Indications for use
All release forms are intended for the treatment of diseases in adults:
- Coronary disease is damage to the myocardium of the heart.
- Heart failure is a dysfunction of the myocardium.
- Overtraining syndrome in athletes is the appearance of pain that does not go away after resting and fatigue.
- Increased mental stress, decreased concentration and memory.
- Hangover syndrome is the appearance of symptoms of alcohol withdrawal.
- Dysfunction of cerebral circulation.
- Decreased performance, chronic fatigue syndrome;
- Hemophthalmos is the penetration of blood or the formation of blood clots into the vitreous body of the eye.
- Retinopathy is damage to the retina of the eye.
For diseases of the cardiovascular system, this drug is used for treatment as an addition to the main therapy. It improves blood circulation and normalizes myocardial contractility.
For several weeks, athletes are recommended to use Mildronate to increase physical strength and improve metabolism. This happens due to the fact that the composition contains Meldonium, which is a synthesized analogue of gamma-butyrobetaine (a substance present in cells).
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Reviews from doctors
Kutina Marina Aleksandrovna, 34 years old, cardiologist, Saratov
I am a cardiologist, and I have been using Mildronate as part of my job for almost 7 years. I usually use it for intravenous administration and preorally for ischemia, myocardial dystrophy and dystrophic diseases of the organs of vision. Patients notice its effect already in the second week and are very pleased with the effect.
Chernyshenko Natalya Mikhailovna, 58 years old, cardiologist, Krasnodar
I prescribe Mildronate to patients with astheno-neurotic syndrome and nervous overload. I consider it quite effective, but patients over 60 years of age should take it only after a thorough examination. As for healthy people, they should absolutely not use Mildronate! It will bring nothing but harm. There is no need to overload the heart, which functions without failures.
Pharmacodynamics and pharmacokinetics
The main substance of this medicine is meldonium dihydrate. It was synthesized about half a century ago in Latvia.
Initially, the drug was prescribed to the military, in particular, to eliminate drowsiness and syndrome
chronic fatigue. But later, scientists established the positive properties of Mildronate for the functioning of the cardiovascular system and the body as a whole.
The active substance acts in a complex manner. It restores the balance between the cells' needs for
oxygen and its delivery, removes accumulated toxins and the consequences of their effects on the body.
As a result of the use of Mildronate, the body increases endurance to physical and
mental stress, metabolism is normalized.
Other pharmacodynamic properties of the drug include:
- normalization of cerebral circulation;
- improvement of blood circulation in the area of ischemia;
- slowing down the formation of the necrotic zone;
- elimination of functional disorders of the nervous system;
- reduction of the rehabilitation period in the treatment of heart disease, stroke and alcoholism.
After oral administration, Mildronate is rapidly absorbed from the gastrointestinal tract. Excreted in urine after 3-6 hours.
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Is it possible to lose weight?
Oddly enough, another area of application of this medicine is the fight against excess weight. According to reviews, the benefits and harms of Mildronate for weight loss are extremely difficult to assess. After all, we are talking about using the medication for purposes other than its intended purpose. According to users, in such cases, taking the medicine should be treated with extreme caution, so as not to cause irreparable harm to your body instead of the desired benefit.
The properties of meldonium actually help to get rid of extra pounds by improving metabolism. However, using the drug as an independent means for losing weight is strictly prohibited. In fact, Mildronate can help with weight loss, but only in combination with active sports training and proper nutrition. This is confirmed by numerous reviews on the Internet.
Compound
The composition of the medicine depends on the form of release. Intravenous ampoules contain two substances:
- meldonium;
- water for injections.
Oral capsules contain more substances:
- meldonium;
- potato starch;
- calcium stearate;
- colloidal silicon dioxide;
- titanium dioxide and gelatin in the shell.
Mildronate syrup includes:
- meldonium;
- purified water;
- cherry essence;
- glycerol;
- dyes;
- propylene glycol.
