Meratin Combi N10 suppositories - Mepro Pharmaceuticals Privat Limited: price, instructions, reviews. Buy Meratin Combi N10 candles in Ukraine

Every year, gynecologists note that the number of women affected by candidiasis is increasing, but this is not strange, because there are more than 150 species of fungi. Some women do not even know that they are a carrier of the infection, infecting their sexual partners and allowing the fungus to become chronic. Pharmaceutical companies are aware of the critical situation regarding fungi and therefore offer a wide range of antimicrobial drugs. Meratin performed better than the others, with instructions for use included in the kit.

Pharmacological authorities

Pharmacodynamics.

, as well as certain anaerobic bacteria, such as
Bacteroides
and
Clostridium spp., Fusobacterium spp.
and anaerobic cocci.

Neomycin is an antibiotic that belongs to the group of aminoglycosides. Aminoglycosides exhibit high activity in both gram-negative and gram-positive bacteria. Nistatin is an antifungal drug that belongs to the polyene group. Nystatin flows onto the fungal membrane, binding to one of the components - ergosterol. As a result, the structure of the fungal cell and tissue is destroyed. This component of the drug is toxic to fungi, so that human cells and bacteria replace ergosterol with cholesterol.

Prednisolone is a synthetic corticosteroid drug that is used to reduce the symptoms of inflammation. Prednisolone inhibits the secretion and suppression of inflammation mediators. Prednisolone suppresses proliferative processes in acute illnesses and reduces the severity of scar formation.

Pharmacokinetics.

With local stagnation, the concentration of the drug in the meat tissues significantly exceeds the concentration achieved with oral and internal stagnation.

Meratin Combi N10 candles

INSTRUCTIONS

for medical purposes

MERATIN
COMBI
_ _ _

Stock:

dyuchi speeches:

ornidazole, neomycin sulfate, nistatin, prednisolone;

1 tablet of the following: ornidazole 500 mg, neomycin sulfate 100 mg, nistatin 100,000 MO, prednisolone 3 mg;

additional speeches:

corn starch, microcrystalline cellulose, propyl galate, sodium methylparaben (E 219), sodium propylparaben (E 217), anhydrous silica, talc, magnesium stearate, sodium starch glycolate (type A ), carmellose sodium.

Medicine form.

Vaginal tablets.

Main physical and chemical authorities:

cream-colored tablets, cartridge-shaped, biconvex, uncoated, embossed “MERATIN COMBI” on one side. The presence of small dark spots and marmuriness is allowed.

Pharmacotherapeutic group.

Antimicrobial and antiseptic properties that can be obtained from gynecology. Similar to imidazole and corticosteroids. ATX code

G01B F.

Pharmacological power.

Pharmacodynamics.

Ornidazole. The mechanism of ornidazole binding to damaged DNA structure in sensitive microorganisms. The drug easily penetrates microbial cells and, by binding to DNA, disrupts the replication process. Ornidazole is an active drug for Trichomonas
vaginalis
,
Entamoeba histolytica , Giardia lamblia ( Giardia intestinalis ),
as well as several anaerobic bacteria such as
Bacteroides and Clostridium spp ., Fusobacterium spp
. and anaerobic cocs. Neomycin is an antibiotic that belongs to the group of aminoglycosides. Aminoglycosides exhibit high activity in both gram-negative and gram-positive bacteria. Nystatin is an antifungal drug that belongs to the polyene group. Nystatin flows onto the fungal membrane, binding to one of the components - ergosterol. As a result, the structure of the fungal cell and tissue is destroyed. This component of the drug is toxic to fungi, so that human cells and bacteria replace ergosterol with cholesterol. Prednisolone is a synthetic corticosteroid drug that is used to reduce the symptoms of inflammation. Prednisolone inhibits the secretion and suppression of inflammation mediators. Prednisolone suppresses proliferative processes in acute illnesses and reduces the severity of scar formation.

Pharmacokinetics.

With local stagnation, the concentration of the drug in the meat tissues significantly exceeds the concentration achieved with oral and internal stagnation; systemic administration is not avoided.

Clinical characteristics.

Showing.

