Xymelin nasal drops 0.05% 10ml buy in Moscow at a price of 77.5 rubles

Pharmacodynamics and pharmacokinetics

The main component of Xymelin is included in the group of local vasoconstrictors or decongestants that have an α-adrenomimetic effect. Its use causes a significant narrowing of the blood vessels in the area of the nasal mucosa, thereby eliminating swelling and hyperemia of the mucous membranes of the nasopharynx. Helps ease nasal breathing during the treatment of rhinitis . Therapeutic concentrations of the drug do not cause irritation of the mucous membrane and the development of hyperemia . The effect appears after a few minutes, lasting an average of 10-12 hours.

The drug is applied topically and is almost not absorbed. The composition of the plasma contains a completely insignificant content of the active substance.

Indications for use

Xymelin drops or spray are recommended for use when:

allergic rhinitis in acute form;
acute respiratory diseases accompanied by rhinitis;
hay fever;
sinusitis;
otitis media;
preparing patients for diagnostic procedures in the nasal passages.

Xymelin

Xymelin (xylometazoline) is a local vasoconstrictor, decongestant, alpha-adrenergic agonist. It is used for acute respiratory infections with symptoms of rhinitis, acute allergic rhinitis, seasonal allergic rhinoconjunctivitis, to eliminate swelling of the mucous membranes during inflammation of the paranasal sinuses, middle ear, auditory (Eustachian) tube and tympanic cavity, in preparing the patient for diagnostic procedures in the nasal cavity. Causes a decrease in the lumen of blood vessels, which are part of a dense network of capillaries that penetrate the nasal mucosa. As a result, hyperemia (excessive filling of blood vessels) and swelling of the mucous membrane are eliminated, which makes breathing through the nose easier. In the doses recommended in the instructions for use, it does not irritate the mucous membranes and does not cause excessive blood supply to them. The therapeutic effect develops a few minutes after intranasal administration and is maintained at a sufficient level for 10-12 hours. When used intranasally, it practically does not penetrate into the systemic bloodstream: the concentrations of the active substance in the blood are so insignificant that they are not detected by modern analytical methods. Xymelin is contraindicated in case of individual intolerance to the components, hypertension, pathologically rapid heartbeat, atherosclerosis at an advanced stage, glaucoma, ozena (chronic atrophic inflammation of the nasal mucosa, affecting the nerve endings), hyperfunction of the thyroid gland, and a history of operations on the meninges. In pediatric practice, the drug is used starting from 2 years. Frequency of use – 1-3 times a day. Single dose - 1-2 injections (for persons under 6 years of age), 3 injections (for persons over 6 years of age).

The maximum duration of use is 7 days. With more frequent or prolonged use of the drug, side effects may develop: irritation and dehydration of the mucous membrane, sneezing, increased mucus production; less often - swelling, rapid heartbeat, cardiac arrhythmias, arterial hypertension, sleep disorders, headaches. Xymelin should not be combined with MAO inhibitors (selegiline, nialamide), tricyclic antidepressants (amitriptyline, imipramine). The drug is not suitable for use in chronic rhinitis, because not intended for long-term pharmacotherapy. During pregnancy and breastfeeding, the drug can be used if the expected benefit from drug therapy outweighs the potential risk of undesirable effects for the mother and child. It is recommended to start treatment with a lower concentration of the solution (0.05%), and if the therapeutic effect is insufficient, proceed to a concentration of 0.01%. To reduce the risk of side effects, it is recommended to adhere to the doses indicated in the instructions for use. Among all decongestants, xylometazoline preparations and, in particular, Xymelin, are among the safest. Metered-dose sprays have a more favorable safety profile compared to drops. The likelihood of side effects can be reduced by combining the use of decongestants with rinsing the nasal cavity with saline solution.

Based on the results of 2015, xylometazoline preparations occupy a leading position in sales among all medicines included in the list of Vital and Essential Drugs.

Contraindications

Taking the drug is not recommended for:

high sensitivity to it;
arterial hypertension;
tachycardia;
severe atherosclerosis;
glaucoma;
atrophic rhinitis;
hyperthyroidism;
children under 2 years of age;
surgical operations in the area of the meninges.

Caution is required when treating patients with diabetes.

Special instructions for the use of Xymelin extra

Before use, it is necessary to clean the nasal passages. Should not be used for a long time, for example for chronic rhinitis. If no more than 1 hour has passed since a missed dose, the missed dose should be administered; if 1 hour - the next dose according to the dosage regimen; the dose cannot be doubled. Do not allow the drug to get into or around the eyes. In case of contact, temporary blurred vision, irritation, pain, redness of the eyes may occur, and an exacerbation of angle-closure glaucoma may develop. You should rinse your eyes generously with cold water if the drug gets into them and consult a doctor if there is eye pain or blurred vision. Use the drug with caution in patients with a tendency to nosebleeds (for example, in elderly patients), with paralytic intestinal obstruction, and in patients with cystic fibrosis. In patients with hypersensitivity to adrenergic drugs, sleep disturbances, dizziness, tremor, arrhythmia or increased blood pressure may occur. During pregnancy and breastfeeding . The drug can be used only after assessing the benefit/risk ratio for the mother and child. Exceeding the recommended dose is not permissible. The drug does not affect the ability to drive vehicles or operate machinery.