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Release form
Mildronate is available in three forms:
- Capsules. Sometimes they are mistakenly called tablets, but this concept is not correct. The tablet form of this drug is not available. Capsules come in two types: with 250 mg and 500 mg of active substance. Sold in cardboard packaging containing 40 and 60 pieces.
- Syrup. Sold in two types: 150 ml and 250 ml. 5 ml (one dose) of the medicine contains 250 mg of the active substance. Available in cardboard packaging. Includes a 5 ml measuring spoon.
- Ampoules. One ampoule contains 5 ml of the drug, which contains 250 mg of the active substance. Available in cardboard packaging of 10 ampoules.
The variety of forms of the drug allows you to choose the most convenient method of use for yourself.
Mildronate, produced in ampoules, has the fastest absorption. The solution is injected into a muscle or vein and reaches its maximum concentration in the blood immediately after administration. In second place in terms of absorption rate is syrup. But it is more convenient to take capsules with water.
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Possible consequences of use
Unintentional overdose of the drug is expressed in the form of low blood pressure, arrhythmia, and general malaise. In this case, patients do not require specific therapy. Treatment is purely symptomatic. In this case, the risk of death is completely absent.
In fact, the balance of benefits and harms from the drug Mildronate will be positive if its dosage and method of administration are chosen by a specialist. The general strengthening effect that the medicine has encourages many to use it without a doctor’s prescription. But in such cases, no one is immune from the negative consequences of the drug.
- Most often, the harm of Mildronate to the body is expressed in addiction. Typically, addiction occurs due to too much use and a decrease in the therapeutic effect. In such a situation, a person simply gets used to working only under the influence of the drug. But its absence leads to general fatigue and lack of ability to work.
- According to reviews, the benefits and harms of Mildronate are simultaneously expressed in one feature - the drug actively enhances the effect of medications taken in parallel. That is why any combination of drugs must be discussed with a specialist. It is worth considering that an uncontrolled combination of drugs is fraught with negative consequences.
- Side effects of Mildronate cannot be ruled out.
Due to the possible harm of uncontrolled use of the drug, a prescription will be required to purchase it at the pharmacy.
pharmachologic effect
The drug has several pharmacological actions:
- angioprotective – dilation of blood vessels, reduction of tissue edema, stimulation of metabolism in cells, restoration of blood composition;
- cardioprotective – strengthening the heart muscle, accelerating cell regeneration processes, reducing the concentration of toxins in the body;
- antihypoxic – reducing tissue oxygen demand, activating cellular metabolism, stimulating the regeneration process, improving tissue nutrition;
- antianginal – prevention and relief of angina attacks, oxygen delivery to the myocardium.
As a result of its complex effect on the body, the drug shows high efficiency. Athletes who need additional stimulation of metabolism note particular benefits.
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Demand among bodybuilders
In addition to professional athletes, Mildronate is also popular among amateurs. By using this product correctly, you can achieve several important effects:
- improving muscle nutrition and increasing their growth rate;
- muscle growth due to increased loads;
- maintaining the optimal concentration of fatty acids necessary for tissue development;
- reducing the load on the heart, which prevents the development of all kinds of complications;
- strengthening all cells of the body, in particular nerve tissue;
- normalization of metabolic processes in the body.
In just two months, athletes notice positive results. This drug, of course, will not help you master fundamentally new indicators in the form of, for example, adding 100 kg to the weight you lift. Such a result certainly does not shine for anyone.
But fatigue will not set in after an hour from the start of classes, as usual, but, say, after an hour and a half. It is this difference in time that a bodybuilder spends on additional training that gives him the opportunity to improve his own performance and achieve the necessary endurance. And the desired muscle relief will be noticeable much earlier, but again, only thanks to intensive training.
Directions for use and doses
Before starting treatment, you should study mildronate instructions for use and recommendations.
manufacturer. But only a doctor can prescribe the drug and select the dosage. You cannot take Mildronate on your own.
Dosage and rules of use depend on the form of the medicine.
