Ketoconazole suppositories: instructions for use, analogues and reviews

Medicines for vaginal use are topical medications. With their help, you can directly influence the area of ​​pathology development. Often these medications are used in combination with other medications, such as oral medications. This article will tell you about how Ketoconazole suppositories are prescribed and used. Information from the annotation and reviews available about the drug will be described below.

When should the drug be used?

Often the medicine is prescribed for systemic and superficial mycosis, dermatomycosis, and candidiasis. Complex treatment is allowed. For example, combine tablets and shampoo. The dosage and duration of therapy is determined by the attending physician depending on the physiological characteristics of the patient’s body and the general clinical picture.

The doctor prescribes the drug in the form of ointment and cream to the patient in the following cases:

• superficial and systemic mycosis;
• dermatomycosis;
• onychomycosis;
• mycosis;
• vaginal mycosis;
• mycosis of an internal organ;
• for the prevention of infectious disease.

The doctor prescribes tablets during treatment:

• fungal infection of the scalp;
• dermatomycosis;
• athlete's foot;
• candidiasis.

For acute and chronic vaginal candidiasis, blastomycosis, histoplasmosis. The shampoo is used in the treatment of fungal skin disease (the product must be used after consultation with a dermatologist) and if the patient has:

• dermatophytosis;
• candidiasis;
• trichophytosis;
• pityriasis versicolor;
• dandruff;
• dermatitis.

Only a doctor should prescribe the medicine. Self-medication can be harmful.

Analogs

If, after dissolving the suppository in the vagina, there is no positive dynamics of candidiasis at all, or side effects appear, doctors recommend replacing the medicine with an analogue from the antifungal pharmacological group. Such a replacement should be introduced into the intensive care regimen by a gynecologist. Here are reliable analogues of Ketoconazole, which have approximately the same cost and principle of action directly on the site of pathology:

What is important to know before using the product?

Before starting treatment, it is important to consult a doctor, as self-medication can be harmful. The instructions for use of Ketoconazole suppositories state that it is not recommended to use the drug in the treatment of a fungal disease, since the active substance is not able to penetrate the blood-brain barrier.

Given the fact that hepatotoxicity may occur, it is important to evaluate the potential benefit, which should outweigh the risk of therapy. It is forbidden to carry out treatment with Ketaconazole for those people who have increased liver enzyme activity.

During therapy, it is important to monitor the functions of the adrenal cortex. If the patient used glucocorticosteroids, then Ketoconazole should be used no earlier than 14 days after their discontinuation. Drinking an acidic drink may increase the absorption of the medicine.

To reduce the risk of recurrence of vaginal candidiasis, it is important to treat your sexual partner as well. During treatment, an allergic reaction in the partner is possible. During Ketoconazole therapy, you should be aware that suppositories reduce the reliability of contraceptive methods. It is allowed to drive after using the drug, since it does not affect attention and psychomotor reactions. You should consult a specialist before treatment with Ketoconazole suppositories. The instructions should not act as a basis for treatment; the duration of the course of therapy will be determined strictly by the attending physician after examining the patient.

Directions for use and dosage

If unpleasant symptoms of thrush appear, you can safely use Ketoconazole. The suppositories are intended for intravaginal administration into the patient’s external genitalia. If the disease predominates in the acute stage, it is recommended to use 1 suppository at night deep into the vagina. Treatment in this way will last for 5 – 7 days. For chronic candidiasis, doctors prescribe 1 suppository vaginally for 10 days. Simultaneous treatment of thrush in the sexual partner is necessary, but it is better for him to take Ketoconazole tablets orally.

Side effects

Ketoconazole can also cause side effects, which manifest themselves as:

• headache;
• dizziness;
• increased intracranial pressure;
• nosebleeds;
• skin itching;
• hepatitis A;
• nausea;
• stomach ache.

If an overdose occurs, these reactions may intensify. Under such conditions, treatment must be carried out using gastric lavage and activated charcoal.

general characteristics

The drug "Ketoconazole" has a simple composition: the main active ingredient is the component of the same name - ketoconazole. One suppository contains 400 mg of this medicinal substance. The suppositories also include additional components: butylated hydroxyanisole and glycerides. These substances allow you to obtain the appropriate consistency.

The manufacturer also produces Ketoconazole cream. This product is intended for topical use. It contains the same component (ketoconazole) in an amount of 20 mg.

In what cases is it prohibited to use the drug?

The instructions say that it is not recommended to use the drug:

• for acute and chronic kidney diseases;
• during lactation and pregnancy (strictly according to doctor’s recommendations);
• if there is a dysfunction of the pituitary gland;
• with hypersensitivity to one of the components of the drug;
• It is not recommended to combine with sleeping pills.

Must be stored out of the reach of children. Candles should be stored for 2 years in a cool place.

Ketoconazole during pregnancy

This antifungal medication is often prescribed to women during pregnancy, since in their case thrush progresses twice as often. Vaginal suppositories Ketoconazole are not recommended in the first trimester (up to the 12th obstetric week), since at such a short period they can disrupt intrauterine development and provoke a miscarriage. In the second and third trimesters, a synthetic antifungal agent is not prohibited, but the prescription should be carried out exclusively by the leading gynecologist. There are no absolute restrictions on breastfeeding in the instructions.

