Every representative of the fair sex encounters such an unpleasant phenomenon as thrush at least once in her life. This disease is transmitted to the partner. But fortunately, there are now many ways to fix this problem. One of these drugs is Pimafucin. It is available in the form of capsules and suppositories, and since both partners need to be treated, there is a cream for men.
Pimafucin tablets - instructions for use
The antifungal drug Pimafucin in tablets is available for the treatment of intestinal candidiasis, internal mycoses and other fungal diseases. According to the pharmacological classification, the drug belongs to the group of natamycin antibiotics, which selectively act on pathogenic pathogens. The active ingredient in the medication is natamycin.
Compound
One tablet of an effective antifungal antibiotic contains 100 mg of natamycin. The full composition of Pimafucin is shown in the table below:
| Excipients | Potato starch, povidone K 30, magnesium stearate, lactose monohydrate |
| Shell components | Cellacephate, triacetin, sucrose, methyl parahydroxybenzoate, calcium carbonate, kaolin, talc, titanium dioxide, acacia gum, gelatin, white beeswax |
Other forms of the drug contain:
- Suppositories - 100 mg of natamycin, excipients cetyl alcohol, solid fat, sorbitol, polysorbate, sodium bicarbonate, adipic acid.
- Per 1 g of cream there are 20 mg of natamycin, additional components are decyl oleate, cetyl ester wax, cetostearyl alcohol, sodium lauryl sulfate, methyl parahydroxybenzoate, propyl parahydroxybenzoate, propylene glycol, purified water.
Release form
Pimafucin is available in the format of round tablets, enteric-coated, white or almost white. The medicine is contained in 20 pieces in dark glass bottles and cardboard packs. Other formats of Pimafucin are vaginal suppositories (3 and 6 pieces each in blister packs made of PVC or aluminum), cream for external use (plastic or metal tube 30 g), suspension for treating the oral cavity and ear canal (2.5%).
Pharmacodynamics and pharmacokinetics
The active substance of Pimafucin, natamycin, is part of the group of polyene antimycotics from the group of macrolide antibiotics and has a wide spectrum of action. Suppresses candida fungi; dermatophytes and other pathogenic microorganisms are considered less susceptible. The instructions for use emphasize that natamycin is active against all fungi, but doctors prefer to treat only candidiasis with it.
Natamycin has fungicidal activity, blocks special components (sterols) of the cell membranes of pathogens, which leads to their death. In clinical practice, no cases of resistance (resistance) to the active substance have been observed. It is practically not absorbed in the digestive canal, and is not absorbed from the mucous membranes and skin. Due to the enteric coating of Pimafucin tablets, their action occurs inside the intestine.
Indications for use
According to the instructions for use of the drug, the following indications for its use are distinguished:
- intestinal candidiasis;
- treatment of dermatomycosis, skin lesions;
- elimination of thrush symptoms;
- acute pseudomembranous and acute atrophic candidiasis;
- treatment of patients with cachexia, immune deficiency, treated with antibiotics, corticosteroids, cytostatics;
- sanitation of the intestinal reservoir for candidiasis of the skin, mucous membranes, for advanced or chronic vaginal candidiasis, vulvitis, vulvovaginitis, balanoposthitis with increased secretions;
- complex treatment of systemic skin diseases;
- fungal infections of the genital organs, skin, skin appendages, nail candidiasis.
Release form and manufacturer
The drug Pimafucin is available simultaneously in several forms. Each form is focused on a specific problem, which greatly facilitates the treatment process itself and speeds up recovery.
- Pimafucin tablets are small white tablets coated with a special soluble coating. Most often, tablets are prescribed for various types of candidiasis, to suppress infection in the intestines.
- Pimafucin vaginal suppositories are oblong, torpedo-shaped suppositories. They are white or pale yellow in color. In some cases, there may be a brown tint. Suppositories are most effective in cases with vaginal candidiasis. One Pimafucin suppository contains 100 mg. active substance (antibiotic).
- Pimafucin cream is a mixture with a white or light yellow tint. The cream has no specific odor. 1 gram of the product contains 20 mg. antibiotic. You can purchase the drug in a tube, which has a volume of exactly 30 mg. The main advantage of the cream is its ease of use and light texture, which allows you to easily apply the substance over the skin. Most often used to suppress candidiasis of the nails and skin.
The manufacturer of Pimafucin is the leading company Astellas, located in the Netherlands. European quality and reasonable price have allowed this product to become advanced in the treatment of the main women's problem - thrush.
