A sore throat that occurs due to inflammatory and infectious diseases of a cold nature is an unpleasant symptom that every person encounters repeatedly throughout life. Most often, such diseases (acute respiratory infections, acute respiratory viral infections, tonsillitis, pharyngitis, tonsillitis, laryngitis) develop due to a decrease in the body's defenses as a result of stress, overwork, hypovitaminosis, and some chronic diseases. has been successfully used to treat sore throat and suppress inflammation .
The product effectively relieves pain and eliminates discomfort in just a few days.
Medicinal properties
The drug has a local effect. Dorithricin is used for complex therapy and is used for infectious and inflammatory processes in the oral cavity, which result in painful sensations. Dorithricin is a broad-spectrum drug that destroys various types of fungal microflora and is effective in combating Candida fungi.
Sluggish adsorption is explained by the fact that benzocaine is almost insoluble in water. Essential oils, which are products of aminobenzoic acid, dissolve in the blood plasma and liver. As a result of this process, a pair appears - aminobenzoic acid and ethyl alcohol. Benzocaine relieves discomfort in a short time. The substance does not have a negative effect on body functions.
Benzocaine is completely excreted in the urine. Benzalkonium chloride does not have a negative effect on the body and is completely excreted by the kidneys. It is a surfactant that inhibits enzymatic processes. The substance is active against viruses, fungi, bacteria and protozoa. There is no accumulation of the substance in the body.
The concentration of tyrothricin does not increase when taken orally. Does not have a negative effect on intestinal microflora. Tyrothricin actively destroys streptococcal and staphylococcal infections. The substance can also slow down the transport of nutrients to membranes.
DORITHRICIN
A drug with antimicrobial and local anesthetic action for local use in ENT practice and dentistry
Release form, composition and packaging
Lozenges
round, flat-cylindrical in shape, chamfered, marked DORITHRICIN on one side, white with a mint smell.
| 1 tab. | |
| benzalkonium chloride | 1 mg |
| benzocaine | 1.5 mg |
| tyrothricin | 0.5 mg |
Excipients: sorbitol 871 mg, talc 80 mg, povidone (polyvidone K25) 10 mg, carmellose sodium 10 mg, sucrose stearate 20 mg, peppermint leaf oil 5 mg, sodium saccharinate 1 mg.
10 pieces. – Al/PVC blisters (1) – cardboard packs.
pharmachologic effect
A complex drug whose effect is determined by its constituent components.
Benzocaine is a local anesthetic that reduces pain when swallowing, which often accompanies infectious and inflammatory processes in the mouth and throat.
Benzalkonium chloride is a quaternary ammonium compound, belongs to cationic surfactants, interacts with lipoproteins and disrupts the permeability of cell membranes. It has antiseptic properties, is active against gram-positive bacteria, and has a fungicidal effect on Candida albicans and some lipophilic viruses.
Tyrothricin is a local antibiotic, which is a mixture of antimicrobial linear and cyclic polypeptides isolated at the fermentation stage of Brevibacillus brevis Dudos, consisting mainly of gramicidin and tyrocidin.
Tyrothricin acts bactericidal, causing disruption of phosphorylation processes in the chain of cellular respiration and destroying the membranes of bacterial cells.
Due to the special mechanism of action of tyrothricin, which is absent in systemic antibiotics, cross-resistance to the drug does not occur.
Pharmacokinetics
Benzocaine is slightly soluble in water, which causes its slow absorption. Like all ether derivatives of para-aminobenzoic acid, it is cleaved by esterase in the blood plasma and liver. As a result, para-aminobenzoic acid and ethyl alcohol are formed, which is metabolized to acetyl coenzyme A.
Para-aminobenzoic acid undergoes conjugation with glycine or is excreted unchanged by the kidneys.
Benzalkonium chloride is practically not absorbed, has no resorptive effect and is excreted by the kidneys. No accumulation of the substance was detected in body tissues.
Tyrothricin - due to low systemic absorption, pharmacokinetic data are not available. Does not affect intestinal microflora.
Indications
Infectious and inflammatory diseases of the oral cavity and pharynx, accompanied by pain:
- pharyngitis, laryngitis, initial stage of tonsillitis;
- inflammation of the gums and oral mucosa (gingivitis, stomatitis).