Meratin Combi is frozen:

- for the treatment of gynecological diseases, such as bacterial vaginosis and vaginitis, trichomonas vaginitis, fungal vaginitis, causes of Candida
albicans ;
vaginitis caused by mixed infections (Trichomonas, anaerobic flora, including Gardnerella and yeast-like fungi);

- with a preventive method before surgical treatment of gynecological illnesses, for sanitation of the skin before the canopy or abortion, before and after the introduction of intrauterine contraceptives, before and after diathermocoagulation cervical erosion, before intrauterine stitching.

The drug can be stocked at the complex therapy warehouse together with the oral form of ornidazole.

Contraindicated.

Increased sensitivity to any of the components of the drug other than imidazole.

Take special care.

Intravaginal preparations, such as Meratin Combi, can damage latex contraceptives and reduce the effectiveness of contraceptives, so during the course of treatment with the drug they may be eliminated due to physical contacts and not stagnation you contact methods of contraception.

Patients need to use certain methods of special hygiene (washcloth, towel, etc.) and wear natural linen.

Interactions with other medicinal drugs and other types of interactions.

To date, no clinically significant interactions with drugs have been identified.

Features of stagnation.

Meratin Combi is a non-toxic drug that does not cause sensitization. The drug is well tolerated. It is necessary to carry out a daily disinfection of the partner immediately to prevent re-infection.

Suspension during pregnancy or breastfeeding.

In the first trimester of pregnancy there are contraindications. Stagnation in the 2nd and 3rd trimesters of gestation may be due to the low absorption of the drug, the concentration of its components in the systemic bloodstream is minimal and the cortical tissue for the mother outweighs the possible risk. for the fetus. The drug can be taken during breastfeeding. When taking the drug at the warehouse of complex therapy with the oral form of ornidazole, breastfeeding is necessary.

This is due to the fluidity of the reaction when using vehicles or robots with other mechanisms.

Doesn't flow in.

Method of congestion and dosage.

Inject deeply into the mouth, 1 tablet per day; After administration, the patient must lie down for at least 15 minutes. The average duration of a bath is 10 days. The celebration should not be interrupted during the hour of menstruation. The drug can be taken one hour with the oral form of ornidazole.

Entry procedure:

1. Dispense the vaginal tablet into the applicator.

2. Soak the applicator with the tablet in warm (30–40 °C) boiled water or physiological water (for individuals susceptible to allergic reactions) for 15–30 s.

3. Carefully insert the applicator with the yakmoga tablet closer to the floor (preferably when lying on your back).

4. Remove the tablet from the powder by removing it from the applicator.

Children.

Meratin Combi should not be used for children or even for the first time in life.

Overdose.

In connection with the local dose of the drug, overdose was not prevented, which may increase the manifestation of adverse reactions.

Likuvannya, more symptomatic.

Adverse reactions.

Allergic reactions to various forms of the drug, including urticaria, skin weeping; reactions at the site of congestion, which may manifest themselves as liver pain, pain, itching, tingling or irritations; erosion; sensitivity is enhanced.

Systemic effects: with local stagnation, absorption of the components of the drug may be insignificant. In case of systemic effects caused by corticosteroids, there may be further healing of wounds and cracks, atrophy of the mucous membrane.

Likuvannya

. Be careful when using the drug to avoid hypersensitivity and teasing when it is frozen.

Term of attribution.

2 rocks.

Save your mind.

Store at a temperature not exceeding 25 °C in the original packaging and out of the reach of children.

Package.

10 tablets per blister. 1 blister with 10 applicators at a time in a cardboard box.

Release category.

For the recipe.

Virobnik.

Mepro Pharmaceuticals Pvt. Ltd., India/

Mepro Pharmaceuticals Pvt. Ltd, India.

Mіstseznahodzhennya virobnik.

(Unit II) Q-Road, Phase-IV, GIDC Wadhwan city-363035, Surendranagar, Gujarat st. India/

(Unit II) Q-Road, Phase IV, GIDC Wadhwan City-363 035 Surendranagar, Gujarat, India.

Applicant.

Miles Healthcare Limited, Great Britain/

Mili Healthcare Limited, Great Britain.

The applicant's location.

15 Fairfax House, Falwood Place, London, WC1V 6AY, Great Britain/

Fairfax House 15, Fulwood Place, London, WC1V 6AY, Great Britain.