How to take Pimafucin
The tablets are taken orally, regardless of food intake, since it does not affect the effectiveness of the antifungal components. Pimafucin dosage:
- for intestinal damage, adults take 100 mg of natamycin (1 tablet) four times a day, children - twice, the course of treatment is a week;
- in case of persistent vaginitis caused by fungi of the genus Candida, together with local antifungal drugs (Pimafucin suppositories) to sanitize the source of infection inside the intestines, you need to take tablets 4 times a day, for a course of 10-20 days;
- when treating thrush and its variety on the genitals, the duration of treatment lasts up to three weeks (a break during menstruation is done only when using suppositories), together with a sexual partner;
- for nail candidiasis, tablets are taken along with cream four times a day for a course of 2-3 months;
- for widespread candidomycosis of the skin, 4 tablets per day are taken in a weekly course along with topical application of the cream;
- for onychomycosis, together with the use of natamycin and cream, 4 tablets are taken per day for a course of 2-3 months;
- The duration of treatment for a fungal infection is determined individually; after the symptoms disappear, treatment continues for several more days.
Storage conditions
The use of Pimafucin is possible only if the drug storage rules are followed:
- The drug must be stored in conditions where the air temperature is from +15 to +25 degrees Celsius.
- Do not store cream and vaginal suppositories in the refrigerator, the drug may lose its properties.
- The drug must be stored in a place protected from direct sunlight.
- The drug should not be stored in a place accessible to children and animals.
- Suppositories and cream should not be allowed to freeze or melt.
The drug should not be used after the expiration date:
- The shelf life of the tablets is 4 years from the date of issue.
- The shelf life of vaginal suppositories is 2 years from the date of release.
- The shelf life of the cream is 4 years from the date of release of the drug.
special instructions
The instructions for use of the medicinal product contain a special instructions section. Small excerpts from it:
- the medication contains 66 mg of lactose monohydrate (milk sugar) and 122 mg of sucrose - patients with rare congenital intolerance to galactose, fructose, lactase deficiency, glucose-galactose malabsorption or sucrase-isomalt deficiency should consult their doctor before taking it;
- tablets are not recommended for use in infants due to difficulty swallowing;
- the medicine does not affect the speed of psychomotor reactions, therefore it can be used when driving cars and dangerous mechanisms.
Experts' opinion
Most experts speak well of this drug. They note the high effectiveness of the drug, its tolerability and the absence of risks associated with side effects. The only contraindication to the use of the medicine is individual intolerance to its individual ingredients.
The main advantage of Pimafucin is that when applied externally in the form of ointments, the drug does not enter the bloodstream. This prevents the possibility of its composition entering the body.
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Pimafucin for children
The peculiarity of the drug is the lack of penetration into the gastrointestinal tract, which makes it attractive compared to other antibiotics for use by children. Pimafucin does not cause a large number of adverse reactions; it is prescribed for candidiasis of the gastrointestinal tract. The children's dosage is 100 mg (one tablet) twice a day. Older children can be prescribed up to four pieces, up to a year - part of the tablet. Complex therapy with suppositories or cream is allowed.
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How to replace the drug
Today, the pharmacy chain offers a huge selection of antifungal drugs similar to Pimafucin. With all this, regarding the issue of replacing the drug with another more suitable one, it is best to consult with a specialist. In urological practice, the following medications with pharmacological effects identical to Pimafucin are mostly used:
- Clotrimazole;
- Flucostat;
- Nystatin;
- Diflucan;
- Fluconazole.
Drug interactions
Instructions for use of Pimafucin in tablet form indicate that drug interactions with other medications have not been detected. This means that you can safely combine drugs, but only after consulting a doctor. It is allowed to take several types of Pimafucin in parallel to speed up recovery and reduce the time for therapy.
What does it consist of?
The medicine consists of the main active ingredient - natamycin and auxiliary agents. It is included in all forms of manufactured products.
The medicine can be found in the form:
- candles;
- creams for men;
- tablets for oral administration.
The tablets are packaged in dark bottles that do not allow light to pass through. Usually they contain twenty tablets.
The cream is produced in tubes of thirty grams.
Candles are packaged in foil and sold three pieces per package. Usually so many pieces are enough for one course.