Contraindications
- increased individual sensitivity to any of the components of the drug;
- hereditary fructose intolerance and glucose/galactose malabsorption syndrome or sucrase/isomaltase deficiency;
- children under 6 years of age.
Dosage
Inside. For adults and children over 6 years of age, slowly dissolve 1 tablet in the mouth every 3 hours. The maximum daily dose is 6 tablets. The course of treatment is 7 days. Increasing the course of therapy if necessary - on the recommendation of a doctor
Allergic reactions are possible, rarely - gastrointestinal disorders (nausea, diarrhea).
If any of the side effects indicated in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.
Drug interactions
There are no cases of clinically significant interactions between Dorithricin and other drugs.
special instructions
Information for patients with diabetes: in 1 tablet of the drug the carbohydrate content is approximately 0.07 bread units (XE).
Impact on the ability to drive vehicles and operate machinery
Does not affect.
Pregnancy and lactation
The use of Dorithricin during pregnancy and lactation is possible if the expected benefit to the mother outweighs the potential risk to the fetus.
Use in childhood
Contraindicated for children under 6 years of age.
Storage conditions and periods
At room temperature no higher than 25°C in a dry place, protected from light. Shelf life – 5 years.
The description of the drug DORITHRICIN is based on the officially approved instructions for use and approved by the manufacturer.
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Source: https://health.mail.ru/drug/doritritsin/
Directions for use and doses
Apply orally. The tablets should be dissolved slowly, and do not drink or eat for an hour after use. Adults should take no more than 4 tablets per day. The drug should be used in children under 6 years of age at the dosage prescribed by the doctor.
Use during pregnancy and lactation
The use of the drug during pregnancy is not prohibited when the positive effect for the mother is greater than the negative risk for the normal development of the fetus. Studies of the drug's effect in pediatrics and neontology have not been conducted. Before using Dorithricin, you should consult your doctor.
Features of the use of the drug Dorithricin
Dorithricin is a combination antiseptic. The components of the drug fight microbes and have a local anesthetic effect, so this medicine is very often used in ENT practice, as well as dentistry.
Reviews of the drug can be found at the end of the article!
Release form, composition
Dorithricin is available in the form of lozenges with a mint flavor. The shape is round, flat-cylindrical, white. One side is marked DORITHRICIN.
Active substance of the drug:
- benzocaine (1.5 mg per tablet);
- Benzalkonium chloride (1 mg per tablet);
- tyrothricin (0.5 mg per tablet).
Some excipients include:
- talc;
- sorbitol;
- povidone;
- sodium saccharinate;
- peppermint leaf oil;
- sucrose stearate;
- carmellose sodium.
Available in tablets of 10 pieces in a blister. The number of blisters in one package is 1.
What explains the effectiveness of the drug?
Dorithricin comprehensively combats the problem, which is explained by the specifics of its components:
- Benzocaine. This substance is a local anesthetic, which can significantly reduce painful sensations when swallowing, which are typical in the presence of inflammatory or infectious processes in the oral cavity and nasopharynx.
- Benzalkonium chloride. This component is a quaternary ammonium compound and belongs to cationic surfactants. Benzalkonium chloride can interact with lipoproteins and can also prevent the penetration of foreign bodies through cell membranes. In addition to the above characteristics, benzalkonium chloride has pronounced antiseptic properties and is especially active against gram-positive bacteria. This substance is capable of having a fungicidal effect on Candida albicans, as well as some lipophilic viruses.
- Tyrothricin. This component is a local antibiotic. It is a mixture of cyclic and antimicrobial linear polypeptides. The above substances were isolated during the fermentation process of Brevibacillus brevis Dudos (it consists mainly of tyrocidin and gramicidin). Tyrothricin has a bactericidal effect, uncouples phosphorylation processes in the cellular respiratory chain, and is also capable of destroying bacterial cell membranes. Patients do not develop cross-resistance to this drug due to its special mechanism of action, different from systemic antibiotics.
Pharmacokinetics:
- Benzocaine. It is a substance that is slightly soluble in water, which is the reason for its slow absorption. Since this substance is an ester derivative of PABA, it is broken down in the blood plasma and liver using esterase. The result of this process is the formation of PABA and ethyl alcohol, which is subsequently metabolized to acetyl coenzyme A. PABA is conjugated with glycine, but can also be excreted unchanged by the kidneys.
