Haemophilus influenzae b – 7 mg;
- auxiliary components: mint flavor – 0.8 mg; glycine – 43 mg (as part of bacterial lysate); calcium hydrogen phosphate dihydrate – 35 mg; microcrystalline cellulose – 150 mg; Magnesium stearate – 3 mg; colloidal silicon dioxide – 10 mg; ammonium glycyrrhizinate – 1.2 mg.
special instructions
Ismigen for children (reviews about the product may be negative, which does not prove low effectiveness) is used only for resorption. The tablets should not be swallowed whole or simply chewed. During resorption, the active ingredients are gradually delivered to the mucous membranes, which ensures a long-lasting effect.
It is worth remembering that independently exceeding the daily dosage or course duration can lead to complications. Children from 3 years of age should dissolve tablets under adult supervision, which will avoid unpleasant consequences.
The drug has a rather specific aroma and taste, which children and some adults do not always like. Patients suffering from chronic heart pathologies react especially sharply to this. Despite this, the drug is not contraindicated in such cases, but it should be used with caution and as directed.
It is not recommended to eat or drink liquids for 15 minutes after dissolving the tablet. This will allow the active ingredients to have maximum therapeutic effects. If complications occur, you should not delay visiting your doctor.
Pharmacological properties
Pharmacodynamics
Ismigen is a combined immunostimulating drug of bacterial origin for sublingual (sublingual) administration, which is a polyvalent antigenic complex that includes lysates of bacteria - the most common pathogens of respiratory infections. It has a specific vaccinating and nonspecific immunostimulating effect.
The drug affects various parts of the immune system. Stimulates systemic immune, humoral immune and local cellular responses. Activates phagocytosis, helps increase the number of immunocompetent cells and increases the content of lysozyme in saliva.
Increases the metabolic and functional activity of macrophages (including alveolar) and polymorphonuclear leukocytes; stimulates the secretion of prostaglandin E2 by macrophage-monocyte cells; reduces the concentration of serum IgE; activates natural killer cells; inhibits the synthesis of IL-4, IL-12; stimulates the release of anti-inflammatory cytokines; increases the concentration of secretory immunoglobulin IgA in saliva, serum immunoglobulins IgA, IgG, IgM.
As a result of the use of Ismigen, the severity, frequency and duration of acute respiratory tract infections are reduced; there is relief and leveling of accompanying symptoms (cough, fever, shortness of breath); the need for antibacterial and anti-inflammatory treatment is reduced. In the presence of chronic diseases of the respiratory tract, the drug prevents exacerbations.
The lysates included in Ismigen tablets are obtained by mechanical action.
Overdose
The drug does not provoke overdose symptoms if used correctly, taking into account the doctor’s recommendations. However, when taking a large number of tablets at the same time, all negative reactions may worsen. The headache may intensify, and weakness is noted, developing against the background of a lack of normal night sleep.
The patient becomes lethargic, shows no interest in normal activities, and refuses food. If symptoms persist for a long time, the condition worsens, which is accompanied by depressive disorders and some other disorders. It is also worth noting that an overdose worsens the course of the allergic reaction.
The rash spreads to large areas of the skin, the itching intensifies, forcing the patient to scratch the affected areas. As a result, the outer layer of skin is damaged and the risk of infection increases. Severe allergies are always accompanied by general disorders such as rhinitis and conjunctivitis. In the latter case, swelling of the mucous membranes of the eyes, tearing, and pain are observed. Patients' eyes become sour, especially after a night's sleep.
An overdose is considered a reason to immediately stop using the drug and contact a specialist for help. In a hospital setting, the patient’s stomach is washed and symptomatic treatment is prescribed depending on the manifestations.
Instructions for use of Ismigen: method and dosage
The tablets should be taken on an empty stomach sublingually (until completely dissolved under the tongue; should not be swallowed, chewed or dissolved).
Daily dose – 1 tablet.
Recommended application:
- subacute/acute infections of the upper and lower respiratory tract – at least 10 days (until the symptoms of the disease disappear);
- recurrent infectious processes of the upper and lower respiratory tract, exacerbations of chronic respiratory diseases (prevention) - 3 cycles of 30 days, including 10 days of taking Ismigen and a break of 20 days; Preventive courses can be carried out no more than 1–2 times a year.
If you accidentally miss the next dose, you should not double the next one.
Contraindications
The medication is not used for patients who are allergic to the components of the composition or have a tendency to such manifestations. The drug is also contraindicated in children who have purulent lesions on the mucous membranes of the mouth and throat.
During pregnancy and lactation, the drug is not prescribed, which is due to the lack of data on its effect on the body of the mother and child. You should not use the drug if severe liver and kidney failure with severe organ dysfunction is detected.
Internal bleeding is considered a reason to stop using the pills. Acute pathologies of the digestive tract, for example gastritis, peptic ulcers or pancreatitis, are considered an obstacle to therapy, which is associated with the negative effect of the drug on the mucous membranes of the stomach, intestines, and the functioning of the pancreas.
If allergic diseases of various origins progress, you should not use the product without prior examination by a specialist. In each case, it is worth studying contraindications to avoid negative reactions.
Video
Everything about immunity. Interesting and useful information from Dr. Komarovsky.
Modern parents must have information about everything that happens to their children, about what they are prescribed. The topic of immunomodulators is not as simple as it seems (by the way, like the topic of vitamins), and you need to understand that these drugs are different, some activate the immune system, others increase the body’s natural defenses, and others suppress the immune system.
