Cortexin powder for injection 10 mg No. 10 in Nur-Sultan

Release form

The drug is available in the form of a sterile lyophilized powder for the preparation of a solution for intramuscular administration.

The cardboard packaging is completed with two blister packs, each containing 5 bottles of lyophilisate, and instructions for use.

In pharmacies you can buy Cortexin 10 mg No. 10 and Cortexin 5 mg No. 10.

Cortexin 10 mg is available in 22 mg doses in 5 ml bottles. The product is intended for the treatment of adult patients.

Cortexin 5 mg was created specifically for use in pediatrics. It is available in 11 g bottles with a capacity of 3 ml.

Medicinal properties

This is a nootropic medicine. Under the influence of Cortexin, the functioning of the brain improves, and attention also increases. When using this medicine, a person becomes more susceptible to stressful situations and psycho-emotional stress.

Frequent use of this medication has an antioxidant effect on the body, and also protects cells from the effects of free radicals, strengthens the resistance of nerve cells in stressful situations and oxygen starvation. What is "Cortexin" for?

Pharmacodynamics and pharmacokinetics

Cortexin is a bioregulator with a polypeptide structure, which is a complex of water-soluble neuropeptides . The molecular weight of these polypeptide fractions does not exceed 10 thousand daltons, which allows them to penetrate the physiological barrier separating the central nervous and circulatory systems .

The mechanism of action of the drug is realized through:

• activation of regulatory peptides, neurons and brain-derived neurotrophic factors ;
• normalization of the ratio of amino acids that perform mediator functions of excitatory and inhibitory types of action, as well as important brain neurotransmitters dopamine and serotonin ;
• moderately expressed GABA-ergic effects;
• reducing the level of paroxysmal (attack-like) convulsive activity of the brain and the ability to normalize indicators of its bioelectrical activity;
• preventing the formation of products of oxidative degradation of lipids (free radicals).

The nootropic effect of Cortexin is accompanied by an improvement in higher brain functions , improved memory, increased learning ability and stress resistance.

The neuroprotective effect is manifested in the ability of the drug to increase the resistance of brain to the damaging effects of various endogenous neurotoxic factors and reduce the toxic effects of neurotropic substances.

The antioxidant effect is manifested in the drug’s ability to influence oxidative stress (cell damage provoked by oxidative processes) and increase the survival rates of neurons under conditions of oxygen starvation.

The mechanism of this action is associated with the suppression of free radical processes and lipid peroxidation of cell membranes , as well as with the correction of oxygen-dependent pathological conditions.

As a result: the process of destruction of cell membranes , microcirculation improves, the permeability of vascular walls of cholesterol and triglycerides in the blood is normalized .

The tissue-specific effect of the drug is associated with an increase in the intensity of metabolism of neurons in the central nervous system and PNS , stimulation of reparative processes in nervous system , improvement of the functional state of the cerebral cortex and the general tone of the somatic and autonomic nervous system .

Pharmacokinetic characteristics cannot be determined, since the disintegration time of the L-series amino acids and neuropeptide fractions included in the active substance Cortexin is no more than 3 minutes.

This makes it impossible to establish the rate and extent of absorption of peptide residues, their distribution among various organs and tissues, as well as the rate and routes of their excretion from the body.

Adviсe

"Cortexin" is used only on the recommendation of a doctor. The bottle with the dissolved medicine must be used immediately; if the medicine still remains, then for the next injection a new ampoule with powder is opened, and the previous one is thrown away.

If the patient has forgotten to give an injection, a double dosage of Cortexin cannot be administered; during the next injection, the usual concentration of the active substance is used. When carrying out the procedure, you must adhere to the rules of antiseptics so as not to provoke the occurrence of post-injection complications. Is it possible to take Cortexin for a cold?

It must be remembered that if the temperature rises, therapy with this drug is discontinued until recovery. This must be done to avoid complications. The same goes for colds.

This medication does not suppress the functioning of the central nervous system and does not inhibit the speed of psychomotor reactions, therefore it can be used for the treatment of vehicle drivers. The drug is dispensed with a prescription from a medical specialist.

Indications for use of Cortexin: for which the medicine is prescribed to adults and children

Indications for use of the drug are:

• infectious diseases of the nervous system provoked by bacteria or ;
• conditions accompanied by circulatory disorders in the brain ;
• TBI and its consequences;
• syndrome of diffuse brain damage of various origins;
• cerebral (suprasegmental) autonomic disorders.