- Benzalkonium chloride. This substance is practically not absorbed and also has no resorptive effect. Excreted via the kidneys. Studies have shown that this substance does not accumulate in body tissues!
- Tyrothricin. There are no studies on the pharmacokinetics of this substance due to the low degree of systemic absorption. Tyrothricin has no effect on the intestinal microflora!
Directions for use, dosage
Dorithricin tablets should be taken orally, dissolving slowly. The optimal dosage is one tablet every 3 hours. The maximum number of tablets per day is 6.
To complete the course of treatment, it is enough to take Dorithricin for 7 days.
If there is a need to continue the course of treatment, it is highly advisable to consult your doctor before doing so.
Side effect
The following symptoms are possible:
- Allergic reactions.
- Gastrointestinal disorders: nausea, diarrhea, etc.
During pregnancy and lactation
Taking Dorithricin during pregnancy and breastfeeding is only possible if the benefits to the mother's health outweigh the possible risks to the fetus.
Price
The average price in Russia is 220 rubles. The average price in Ukraine is 37 hryvnia.
Reviews
Most reviews about the drug Dorithricin on the Internet are positive. Users note the high effectiveness of the drug along with a very reasonable price for a real product of German quality.
The components of the medicine act very quickly, treat the throat comprehensively and severe pain subsides for a long time. Painful sensations also disappear in diseases such as stomatitis and gingivitis.
The drug does not have a negative effect on the intestinal microflora, and therefore is very popular among people who are careful about their health. Users also appreciated the pleasant taste and smell of Dorithricin tablets.
In conclusion, it is worth saying that Dorithricin can provide you with an excellent service in the fight against sore throat and a number of other problems, since the components included in its composition solve the problem comprehensively and are not addictive.
Before using this drug, it is highly advisable to read the instructions for contraindications and consult with your doctor.
Source: https://doctorlor.org/lechenie/lechenie-boleznej-glotki/osobennosti-primeneniya-lekarstvennogo-sredstva-doritritsin.html
Medicines for the treatment of throat are often prescribed in the form of lozenges. Such medications must be dissolved slowly until completely dissolved.
Instructions and reviews of the medicine will be presented to your attention below. You will learn about the features of using this medicine and get acquainted with its composition.
What the instructions tell the consumer about the drug "Doritricin"
The abstract says that the medication contains the following compounds: benzocaine, benzalkonium chloride and tyrothricin. All these substances complement each other in a complex.
The medicine is available in the form of lozenges of 10 pieces per package. Additional components of this medicine include sodium saccharinate, peppermint extract, povidone, talc, sorbitol and many others.
How does Dorithricin work? The instructions for use say that the effect of this medicine is due to the components it contains. With prolonged resorption, the contents of the tablets come into direct contact with the inflamed mucous membranes.
As a result, tyrothricin inhibits the synthesis of bacterial colonies. It is effective against many pathogenic microorganisms, including fungi.
The antibiotic blocks the proliferation of pathogenic microflora, gently eliminating inflammation.
The anesthetic benzocaine relieves discomfort in the throat, which is often accompanied by a viral or bacterial infection. The feeling of comfort and easy breathing returns.
Recommendations for use
In what case is a patient prescribed a drug such as Dorithricin? The instructions for use say that the composition is recommended for use in pediatrics, dentistry, otorhinolaryngology and other branches of modern medicine. Indications for use will be the following situations:
- symptomatic treatment of viral and bacterial infections;
- a sore throat;
- laryngitis, tonsillitis;
- stomatitis and gingivitis;
- condition after tooth extraction or surgery;
- preparation for surgical treatment in the oral cavity.
Despite the clear indications, you should not prescribe the medicine yourself. Uncontrolled and incorrect use of antibiotics leads to the development of microbial resistance.
Contraindications reported in the abstract
Before starting a course of treatment, you should definitely study what the instructions say about the drug Dorithricin. Every medication has contraindications, and this one was no exception.
The drug should not be prescribed to persons with hypersensitivity to the components. Also, the composition is not prescribed for lactose intolerance. The medicine is not recommended for use in diabetes mellitus. If such a correction is carried out, then you should carefully monitor your blood sugar levels.
As is known, antibiotics are not used among pregnant and lactating women. The active substance of the described medication can pass into breast milk. If such treatment is necessary, it is worth deciding on the temporary cessation of lactation.