Showing

Meratin Combi is frozen:

for the treatment of gynecological diseases, such as bacterial vaginosis and vaginitis, trichomonas vaginitis, fungal vaginitis, causes of Candida albicans
; vaginitis caused by mixed infections (Trichomonas, anaerobic flora, including Gardnerella and yeast-like fungi);
with a preventive method before surgical treatment of gynecological illnesses, for sanitation of the pelvis before the canopy or abortion, before and after the introduction of intrauterine contraceptives, before and after diathermocoagulation cervical erosion, before intrauterine stitching.

Indications for use of Meratin

Meratin according to the instructions is prescribed for the treatment of:

Extraintestinal and intestinal forms of amebiasis, including treatment of liver abscess in amoebic dysentery;
Trichomonosis.

The medication is also effective for the prevention of postoperative infectious complications that usually arise after gynecological operations and interventions on the rectum.

Meratin Combi suppositories are prescribed for the treatment of gynecological diseases:

Bacterial vaginosis and vaginitis;
Trichomonas and fungal (caused by Candida albicans) vaginitis;
Mixed vaginitis caused by Trichomonas, anaerobic infections, including yeast-like fungi and gardnerellosis.

As a prophylactic agent, Meratin Combi is used before gynecological operations, for sanitation of the vagina before abortion or childbirth, when using intrauterine contraceptives (before and after insertion), before intrauterine examination, during diathermocoagulation of cervical erosions (before and after the procedure).

Interactions with other medicinal drugs and other types of interactions

Interaction associated with prednisolone

Unknown combinations:

with acetylsalicylic acid: increased risk of bleeding during one-hour stagnation with an anti-inflammatory dose of acetylsalicylic acid (≥ 1 g per dose or ≥ 3 g per dose).

Combinations that require careful curing:

with anticonvulsants, inducers of enzyme synthesis: a decrease in plasma concentration and activity of corticosteroids leads to an increase in their metabolism in the liver. The implications of this are particularly serious (and important) for patients with Addison's disease who are treated with hydrocortisone or undergo organ transplantation. Necessary monitoring of clinical and laboratory indicators, as well as correction of the dose of corticosteroids during and after treatment with inducers of enzyme synthesis;
with isoniazid: a decrease in the plasma concentration of isoniazid leads to an increase in its metabolism in the liver and a decrease in the metabolism of glucocorticosteroids in the liver;
with rifampicin: a decrease in plasma concentration and activity of corticosteroids by increasing their metabolism in the liver after interaction with rifampicin. The implications of this are particularly serious (and important) for patients with Addison's disease who are treated with hydrocortisone or undergo organ transplantation. Necessary monitoring of clinical and laboratory indicators, as well as correction of the dose of corticosteroids during and after treatment with rifampicin;
with other hypokalemia drugs: increased risk of hypokalemia. Monitor blood serum potassium levels and adjust them as necessary;
with digitalis preparations: hypokalemia aggravates the toxic effects of digitalis preparations. Before administering the drug, assess the presence of hypokalemia, measure blood serum potassium level and perform electrocardiography;
with medicinal methods that cause polymorphic ventricular tachycardia of the “pirating” type: advances in ventricular arrhythmia, including polymorphic ventricular tachycardia of the “pirating” type. Before administering the drug, assess the presence of hypokalemia, measure blood serum potassium level and perform electrocardiography;
with cyclosporine: enhanced effects of prednisolone, including Cushing-like symptoms, decreased tolerance to carbohydrates (reduced clearance of prednisolone);
with acetylsalicylic acid: bleeding from the hips with antipyretic and analgesic doses ≥ 500 mg per dose or < 3 g per dose;
with non-steroidal anti-inflammatory drugs: increased risk of virologic disease and bleeding of the intestinal tract;
with fluoroquinolones: increased risk of tendonitis or tendon rupture (rarely), cramps in patients who have been treated with corticosteroids.

Directions for use and dosage

Meratin tablets are taken orally, preferably after meals. A single dosage varies from 0.5 to 2.0 g and depends on the regimen prescribed by the doctor, the disease and body weight.

Children weighing less than 35 kg per day are usually prescribed from 20 to 40 mg/kg.