In combination with other drugs, the drug is prescribed for the treatment of epilepsy , as well as for the treatment of acute and chronic inflammatory diseases of the brain and/or spinal cord of various etiologies.

For children, indications for the use of Cortexin are reduced learning ability, memory and thinking disorders, psychomotor and speech development (CPRD), various forms of cerebral palsy .

How to store

The medicine is kept in a dry, dark place at room temperature. Storage conditions allow its fluctuation range of +2°С…+20°С.

You must be vigilant to ensure that the medication does not fall into the hands of a small child or pet.

Must be used within 36 months of date of issue.

It must be concluded that Cortexin for adults and children is a strong nootropic agent. It is indicated for a wide range of patients suffering from pathologies of the brain and nervous system. However, the drug has some peculiarities in its release form, and therefore requires strict adherence to the instructions for its use.

Contraindications

The drug is contraindicated in patients with hypersensitivity to cortexin and/or glycine.

Clinical studies to establish the effect of the drug on the body of a pregnant woman and the developing fetus have not been conducted. For this reason, the drug is not recommended for use at any stage of pregnancy.

Since there are no data from clinical studies regarding the use of the drug during breastfeeding, if it is necessary to prescribe Cortexin, it is recommended to stop breastfeeding.

special instructions

To properly administer the medication and achieve the maximum therapeutic effect, certain rules must be followed during treatment with Cortexin.

1. The lyophilisate solution must be administered slowly, since rapid administration will cause pain.
2. The medicine must be diluted immediately before its administration.
3. If there is any solution left in the bottle, it should not be reused.
4. When a Cortexin injection is missed for some reason, there is no need to administer a double dose.
5. During the injection process, you must strictly adhere to the rules of antiseptics.
6. The drug does not affect driving a car or working with complex equipment.
7. During the treatment process, the dosage and duration of treatment must be strictly observed.
8. The drug can be used with other nootropics only on the recommendation of a doctor.

By following the basic rules, Cortexin treatment will be effective and completely safe for the patient’s health.

Cortexin injections, instructions for use (Method and dosage)

The drug is intended for injection into the muscle.

How to dilute Cortexin?

Before injection, the powder contained in the bottle should be diluted with one or two milliliters of a 0.5% solution of procaine ( novocaine ), physiological solution (isotonic sodium chloride solution (0.9%)) or water for injection.

To prevent the formation of foam, they try to direct the needle towards the wall of the bottle.

How to inject a child with Cortexin?

Cortexin can be prescribed from the first days of life. In some situations, parents have to give their child injections themselves. And here questions arise about how to properly inject Cortexin and what is the best way to dilute the powder.

Before making an injection, water for injection, novocaine or saline , then the cap of the bottle is pierced and the collected liquid is poured into it.

The syringe should be removed (the needle remains in the cap) and the contents of the bottle should be thoroughly shaken until the powder is completely dissolved. After this, the syringe is reattached and the required amount of solution is drawn into it.

For an injection, it is better to take a new needle, since the needle with which the solvent for the lyophilisate was injected may already be fairly dull.

The medicine is administered slowly, as rapid administration can cause very severe pain.

For babies up to six months old, an intramuscular injection is given into the anterior surface of the thigh (so as not to accidentally damage the sciatic nerve).

For children, especially very young children, all injections are given with saline or water for injection. Injections with novocaine are less painful than injections with saline solution , however, diluting the drug with novocaine is allowed only if there is firm confidence that this will not cause an allergic reaction in the child ( novocaine can cause severe allergies and convulsions ).

Like other neurometabolic drugs , Cortexin is recommended to be injected before 12 noon, given its activating effect and ability to provoke psychomotor agitation .

Instructions for use of Cortexin for adults

Adult patients are given Cortexin injections once a day, daily for ten days, at a dose of 10 mg.

In case of massive ischemic stroke (MIS) in the acute phase, as well as in the early recovery period, the indicated dose is recommended to be administered to the patient twice a day (morning and evening) for ten days. After ten days, the course should be repeated.

Instructions for use of Cortexin for children

In pediatric practice, the medicine is used to treat children from the first days of their life.

