Indications and instructions for use of Corvalment and its analogues in Russia

Pharmacology

Corvalment is a serious medicine used for heart disease. The drug belongs to the group of cardiological drugs.

However, cardiovascular diseases are not the only indications for the use of capsules. They are often prescribed to people who cannot endure sea travel or fly comfortably on an airplane. When taking, you should carefully monitor the dosage.

Pharmacodynamics and pharmacokinetics

The effect is achieved due to irritation of cold sensitive receptors located in the oral mucosa. Irritation of nerve receptors has a calming effect on the nervous system. of opioid peptides increases , under the influence of which the permeability of the vascular wall is normalized, the severity of pain is reduced, and the functioning of the nervous and cardiovascular systems is regulated.

Corvalment stimulates the production of kinins , histamine and other physiologically active substances. The antispasmodic, sedative effect is caused by the action of isovaleric acid , which is part of the drug Corvalment.

When administered sublingually, the drug is absorbed from the oral mucosa. The effective effect of the drug appears after 5 minutes. Biotransformation of the drug occurs in the hepatic system, metabolites are excreted in the form of glucuronides through the urinary system.

Description of the medicine

Corvalment is a popular sedative, but few know that the drug also has other properties, namely:

• vasodilator;
• antianginal (weakly expressed);
• antiemetic.

Components and their action

The active component is menthol extract dissolved in isovaleric acid menthyl ester. This component is used in the production of many sedatives (Validol, Valoserdina, Valocordin, etc.), as well as in the food industry.

The use of menthol-containing products in medicine

Additional components include:

• gelatin;
• glycerol;
• propyl parahydroxybenzoate;
• methyl parahydroxybenzoate.

The work of the drug is based on the fact that menthol acts on nerve receptors once it enters the oral cavity. The body's response to irritation is to expand the lumen of the coronary vessels, which leads to the fact that the entire central nervous system calms down.

Also, under the influence of the main component of the product, the production of neuropeptide hormones such as histamines, endorphins, and kinins is activated. This, in turn, relieves pain in the heart.

Forms and price

Corvalment is available in only one form - in the form of yellowish capsules, soft to the touch, consisting of a gelatin coating and liquid contents. The price of the drug depends only on the number of tablets in the package and the pricing policy of a particular pharmacy. Let's look at the average prices for the drug in Russia and Ukraine (Table 1). It is worth saying that today this drug is quite difficult to find in Russian pharmacies, but it is available for online sale.

Table 1 – Cost of Corvalment

Indications for use

The sedative drug Corvalment is recommended for use in the following cases:

• nervousness, excessive excitability, hysteria;
• neuroses of any etiology;
• seasickness;
• problems with the vestibular system;
• heartache.

Seasickness

In addition to treating the heart, Corvalment can be used as a remedy for motion sickness and vomiting. The therapeutic effect occurs 15-25 minutes after application. In addition, the drug is often used after taking Nitroglycerin and its derivatives to relieve negative symptoms, in particular frequent headaches, as well as to enhance the effect of drugs.

This drug also worked very well for sleep problems. It should be remembered that before starting drug treatment with such a drug, you must consult a cardiologist or therapist.

Side effects

Dyspeptic disorders , lacrimation, nausea, and dizziness are rarely observed Long-term use of the drug is manifested by increased drowsiness and arterial hypotension. Symptoms disappear on their own after stopping use of the drug.

If you are allergic to the components, itching, Quincke's edema and other allergic reactions are noted.

Corvalment sublingual capsules 100 mg No. 30 in Almaty

Instructions for medical use of the drug
CORVALMENT

Trade name Corvalment

International Nonproprietary Name No

Dosage form Sublingual capsules, 100 mg

Composition One capsule contains active substances: a solution of menthol in menthyl ester of isovaleric acid - 100 mg, excipients (shell): gelatin, glycerin, methyl parahydroxybenzoate (E218), propyl parahydroxybenzoate (E216).

Description Soft gelatin capsules of spherical or spherical shape, with a seam, colorless or from slightly yellow to light brownish-yellow, filled with a transparent, colorless or yellowish-tinged oily liquid with a menthol odor.

Pharmacotherapeutic group Other combination drugs for the treatment of heart diseases. Code ATX C01EX

Pharmacological properties Pharmacokinetics. When administered sublingually, Corvalment is absorbed from the oral mucosa. The therapeutic effect occurs in approximately 5 minutes. After absorption, it is biotransformed in the liver and excreted in the urine in the form of glucuronides. Pharmacodynamics The drug exhibits a calming effect on the central nervous system, and also has a moderate reflex vasodilator (coronolytic) effect through reflex irritation of sensitive nerve (“cold”) receptors of the oral mucosa. Stimulation of receptors is accompanied by the induction of the release of endorphins, enkephalins, dynorphins and other peptides, histamine, kinins, which play an important role in reducing pain sensitivity, normalizing vascular permeability and regulating other important mechanisms of functioning of the cardiovascular and nervous systems. Indications for use – mild angina attacks – sea and air sickness – hysteria – neurosis – headache associated with taking nitrates Method of administration and dosage Keep the capsule in the mouth (under the tongue) until it is completely dissolved. To speed up the effect, you can crush the capsule with your teeth. Single dose for adults – 1 capsule (100 mg). The maximum daily dose is 6 capsules (600 mg). Duration of treatment – ​​up to 7 days.