During the period of bearing a child (especially in the first trimester), it is not advisable to use the medicine. The active ingredients may adversely affect the development of the embryo.
About the drug "Doritricin" the instructions say that it is not used to treat children under 6 years of age. This restriction was introduced due to the fact that at this age the baby is not yet able to take the medicine correctly. Most children strive to chew a lozenge.
"Doritricin": instructions for use and dosage
The regimen for using the drug is the same for all ages and does not depend on the patient’s body weight. The product is prescribed one lozenge every 2 hours. In this case, you can take up to 6 tablets per day.
The duration of treatment is one week, unless otherwise recommended by the attending physician.
Opinions about tablets
You have learned what the instructions for use say about the composition of Dorithricin. Reviews of this medication are mostly good. Consumers report the rapid action of the medicine, which is due to the presence of an anesthetic in the composition. Patients also talk about the pleasant taste of the medicine. After using it, free breathing is restored and irritation in the larynx goes away.
The medicine usually does not cause adverse reactions if all instructions for use are followed. However, there are officially confirmed cases where the composition led to the development of allergies.
In this case, digestion may worsen, vomiting, nausea, and diarrhea may develop. In this case, the composition should be immediately discontinued and consult a doctor. Non-dangerous side effects include burning and dry mouth.
This symptom usually goes away on its own and does not require additional therapy.
Long-term use of the medicine can cause candidiasis of the oral mucosa. That is why you should not neglect the information from the instructions for use. For more detailed information, consult your doctor. All the best to you, don’t get sick!
Source: https://fb.ru/article/228316/doritritsin-instruktsiya-otzyivyi-protivopokazaniya
Precautionary measures
In case of purulent inflammation of the tonsils accompanied by high fever, you should consult a doctor who can correctly prescribe complex therapy, since the drug is not compatible with some antibiotics. For acute tonsillitis and laryngitis, the drug should be taken for no more than three days without a doctor’s prescription. People prone to allergies should remember that the drug can cause skin reactions. If you have diabetes, you must take into account that the drug contains sorbitol.
pharmachologic effect
Manufacturer: Medice Pharma GmbH & Co.
KG (Germany) Release form: lozenges
Active ingredient: Benzalkonium chloride + Benzocaine + Tyrothricin
The bactericidal, antiseptic, antifungal and local anesthetic effect of Dorithricin is due to the properties of its three components:
- Benzocaine, as a local anesthetic, perfectly relieves pain at the site of application.
- Benzalkonium chloride is an antiseptic that kills bacteria, some viruses, and Candida fungi.
- Tyrothricin, an antibiotic obtained as a result of the improvement of gramicidin and tyrocidin, has an exclusively local bactericidal effect, therefore it is safe for intestinal microflora, unlike most other antibiotics.
Analogs
Lisak
Farmak, Ukraine Price: 100 rubles for 6 tablets
The active substance is lysozyme hydrochloride. The form of the drug is lozenges for resorption.
Pros:
- Can be used by children from 4 years of age
- There are no contraindications for use during pregnancy
- The drug is not adsorbed into the bloodstream.
Minuses:
- Allergic reactions may occur
- Not applicable for patients with lactose intolerance
- Should not be used in conjunction with topical medications without consulting a doctor.
Givalex
Norgine Pharma, France Price: from 305 to 360 rubles per 125 ml bottle
Country of origin: France. It is an antimicrobial transparent solution for rinsing the mouth. The composition includes hexetidine, chlorobutanol hemehydrate, choline salicylate.
Pros:
- Use of the drug in pediatrics
- Local application.
Minuses:
- Inconvenient dosage form
- High price
- Not recommended for use during pregnancy.
Koldakt Lorpils
Ranbaxy, India Price: 20 lollipops vary from 100 to 111 rubles
It comes in tablets with a pleasant orange and lemon flavor. Effectively relieves pain in the mucous membrane of the throat. It is actively used in dental and therapeutic practice.
Pros:
- Pleasant taste
- Fast action
- Convenient dosage form.
Minuses:
- The drug contains dyes
- Do not use during breastfeeding or pregnancy
- Possible side effects.
Dorithricin: analogues, instructions for use, price, reviews
Inflammation of the oral mucosa, manifested in the form of ulcers, is stomatitis. The disease most often has an infectious etiology and requires treatment with antibacterial drugs. Topical antibiotics that act directly on inflammatory lesions help speed up recovery.