For patients whose weight does not exceed 20 kg, the drug is prescribed at a dose of 0.5 mg/kg body weight. For patients weighing more than 20 kg, a dose of 10 mg is indicated.

The duration of treatment is ten days. If necessary, after three to six months the patient may be prescribed a second course.

The drug extremely rarely causes side effects, has almost no contraindications and can be used to treat even newborn babies. Its main disadvantage is considered to be its release form: Cortexin is not available in tablets, and this partly complicates its use in children, if the latter require several courses.

How to use the medicine

According to the annotation, Cortexin is prescribed only for intramuscular injection.
The powder in the bottle is pre-dissolved in 1-2 milliliters of novocaine solution (0.5%), water for injections or isotonic sodium chloride solution.

The injection is given once a day, the dosage of the medicine is calculated by the doctor individually for each person, which depends on the weight, as well as the severity of the disorders and characteristics.

The duration of treatment should be at least 10 days; if necessary, therapy can be repeated after 3 months.

For people with stroke, a second course of treatment is carried out 10 days after the end of the previous one.

Analogues of Cortexin

Level 4 ATX code matches:
Bravinton

Acefen

Carnicetine

Pyracesin

Nooclerin

Semax

Piracetam

Olatropil

Fezam

Vinpocetine

Cerebrocurin

Cavinton Forte

Calcium Hopanthenate

Glutamic acid

Cephabol

Olanzapine

Cerebrolysate

Pramistar

Sidnocarb

Vinpotropil

Analogues of Cortexin in tablets: Armadin and Armadin Long g, Boluses Huato , Borizol , Glycised , Mexidol , Mexiprim , Glutamic acid , Rilutek , Cytoflavin .

Analogues of Cortexin in ampoules: Armadin , Mexiprim , Neurotropin , Nikomex , Nucleo CMF Forte , Cytoflavin .

Cortexin or Cerebrolysiin - which is better?

Studies conducted on laboratory rats have shown that Cerebrolysin and Cortexin, when administered intraperitoneally and administered into the lateral ventricle of the brain, have a similar effect.

A comparative analysis of the central effects of the drugs led to the conclusion that, despite all their similarities, Cortexin is more active.

At the same time, it provokes a much smaller number of adverse reactions and can be used from birth (whereas Cerebrolysin is used in pediatric practice if there are justified indications).

According to some patients, Cerebrolysin are less painful compared to Cortexin injections.

Cortexin and alcohol: compatibility

It is not advisable to use alcohol during treatment of nervous dysfunction with Cortexin. Neuropeptides interact with ethanol and lose their effectiveness.

In addition, after drinking alcohol, toxic products are formed in the body that negatively affect the cerebral cortex. In this case, Cortexin loses its protective effect.

Cortexin is used in drug treatment practice to reduce cravings for alcohol and improve the well-being of patients.

Let's look at what Cortexin helps with alcohol poisoning:

• nervousness, irritability, depressed mood go away;
• emotional state stabilizes;
• the craving for alcoholic beverages disappears;
• hangover syndrome is relieved.

Cortexin for children

The instructions for use of Cortexin for children permit the use of this drug from the first days of a child’s life.

Doctors' reviews of Cortexin for children confirm the manufacturer's statements that the drug practically does not cause adverse reactions, allergies , does not have a teratogenic or carcinogenic effect and is well tolerated by patients.

Its use in neurology, neonatology and pediatrics can improve the child’s behavior and his general condition with various types of tones, normalize memory function and speech, and relieve headaches.

Doctors' opinions and parents' reviews

Reviews from doctors and patients about Cortexin are very mixed. Most doctors view the drug favorably, noting its high effectiveness and good tolerability. However, there are specialists who try not to use this nootropic in their practice, because they consider its effectiveness unproven and its price unreasonably high.

Feedback from parents is distributed in a similar way: many mothers are delighted with Cortexin, seeing how, after a course of treatment, their children begin to develop physically and speak, but there are also negative experiences with using the drug.

3 days passed after using the “talkers”, and I began to notice a slight rash, the injections were stopped, but the rash got worse, and later the diagnosis was disappointing - atopic dermatitis. In general, the solution is very good, and the packaging is convenient - special disposable bottles, and, by the way, the child’s condition has become much better. And the most significant advantage is that even without completing the entire course of treatment, what would you think? A week after the injections, my son began to talk more and more, it’s not for nothing that they call Cortexin for children - talkers! And the baby has an excellent memory - he retells and remembers everything the first time!

