The drug Lazolvan is included in the group of potent mucolytics. The drug has a pronounced expectorant effect, which allows it to be used for respiratory pathologies occurring in the acute or chronic stage.
To treat respiratory tract defects, doctors often recommend Lazolvan for inhalation. Delivering medication using a nebulizer helps improve the patient's condition and speed up the healing process.
Compound
All forms of the drug Lazolvan include the active ingredient ambroxol hydrochloride (INN - ambroxol ).
- Lazolvan solution contains 7.5 mg of the ambroxol hydrochloride component, as well as additional ingredients: citric acid monohydrate, sodium chloride, sodium hydrogen phosphate dihydrate, benzalkonium chloride, water.
- Lazolvan tablets (1 piece) contain 30 mg of ambroxol hydrochloride, as well as additional ingredients: magnesium stearate, corn starch, lactose monohydrate, colloidal silicon dioxide.
- Cough syrup contains 15 mg of ambroxol hydrochloride, as well as inactive components: hyethellose (hydroxyethylcellulose), benzoic acid, acesulfame potassium, 85% glycerol, liquid sorbitol , flavorings, water.
- Lozenges (1 piece) contain 15 mg of ambroxol hydrochloride, as well as inactive components: acacia gum, sorbitol, carion 83, eucalyptus oil, peppermint oil, sodium saccharinate, liquid paraffin, water.
Release form
Several forms of release of this drug are produced.
Lazolvan solution for inhalation and for oral administration is colorless or has a light brown tint, transparent, contained in a vial. 100 ml each. Each bottle is equipped with a dropper and a special measuring cup is included.
Lazolvan tablets have a white or yellowish color and a round shape. The tablets are flat on both sides, have beveled edges, on one side there is an engraving “67C” and a risk mark, on the other - the company symbol. Tablets are packed in 10 pcs. in blisters.
Lazolvan children's syrup is colorless, transparent, has a slightly viscous consistency, and may have a strawberry or wild berry aroma. Contained in fl. 100 ml or 200 ml. A measuring cup is included in the pack.
The lozenges are round in shape, light brown in color, and have a peppermint aroma. Packed in 10 pcs. in blisters, which are placed in cardboard packs.
A solution is also produced in ampoules for intravenous administration of the drug Lazolvan.
pharmachologic effect
The abstract indicates that the active component of ambroxol hydrochloride activates the secretion of mucus in the respiratory tract. This substance stimulates ciliary activity and also activates the process of synthesis of pulmonary surfactant. As a result of this action, there is an active secretion of mucus and its elimination (the so-called mucociliary clearance). Since the removal of mucus is facilitated, the frequency and intensity of coughing decreases.
It was noted that in people suffering from COPD, after long-term treatment with Lazolvan (for at least two months), the frequency of exacerbations, as well as their duration, significantly decreased. Thanks to this treatment, it was possible to reduce the duration of antibiotic treatment.
Composition of the drug
The main active ingredient of the medication in question is Ambroxol. In addition, the product contains the following auxiliary components:
- sodium chloride;
- monohydrate;
- distilled water;
- hydrogen phosphate
The main active substance enhances the production of secretions in the respiratory system. Due to this, the process of removing phlegm is accelerated, and the cough is converted into a productive one.
Long-term studies of the medication in question allowed scientists to prove that a course of treatment with Lazolvan helps reduce relapses in people suffering from COPD.
Pharmacokinetics and pharmacodynamics
Ambroxol is absorbed quickly and almost completely. In this case, there is a linear dependence on the dose taken. When taking a dose orally, the maximum concentration is observed after 1-2.5 hours. Approximately 90% protein bound. When taken orally, ambroxol quickly passes from the blood into the tissues in the body. At the same time, the highest concentration of the active component of the substance was observed in the lungs.
About 30% of an orally administered dose of the drug is subject to the “first pass” effect through the liver. Metabolism of the remainder of ambroxol occurs in the liver, mainly by glucuronidation and partial breakdown of the substance to dibromoantranilic acid and additional metabolites .
The half-life of ambroxol is approximately 10 hours.
Pharmacokinetics are not affected by the patient's age and gender.