The modern drug Dorithricin effectively copes with the symptoms of stomatitis and helps with sore throat. Read the instructions for use, prices and reviews of cheap Dorithricin analogues below.
Composition and properties
The main active ingredients of the drug:
- local antibiotic – tyrothricin. Active against gram-positive bacteria and their reproduction process. It is not addictive and does not affect the intestinal microflora.
- a local anesthetic that blocks the occurrence and conduction of nerve impulses - benzocaine. Relieves pain.
- antiseptic with antifungal effect – benzalkonium chloride. Affects pathogenic microorganisms.
Additional ingredients are: food additive E 420, peppermint, talc, sucrose, disinfectant polyvidone.
Indications and contraindications
The drug is used for inflammation of the throat and oral cavity of an infectious nature, accompanied by painful sensations. The main purposes are:
- inflammation of the gums (gingivitis);
- inflammatory lesions of the oral mucosa (stomatitis);
- acute infectious disease of the throat (tonsillitis);
- colds or infectious inflammation of the mucous membranes of the larynx (laryngitis);
- inflammatory process of the lymphoid tissue of the pharynx (pharyngitis).
The drug is most effective in the initial period of the listed diseases.
https://www.youtube.com/watch?v=HY6fBL0j4NE
Dorithricin has a minimum of contraindications , which include: preschool age of the child, individual sensitivity to the components of the drug, congenital intolerance to sucrose.
Release form and dosage
The drug is produced in tablet form. The tablets have a pronounced mint taste and aroma. Directions for use: dissolution in the mouth.
At the first symptoms of the disease, it is recommended to dissolve one tablet at three-hour intervals. The permissible dose is six pieces per day. The course of treatment lasts one week . It is not recommended to drink or eat food for an hour after dissolving the tablets in the mouth.
If there is no positive therapeutic effect, the medication should be replaced after consulting a doctor.
Peculiarities
The medicine is well tolerated by children and adults. Undesirable manifestations include epidermal allergy, which manifests itself in the form of a rash. In rare cases, swelling of the mucous membrane and side effects from the digestive system (nausea, upset stool) are observed.
The drug should be prescribed with caution to people suffering from diabetes. Not recommended for women during pregnancy.
The medication is produced by the German company Riemser Specialty ProductionGmbH, the average price per package ranges from 280 to 340 rubles.
Storage conditions and periods
The drug is valid for 5 years after purchase. After the expiration date, it becomes unfit for consumption. It is recommended to store Dorithricin in a safe place, away from children. The optimal temperature is 14-24 degrees.
See also
Instructions for use of Nazol spray and nasal drops, contraindications and analogues
Read
Overdose
If you take the drug according to the rules, intoxication and poisoning are excluded. In case of an overdose, problems in the functioning of housing and communal services are possible - diarrhea, vomiting, nausea, bluish skin and rapid breathing. Then they do gastric lavage, consume charcoal and report the condition to a specialist. If symptoms of methemoglobins occur, you should immediately call a doctor.
Release form and composition
Dorithricin is sold as lozenges. There are 10 pieces in one box. They are white, round in shape, approximately 16 millimeters in size, and have a mint flavor. Each tablet is labeled "DORITHRICIN".
Dorithricin contains the following components:
- tyrothricin – 0.5 milligrams;
- benzocaine – 1.5 milligrams;
- benzalkonium chloride – 1 milligram.
The tablets also contain peppermint oil, sorbitol, talc, sodium saccharin, sucrose stearate, povidone.
What it is
Dorithricin is a local antibiotic that is produced in Germany and has an anesthetic and antiseptic effect. Thanks to its complex composition, it suppresses the growth of bacterial colonies, fungi and other pathogenic microorganisms, and blocks their reproduction.
The drug effectively relieves unpleasant symptoms that often accompany bacterial and viral infections. Already on day 3, pain and discomfort disappear. Does not affect the microflora of the stomach and intestines.
Indications for use
Dorithricin is prescribed in case of:
- tonsillitis;
- pharyngitis;
- laryngitis;
- gingivitis;
- stomatitis.
It is used to relieve symptoms of throat diseases with severe pain. For purulent tonsillitis with elevated temperature, Dorithricin is taken as an addition to first-line treatments.