Irinchik

https://otzovik.com/review_50575.html

When the child was three years old, we went to see a wonderful neuropsychiatrist who looked at all the studies, the drugs prescribed before, and prescribed 10 ml of Cortexin to be injected every day, diluted with lidocaine. So, 10 injections were given every day. But all the torment and pain were worth it!!! A month later, my son began to speak a little!!! If before this he had 5–8 understandable words plus onomatopoeia in his active vocabulary, there was no talk of sentences at all, the child began to say more and more words every week.

Margo44

https://otzovik.com/review_690730.html

This drug was prescribed to us by a neurologist. My son is 3 years and 3 months old, but he hardly speaks, eats poorly, and develops slowly. Of course, I feel sorry for the child. He is crying. But we liked the result. It is clear that the child does not tell us poetry. But he began to fall asleep better during the day, became more attentive, looks with interest, studies, tries to repeat words and actions. He couldn't do it before.

Leaf

https://otzovik.com/review_603261.html

Read also:  Elidel for children. Reviews, instructions for use, cheaper analogues

My son was prescribed Cortexin at the age of 1 year. Diagnosis: delayed speech development. Completed the course - 10 injections. I won’t tell you how the child cried in front of the door of the treatment room, starting from the second visit, it’s easy to imagine. The result is zero. There were no changes. When I asked the neurologist the question “why?”, they explained to me that neurology cannot be treated so quickly, that we give injections now, and we will see the result in at least 2 weeks, or even in a month. We waited - there was no result.

altai2002

https://otzovik.com/review_92696.html

After the injections, the son began to behave even worse, all his rocking only intensified. The child became aggressive, nervous, just a little devil. As soon as the effect of the drug came to an end, the child calmed down and became the same again. This pattern continued throughout the course of treatment. The doctor said this happens and will soon return to normal. But after taking it and even after a while there are no changes. Everything became the same as it was, perhaps even worse.

Yankovskaya Sasha

https://otzovik.com/review_2395824.html

My son was prescribed Cortexin by his neurologist at the age of 8 months. The child has delayed motor development, according to the doctor, and nothing more!!! The child does not sit independently, only with support. And he sits when he was imprisoned. And he doesn’t crawl, he just lies on his tummy. AFTER A WEEK of using Cortexin, the child began to have CONVISIONS!!! I threw these injections away immediately! And I advise you: NEVER BUY!!!

Anonymous176815

https://otzovik.com/review_539426.html

We placed it at 2 months. simultaneously with massage and Phenibut. Helped us a lot! At four months We saw a neurologist and he said everything was fine. We had intracranial pressure due to fetal hypoxia (the baby was premature) and a small cyst. Now everything is normal! The injections were painful, but my son cried very little and quickly calmed down. The massage therapist herself gave us insulin syringes, they are small, just right for a baby.

MariMarka

https://38mama.ru/forum/index.php?topic=62424.0

Thus, we can conclude that Cortexin helps many children, even despite the stress from painful injections. However, the use of any medicine always carries the risk of adverse reactions, and in some children they can be quite pronounced, even leading to the appearance of seizures.

Reviews about Cortexin

Cortexin is a drug widely used in neurological practice. Reviews of Cortexin for adults, which can be found on numerous thematic forums, indicate the effectiveness of this drug for treating patients of all ages (both infants and the elderly).

Taking the drug allows you to speed up the recovery process after injuries and strokes , and in older people it stimulates brain , increases the ability to remember and concentrate, and also prevents a decrease in intellectual abilities.

Reviews of Cortexin for children allow us to conclude that the drug is most often prescribed to children who have certain deviations in neuropsychic development. In particular, indications for the use of the drug are cerebral palsy and brain lesions that occurred in the prenatal period (close to the date of birth) or directly during childbirth.

Injections for children - and reviews of Cortexin confirm this - can achieve significant improvements: after a course of treatment with the drug, the child becomes calmer, he has an improvement in brain activity, an increased interest in learning, and improved memory and speech.

