Maxicold: instructions for use of tablets and powder

Release form and composition

Maxicold is produced in the form of oval, biconvex, pinkish-orange, film-coated tablets containing:

• 500 mg paracetamol;
• 10 mg phenylephrine hydrochloride;
• 30 mg ascorbic acid.

The tablets contain excipients: ethylcellulose, croscarmellose sodium, sunset yellow dye, magnesium silicate, talc, calcium hydrogen phosphate, hyprolose. In blister packs of 2, 10 and 12 pcs.

Maxicold is also produced in the form of a crystalline light yellow powder for the preparation of a solution for oral administration (the resulting solution has a characteristic odor of orange). 1 sachet (5 g) contains:

• 750 mg paracetamol;
• 60 mg ascorbic acid;
• 10 mg phenylephrine hydrochloride.

The excipients included in the product are: sodium saccharin, quinoline yellow dye, colloidal silicon dioxide, sodium citrate, flavoring, potato starch, citric acid, lactose.

Overdose

The patient should be warned to seek immediate medical attention in case of overdose, even if feeling well, as there is a risk of delayed symptoms of serious liver damage.

Overdose is usually caused by the action of paracetamol.

Symptoms: possible pallor of the skin, anorexia, nausea, vomiting, increased activity of liver transaminases, hepatonecrosis, increased prothrombin time.

Treatment: gastric lavage, followed by the administration of activated charcoal; symptomatic therapy. A specific antidote for paracetamol poisoning is N-acetylcysteine.

Contraindications

The use of Maxicold is contraindicated for:

• Hyperthyroidism, including thyrotoxicosis;
• Severe liver/renal failure;
• Arterial hypertension;
• Heart disease, including acute myocardial infarction, severe stenosis of the aortic mouth, tachyarrhythmias;
• Angle-closure glaucoma;
• Prostatic hyperplasia;
• Hypersensitivity to any of the components included in the medication.

Concomitant use of Maxicold with:

• Monoamine oxidase inhibitors;
• Beta-blockers;
• Tricyclic antidepressants;
• Other medicines containing paracetamol, as well as medicines intended to relieve symptoms of flu, fever and nasal congestion.

In pediatrics, Maxicold, according to the instructions, is approved for use:

• Tablets – from 9 years of age or with a body weight of more than 30 kg;
• Powder - from 12 years old.

Nursing and pregnant women may use the medication with caution. Elderly people should also be careful.

Drug interactions

Please note that when used simultaneously with Maxicold:

• Domperidone and metoclopramide increase the rate of absorption of paracetamol, and cholestyramine reduces it;
• Antipsychotic and antiparkinsonian drugs, antidepressants, phenothiazine derivatives - increase the risk of constipation, dry mouth, urinary retention;
• Glucocorticosteroids (GCS) increase the risk of glaucoma, and halothane increases the risk of ventricular arrhythmia;
• Tricyclic antidepressants - enhance the sympathomimetic effectiveness of phenylephrine;
• Guanethidine – increases the alpha-adrenergic stimulating effect of phenylephrine, and the latter in turn reduces the hypotensive effect of guanethidine;
• Carbamazepine, diphenin, zidovudine, rifampicin, barbiturates and other inducers of microsomal liver enzymes increase the risk of hepatotoxicity.

It should also be remembered that Maxicold enhances the effectiveness of sedatives, monoamine oxidase inhibitors and ethanol, paracetamol reduces the therapeutic effect of diuretics, and in high doses increases the effect of anticoagulant drugs.

Directions for use and dosage

Maxicold is taken orally before meals or several hours after meals. It is recommended to take the medicine with plenty of liquid.

The medication in tablets is taken every 4-6 hours, and the interval between doses should not be less than 4 hours. Dosage is determined by age:

• Adults and children over 12 years old or weighing more than 40 kg – 1-2 tablets;
• Children 9-12 years old – 1 tablet.

Before taking the powder, the contents of the sachet should be completely dissolved in 150-200 ml of hot water.

Adults are advised to take 1 sachet every 4-6 hours, but not more than four per day, children - 1 sachet every 6 hours, but not more than three per day.

To avoid the development of side effects, do not exceed the indicated dosages.

Without consulting a doctor, the duration of use of Maxicold should not exceed:

• 5 days – as a pain reliever;
• 3 days – as an antipyretic.

If the symptoms of the disease do not go away with the therapy, you should consult a doctor.

special instructions

Before starting therapy with Maxicold, patients using cholestyramine, metoclopramide, domperidone and anticoagulants should consult with their doctor.

During pregnancy, the product can only be used as prescribed by a specialist.