As a rule, Meratin is prescribed:

When treating trichomoniasis, the duration of therapy is 10 days. The daily dosage is 2 tablets, divided into two doses (morning and evening). However, the regimen can be changed against the background of complicated or mixed forms of infection. Children take a single dose of 25 mg/kg per day;
When treating amoebic dysentery, a three-day course of treatment is usually carried out, and when treating other types of amoebiasis, the duration increases to 5-10 days. Adults are usually prescribed 1.5 g once in the evening or 0.5 g twice a day (morning and evening), with the duration of therapy increasing. Children are prescribed 0.025 g/kg once;
When treating complicated and mixed forms of giardiasis, the doctor determines the treatment regimen and duration of therapy individually;
To prevent anaerobic infection, as a rule, 1 g of Meratin is prescribed an hour before the operation, and after the operation - 2 tablets twice a day for 3-5 days.

Meratin injection solution is administered intravenously (over 20-30 minutes), having previously dissolved it in a 5% glucose solution. Adults and children over 12 years old - in a single dosage of 500-1000 mg on the first day of therapy, then 0.5 g every 8 hours. The maximum daily dosage of Meratin is 4 g. Duration of treatment is 5-10 days.

For long-term use, intravenous infusions are preferable to tablet dosage forms, since they are less likely to cause side effects.

Meratin suppositories are administered once a day (at night) deep into the vagina using an applicator. After administering the medicine, you must lie down for at least 15 minutes. The duration of treatment is usually 10 days. It is not recommended to interrupt the use of Meratin suppositories during menstruation.

Features of good stagnation

The doctor should use caution under the constant medical supervision of specialists to treat patients with systemic corticosteroids, osteoporosis, arterial hypertension, heart failure, serious emotional disorders, including a history of tuberculosis, celiac diabetes, glaucoma, myopathy, etc. Caused by depleted corticosteroids, liver failure, epilepsy, peptic virosis, hypothyroidism, and recent myocardial infarction.

The drug should be administered with caution to patients with severe pseudoparalytic myasthenia, nonspecific colitis, diverticulitis and fresh intestinal anastomoses.

Although the drug may not be effective locally, systemic absorption is possible, especially in case of inflamed soil.

Adverse reactions can be minimized by stagnating the drug with a minimal period of treatment and under constant medical supervision.

Meratin Combi may damage latex contraceptives and reduce the effectiveness of contraceptives for musculoskeletal congestion; therefore, during the course of treatment with the drug, avoid physical contacts and do not stagnate contraceptives for musculoskeletal problems. products (contraceptive pills, latex condoms, spermicides).

Patients need to use certain methods of special hygiene (washcloth, towel, etc.), wear natural linen, and use pads instead of tampons.

It is necessary to carry out a daily disinfection of the partner immediately to prevent re-infection.

Sodium methylparaben (E 219) and sodium propylparaben (E 217), which are included in the drug, may cause allergic reactions (possibly, intensified).

Suspension during pregnancy or breastfeeding.

In the first trimester of pregnancy there are contraindications. Stagnation in the 2nd and 3rd trimesters of gestation is possible, when the crust for the mother is exposed to the risk for the fetus, and due to the low absorption of the drug, the concentration of its components in the systemic blood flow is minimal alna. The drug may become congested during breastfeeding. When taking the drug at the warehouse of complex therapy with the oral form of ornidazole, you need to wash your chest.

This is due to the fluidity of the reaction during treatment with vehicles or other mechanisms.

Doesn't flow in.

Contraindications

Meratin according to the instructions is contraindicated for use:

Against the background of acute neurological diseases;
For diseases of the central nervous system;
During pregnancy (up to the twelfth week inclusive);
During breastfeeding;
In case of hypersensitivity manifested to the active or auxiliary components of Meratin.

Due to the fact that there have been no adequate studies on the use of Meratin during pregnancy, the medication after the 12th week of pregnancy is prescribed only in exceptional cases according to strict indications and the prescription of a doctor who balances the risk for the mother and child with the benefits of using the drug.

Meratin Combi suppositories can be used during pregnancy and lactation, since when applied topically, the medication does not cause a high concentration of active components in the systemic bloodstream.

Method of congestion and dosage

Inject deeply into the mouth, 1 tablet at night. After the injection, the patient must lie down for at least 15 minutes. The average duration of a bath is 10 days.

Entry procedure:

1. Dispense the vaginal tablet into the applicator.

2. Soak the applicator with the tablet in warm (30–40 °C) boiled water or physiological water (for individuals susceptible to allergic reactions) for 15–30 s.