Analogs
The tablet format of the drug is used only for the treatment and prevention of candidiasis, but it cannot be used to treat thrush (vaginal and other). For the latter, candles and cream are used. There are no complete analogues of Pimafucin, but there are approximate substitutes for the treatment of gastrointestinal candidiasis that have a systemic effect - they enter the blood, act on all systems and organs of the body, have some toxicity to the liver and side effects, according to reviews:
- Irunin;
- Itraconazole;
- Mycozoral;
- Mikosist;
- Nystatin;
- Terbinafine;
- Fluconazole.
Side effects
Among the side effects of Pimafucin are:
- slight burning sensation in the area where suppositories are used;
- mild irritation of surrounding tissues;
- nausea, short-term lack of appetite in the first days of use;
- diarrhea, followed by mild cramps in the intestinal area at the beginning of taking the drug.
It is important to inform your doctor about side effects not listed in the instructions if they occur. If suspicious symptoms appear or in case of persistent diarrhea or persistent nausea, you should immediately contact the clinic to receive medical help and doctor’s recommendations for further use of Pimafucin.
Pimafucin price
You can buy Pimafucin on the Internet or in regular pharmacy departments. The price depends on the pricing level of trading enterprises and the form of release. The approximate cost of Pimafucin in different formats is indicated below:
| Variety | Price when purchasing online, rubles | Price on the pharmacy shelf, rubles |
| Tablets, 100 mg, 20 pcs. | 508 | 550 |
| Cream 2% 30 ml | 323 | 350 |
| Vaginal suppositories 100 mg 3 pcs. | 270 | 300 |
Features of treatment
Treatment of thrush is carried out in two aspects:
- General therapy is aimed at eliminating conditions conducive to the growth of the fungus;
- Medication to fight candida.
At an appointment with a doctor, you should discuss such issues as the presence of allergies to certain medications, whether certain medications can be used.
During treatment, you need to constantly humidify the air in the room where the child is and spend more time in the fresh air, which will ensure a speedy recovery. In case of illness, proper nutrition is prescribed, excluding sweets, which provoke the spread of the fungus. If the baby spits up, you need to change the feeding method.
When a child is infected with candidiasis, a white coating forms in his mouth, under which red, inflamed spots can not only bleed, but also become a hotbed for more dangerous infections. This happens with stomatitis.
If the disease is not treated on time, it spreads to the throat, and then to the gums and lips, where cracks form and begin to bleed.
With stomatitis, wounds in the mouth cause such pain to the baby that he cannot swallow and refuses to breastfeed. The baby may develop a fever. In addition, children experience insomnia and become irritable. The immune system deteriorates and contributes to the occurrence of allergies, as well as severe diseases, including bronchial asthma.
Reviews
Alena, 23 years old:
For thrush in the 3rd trimester, I was prescribed vaginal suppositories Pimafucin. The daily dose is one suppository.
I used the product for 4 days. I did not feel any negative effects while using the drug.
The test results showed the absence of fungus in the vagina. Among the main advantages of the medicine: a very convenient form of treatment, safe composition, and affordable price.
Natalya Nikolaevna, 42 years old:
To treat mycosis of the feet, I used Clotrimazole ointment. After two weeks of treatment there was no result or dynamics of recovery. The dermatologist prescribed Pimafucin cream in combination with tablets.
In just 1 month we managed to get rid of the fungal disease. The skin on the feet became soft, thickening and peeling disappeared.
Tatyana, 30 years old:
Suppositories during pregnancy called Pimafucin were recommended by an obstetrician-gynecologist with whom I am registered.
The news that I was diagnosed with thrush provoked stress.
I calmed down a little when I found out that all pregnant women are predisposed to this disease.
Already 3 days after using the suppositories, I took the tests again. No fungus was found. I recommend the product!
Precautionary measures
- The use of pharmaceuticals for the treatment of pathologies is permitted only with drugs with appropriate expiration dates . Expired medicine must be disposed of.
- After inserting the suppository into the vagina, a slight burning sensation . This is due to the aggressive environment of cetyl alcohol. The unpleasant feeling goes away spontaneously after a couple of minutes.
- The use of vaginal suppositories does not require abstinence from sexual activity . You should stop using suppositories only during menstruation.
- There is no information about the negative effects of natamycin on the fetus. Therefore, Pimafucin suppositories can be prescribed for thrush during pregnancy . There are no contraindications for women who are breastfeeding.
- The safety of the composition allows the use of Pimafucin in pediatrics. The drug is even prescribed for the treatment of newborns.
In complex therapy, the medicine in question is used in combination with other pharmacological products.
The manufacturer does not warn about dangerous combinations in the official instructions.