For a course lasting more than 5-7 days, it is necessary to monitor the functional state of the liver and peripheral blood parameters.

The use of the drug may distort the results of laboratory tests that determine the level of uric acid and glucose in the blood plasma.

Due to the risk of developing toxic liver damage, it is not recommended to take the drug for people suffering from chronic alcoholism, or to consume ethanol during treatment.

Maxicold does not have a sedative effect and, when used in recommended doses, does not affect the ability to drive vehicles and other complex mechanisms.

Side effects

When using Maxicold, allergic reactions may develop, most often manifested in the form of skin hyperemia, skin rash, angioedema or urticaria.

Also, with hypersensitivity to the components included in Maxicold, the following may develop:

• Phenylephrine - headache, nausea, vomiting, angina pectoris, bradycardia, shortness of breath, increased or decreased blood pressure, palpitations, tachycardia, ventricular arrhythmia, irritability, restlessness;
• Paracetamol – anemia, thrombocytopenia, methemoglobinemia (blood formation disorders);
• Ascorbic acid – irritation of the mucous membrane of the gastrointestinal tract, nausea, vomiting, diarrhea, decreased capillary permeability, thrombocytosis, erythropenia, hyperprothrombinemia, neutrophilic leukocytosis, hypokalemia.

With prolonged use of Maxicold in dosages significantly higher than those recommended by the instructions, the likelihood of:

• Development of headache and insomnia;
• Increased excitability of the central nervous system;
• Renal dysfunction, including nephrolithiasis, moderate pollakiuria, hyperoxaluria.

If adverse reactions develop, you should consult a doctor.

Analogues of the drug according to ATC codes:

PARACETAMOL + PHENYLEPHRINE + ASCORBIC ACID CHLORPHENAMINE + PHENYLEPHRINE + PHENYLTOLOXAMINE

Before using MAXICOLD you should consult your doctor. These instructions for use are for informational purposes only. For more complete information, please refer to the manufacturer's instructions.

Medicinal properties

The drug Maxicold has a combined composition, exhibits antipyretic properties, and has an analgesic effect (like Maxicold Rhino). It quickly alleviates the course of the disease and relieves symptoms of acute respiratory viral infections, colds or flu. The mechanism of action on the body is determined by the properties of each active component.

Paracetamol is an analgesic substance, normalizes body temperature, relieves pain due to the blockade of cyclooxygenase in the central nervous system and a specific effect on the thermoregulatory and pain center of the hypothalamus. Paracetamol relieves muscle and head pain, eliminates fever.

Fenlephrine is an alpha1-adrenergic agonist that acts on specific beta receptors of the heart and is not a catecholamine. This substance helps to narrow the arterioles by reducing the severity of edema and hyperemia in the nasal cavity, and normalizes nasal breathing.

Ascorbic acid (vit. C) helps increase the body's resistance to infectious diseases, replenishes the lack of vitamin. C in the body. This component significantly improves the tolerability of paracetamol and prolongs its action.

Pharmacokinetics

Paracetamol: well absorbed in the intestine, time to reach maximum concentration (Tmax) is 0.5-2 hours; connection with plasma proteins – 15%. Metabolized in the liver to form both active and inactive metabolites. The half-life (T1/2) is 1-4 hours. It is mainly excreted by the kidneys in the form of metabolites - glucuronides and sulfates, 3% - unchanged.

Phenylephrine: After oral administration, phenylephrine is poorly absorbed from the gastrointestinal (GI) tract. Metabolized with the participation of monoamine oxidase (MAO) in the intestinal wall and during the “first pass” through the liver. The bioavailability of phenylephrine is low.

Ascorbic acid: Absorbed in the gastrointestinal tract (mainly in the jejunum). Tmax after oral administration – 4 hours. Easily penetrates into leukocytes, platelets, and then into all tissues; the highest concentration is achieved in the glandular organs, leukocytes, liver and lens of the eye; penetrates the placenta. Metabolized primarily in the liver into deoxyascorbic acid and further into oxaloacetic acid and ascorbate-2-sulfate. It is excreted by the kidneys, through the intestines, with sweat, breast milk unchanged and in the form of metabolites.

