Hepatrombin G is available in two forms: ointment and suppositories
Gepatrombin G is a drug with localized action, which is prescribed by proctologists to combat hemorrhoids. I would like to immediately make a reservation that “Hepatrombin” combines several drugs for the treatment of various diseases, and if you choose the wrong drug, there is a risk of serious complications (for example, a burn of the rectum).
Therefore, before starting treatment, you should definitely consult a specialist. And for greater awareness, you can also read the experience of consumers who have previously used Hepatrombin G for hemorrhoids - reviews.
Compound
The ointment contains the main substances: sodium heparin, prednisolone acetate and lauromacrogol 600 .
Additional components: solid and liquid paraffin, silicon dioxide, lanolin .
Rectal suppositories include the following active ingredients: sodium heparin, prednisolone acetate and lauromacrogol 600.
Additional components: medium chain triglycerides, solid fat, colloidal silicon dioxide, glyceryl tristearate.
Overdose
With too frequent administration or simultaneous use of drugs with similar components in the composition, the development of systemic side effects associated with exceeding the permissible amount of glucocorticoids is possible:
- increased nervous excitability;
- interruptions in the functioning of the heart and blood vessels;
- depressive states;
- intestinal bleeding;
- steroid ulcers in the gastrointestinal tract;
- liver dystrophy;
- sleep disorders;
- pancreatitis;
- osteoporosis;
- obesity;
- alopecia;
- euphoria;
- psychoses.
The listed deviations during normal use occur only in very rare cases.
Pharmacodynamics and pharmacokinetics
This combined drug is actively used in proctology, exhibiting antithrombotic, anti-inflammatory and venosclerotic effects.
Its main component, heparin , is a well-known direct-acting anticoagulant. It is also characterized by increasing the ability to regenerate connective tissue and preventing blood in the area of hemorrhoids.
As for prednisolone , which belongs to GCS, it exhibits anti-inflammatory, antiexudative and antiallergic effects, reducing itching and burning sensations, pain in the anorectal area.
Lauromacrogol 400 or polidocanol has a local anesthetic effect, providing sclerosis in the area of hemorrhoids .
Penetrating into the body, Hepatrombin G ointment, like suppositories, undergoes biotransformation in the liver and reticuloendothelial system. Plasma protein binding can reach at least 95%. The drug is excreted through the kidneys in several stages.
Indications for use
Hepatrombin G treats external and internal hemorrhoids. The drug is prescribed as part of complex therapy or to prevent relapses of a chronic disease. Among the medical indications:
- thrombophlebitis of the anal veins;
- eczema, fistulas, anal itching;
- cracks, microcracks of the anus;
- boils, carbuncles;
- varicose veins;
- lymphedema;
- soft tissue infiltration;
- venous insufficiency;
- preparing the patient for surgery in the anus or rectum;
- rehabilitation period after surgery (in the field of proctology).
Contraindications
This drug in any form is not prescribed for:
- bacterial, viral and fungal skin lesions;
- tuberculosis;
- syphilis;
- skin tumors;
- reactions to vaccination;
- early pregnancy ;
- predisposition to bleeding;
- sensitivity to the drug.
special instructions
The drug does not inhibit the functions of the nervous system and does not reduce the psychomotor reactions of the body. During treatment, you are allowed to drive a vehicle. The medication does not affect concentration. Hepatrombin G is prescribed with caution for recurrent pathologies of the kidneys and liver. Information about drug interactions:
- Gepatrombin G suppositories for hemorrhoids are not recommended to be combined with non-steroidal anti-inflammatory drugs, anticoagulants, since there is a high probability of rectal bleeding.
- The combination of Prednisolone and other hormones disrupts the functioning of the endocrine system - the adrenal glands, pancreas and thyroid glands.
Instructions for Gepatrombin G (Method and dosage)
Gepatrombin G ointment instructions for use recommend applying a thin layer to the affected areas until the symptoms of the disease disappear and some more time to consolidate the result. During the main therapy, the ointment can be applied 3 times a day, and then 1 time throughout the week.
The ointment can also be used rectally - inserted into the rectum using the tip, lightly pressing on the tube and squeezing out a little of the drug.
Gepatrombin G suppositories instructions for use recommend administering rectally 1-2 times a day, preferably after defecation.