Side effects With prolonged use, mild nausea, abdominal discomfort, lacrimation, dizziness, short-term arterial hypotension, and drowsiness may occasionally occur, which quickly resolve on their own. Allergic reactions may develop, including angioedema, urticaria, rash, itching. Methyl parahydroxybenzoate and propyl parahydroxybenzoate, which are part of the drug, can cause allergic reactions (possibly delayed).

Contraindications - hypersensitivity to the components of the drug - severe arterial hypotension - acute myocardial infarction

Drug interactions Corvalment enhances the sedative effect of psychotropic drugs, opioid analgesics, alcohol and anesthetics when used simultaneously. It is possible to potentiate the effect of antihypertensive drugs when used simultaneously with the drug Corvalment. Corvalment reduces the severity of headaches caused by taking nitrates. Special instructions In cases where pain in the heart area does not go away after taking the drug, you must consult a doctor to rule out acute coronary syndrome. The drug does not contain sugar and can be used by patients with diabetes. Use during pregnancy or breastfeeding. The use of the drug during pregnancy or breastfeeding is possible if, in the opinion of the doctor, the expected positive effect for the mother exceeds the potential risk for the fetus/child. Pediatrics There is no experience in using the drug to treat children. Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms Caution is required in the first hours after taking the drug when driving or working that requires increased attention, due to possible side effects (dizziness and drowsiness).

Overdose Symptoms: headache, nausea, agitation, cardiac dysfunction, decreased blood pressure, depression of the central nervous system, hypersensitivity reactions to the components of the drug (angioedema, urticaria, itching, rash). Treatment: drug withdrawal and symptomatic therapy. Release form and packaging 10 capsules each in a blister pack made of polyvinyl chloride film and printed varnished aluminum foil. 3 contour strip packs together with instructions for medical use in the state and Russian languages ​​are placed in a pack of cardboard for consumer packaging.

Storage conditions Store in original packaging at a temperature not exceeding 25 ºС. Keep out of the reach of children!

Conditions for dispensing from pharmacies Without a prescription

, Ukraine

Corvalment, instructions for use (Method and dosage)

According to the instructions for use, the Corvalment capsule is placed under the tongue and held until completely dissolved. When crushing the capsule with your teeth, the effect is achieved faster.

The frequency of administration depends on the frequency and duration of angina attacks.

For heart failure, it is recommended to take one capsule sublingually.

The daily dosage can reach up to 6 capsules for the treatment of angina pectoris in combination with other conditions.

The course of treatment should not exceed a week if the drug is taken regularly.

Release form

The product is available in the form of gelatin capsules, which are packaged in a blister pack of 10 pieces. Along with this, the cardboard box contains instructions for its use. The medication is available without a prescription. It is recommended to store it in an inaccessible place where the temperature does not exceed 20 degrees. Shelf life – 24 months.

The drug is presented in the form of tablets

Interaction

Corvalment can be used simultaneously with riboxin , asparkam , vitamin complexes and other drugs that improve metabolic processes in the body.

Corvalment enhances the effective effect of antihypertensive drugs, opioid analgesics, psychotropic drugs, anesthetics, and alcohol.

Combined use with neurotropics leads to depression of the nervous system and increased drowsiness.

Reviews

My daughter constantly gets sick on the bus. We thought that this feature would go away with time. But still nothing. When we were advised to use Corvalment, I was not sure that it would help. It turned out that I was wrong. A tablet under the tongue and we can go anywhere.

Olga, 28 years old

Quite recently I began to feel pain in the heart area, which worsens with excitement. I went to the doctor. He advised Corvalment. I am very pleased with the drug. Just one tablet and the heart calms down and the pain disappears. I recommend Corvalment to everyone.

Evgeniya, 43 years old

special instructions

Corvalment does not relieve attacks of severe angina. The drug is approved for use in patients with diabetes and does not contain sugar.

During breastfeeding and pregnancy, taking Corvalment is allowed only in situations where the therapeutic effect is more important than the possible negative effect of the drug components on the fetus (child).

There is no experience in using the drug in pediatrics.

In the first hours of use, dizziness and drowsiness are possible, so it is recommended to refrain from operating complex mechanisms, driving vehicles, or activities that require concentration or increased concentration.

Indications and contraindications

The medicine is indicated for various diseases. From what exactly:

• mild angina;
• hysteria;
• headache;
• neuroses;
• cardialgia.

Also, tablets are widely used for sea and air sickness. They easily cope with motion sickness syndrome. But, despite the versatility of the drug, there are some contraindications to its use. The doctor takes these features into account at the stage of prescribing the drug. So, when is it not recommended to take Corvalment:

• hypersensitivity;
• stroke;
• myocardial infarction;
• impaired blood flow in the brain;
• diabetes;
• young age of the patient (up to 6 years);
• arterial hypotension.

Using the drug contrary to contraindications can lead to various complications. Therefore, it is very important to study the entire list of pathologies for which Corvalment is undesirable to use.

As for pregnant and lactating women, there is no information about the effects of the drug. Therefore, it can only be prescribed by a doctor after a comprehensive examination. Of course, it is believed that a medicine can only be taken if the benefits outweigh any risks for the mother and child.

Analogues of Corvalment

Level 4 ATC code matches: Eltacin
Validol

Tonginal

Tricardin

Instenon

Pumpan

Barboval

It has no structural analogues.

Corvalment price, where to buy

The price of Corvalment in Ukraine is approximately 60 UAH per pack of 30 pieces.

Tablets are not available in Russia at this time.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine

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• Corvalment 0.1 g N80 capsules
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• Corvalment 0.1 g N80 capsules PAT "Kiev Vitamin Plant", Kiev, Ukraine

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