The use of the drug for infants (in particular, for newborns born ahead of schedule) allows you to notice obvious improvements in a fairly short time, which are manifested in the child’s calmer behavior or the emergence of new skills (for example, the ability to independently roll over from his back to his tummy and back).

Mothers whose children were prescribed Cortexin note that after the course of treatment the child literally “came to life before our eyes.” Many consider the advantages of the drug to be the absence of side effects and low toxicity of the drug. The disadvantages most often cited are the rather high price of the product and the pain of the injections.

As for doctors’ reviews of Cortexin, they, despite the rather high rating of the drug on forums (an average of 4.1-4.3 on a 5-point scale), are quite contradictory: some doctors consider it a panacea, others - a dummy with unproven effectiveness .

Patient reviews after use

Natalya, 38 years old:

I have low blood pressure and also suffer from dizziness and headaches. A neurologist prescribed Cortexin injections for me in the spring. After them, my head seemed to clear up and I began to feel much better. The dizziness went away completely, although I still had a headache once a month. And at work I became calmer, less irritated.

Irina, 25 years old:

My son is already 4 years old, and he still doesn’t speak. She took me to neurologists and showed her to a psychiatrist. Doctors say that there are no deviations in his health. Then suddenly a diagnosis: delayed speech development. I read reviews on the Internet about the drug Cortexin and decided to try it. I consulted with a neurologist, the doctor gave the go-ahead.

After a 10-day course, there were positive changes. No, the child did not immediately start speaking in sentences. But instead of mooing, I suddenly heard the words “give”, “drink” and others. It is clear that not everything works out for my boy, but he has a great desire to talk.

Cortexin price, where to buy

The average price of Cortexin in ampoules of 5 ml of 10 mg each in Russia is 1100-1200 rubles, the average cost of ampoules of 5 mg is 700-850 rubles.

The price of Cortexin 10 mg in Ukraine is 598-685 UAH, the price of Cortexin injections for children varies from 440 to 520 UAH. In Dnepropetrovsk, Zaporozhye and other large cities, you can buy the drug both in a network of retail pharmacies and through online pharmacies with delivery directly to your home.

The drug is not available in tablets.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Cortexin lyof.
  for injection solution for intramuscular injection. 5mg/11mg 10 pcs. Geropharm LLC 792 rub. order
• Cortexin lyof. for injection solution for intramuscular injection. 10mg/22mg 10 pcs. Geropharm LLC

  RUB 1,228 order

Pharmacy Dialogue

• Cortexin (vial 10 mg No. 10) Geropharm

  RUB 1,335 order

• Cortexin (vial 5 mg No. 10) Geropharm

  RUR 841 order

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Pharmacy24

• Cortexin 5 mg No. 10 powder TOV "Geropharm", Russian Federation
  479 UAH. order

PaniPharmacy

• Cortexin bottle Cortexin lyophilized powder for the preparation of solution 5 mg No. 10 Russia, Geropharm

  471 UAH. order

• Cortexin bottle Cortexin lyophilized powder for the preparation of solution for injection 10 mg No. 10 Russia, Geropharm

  849 UAH. order

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Dosage

• For babies weighing up to 20 kg, the dose should be calculated by weight. To do this, the number of kilograms is multiplied by 0.5, for example, if a child weighs 8 kg at 10 months, then he needs 8x0.5 = 4 mg of cortexin per day. For such a baby, take bottles with 5 mg of the active ingredient, dilute with 2 ml of water for injection and administer 1.6 ml of the finished medicine to the baby (it is from this amount that the baby will receive 4 mg of the active complex). If the medication is diluted with 1 ml of saline solution or sterile water, then the child needs to administer 0.8 ml. The remainder of the drug is discarded.
• For a child weighing more than 20 kg, Cortexin is prescribed 10 mg per day. One bottle with this content of the active complex is diluted with 1 ml of water for injection or saline solution.
• The drug is administered once daily for ten days. It is recommended to give the injection in the first half of the day, because the medication has a stimulating effect. After a 10-day course of treatment, a break is taken for 3-6 months, after which the therapy can be repeated.
• For stroke, 2 injections of 10 mg are given daily. One of them is given in the morning, and the second - in the daytime, since an injection given in the evening can interfere with falling asleep.
• If for some reason the injection was missed, the next day there is no need to administer the drug at a double dose. In such a situation, the course is extended so that there are 10 injections in total.