Action of Lazolvan drops
The medication belongs to the group of mucolytic, expectorant drugs. Ambroxol hydrochloride increases the rate of secretion into the respiratory tract. Stimulates ciliary activity, the production of surfactant - it is a complex of surfactants that cover the inner surface of the pulmonary alveoli.
Due to these actions, mucociliary clearance is improved - a system that protects the mucous membranes of the respiratory system from infectious agents and irritants. The sputum thins, its elimination accelerates, the cough decreases, and the cough becomes easier.
When taking the drug for about 2 months for chronic obstructive pulmonary disease, the frequency of exacerbations is significantly reduced.
Indications for use, what the tablets are for
The instructions indicate the following indications for the use of Lazolvan:
- respiratory tract diseases, both acute and chronic, in which viscous sputum is produced;
- pneumonia;
- bronchitis acute and chronic;
- bronchial asthma , in which there is difficulty in sputum discharge;
- bronchiectasis;
- COPD;
- respiratory distress syndrome.
Indications and contraindications for the use of Lazolvan drops
The medication is used for diseases of the respiratory system, accompanied by a cough with poorly discharged sputum, making breathing difficult. Indications:
- inflammatory diseases combined with dry cough in the form of attacks;
- cough due to inflammation of the lung tissue;
- bronchial asthma outside of an acute attack;
- bronchiectasis.
Contraindications to the use of mucolytic solution:
- first trimester of pregnancy;
- breast-feeding;
- taking cough suppressants;
- age up to 2 years;
- whooping cough;
- intolerance to substances in the drops.
The solution is taken with caution in the 2.3 trimester of pregnancy, renal, liver failure - the organs take part in the metabolization of the drug and the excretion of its components.
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Side effects
As a rule, Lazolvan for children, drops for adults and other forms of medication are well tolerated.
During administration, the following side effects may rarely occur:
- disorders of the digestive system, which are manifested by heartburn , dyspepsia, diarrhea , and in rare cases, vomiting and nausea;
- allergic reactions (itching , urticaria , skin rash);
- disturbances in the sense of taste.
Side effects of the drug Lazolvan
As a rule, taking Lazolvan is well tolerated. Gastrointestinal disorders: mild manifestations of heartburn, dyspepsia, nausea, vomiting, diarrhea; disorders of the immune system, skin and subcutaneous tissues: skin rash, urticaria, angioedema, anaphylactic reactions (including anaphylactic shock) and allergic reactions. If lesions of the skin or mucous membranes progress, you should immediately consult a doctor and stop treatment with ambroxol. Severe skin lesions, such as Stevens-Johnson and Lyell syndromes, have been reported extremely rarely in association with the use of mucolytic agents such as ambroxol. As a rule, they could be explained by the severity of the underlying disease or the use of concomitant medications.
Instructions for use of Lazolvan (Method and dosage)
Lazolvan solution, instructions for use
When taking the drug orally, it should be borne in mind that the drops can be diluted in any liquid - tea, water, juice. Application does not depend on food intake. 25 drops of Lazolvan equal 1 ml of product.
It is recommended to take 4 ml 3 times in patients over 12 years of age. in a day. Patients from 6 to 12 years old - 2 ml 2-3 r. in a day. Patients from 2 to 6 years old - 1 ml three times a day. Children under 2 years old receive 1 ml twice a day.
Instructions for use of Lazolvan for inhalation
The inhalation solution can be used using any equipment used for inhalation . The exception is steam inhalers.
Children over 6 years of age and adults should take 1-2 inhalations per day, using 2-3 ml of solution.
To achieve optimal hydration during inhalation, Lazolvan is mixed with a solution of 0.9% sodium chloride , ratio 1:1. It is necessary to carry out inhalations in normal breathing mode, taking into account that with deep breaths a strong cough may develop. Before starting the procedure, the inhalation solution should be warmed to body temperature. People who suffer from bronchial asthma should carry out the procedure after taking bronchodilators to prevent spasm of the airways and their nonspecific irritation. If symptoms persist for 4-5 days after starting inhalations, you should consult a doctor.