Side effects

Frequent and prolonged use of drops can lead to the development of side effects such as:

irritation, dry mucous membranes;
burning and tingling in the nose;
increased sneezing;
hypersecretion;
swelling of the mucous membrane;
heartbeat irregularities;
tachycardia;
arrhythmias;
increased ;
headache;
vomiting and so on.

Consequences of an overdose of Xymelin

Cases of Xymelin overdose in medical practice are recorded quite rarely. In most cases, overdose leads to increased characteristic side effects. The active ingredients of the drug in high concentrations can have a suppressive effect on the patient’s nervous system, causing the development of the following clinical signs:

Increased anxiety;
Weakness;
Increased fatigue;
Unreasonable anxiety;
Sleep disturbances;
Drowsiness during the daytime;
Depressive and apathetic state.

If the above symptoms appear, you must stop using Xymelin and seek professional medical help to prescribe symptomatic treatment! Severe overdose is possible with internal use of the drug, which occurs when the drug is stored in a place accessible to small children. In this case, the following alarming symptoms are likely to occur:

Increased body temperature;
Sudden changes in blood pressure;
Heart rhythm disturbances;
Convulsive syndrome;
Falling into a comatose state.

It should be noted that this condition poses a serious threat to the patient’s life. Therefore, when the above clinical signs appear, it is necessary to perform gastric lavage on the child, inducing artificial vomiting and, as soon as possible, call an ambulance!

In case of prolonged permanent use, Xymelin spray, like other vasoconstrictor drugs, can lead to addiction, decreased effectiveness, the development of atrophic changes in the nasal mucosa, as well as drug-induced rhinitis.

Instructions for use of Ximelin (Method and dosage)

Xymelin spray instructions for use recommend intranasal use. In this case, a 0.1% solution can be injected into patients over 6 years of age. The permissible daily dosage is 2-3 injections for 3 times a day.

The instructions for use recommend using Xymelin drops in the same way. Only 2-3 drops are instilled into the nose.

The drug, the concentration of which is 0.05%, or children's Xymelin, is intended for the treatment of young patients aged 2-6 years. For children, 1-2 drops are dripped into each nostril 1-2 times daily.

The duration of treatment should not exceed a course of 7 days.

How to store the drug?

The shelf life of Xymelin nasal spray and drops is 2 years. The manufacturer recommends storing the medicine in a place protected from direct sunlight and out of reach of small children. The optimal storage temperature for Xymelin is +20 ± 25 degrees.

Xymelin is an effective nasal medication with a pronounced vasoconstrictor effect. The spray facilitates nasal breathing and improves the patient's condition during acute manifestations of rhinitis and other otolaryngological diseases accompanied by nasal congestion. Children, nursing mothers and pregnant women should use Xymelin with extreme caution, only as prescribed by the attending physician and under the strict supervision of a specialist!

Analogs

Level 4 ATX code matches:
Xymelin Eco

Nazivin

Galazolin

Lazorin

Nazivin Sensitive for children

Otrivin

Naphthyzin

Sanorin

Knoxprey

For the nose

Lazolvan Rino

Afrin

Rhinorus

Eucazoline Aqua

Rinazolin

Grippostad Reno

Farmazolin

Xylometazoline

Nazol Advance

Nazol Baby

The main analogs: Snoop, Otrivin, Rinonorm, Tizin, Galazolin, Rinostop, Influrin, Rinorus, Ximelin Eco, Zvezdochka NOZ, Sanorin-Xylo, Espazolin, Xylometazoline, Xylene active.

Reviews about Xymelin

It is generally accepted that nasal drops are the easiest auxiliary drug that can be used independently. However, reviews of Xymelin confirm the fact that such drugs can only be used as prescribed by a doctor.

Many patients talk about the emergence of real drug addiction. This usually happens during the season of colds and allergic reactions , when people begin to actively use such drugs and then cannot give them up due to addiction.

Those patients who used this drug in acceptable dosages and for the time determined by the doctor were divided into those for whom the treatment turned out to be quick and effective and those who did not notice much improvement.

The main thing is to use any treatment for rhinitis with basic caution. Each vasoconstrictor drug must be applied to clean and moistened mucous membranes. For this, simple saline solutions or special products are used, for example, Physiomer or Aquamaris . It is interesting that sometimes just these washings become enough for recovery and the need for medications simply disappears.

Drug interactions of Xymelin

Xymelin and Xymelin Extra should not be used simultaneously with:

MAO inhibitors - due to a possible increase in blood pressure;
Tri- and tetracyclic antidepressants - due to a possible increase in the sympathomimetic effect of the active component (xylometazoline).

Xymelin Extra is not recommended for use simultaneously with other anticholinergic medications, as this may cause an increase in the anticholinergic effect.