Maxicold ENT spray 0.2% fl. 40ml

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• Nosology Influenza, acute respiratory infections, acute respiratory viral infections Influenza, acute respiratory infections, acute respiratory viral infections Pharyngitis Pharyngitis Stomatitis Stomatitis Angina Angina
• Active ingredient Hexetidine Hexetidine
• Prescription Without a prescription Without a prescription
• Release form Spray for topical use Spray for topical use
• Brand Maxicold Maxicold
• Manufacturer Pharmstandard-Leksredstva, OJSC Pharmstandard-Leksredstva, OJSC
• Country Russia Russia
• Storage method Not higher than 25 C Not higher than 25 C
• Article 212272

• Allowed for children
• With caution during pregnancy
• With caution during lactation

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Release formCompositionPharmacological propertiesIndications for useMethod of administrationContraindicationsSide effectsSpecial instructionsDispensing conditions from pharmacies and shelf life

• Spray. Packaging: 40 ml bottle.
• hexethidine 200 mgExcipients: sodium saccharinate dihydrate – 40 mg, citric acid monohydrate – 70 mg, sodium hydroxide (sodium hydroxide) – 19 mg, glycerol (glycerol) – 17000 mg, ethanol (rectified ethyl alcohol) – 4000 mg, lauromacrogol (macrogol lauryl ether) – 1500 mg, cineole (eucalyptol) – 20 mg, levomenthol (L-menthol) – 20 mg, peppermint leaf oil – 10 mg, purified water – up to 100 ml.
• Antiseptic. Shows activity against gram-positive and gram-negative microorganisms and fungi.
• Inflammatory diseases of the oral cavity and larynx, fungal diseases of the oral cavity and larynx, for antiseptic treatment of the oral cavity and larynx before and after surgery and for injuries, as an adjuvant for ARVI, for oral hygiene.
• Maxicold Lor spray is used topically by spraying onto the affected areas of the mouth and pharynx. The drug should be used between meals or after meals. Recommended frequency of procedures: 2–3 times a day. If it is necessary to achieve a more pronounced effect, the spray frequency can be increased. The duration of the course of therapy is 5–7 days. Before first use, you must remove the cap from the bottle and, after installing the sprayer, make several test sprays. The drug can be used after visually verifying that the spray is evenly sprayed. Holding the balloon in a vertical position, the sprayer should be inserted into the oral cavity and, while breathing held, press all the way 3-4 times. After the procedure, the nebulizer should be removed, washed and dried. Store the container with the cap tightly closed.
• atrophic pharyngitis; children under 3 years of age;
• individual intolerance to the components of the drug. Maxicold Lor should be used with caution, only as prescribed by a doctor, during pregnancy and breastfeeding.

Product description missing

• Spray. Packaging: 40 ml bottle.
• hexethidine 200 mg Excipients: sodium saccharinate dihydrate – 40 mg, citric acid monohydrate – 70 mg, sodium hydroxide (sodium hydroxide) – 19 mg, glycerol (glycerol) – 17000 mg, ethanol (rectified ethyl alcohol) – 4000 mg, lauromacrogol ( macrogol lauryl ether) – 1500 mg, cineole (eucalyptol) – 20 mg, levomenthol (L-menthol) – 20 mg, peppermint leaf oil – 10 mg, purified water – up to 100 ml.
• Antiseptic. Shows activity against gram-positive and gram-negative microorganisms and fungi.
• Inflammatory diseases of the oral cavity and larynx, fungal diseases of the oral cavity and larynx, for antiseptic treatment of the oral cavity and larynx before and after surgery and for injuries, as an adjuvant for ARVI, for oral hygiene.
• Maxicold Lor spray is used topically by spraying onto the affected areas of the mouth and pharynx. The drug should be used between meals or after meals. Recommended frequency of procedures: 2–3 times a day. If it is necessary to achieve a more pronounced effect, the spray frequency can be increased. The duration of the course of therapy is 5–7 days. Before first use, you must remove the cap from the bottle and, after installing the sprayer, make several test sprays. The drug can be used after visually verifying that the spray is evenly sprayed. Holding the balloon in a vertical position, the sprayer should be inserted into the oral cavity and, while breathing held, press all the way 3-4 times. After the procedure, the nebulizer should be removed, washed and dried. Store the container with the cap tightly closed.
• – atrophic pharyngitis; children under 3 years of age; – individual intolerance to the components of the drug. Maxicold Lor should be used with caution, only as prescribed by a doctor, during pregnancy and breastfeeding.
• – local reactions: burning of the oral mucosa, development of allergic reactions; - other: if the drug is swallowed - nausea, with long-term use - impaired taste.
• The spray should not be inhaled; contact with the mucous membranes of the eyes should be avoided. It should be taken into account that the ethanol content in the daily dose of Maxicold Lor is up to 48 mg. Since the contents of the cylinder are under pressure, it should not be stored near a fire, or attempted to be opened or punctured, even if it is empty. Hexethidine at the recommended dose is not toxic.
• Store at temperatures up to 25 °C, do not allow freezing. Keep away from children. Shelf life – 2 years. Available without a prescription.

The manufacturer reserves the right to change the appearance and description of the product without prior notice.

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