Lazolvan tablets, instructions for use
Lazolvan tablets 30 mg should be taken orally, 1 tablet. three times a day. A different treatment regimen may be prescribed if necessary to enhance the effect: 2 tablets twice a day. You need to take the tablets with liquid; taking them does not depend on meals. If there is no effect within 4-5 days of treatment, you should consult a doctor.
Children's syrup Lazolvan, instructions for use
Cough syrup for children 15 mg; patients over 12 years old should drink 10 ml 3 times. per day, patients from 6 to 12 years old - 5 ml 2-3 r. per day, children from 2 to 6 years old receive 2.5 ml per day, 2-3 r. Children under two years old receive the same dose 2 times a day.
Instructions for use of Lazolvan for children
Children's Lazolvan syrup 30 mg: patients over 12 years old receive 5 ml three times a day, patients from 6 to 12 years old - 2.5 ml per day 2-3 r.
The instructions for the lozenges stipulate that they are slowly dissolved in the mouth; patients over 12 years of age are prescribed 2 pieces. 3 rubles per day, children from 6 to 12 years old - 1 pc. 2-3 r. The use of lozenges does not depend on food intake.
Mode of application
Lazolvan instructions for use are indicated for performing treatment sessions, you need to prepare a solution. For these purposes, the product is mixed with saline or Borjomi in a 1:1 ratio.
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The annotation states that the recommended multiple dosage of the solution for adults should be 100 drops of medication and the same amount of saline solution. All components are mixed and the output is 4 ml of the finished mixture. Carrying out steam procedures with lazolvan 2 times a day. Before each inhalation, a fresh medicinal solution is prepared. The duration of one manipulation should not exceed 10 minutes.
Important: Therapy sessions with Lazolvan and Saline are carried out using an ultrasonic or compressor inhaler. But steam models are not recommended. Because when heated, all medicinal substances evaporate.
To use the drug in question, you must perform the following steps:
- Before use, the portable device is disinfected;
- the prepared solution is poured into the medicine chamber;
- then, the inhaler is started;
- breathe medicinal vapors for 7-10 minutes.
Important: It is recommended to perform inhalations at least an hour after eating. In addition, it is not recommended to drink anything within 20 minutes after the procedure.
At the end of the treatment session, the oral cavity should be rinsed, and the inhaler should be disassembled and disinfected.
Interaction
Provided that Lazolvan solution for oral administration and inhalation and other forms of drugs are combined with antibiotics ( Cefuroxime , Amoxicillin , Doxycycline , Erythromycin ), then the concentration of antibacterial drugs in the lung tissues increases.
With the simultaneous use of Lazolvan and other cough medications, there may be difficulty in the process of sputum discharge due to a decrease in cough.
special instructions
The solution contains the preservative benzalkonium chloride. It should be borne in mind that this substance can provoke bronchospasm in people who have been diagnosed with increased reactivity of the respiratory tract.
The syrup contains sorbitol, so when taking this product, a mild laxative effect may be observed.
People who have fructose intolerance should not take the drug.
Those who adhere to a diet with a reduced sodium content should take into account that the Lazolvan solution contains 42.8 mg of sodium (in a dose of 12 ml).
There is no data on the effect of the drug on the ability to drive vehicles or operate precision machinery.
Before using the drug for children, you should visit a doctor who will tell you in detail how to take the solution or other forms of medication, for what cough, and according to what scheme to use the drug. Inhalations with Lazolvan and saline solution are carried out only on the recommendation of a doctor.
How to dilute Lazolvan for inhalation
To prepare a solution for inhalation with Lazolvan, it is diluted with saline solution (sodium chloride 0.9%) in a 1:1 ratio; it is not recommended to use water.
With saline solution
Inhalation of Lazolvan with saline solution helps to simultaneously reduce the risk of bronchospasm in response to the influx of aerosol, as well as additionally moisturize the mucous membrane. This helps make coughing easier and improves mucus movement.
Lazolvan and sodium chloride: proportions
For inhalation, you need a sodium chloride solution in equal proportions with Lazolvan. They must be strictly dosed in volume. To do this, use a syringe or measuring cup, which is attached to the bottle of medication.