3. Carefully insert the applicator with the yakmoga tablet closer to the floor (preferably when lying on your back).

4. Remove the tablet from the powder by removing it from the applicator; remove the applicator.

Practical pleasure.

For hygienic administration of the tablet, use an individual applicator for skin application.

Bathing must be accompanied by special hygiene measures: after wearing white linen, douching and scrubbing with pads instead of tampons during the bathing hour, using other special hygiene methods (washcloth Yu, a towel then.

You should not interrupt the course of treatment during menstruation.

Children.

Meratin Combi is not suitable for children.

Release form

Meratin is produced in the form:

White film-coated round tablets for internal use, 500 mg each (embossed “MERATIN” on one side and “500” on the other). 10 tablets per package;
A light yellow transparent solution for infusion containing 500 mg of the active substance (ornidazole) in one 100 ml bottle;
Suppositories (Meratin Combi) containing active ingredients: neomycin sulfate, ornidazole, nystatin and prednisolone. 10 candles per package.

Analogues of Meratin are the medications Dazolic, Orniona, Ornidazole, Tiberal, Secnidazole, Lornizol, Avrazor, Gairo, Ornisid forte, Ornisid.

Side effects

On the side of the immune system: hypersensitivity.

On the side of the skin and under the skin tissues: allergic dermatitis, visip, itching, kropivyanka.

On the side of the reproductive system: reactions in the place, stagnation in the appearance of prickling or excoriation, erosions, swelling of the skin, swelling of the liver in the skin, vulvovaginal erythema, vulvovaginal pain, vulva vaginal itching. In case of systemic effects caused by corticosteroids, there may be further healing of wounds and cracks, atrophy of the mucous membrane.

Once adverse reactions develop, it is necessary to stop taking the drug and contact the doctor.

Side effects of Meratin

Meratin, according to reviews, is well tolerated in most cases. Against the background of hypersensitivity to the components of the drug or for other reasons, Meratin, according to reviews, can lead to the development of transient and mild:

Dry mouth;
Headache;
Drowsiness;
Fatigue;
Dyspepsia;
Excitement.

It is extremely rare that during long-term use of Meratin in high doses, the hepatotoxic effect of the drug occurs.

Allergic reactions that occur during the use of Meratin are expressed in the form of urticaria, angioedema, skin rash and itching.

In very rare cases, Meratin, according to reviews, can lead to the development of rigidity, impaired coordination of movements, tremors, confusion, and convulsions.

Most often, disorders develop against the background of liver disease and alcohol abuse.

Meratin should be used with caution against the background of diseases of the central nervous system:

Multiple sclerosis;
Epilepsy;
Brain lesions.

Meratin suppositories, as a rule, do not have a toxic effect and do not cause sensitization. In rare cases, irritation may occur during treatment.

Analogs

Ornidazole

Vertex, Russia

Price from 61 to 385 rubles.

Ornidazole is a complete analogue of Mirastin, therefore its physical characteristics, as well as the mechanism of action on the body, are similar. Ornidazole is available in the form of tablets and solution for infusion.

Pros:

Low price
Effectively treats a number of gynecological ailments
Can be used to prevent infections caused by anaerobes.

Minuses:

Available with prescription
Contraindicated for children
Allergic manifestations may occur while taking the medication.

Medicinal properties

The mechanism of action of ornidazole is characterized by disruption of the DNA structure of pathogenic cells that are sensitive to it. The activity of the main component of Meratin is observed against anaerobes, Giardia, dysenteric amoeba, as well as Trichomonas.

The drug is quickly absorbed by the mucous membranes of the gastrointestinal tract, the connection with albumin is observed at the level of 13%. The highest concentration of the active substance in plasma is diagnosed after 3 hours from the moment of administration. The half-life of metabolic products is about 10 hours. Excretion is carried out by the kidneys and intestines over 5 days.

Thanks to the combined composition of Meratin Combi, the effect of ornidazole is enhanced by an antibiotic from the group of aminoglycosides - nystatin; it is active against gram-positive and gram-negative microorganisms. Nystatin has a detrimental effect on the membranes of fungal cells, disrupting their structure and stopping their reproduction. Prednisolone eliminates the inflammatory process, inhibits the production of inflammatory mediators, and prevents the formation of scar tissue.

The effectiveness of Meratin Combi is enhanced by the simultaneous use of tablets containing ornidazole.