Today we’ll talk about analogues of Ketorol, because pain is a response to the discomfort caused to it, which can lead to damage to the entire body. Most people do not tolerate pain from bruises or after surgery very well. Since not all pain can be easily tolerated, painkillers are in great demand today.
The drug "Ketorol": composition and release forms
Of course, first you should familiarize yourself with the list of ingredients and other useful information. This drug is produced in the form of round convex tablets with a green hard shell (on the cut you can see a white or slightly grayish tablet core).
What components does the medicine “Ketorol” consist of? Composition is an important point. The main active substance is ketorolac tromethamine (each tablet contains 10 mg). Other components are also present, in particular corn starch, lactose, magnesium stearate, microcrystalline cellulose, sodium carboxymethyl starch and silicon dioxide (colloidal) are excipients. The film shell contains propylene glycol, green dye and hypromellose.
By the way, you can also buy Ketorol injection solution at the pharmacy. Injections are indicated for severe pain. This product is also produced in the form of a gel for external treatment of tissues.
Characteristics of ketorol
According to reviews from doctors and patients, a medication such as Ketorol has proven itself to date. In order to learn in detail about ketorol, its characteristics, side effects and what substitutes exist on the pharmacological market, we will consider this drug in detail.
Similar medications, ketorol, due to the main substance that is included in their composition, are classified as a number of drugs that relieve pain, fever and inflammatory processes. Its effectiveness is predetermined by its effect on enzymes that are directly related to pain syndromes, fever and swelling.
Composition of the drug
The main component of this medicine is ketorolac tromethamine. It is not addictive, as it is not a sedative or psychotropic substance. Reviews from both patients and doctors confirm that during the course of therapy, no mental or physical abnormalities were observed.
This medication is produced in the form of tablets, ointments, gels and solutions (both for intramuscular and injection into a vein). All these forms are used to reduce pathological actions in the joints.
1 Ketorol tablet contains 10 mg of the active ingredient - tromethamine, and lactose, corn starch, magnesium stearate, hypromellose, titanium oxide and other elements are used as excipients. And 1 ml of solution includes 30 mg of ketorolac tromethamine and in addition - alcohol, water for injection, sodium chloride, etc. The medication begins to act in approximately 30 minutes, and the greatest effect occurs after two hours.
Mechanism of action on the body
How does this medicine (or its analogue) affect the body? "Ketorol" is a non-steroidal anti-inflammatory drug. The drug is also able to relieve fever and has a pronounced analgesic effect.
The mechanism of its effect is associated with non-selective inhibition of cyclooxygenase activity. The medicine does not affect opioid receptors in any way and, accordingly, does not cause addiction. The drug is not a sedative and does not depress the patient's breathing.
Recommendations for use
Drugs containing ketorolac tromethamine in mixtures are prescribed for the following conditions and diseases:
- pain after surgery;
- arthralgia;
- ligament sprains;
- neurological disorders;
- malignant tumors;
- toothaches;
- bone displacements;
- rheumatological diseases;
- moderate to severe pain after injury;
- myalgia.
Drugs of the ketorolac group and analogues can differ significantly in price and are intended to relieve symptoms and influence the inflammatory process. They do not affect progressive diseases in any way.
The effect of the drug is that the main substance delays the synthesis of a specific enzyme - cyclooxygenase, as a result of which it converts arachidonic acid into prostaglandins, which cause pain, inflammation and fever. It is as a result of suppressing the formation of these enzymes that Ketorol demonstrates its properties: antipyretic, anti-inflammatory and analgesic. The analgesic property is the most pronounced, therefore it is most often used for pain in various areas of etiology.
In what cases is the drug indicated?
Of course, it is worth learning about the main indications for use. In what cases is it advisable to take Ketorol tablets? What does the medicine help with? Doctors prescribe the drug in the presence of moderate or severe pain:
- the drug helps with injuries, including fractures, sprains and dislocations of joints;
- it is taken for severe toothache;
- indications include radiculitis, neuralgia, myalgia and arthralgia, regardless of their origin;
In what other cases does modern medicine use the drug “Ketorol”? What does the remedy help with? It is prescribed to patients in the postoperative period, as well as to women after childbirth - it helps relieve pain and give the patient time to rest. Naturally, the drug only eliminates pain and inhibits the inflammatory process, but this is symptomatic therapy - it is impossible to eliminate the root cause in this way.
special instructions
The choice in favor of one or another dosage form is made taking into account the indications for use and the intensity of pain.