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Patient reviews

Many doctors prescribe Ketoconazole suppositories to patients for thrush; reviews from people indicate that the drug effectively helps cure the disease. Among the main advantages of the drug are the following:

• efficiency;
• affordable price;
• ease of use.

To avoid side effects, according to patients, it is important to consult a doctor before carrying out therapy. The instructions for using Ketoconazole suppositories in gynecology say that before using the drug it is important to undergo an examination by a specialist.

Contraindications

Ketoconazole has a stable antifungal effect, however, the use of this medication is not permitted for all patients. There are contraindications that force doctors to select other medications for this kind of mycotic lesions - with a milder therapeutic effect. Medical restrictions are as follows:

• the first of three trimesters of pregnancy;
• children under 12 years of age (up to 18 years of age with great caution);
• increased sensitivity of the body to synthetic components.

A little summary

You have learned about an antifungal agent with the trade name “Ketoconazole” (suppositories). Price, instructions for use, reviews and analogues of the drug are presented to your attention. After completing therapy, be sure to get tested again. The study will help determine the effect of treatment. Perhaps the doctor will give additional recommendations. Often, after antifungal therapy, agents are prescribed that restore the vaginal microflora. This is necessary to strengthen the immune system and prevent the re-development of pathology. All the best to you, don’t get sick!

Price for Ketoconazole suppositories

There are many real reviews in which patients praise Ketoconazole treatment. One of the arguments is the affordable price of the antifungal drug and its constant availability in city pharmacies. Below are retail prices for Moscow, which help women quickly make their choice and not delay the start of intensive care. So:

Drug interactions

Suppositories, ointment and shampoo with ketoconazole do not affect the effectiveness of taking other drugs; no drug interactions have been identified. Beta blockers and antacids may impair the absorption of Ketoconazole tablets in the gastrointestinal tract, which leads to a decrease in the effectiveness of therapy. In order to avoid such interactions, you should maintain a two-hour break between taking different medications.

Rifampicin reduces the bioavailability of Ketoconazole tablets. Ketoconazole enhances the effect of Cyclosporine and indirect anticoagulants. Ketoconazole should not be taken during treatment with astemizole.

If the patient takes any medications on an ongoing basis, be sure to inform the doctor. In some cases, a change in medication regimen and dosage adjustments are required.

Release form

Vaginal suppositories

cylinder-shaped with a pointed end, white or white with a yellowish tint; An air rod or funnel-shaped depression is allowed on the cut.

Excipients

: patented form - Suppotsir AM® (semi-synthetic glycerides) for the most uniform distribution of the active substance, butylated hydroxyanisole - 0.5 mg.

pharmachologic effect

Ketoconazole is a broad-spectrum antifungal agent. The drug has a fungicidal and fungistatic effect, depending on the type of fungal flora. Ketoconazole is active against:

• dermatophytes;
• yeast fungi;
• yeast-like fungi;
• dimorphic fungi;
• gram-positive cocci.

The exact mechanism of action of the drug depends on the type of infection. The medicine has a fungicidal effect against yeast fungi. The drug disrupts the synthesis of ergosterol in the cells of pathogenic microflora, which disrupts the colony’s ability to reproduce itself. At the same time, the drug changes the cellular connections in the spores, thereby destroying them. As a result, this leads to the complete death of the colony of pathogenic fungi.

Some forms of the drug have an additional antiseptic effect. This is true for shampoo and cream. The use of these forms of drug release additionally protects healthy skin from the spread of fungal spores, which makes it possible to localize the colony strictly in the area of ​​skin lesions and prevent further progression of the disease. The antiseptic properties of the drug are due to the presence of alcohols and imidourea in the composition.

Indications for use

Ketoconazole is prescribed to combat various mycoses.

1. The use of shampoo is indicated for mycoses of the scalp and areas of the epidermis densely covered with hair, for example, the groin area. The shampoo is also used for dandruff caused by the proliferation of yeast fungus of the Malasesia genus.
2. The cream is used in the treatment of mycoses caused by Candida or dermatophytes, including ringworm. The product can also be used to treat genital thrush in men.
3. Indications for the use of suppositories containing ketoconazole are vaginal candidiasis. As part of complex therapy, the drug can be prescribed for vulvovaginal candidiasis and vaginitis aggravated by fungal microflora.
4. Ketoconazole tablets are prescribed for the systemic treatment of severe forms of mycosis.

The drug exhibits pronounced activity against yeast fungi, due to which it is used in the treatment of various candidiasis. General indications for use:

• mycosis of smooth skin;
• epidermophytosis of inguinal folds;
• mycosis of hairy areas of the skin of the body and head;
• onychomycosis;
• skin candidiasis;
• genital candidiasis;
• systemic fungal infections.

Indications for the use of Ketoconazole tablets also include fungal infections of the oral mucosa, candidiasis of the throat and stomach. As part of complex therapy, tablets can be used for advanced forms of mycosis of the skin and systemic fungal diseases, in which the infection affects the skin, mucous membranes and internal organs.

The drug in tablets is additionally prescribed for the treatment of severe forms of onychomycosis, foot fungus and vaginal candidiasis in women. It is advisable to take the tablets for chronic thrush.

The choice of the optimal form of release of the drug in each case is made by the doctor and depends on the severity of the symptoms. In some cases, it is advisable to carry out therapy by using several dosage forms of the drug at once.