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Capsules
The drug has a tonic and stimulating effect, so it is recommended to take it
in the first half of the day. Athletes can use it 1-2 hours before physical activity.
The dosage depends on the purpose of use:
- For the treatment of cardiovascular diseases in complex therapy, the dosage is 0.5-1 grams per day. 250 mg capsules are taken up to 4 per day, 500 mg tablets - up to 2 per day. The daily dose should be divided into 1-2 doses. The duration of treatment should not exceed 6 weeks.
- For the treatment of chronic dysfunctions of cerebral circulation, the dosage is the same. During the year you can take 2 courses lasting no more than 6 weeks each.
- For the treatment of chronic alcoholism and detoxification, the dosage is 500 mg 4 times a day. The duration of therapy reaches 10 days.
- To increase endurance and physical strength, athletes need to take the drug 1-2 capsules twice a day before training. Duration of treatment is 21 days, during competitions – up to 14 days.
Capsules are washed down with water for ease of swallowing.
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Syrup
One portion of the medicine is 5 ml (1 scoop). For the treatment of heart disease and when it worsens
for cerebral circulation, you need to take 1 scoop of syrup twice a day.
The dosage for athletes is selected individually. Daily norm – 1 gram (4 scoops),
divided into two doses.
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Ampoules
The solution, produced in ampoules, is administered in three ways:
- intravenously;
- intramuscularly;
- parabulbar (eye prick).
Dosage:
- For pathologies of the heart and brain, the drug is injected into a vein, 2 ampoules per day. The dosage is divided into 2 doses. The course of therapy lasts from 4 to 6 weeks.
- For chronic alcoholism, the dosage is 1 gram per day for 10 days. It can be administered intravenously or intramuscularly.
- Athletes need to administer 500 mg intravenously once. The duration of treatment should not exceed 3 weeks.
- To treat diseases of the retina, the drug is administered by eye injection of 0.5 ml of solution per day. Duration of therapy is 10 days.
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"Mildronat" for a long term without a doctor's prescription: dangerous or not?
Metabolic drugs are one of the components of complex therapy for neurological and cardiovascular diseases (sometimes during the recovery process in oncology, surgery and traumatology). The peculiarity of the use of drugs in this group is a wide range of dose-dependent effects on various organs of the body, therefore a specific amount is selected for each patient in a short course (maximum 6 weeks).
Uncontrolled use of Mildronate is accompanied by the risk of:
- development of arrhythmias;
- formation of cardiomyopathy (due to restructuring of the heart muscle);
- drop in blood pressure;
- violations of the excretory function of the liver and kidneys.
If it is necessary to take the drug for a long time (according to indications), it is recommended to take 30-day breaks every 2 weeks.
For athletes
The main advantage of Mildronate is its ability to improve metabolism in cells. This leads to accelerated elimination
from organisms of free radicals and breakdown products. The drug can be safely called an antioxidant, which improves well-being, slows down the aging process of cells and helps rapid muscle recovery.
Athletes are recommended to take the drug to reduce pain after training and speed up recovery.
The components included in the composition eliminate the symptoms of overtraining and help fight physical fatigue. This has a beneficial effect on the general condition of the athlete and his personal performance.
The product is most effective during heavy physical activity and active training. It is recommended to take the drug
in situations where the body does not have time to rest between workouts. For example, when preparing for competitions. However, Mildronate is not a prohibited doping drug.
You can take the drug for no more than 6 weeks without a break. Longer use causes addiction, that is, the body stops responding to the incoming substances.
But Mildronate alone is not enough to increase the effectiveness of training and endurance of the body. It only works in
complex with proper nutrition and a rational daily routine, when rest alternates with hard work.