With water
It is not recommended to carry out inhalation therapy with ordinary, boiled or distilled water. A negative effect occurs when combined with an alkaline solution (for example, mineral waters such as “Borjomi”). In this case, the active substance precipitates and does not have a therapeutic effect.
Lazolvan's analogs
Level 4 ATX code matches:
Mukolik
Abrol
Ambrosan
Bronchorus
ACC 100
ACC 200
ACC Long
ACC
Mukolwan
Bromhexine 8
Bromhexine 8 Berlin-Chemie
Bromhexine
Bronchobos
Carbocisteine
Erdomed
Pulmozyme
Pectolvan C
Halixol
Ambrobene
Acetylcysteine
There are a number of drugs that are analogues of Lazolvan. At the same time, the price of analogues can be significantly lower. When choosing an analogue for children and adults, you should definitely take into account the doctor’s recommendations. Analogs of this drug for the active substance are the drugs Ambroxol , Ambrobene , Medox , Ambrohexal , Halixol , Flavamed , Lazolvan Uno , etc.
Lazolvan or Ambrobene - which is better?
The drug Ambrobene also contains the active component ambroxol hydrochloride and is used in case of wet cough. These drugs are produced by different manufacturers. Compared to Lazolvan, Ambrobene has more contraindications and causes more side effects.
ACC or Lazolvan - which is better?
The active component of the drug ACC is the substance acetylcysteine. This drug reduces the viscosity of mucus, facilitates the process of sputum discharge, and is active if there is purulent sputum. The drug ACC has more indications for use, but it is not prescribed for the treatment of children under 2 years of age. Which of the two drugs to choose can only be determined by a doctor individually.
Which is better: Bromhexine or Lazolvan?
Bromhexine , like Lazolvan, thins sputum without blocking the cough reflex. The active substance is bromhexine hydrochloride. Used for diseases of the lungs and bronchi. The drug is not prescribed to children under two years of age. Thus, both drugs act similarly; the doctor determines which one to prescribe individually.
Which is better: Lazolvan or Ascoril?
Ascoril is a combined drug that has a mucolytic, bronchodilator and expectorant effect. Compared to Lazolvan, Ascoril has more contraindications. Despite the fact that they are prescribed for similar diseases, Ascoril is prescribed during the period of dry cough, and Lazolvan can be taken at any stage of the disease.
Which is better - Lazolvan or Erespal?
The active ingredient of the drug Erespal is fenspiride . This drug reduces the intensity of inflammatory processes, while Lazolvan stimulates the thinning of sputum. Which drug to choose, and whether Erespal and Lazolvan can be taken at the same time, is determined individually by a specialist.
Syrup 30 mg/5 ml
Cough is one of the most common complaints with which people consult a doctor.1 It can be a symptom of a number of diseases and conditions that require medications that affect the viscosity of sputum and have an expectorant effect. And one of the frequently used mucolytic agents in Russia is Lazolvan®, used in adults and children.2 It is available in various forms, including syrup with a dosage of 30 mg/5 ml, intended for use in adult practice.