Pills:
Use of Ketorol for more than five days in a row and/or at a dose exceeding the maximum allowable increases the risk of adverse reactions.
The drug should not be prescribed simultaneously with other NSAIDs, since simultaneous use with them leads to cardiac decompensation, fluid retention, and increased blood pressure .
The effects due to the effect of ketorolac on platelet disappear after 24–48 hours.
Ketorolac can change the properties of platelets, but the drug does not replace the preventive effect of ASA in pathologies of the heart and blood vessels.
To reduce the likelihood of developing NSAID gastropathy , the drug should be taken with Omeprazole , Misoprostol , and antacids .
Before prescribing the solution, you should find out whether the patient has previously had an allergic reaction to the drug or other NSAIDs. Due to the risk of hypersensitivity reactions, the first dose is administered under close medical supervision.
Hypovolemia increases the risk of nephrotoxic effects.
It is not recommended to use the solution as a means to prepare a patient for general anesthesia, as well as to maintain anesthesia during extensive surgical interventions.
During treatment with Ketorol, it is recommended to be careful when driving a car or using machinery.
gel (ointment) is recommended to be applied only to intact skin, avoiding contact with wounds and mucous membranes (including the eyes).
The drug should not be used under dressings made of airtight materials. After applying Ketorol to the skin, you should wash your hands well with soap.
The drug "Ketorol": instructions for use (tablets)
How to take the medicine correctly? You should not use it yourself. Only a doctor can determine the effective and safe dose of Ketorol. Instructions for use (tablets) indicate that if pain occurs, patients take one tablet once.
In case of severe pain, the drug can be taken repeatedly. The maximum daily dose is 40 mg of the active ingredient, which is equal to four tablets. When taken orally, therapy should not last more than five days, as the risk of complications increases.
How to properly use Ketorol injection solution? The injections are given intramuscularly, and the patient is prescribed a minimal but effective dose. As a rule, a person over 16 years of age whose weight exceeds 50 kg is either administered 60 ml of the drug once, or the daily dose is divided into two doses (30 ml each). The injection should be done slowly, and it is important to inject the solution deep into the muscle. How quickly does pain disappear after taking Ketorol? Reviews say that the condition begins to improve 20-30 minutes after the injection. The maximum effect occurs within 1-2 hours and lasts approximately 4-6 hours.
How much do Ketorol tablets, gel and ampoules cost?
The price of Ketorol in tablets in Ukrainian pharmacies is 29-37 UAH. Injections can be bought for 98-105 UAH. The price of Ketorol gel is 55-62 UAH.
In Russia, the average price of Ketorol in tablets is 45 rubles, the price of Ketorol in ampoules is 145 rubles, the cost of ointment (gel) is 215 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Ketorolac solution for intravenous and intramuscular administration.
30mg/ml apm. 1 ml 10 pcs. Biokhimik OJSC 60 rub. order - Ketorolac solution for intravenous and intramuscular injection. 30mg/ml amp. 1ml No. 10Sintez AKO OJSC
94 RUR order
- Ketorolac tablets p.p.o. 10 mg 20 pcs. JSC Tatkhimfarmpreparaty
33 rub. order
- Ketorol express tab. dispersant in the oral cavity 10 mg 20 pcs.Dr. Reddy's lab.