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What is Meldonium
Meldonium, also known as Mildronate, is a medication that speeds up the body's metabolism. It was developed back in 1975 by professor of medicinal chemistry Ivars Kalvins, who nowadays is the head of one of the departments of the Latvian Institute in Riga. In his research, Kalvins discovered a unique substance, gamma-butyrobetaine, which has the beneficial property of redistributing cellular resources if the body is subjected to regular intense overload. Modified gamma-butyrobetaine formed the basis of Meldonium dihydrate, which is the main active component of Mildronate.
Use for liver dysfunction
There is not enough information in medical reference books about the safety of using Mildronate for dysfunctions
liver. If the patient exhibits disturbances, then use is possible only under the strict supervision of a physician.
The drug is strictly contraindicated for liver failure. For chronic forms of diseases, take Mildronate
it is possible, but for a short time and with subsequent medical examination for complications.
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Monotherapy
If an elderly person regularly plays sports, he is periodically prescribed courses of maintenance medications, one of which is Mildronate. It is advisable for people with various heart diseases to prevent their deterioration in advance. This happens if there is stress at home or at work or relatively heavy physical work is planned. The doctor may also prescribe the drug if general health deteriorates, performance decreases, or severe weakness.
Use for renal impairment
Acute renal failure becomes a contraindication. If the patient has a history of
chronic kidney disease, then the drug should be taken for a long time with caution and with medical monitoring of the condition of this paired organ.
At its core, Mildronate does not have a detrimental effect on the kidneys, but it also claims to be safe
drugs are not possible because there are no clinical trials.
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special instructions
In patients who have serious kidney and liver diseases with insufficiency of the functions of these organs, biochemical blood parameters should be monitored. If long-term use of meldonium is necessary, consultation with the attending physician is required to adjust the dosage of the drug.
A person taking Mildronate may be allowed to drive vehicles and operate machinery, since the drug does not cause a slowdown in reactions. Elderly patients should reduce the therapeutically effective daily dose.
Side effects
Side effects are possible if you are hypersensitive to the components of the drug. These include:
- skin rashes;
- malaise;
- decrease or increase in blood pressure values;
- excitability;
- diarrhea.
If the dosage is chosen correctly and the drug is used only for its intended purpose, then side effects
are not observed. If the patient develops the listed symptoms, then it is necessary to stop taking the medication and consult a doctor to review the therapy.
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Overdose
Judging by the number of contraindications listed above, it can be understood that Mildronate is a low-toxic substance and does not cause reactions that are really dangerous to health.
If a person takes an excessively large amount of the drug, then the symptoms listed above may simply intensify. In such situations, symptomatic therapy is prescribed.
Contraindications
All forms of this drug have contraindications:
- minor age;
- period of pregnancy and breastfeeding;
- sensitivity to substances included in the composition;
- intracranial pressure;
- brain tumors.
Consulting a doctor before starting therapy allows you to exclude contraindications and determine whether the drug is suitable for a particular person. It is important to take into account the individual characteristics of the body and existing diseases.
It is not recommended to take the drug together with alcohol. If you are planning a holiday with alcoholic drinks, then they should be consumed no earlier than 12 hours after the administration of the medicine. During this time, the active substance is completely eliminated from the body.
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Analogues of Mildronate
There are many analogues of Mildronate on the pharmacological market. These include:
- Riboxin – from 37 rubles;
- Vasomag - from 200 rubles;
- Melfort - from 500 rubles;
- Midolat - from 128 rubles;
- Cardionate – from 170 rubles;
- Metonate – from 300 rubles;
- Meldonium - from 230 rubles.
The advisability of using analogues is discussed with the attending physician. Prescription of another drug is necessary if side effects from Mildronate occur.
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Interaction with other drugs
In general, Mildronate interacts well with other drugs. But there are a few things to consider:
- Tachycardia is possible when taken simultaneously with nitroglycerin and nifedipine. A similar side effect occurs with the combined use of Mildronate and antihypertensive drugs.
- The drug enhances the effect of taking cardiac glycosides and antianginal drugs.
- Can be combined with drugs from other groups. For example, drugs against lung diseases and arrhythmias.
The issue of taking Mildronate together with other drugs should be decided.
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