But any artificial work with immunity is possible only within certain limits. Which ones - only a specialist can decide, and the schemes for each individual case are different.
Therefore, you need to know, but you shouldn’t use it yourself if you are not a health worker. Be sure to consult your doctor. But we would really like to know about your experience of using Ismigen, write, do you know about it, have you tried it, what effect did you get, did it please you? And be healthy!
Price
The cost of tablets may vary in different pharmacies, but the average price ranges from 500-1400 rubles. depending on the number of tablets in the package.
Ismigen is a popular immunostimulant for children and adults, which is actively used to improve local immunity in the throat. Patient reviews about the effect of the medicine are mostly positive, which proves its effectiveness, but does not allow the use of the medicine without a preliminary examination by a doctor.
Side effects of the medicine
Allergic reactions to some components of the medicine may develop. They manifest themselves in the form of a rash, itching, burning. If such symptoms occur, you should stop taking the drug and take an antihistamine. In rare cases, rhinitis, laryngitis and inflammation of the salivary glands may occur.
The drug should be kept away from children. The air temperature in the room should not exceed 25 degrees. The drug is available at the pharmacy without a prescription. Preschool children should use the product only under adult supervision.
It is necessary to become familiar with the side effects of Ismigen tablets at the beginning of treatment. Analogues that are cheaper should also be used strictly according to the instructions.
Reviews
- Natalia. This is the second time we have been prescribed Ismigen and I see a good effect, since the recovery was faster than before, and now we have been going to kindergarten for months without getting sick, before this period was a week, and in a new way - acute respiratory infections. I would also like to note that these pills are easy to give: I have an obedient child, he put it under the tongue, and we quietly did something for about 10 minutes, then, I saw, the pill melted. The taste is not that pleasant, but does not cause any negative emotions.
- Irina. Our pediatrician advised us when we were planning to go to Turkey. He said that parents need proper rest, too, so that the climate change does not cause the baby to get sick and ruin everything. We drank Ismigen for 10 days. Of course, I don’t know what would have happened without him, you can’t check, but the fact that the vacation went peacefully, absolutely without any reactions, poisoning, or colds is a fact. Therefore, let's be modern, immunomodulators are immunomodulators, although my mother was categorically against it. But there is a result. The drug, the doctor said, is natural. So – what is there to be afraid of?
- Alyona. And I’ve been taking it with me everywhere for two years now – both to my grandmother’s in the village and when we go to the sea. Ismigen is already on the list of our “children’s first aid kit.” Once a friend from Germany brought it to me, my daughter and I drank it together because we were both sick, and I liked it right away, then I bought it myself. She told the doctor, she didn’t mind. One day I forgot about it, and we hadn’t tried drinking it beforehand. My daughter got sick and I immediately gave her Ismigen, 2 days - and no problems. It is important to start drinking from the first minute. And I don’t see any side effects.
"Ribomunil"
What else can replace the immunostimulating drug “Ismigen”? The Russian analogue of this medicine is Ribomunil tablets. This is a drug of bacterial origin. The product has a round and convex shape of white color. The main component of the tablets is ribosomes, titrated to almost 70 percent ribonucleic acid. Indications for use are all types of dental and ENT diseases.
The medicine is taken one tablet in the morning, on an empty stomach. The drug is taken every four days for three weeks. Contraindications include hypersensitivity to the components of the drug. The drug is usually well tolerated by patients. The tablet is odorless and is taken orally. It is not recommended for children under three years of age, as well as pregnant and lactating women. The drug has the same recommendations as Ismigen. Instructions, analogues, correct dosage - all this is important information that should be studied before taking it.
Drug interactions
Experts do not note the development of negative reactions when combining the drug with systemic medications, which is mainly associated with the local effect of the tablets. Despite this, the drug should not be combined with medications that contain the same active ingredients. This may lead to an overdose.
In addition, when using local products in the form of a spray, rinse solution, or lozenges, you should first consult with a specialist. There is no development of negative reactions when the drug is combined with antibiotics, anti-inflammatory and antipyretic drugs, which are often used for viral and respiratory diseases.
Analogs
There are several analogues of the drug that have a similar effect on the mucous membranes.
They may have a similar or different composition and have a pronounced effect:
- Imudon is the most popular analogue, which is available in the form of lozenges. The drug also contains bacterial lysates that have pronounced immunostimulating properties. The drug is used in the acute period of diseases, as well as for the prevention of relapses in patients suffering from chronic forms of pathologies of the throat and tonsils. Tablets are taken according to different regimens depending on the patient’s condition and the severity of symptoms. However, they are allowed for adults and patients over 3 years of age.
- Irs 19 is a popular nasal spray that also contains bacterial lysates and is used to treat and prevent colds. The product is highly effective and is well absorbed through the mucous membranes of the nasal passages. The medication acts not only on the sinuses, but also on the throat, which makes it effective for pharyngitis, laryngitis and other inflammatory diseases.
- Bronchomunal is an immunostimulating drug in the form of capsules for oral administration. The product contains lysates of bacteria, is considered effective and copes well with acute pathologies of the throat, preventing their reappearance. The medication is available in dosages for children and adults, taken in courses of 10 days. Depending on the patient’s condition, the regimen may differ and is determined by the doctor.
Analogues of the product are highly effective, but this does not allow their use without prior examination by a specialist.