46 RUR order
- Ketorolac solution for intravenous and intramuscular administration. 30mg/ml amp. 1ml 10 pcs. Biosynthesis JSC
86 rub. order
Pharmacy Dialogue
- Ketorolac (amp. 30 mg/ml 1 ml No. 10) Biosynthesis OJSC
50 rub. order
- Ketorol (amp. i.v. i.m. 30 mg/ml No. 10)Dr. Reddy's
RUB 141 order
- Ketorol (gel tube 2% 30g)Dr. Reddy's
RUB 263 order
- Ketorolac (amp. 30 mg/ml 1 ml No. 10) Sintez (Kurgan) OJSC
83 RUR order
- Ketorolac (amp. 30 mg/ml 1 ml No. 10) Eskom
59 RUR order
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Pharmacy24
- Ketorol 2% 30 g gel Dr. Reddy's Laboratories Ltd., India
72 UAH.order - Ketorol 30 mg/1 ml N10 solution Dr. Reddy's Laboratories Ltd., India
175 UAH order
- Ketorol 10 mg No. 20 tablets Dr. Reddy's Laboratories Ltd., India
75 UAH order
PaniPharmacy
- Ketorol tablets Ketorol film-coated tablets 10 mg No. 20 India, Dr. Reddy's
93 UAH order
- KETOROLAC ampoule Ketorolac r/r d/in. 3% 1ml. No. 10 Ukraine, Health LLC
99 UAH order
- Ketorol ampoule Ketorol solution d/in. 30mg amp. 1ml No. 10 India, Dr. Reddy's
152 UAH order
- KETOROLAC tablets Ketorolac tablets. 10mg No. 10 Ukraine, Health LLC
18 UAH order
- Ketorol gel Ketorol gel 2% 30g India, Dr. Reddy's
85 UAH order
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Contraindications to taking pain medications
According to the instructions, research results and reviews, the drug “Ketorol” for pain is quite effective. On the other hand, this is a rather powerful drug, so not all patients can take it. Tablets (as well as injection solutions) have contraindications:
- Intolerance to non-steroidal anti-inflammatory drugs (including acetylsalicylic acid), especially if it is combined with bronchial asthma of varying severity or nasal polyposis, which worsens from time to time.
- This drug should not be used by patients with ulcerative or erosive lesions of the mucous membrane of the digestive tract, as tablets can only aggravate the situation.
- Contraindications include gastrointestinal bleeding (pain in this case is relieved with other drugs).
- The drug is not prescribed for chronic inflammatory lesions of the digestive tract at the acute stage (for example, ulcerative colitis, Crohn's disease).
- This pain reliever should not be taken if you have decompensated heart failure.
- Blood clotting disorders are also included in the list of contraindications.
- The drug should not be taken by patients with liver and kidney diseases (including renal and liver failure).
- Since the tablets contain lactose, they should not be taken by people suffering from glucose-galactose malabsorption, lactase enzyme deficiency or lactose intolerance.
- Of course, the list should include hypersensitivity not only to lactose, but also to any component of the drug (it is recommended to study the composition before starting use).
- There are also age restrictions. For patients under sixteen years of age, it is better to choose another pain reliever.
- The medicine is not prescribed during pregnancy. Since the active ingredient passes into breast milk, you should stop feeding your baby while taking the pills.
In some cases, the drug can be taken, but with careful monitoring of the patient's condition. The list of relative contraindications includes arterial hypertension, smoking, diabetes mellitus, severe somatic diseases, alcohol abuse, cerebrovascular diseases.
Are there any possible complications while taking it?
What complications can result from taking Ketorol tablets? Reviews from doctors indicate that the drug is well tolerated at the correct dosage. But the possibility of side effects cannot be ruled out. These include:
- Disorders of the digestive system, in particular nausea, diarrhea, cramps and burning in the stomach, abdominal pain. Some patients develop hepatitis, acute pancreatitis, cholestatic jaundice, and stomatitis while taking it. Constipation and the development of peptic ulcers are possible.
- Adverse reactions from the urinary organs appear much less frequently. Some patients complain of an increased urge to urinate and note a decrease or increase in the daily volume of urine. While taking the pills, swelling and pain in the lower back may appear. It is extremely rare that the drug can trigger the development of acute renal failure.
- Therapy is sometimes accompanied by disruption of the sensory organs and nervous system. After taking the pill, you may experience a headache. Side effects include increased drowsiness, depression, hyperactivity, hallucinations and psychosis. Sometimes patients complain of ringing in the ears, decreased hearing and visual acuity.
- The development of allergic reactions is possible. Sometimes patients' skin breaks out in a rash. It is possible to develop urticaria, swelling, and even severe anaphylactic shock.
- Other violations are also possible. Peripheral edema often appears while taking the medication. Rarely, increased body temperature and increased sweating are observed. Adverse reactions also include the appearance of rhinitis, shortness of breath, and bronchospasm. A sharp increase in blood pressure and loss of consciousness are possible. While using the medicine, the patient may develop anemia, nasal and rectal bleeding.
Any deterioration after taking the drug should be reported to your doctor as soon as possible.
Ketanov tablets as a substitute
What should you do if, for one reason or another, the medicine described above does not suit you? In fact, the modern pharmacological market offers simply a huge amount of painkillers. And often doctors prescribe Ketanov or Ketorol to patients. What's better? By and large, these are one and the same tool.