Restrictions
The medication has restrictions regarding consumption. Contraindications for use include:
- venereal disease;
- lesions of the upper layer of the epidermis;
- tuberculum;
- risk of bleeding – low platelet level;
- tumor of the epidermis in the rectal area;
- intolerance to the components of the drug;
- post-vaccination stage;
- children 0-12 years old.
Taking it against the background of the listed diseases can aggravate their course.
Analogs
Level 4 ATC code matches:
Girudoproct
Heparoid Zentiva
Heparin ointment
Heparin
Lyoton
Trombless
Venolife
Hepatrombin
The main analogues of this drug: Proctosedyl, Proctosan and Girudoproct.
During pregnancy
Hepatrombin G is successfully used in pregnant women both for the treatment of the initial stage of the disease and in more severe cases when hemorrhoids are accompanied by bleeding, pinching and prolapse of inflamed nodes, and the presence of cracks in the anorectal area.
Attention! Treatment with the drug is allowed only from the second trimester, since prednisolone, which is part of the drug, can adversely affect the fetus and cause spontaneous abortion.
During lactation, the medicine can be used only for a short time when indicated, if the expected positive effect for the mother outweighs the potential risk for the child.
Reviews of Gepatrombin G
It should be noted that reviews of Gepatrombin G ointment are mainly related to the treatment of hemorrhoids. Usually the drug is used for the resorption of hemorrhoidal cones . This therapy turns out to be very effective and helps to quickly get rid of unwanted symptoms.
You can also find reviews about Hepatrombin G suppositories, but this form of the drug is used by patients somewhat less frequently, although it is no less effective.
In addition, reviews of Gepatrombin G ointment for hemorrhoids report that sometimes it is not used entirely for its intended purpose. For example, this external remedy can be used to resolve hematomas that form after injections. There are cases when the ointment was used by women to eliminate swelling and bags under the eyes.
In addition to reports of the effectiveness of this drug, one can find stories about the development of side effects during improvement. Usually these are allergic reactions in the form of itching, rashes and swelling.
Despite the fact that this drug helps well in some off-label cases, it should not be used on its own. This is especially true during pregnancy, when any treatment requires maximum caution.
Side effects
When treated with Gepatrombin G, side effects do not occur often. In practice, these are limited to local and allergic reactions. Possible patient complaints:
- hyperemia (redness), swelling of the skin;
- hives;
- rarely – angioedema.
Price Gepatrombin G, where to buy
The price of Gepatrombin G in suppositories varies between 220-300 rubles.
You can buy ointment for 180-250 rubles.
The price of Gepatrombin G ointment in Ukraine starts from 50 UAH.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
ZdravCity
- Gepatrombin gel 50000IU 40gHemofarm A.D.
Vršac, branch Production site Šabac RUB 251 order - Gepatrombin G rectal suppositories. 10 pcs. Hemofarm A.D. Vršac, branch Production site Šabac
290 rub. order
- Gepatrombin G ointment 20g Hemofarm A.D. Vršac, branch Production site Šabac
RUB 253 order
Pharmacy Dialogue
- Hepatrombin gel (tube 50000 units 40 g)Hemofarm
RUB 253 order
- Hepatrombin G suppositories (sup. rect. No. 10) Hemofarm
RUB 263 order
- Gepatrombin G ointment 20g Hemofarm
RUB 248 order
- Hepatrombin gel (tube 30000 units 40 g) Hemofarm
RUB 158 order
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pharmachologic effect
The active ingredients of Hepatrombin G are heparin, lauromacrogol and prednisolone.
- Prednisolone - helps relieve swelling, relieves burning and itching, has an anti-allergic and anti-inflammatory effect.
- Lauromacrogol - this substance scleroses the hemorrhoid, causing its walls to stick together, and has a rapid anesthetic effect.
- Heparin is a direct-acting anticoagulant, it prevents the formation of blood clots, promotes tissue regeneration and healing, and when used externally, reduces swelling and relieves inflammation. The active substance is quickly absorbed and concentrated in the subcutaneous tissues, from where it penetrates further into the surrounding tissues through a network of capillaries, improving blood circulation and microcirculation. In addition, this component prevents the development of stagnation and removes decay products. After absorption, heparin is biotransformed in the liver and excreted from the body by the kidneys.