Use during pregnancy
The active ingredient of Lazolvan® syrup, ambroxol, penetrates the hematoplacental barrier, which separates the blood circulation of the mother and fetus. Consequently, when a woman takes the drug, it enters the child’s blood. The experience of using the drug in pregnant women after 28 weeks is quite extensive. Both clinical practice data and the results of animal studies have not demonstrated any undesirable effects of Lazolvan® on the health of the growing fetus, the course of pregnancy, childbirth, or the condition of the child after birth. In addition, the use of ambroxol in the second and third trimesters of pregnancy (after 28 weeks) has been deeply studied. The research results confirmed that ambraxol does not have a negative effect on the fetus.3
However, when prescribing medication to expectant mothers, a healthcare professional takes into account several factors and carefully weighs the balance between the benefit to the woman and the risk to the developing fetus.3, 4 Special precautions when using medications are observed during critical periods of pregnancy, in particular before 12 weeks, when all the organs and systems of the unborn child are formed. Therefore, it is not recommended to take Lazolvan® syrup in the first trimester.3, 5 But in the second and third trimesters, a cough drug based on ambroxol can be prescribed after a thorough assessment of the potential benefit to the mother and the possible risk to the fetus.4
When breastfeeding
Many medications are excreted in breast milk and, accordingly, enter the baby’s body with it. The concentration of the active substance in the baby’s blood depends on various factors, including the duration of feeding, the volume of milk the child received, and the child’s body’s ability to eliminate the drug. Because a breastfed baby's digestive system is immature, the half-life of drugs in the baby's body may be much longer than in the mother's body.5
Medicines that pass into breast milk include Lazolvan® syrup. Despite the fact that in therapeutic doses it did not have a negative effect on the child, it is not recommended to be taken during breastfeeding. Moreover, lactation, according to the instructions for use, is a contraindication to the use of Lazolvan® syrup.3
If kidney function is impaired
In kidney disease, the elimination of drugs is impaired. As a rule, this takes much longer than usual. In this regard, medications for impaired renal function are prescribed very carefully. Before recommending a drug, a healthcare professional will consider possible changes in the rate of elimination, taking into account a number of factors, including what drug is being prescribed, the severity of the kidney problem in a particular case, and so on. Only after a thorough assessment does a healthcare professional decide to prescribe the medication and adjust the dosage individually.6
For liver disorders
One of the main functions of the liver is the breakdown of substances entering the body, including medications. When a person is healthy, this process occurs harmoniously and efficiently. However, in some cases, when liver function is impaired, medications that are not normally harmful to humans can become toxic. Particular care must be taken in severe liver disease such as cirrhosis.7
The active ingredient of Lazolvan® syrup, ambroxol, like other drugs, is metabolized in the liver. Therefore, if its operation is disrupted, it is necessary to take the medicine with caution, as indicated in the instructions for use, and as prescribed by a healthcare professional.3
Active substance
The active substance of the drug Lazolvan® syrup is ambroxol hydrochloride. It helps to enhance the transport of sputum, improve its discharge and relieve cough.
The dosage of the active substance (ambroxol) is 30 mg in 5 ml of syrup, which is a clear viscous liquid with a pleasant strawberry aroma.3
Lazolvan for children
Reviews indicate that this drug promotes rapid sputum discharge in children. At the same time, it is important that the instructions for syrup for children, as well as for other forms of drugs, are strictly followed. Lozenges are not used for children under 6 years of age, tablets - for people under 18 years of age. Lazolvan for children under one year of age can only be used under the constant supervision of a doctor in the form of a solution.
Inhalations are carried out according to the instructions, using any device. The solution is suitable for a nebulizer. Before starting the procedure, you should read the instructions on how to do inhalations with Lazolvan through a nebulizer for a dry cough in a child in order to do inhalations correctly.
How to do inhalation with Lazolvan
For a dry cough, it is important to inhale Lazolvan without using cough suppressants. For patients with bronchial asthma, a combination with bronchodilators is recommended. Chronic bronchitis is treated for a long time. For pregnant women, the medication is allowed from the second trimester strictly as prescribed by the doctor.
For dry cough
For a dry cough, the usual dose of the drug is prescribed; it, along with saline solution, is poured into the nebulizer container. Drugs that suppress the cough reflex (Libexin, Stoptussin) should not be used simultaneously with Lazolvan. This leads to stagnation of sputum and impairs the process of cleansing the bronchi.
For asthma, dosage
The dosage of Lazolvan for bronchial asthma depends on whether it is used alone or in combination with bronchodilator medications. For example, for combined inhalation, take 2 ml of solutions: Lazolvan, physiological, Berodual.
An option is possible when the patient first uses the drug recommended for dilation of the bronchi (Salbutamol, Astmopent, Berotek and others), and after a few minutes inhales Lazolvan aerosols. If you skip this preparatory stage, then asthmatics often experience an attack of suffocation at the very beginning of the procedure.
For bronchitis
Lazolvan is effective for acute and chronic bronchitis; the dose and number of procedures per day do not differ from the standard regimen. To relieve an acute inflammatory process, 7-10 procedures may be sufficient, and for chronic, often recurrent damage to the bronchi, treatment for 2 months is often recommended.