The main active substance is ketorolac. The drug is available in the form of tablets and solution for intramuscular or intravenous injection. The drug has pronounced anti-inflammatory and analgesic properties. Today it is considered one of the most powerful analgesics. On the other hand, the medicine is only suitable for short-term control of pain, since otherwise the risk of side effects increases, including ulcerative lesions of the walls of the digestive tract.
So what should I take - Ketanov or Ketorol? What's better? There is no definite answer to this question, since everything depends on the patient’s condition and the severity of the pain syndrome. The decision here can only be made by the attending physician. By the way, Ketanov tablets cost patients much less, although taking them is associated with great risks.
Analogs of this substance
But what to do if for some reason the above-mentioned medicine does not work? In this case, do not despair. So today the drug market provides a plentiful variety of pain relievers, such as Baralgin in ampoules.
At the moment, there are many things that can replace ketorol injections. All of them contain ketorolac tromethanine and they can differ in price, as this is determined directly by the manufacturer, the country where this medication was released and the degree of its purification. This medication is produced in the form of tablets, ointments and solution for injection.
Now let’s take a closer look at what similar medications and forms of release are available:
1. In the form of tablets in a special coating:
- Adolor – has antirheumatic and anti-inflammatory effects, used for inflammatory processes in the joints and spine.
- Dolak - very good pain reliever, used in the treatment of ailments of the musculoskeletal system, also for displacements, injuries, tissue ruptures
- Dolomin – characterized by antiseptic and antirheumatic effects;
- Ketalgin, Ketanov, Ketorolac have well-proven anti-inflammatory and pain-relieving effects.
- Ketorolac-OBL, Ketorolac-Eskom, Ketofril - used for ailments of the locomotor system, as well as the musculoskeletal system.
2. Replacing Ketorol with injections:
- Aertal – used for various types of arthrosis (osteoarthrosis, rheumatoid form)
- Almiral - prescribed for such ailments as osteoporosis, rheumatoid arthritis, and embodied pain;
- Bioran - used for a single application for painful sensations;
- Bioran Rapid - used for symptoms of joint inferiority;
- Voltaren with analogues - indicated for rheumatism, mild pain, radiculitis and arthrosis.
3. In the form of an ointment for external application:
- Diclofenac - characterized by an anti-inflammatory effect, used in the treatment of joints, relieves swelling and pain. It can also be produced in the form of solutions and tablets.
- Bystrumgel - used in the treatment of pathological ailments of the locomotor system, joint joints, and damage to muscles and ligaments;
- Fastum gel - used to treat joints and spine;
- Indomethacin ointment - used to treat joints, arthritis and various types of arthrosis, neuralgic pain;
- Dolgit - used to reduce inflammatory processes in joints, used in complex treatment of abnormalities of the locomotor system
- Nise - exhibits a clearly demonstrated effect against inflammation due to joint dysfunction; may also be in the form of tablets and solution
- Deep Relief - gel exhibits irritating and anti-inflammatory effects.
Popular Effective recovery with antibiotic injections
It is important to know about the differences between Ketorol
All medicinal medications that contain the same active ingredient in the mixture have the same effect. Distinctive features will be: release form, manufacturer, quantity and quality of additional components, cost, likelihood and number of side effects, as well as popularity in various branches of medicine. In order to thoroughly decide which analogue is better, it is necessary to study the standard set of indications, contraindications, and adverse reactions.
Next, you need to figure out what exactly is the difference between ketorol and ketonal. From the instructions for these drugs, you can easily understand that they are analogues, since they contain the same substance - ketorolac tromethanine. The main difference is the difference in active substances.
Ketonal or ketorol? Their representatives are completely different companies. As for use, Ketonal can be taken regularly if necessary, as it is easily absorbed, which cannot be said about Ketorol. Because if you abuse it, you can cause bleeding in the stomach or intestines. However, if you compare the instructions of these two drugs, Ketanol is noted for a large list of side effects.
It is also worth noting that Ketanov and Ketorol also differ from each other. In their mixture they have ketorolac tromethanine, but they differ from Indian manufacturers, so Ketorol is created by Dr. Reddys Laboratories Ltd, and Ketanov - Ranbaxy L. Limited. Another point is that the drug Ketanov is produced in tablet form and in injections, and Ketorol, in addition to the above, is also in the form of ointments.