During pregnancy
It has been proven that during pregnancy Lazolvan penetrates the placenta. Although there is no reliable evidence of impaired fetal development, its use in the first trimester poses a potential risk. After the third month, the drug is used only if the preservation of the mother’s health depends on it. Self-medication is strictly prohibited. After childbirth during lactation, it also cannot be recommended, since its presence in breast milk has been detected.
Watch this video on how to use the drug Ambroxol (Lazolvan):
Reviews about Lazolvan
On forums, reviews about Lazolvan tablets are written mainly by those users who themselves used the drug for treatment. They note that for bronchitis and other diseases, after starting to take the pills, the condition improved within a few days. There are many positive reviews on sites where children's Lazolvan is discussed. Parents often use syrup for children, as well as a solution for inhalation. The reviews write about the quick and effective action of the product.
Some users write about side effects - allergic reactions on the skin, diarrhea.
Lazolvan price, where to buy
The price of Lazolvan syrup 15 mg/5 ml is on average 200-230 rubles per 100 ml bottle. Children's syrup 30 mg/5 ml costs an average of 250 rubles. for 100 ml. Syrup for children in Ukraine can be bought at a price of 50 hryvnia. The price of Lazolvan in tablets is on average 300 rubles per pack. 50 pcs. The price of Lazolvan in solution for inhalation is about 400 rubles. The price of Lazolvan IV is approximately 500 rubles for 10 ampoules. More precisely, you can find out how much each form of the drug costs at any pharmacy.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Lazolvan lozenges 15 mg No. 20 Boulder Arzneimittel GmbH and Co. KG.
180 rub. order - Lazolvan - solution for oral administration and inhalation 100 ml, ambroxol, cough suppressant with sputumIstituto de Angeli Srl
RUB 362 order
- Lazolvan Max - capsules No. 10, ambroxol, cough suppressant with sputum Boehringer Ingelheim Pharma GmbH and Co.KG/Delpharm Reims
RUB 243 order
- Lazolvan Fito - syrup of plant origin 100 ml, remedy for cough with phlegmA. Nattermann & Hsieh. GmbH
RUB 246 order
- Lazolvan Rino - spray for nasal congestion 10 mlIstituto de Angeli Srl
RUB 287 order
Pharmacy Dialogue
- Lazolvan PHYTO syrup 100ml A. Nattermann & Sie. GmbH
270 rub. order
- Lazolvan syrup bottle 15mg/5ml 100ml Wild berryBoehringer Ingelheim
RUB 223 order
- Lazolvan tablets 30 mg No. 20 Boehringer Ingelheim
RUB 161 order
- Lazolvan tablets 30 mg No. 50 Boehringer Ingelheim
RUB 268 order
- Lazolvan solution for internal use and inhalation bottle 7.5 mg/1 ml 100 ml Boehringer Ingelheim
RUB 363 order
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Pharmacy24
- Lasolvan 30 mg/5 ml 100 ml No. 1 strawberry syrup with cream Boehringer Ingelheim Spain, CA, Spain
86 UAH order - Lazolvan 30 mg/5 ml 200 ml strawberry and cream syrup
133 UAH order
- Lazolvan syrup 15 mg/5 ml 200 ml wild berries syrup
86 UAH order
- Lazolvan 15 mg/2 ml 100 ml solution
119 UAH order
- Lazolvan 15mg/5ml 100 ml wild berry syrup
48 UAH order
PaniPharmacy
- Lazolvan tablets Lazolvan tablets. 30 mg No. 20 Greece, Boehringer Ingelheim Ellas
70 UAH order
- Lazolvan with strawberry-cream flavor liquid Lazolvan with strawberry-cream flavor syrup 30mg/5ml fl. 200ml Spain, Boehringer Ingelheim Espana
146 UAH order
- Lazolvan liquid Lazolvan d/ing solution. 15mg/2ml 100ml Italy, Instituto de Angeli
137 UAH order
- Lazolvan with wild berry flavor liquid Lazolvan with wild berry flavor syrup 15mg/5ml 200ml Spain, Boehringer Ingelheim Espana
101 UAH order
- Lazolvan max capsule Lazolvan max caps. 75 mg No. 10 Germany, Boehringer Ingelheim Pharma
115 UAH order
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