Ketorol is best used for a minor injury, and Ketanov for a fracture, burn, or severe bruise. Also, the drug Ketorol affects platelets, with the help of its active substance, it heals wounds well. Ketanov has proven itself in anti-inflammatory action. Scientists have already proven that when using Ketanov, absorption by the body occurs quite quickly and at the same time there is a maximum concentration of the substance in the blood than with other medications. So which is better? Only the attending physician can answer this question.
Description of the drug "Ketorolac"
What is the drug "Ketorolac"? It is produced in the form of tablets and belongs to the group of anti-inflammatory and antirheumatic drugs (non-steroidal). The main active ingredient is ketorolac tromethamine.
As you can see, it practically does not matter whether the patient takes Ketorol or Ketorolac, since the main active component is the same and they have the same effect on the body. The medicine copes well with toothache, myalgia, neuralgia, and pain from injuries. It is often prescribed to patients with cancer who suffer from constant discomfort.
pharmachologic effect
Manufacturer: Borisov plant, Grotex, Vertex, Update, Biokhimik, etc., Russia or Belarus
Release form: tablets, ampoules
Active ingredient: ketorolac
Synonyms: Ketorol, Ketanov, Dolak, Ketofril
The drug Ketorolac has a strong analgesic (analgesic) and mild anti-inflammatory effect for 5 hours. In terms of strength and duration of effect, it is classified as a short-acting drug.
With long-term use, exceeding therapeutic doses, there is a risk of unwanted drug interactions and accumulation in tissues and organs. In terms of the strength of the analgesic effect, Ketorolac is similar to opioid analgesics. However, the medicine does not have a pronounced sedative effect or side effects, like the latter. Ketorolac does not cause addiction or withdrawal syndrome, when the dosage is constantly increased for the proper therapeutic effect.
Painkiller "Nise": instructions
The drug "Nise" or "Ketorol" - which is more suitable? In fact, “Nise” is a fairly effective analogue. The composition of these drugs is different, since in this case the main active component is nimesulide. However, the mechanism of action is similar, since the main active ingredient is a selective inhibitor of cyclooxygenase.
This medicine is available in the form of tablets, oral suspension and gel for external use. The drug also helps with pain syndromes arising from injuries, arthritis and radiculitis. In addition, it is prescribed to patients suffering from sciatica, osteoarthritis, lumbago and osteochondrosis with radicular syndrome.
Ketorolac or Diclofenac – which is better?
Manufacturer: Ozone, Nizhpharm, Akrikhin, etc., Russia, Teva (Hungary), Hemofarm (Serbia)
Release form: tablets, ampoules, ointment, gel, suppositories
Active ingredient: diclofenac
Synonyms: Voltaren, Diclonate and Diklak, Ortofen, Naklofen and Diclovit, Dialrapid, etc.
Diclofenac is an analogue in injections and tablets with a pronounced anti-inflammatory effect. The strength of pain relief is inferior to Ketorolac.
The advantage of Diclofenac is the presence of additional forms of release: ointment and gel for topical use, suppositories for quick pain relief and prevention of negative effects on the gastric mucosa.
Both drugs - the analogue and Ketorolac - have an adverse effect on the gastrointestinal tract. What is stronger is individual. For severe pain and inflammation, Diclofenac is prescribed.
The choice of analogues should be entrusted to a specialist and not self-medication. The main selection criteria are the severity of pain and inflammation, the presence of other diseases in the anamnesis, diagnosis, and age.
The drug "Baralgin" and its properties
Many patients ask questions about what is better to choose: Baralgin or Ketorol? In fact, these are different means of action, despite the fact that both of them provide an analgesic effect.
"Baralgin" is available in the form of tablets and solution. This is a complex drug that contains three active substances:
- Metamizole sodium has antipyretic properties and provides an analgesic effect;
- fenpiverinium bromide acts on smooth muscles;
- Pitophenone is another component that causes smooth muscle relaxation.
You can see that the drug "Baralgin" does not have anti-inflammatory properties, but acts as an antispasmodic. Therefore, it is more suitable for pain caused by spasm of smooth muscles. Indications include renal, intestinal and biliary colic, ureteral spasm, chronic colitis and some other disorders of the internal organs.
Naturally, you need to understand that only a specialist can prescribe a drug containing tromethamine or select its effective analogue. Ketorol, if used incorrectly, can lead to extremely unpleasant complications, so you should not self-medicate.
