Category: Published 04/23/2017 · Comments: · Reading time: 5 min · Views: 26,240
A modern pharmacological agent that has proven itself in cardiological practice is Preductal tablets. What does the medicine help with? The drug is a representative of antianginal drugs, the main purpose of which is to improve metabolic processes in the myocardium during established ischemia. The instructions for use of the drug "Preductal MV" prescribes taking it for heart diseases.
Pharmacodynamics and pharmacokinetics
The main substance trimetazidine (this is also the drug) is able to prevent a decrease in the concentration of adenosine triphosphate inside cells, due to the preservation of energy metabolism at the cellular level in a state of hypoxia. At the same time, as Wikipedia reports, the normal operation of membrane ion channels, transmembrane transport of potassium or sodium ions is ensured, and cellular homeostasis is maintained.
The drug Preductal activates several complex processes in the body, due to which the myocardium from possible ischemia.
The pharmacological properties of trimetazidine make it possible to switch energy metabolism from the oxidation of fatty acids to glucose .
In general, during ischemia, trimetazidine is characterized by:
- providing support for cardiac energy metabolism and neurosensory tissues;
- decreased severity of intracellular acidosis and some changes related to transmembrane ion flow;
- reducing the level of infiltration and migration of polynuclear neutrophils in the area of ischemic and reperfused cardiac tissue;
- reducing the size of myocardial damage.
In this case, there is no direct effect on hemodynamic parameters.
As for the treatment of patients suffering from angina , what usually happens:
- an increase in coronary reserve, which slows down the development of ischemia caused by physical activity;
- limiting fluctuations in blood pressure during physical activity, without having a particular effect on the heart rate;
- reducing the frequency of angina attacks and the need for short-acting nitroglycerin;
- improvement of contractile function of the left ventricle in ischemic dysfunction.
After oral administration, Preductal tablets are rapidly absorbed, followed by reaching a maximum concentration in the blood plasma after approximately 5 hours. At the same time, its concentration is maintained throughout the day. Eating food does not affect the bioavailability of the drug. The main substance is well distributed in tissues and body fluids.
The drug is excreted mainly through the kidneys, in unchanged form.
Produced pharmacological effects
Against the background of a course of use of the drug “Preductal”, the instructions for use report this, a pronounced cardioprotective as well as anti-ischemic effect on myocardial tissue is observed. In addition, taking the medication prevents the pathological adhesion of platelets and red blood cells, erythrocytes.
Main pharmacological actions of the drug:
- correction of energetic processes in cardiocytes;
- increasing the physical endurance of people suffering from manifestations of ischemic pathology;
- a significant reduction in the number of angina attacks;
- optimal increase in coronary reserve.
In ENT practice, the drug has also found its niche - thanks to its anti-ischemic properties, it is used to reduce the severity of dizziness. Preductal tablets, which eliminate unpleasant noise in the ear area, best expand the sound range if a person has disorders of sound-receiving structures, for example, with perceptual deafness.
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Contraindications
Taking Preductal is contraindicated if:
- sensitivity to it;
- Parkinson's disease, symptoms of parkinsonism, tremors, restless legs syndrome and other movement disorders;
- severe renal failure ;
- under 18 years of age;
- lactation, pregnancy.
Caution is necessary when prescribing the drug to patients with severe or moderate hepatic and renal insufficiency.
Side effects
When taking Preductal MR, various undesirable reactions may develop that affect the functioning of the digestive, nervous, cardiovascular, circulatory, lymphatic and other systems.
This manifests itself as: abdominal pain, diarrhea, nausea, vomiting, constipation, dyspepsia, dizziness, headaches, tachycardia, irregular heartbeat, and so on.
Possible side effects that appear on the skin are rash, itching and urticaria.
Reviews
For the most part, reviews about the drug “Preductal” are positive. However, both specialists themselves and patients hold diverse points of view. Reviews on the forums are varied. One group of experts classifies the product almost as a dietary supplement. Others believe that the drug actually has a pronounced cardioprotective and anti-ischemic effect on the myocardium. At the same time, patients taking this drug for a long time indicate a significant improvement in their well-being.
Preductal tablets, instructions for use (Method and dosage)
Instructions for use Preductal MV recommends taking the tablets orally, in their entirety, with plenty of water.
This medicine is prescribed in a daily dosage of one tablet taken twice a day. Preferably in the morning and evening, along with food.
Detailed instructions Preductal MR reports that the duration of treatment is determined by the doctor. In this case, the drug can be taken in a maximum daily dosage of up to 70 mg.
It should be noted that the instructions for use of Preductal MR highlight the treatment of special groups of patients. Therefore, for example, for people with kidney failure, Preductal MR is prescribed in a daily dosage of 35 mg. It is better to take the medicine in the morning, along with breakfast.
During treatment of patients over 75 years of age, it is possible that increased exposure to trimetazidine may develop due to age-related decline in kidney function. The dosage of Preductal MB for this group of patients is selected only by a doctor.
Release form and composition
The drug is available in the form of sustained-release capsules: size No. 2, hard gelatin, with a white body and an orange-red cap, with the number “80” and the company logo printed on the cap in white; contents of the capsules are white or almost white spherical granules (in blisters: 9 pcs., 3 blisters in a cardboard pack; 10 pcs., 3 or 6 blisters in a cardboard pack; each pack also contains instructions for use of Preductal OD 80 mg).
1 capsule contains:
- active ingredient: trimetazidine dihydrochloride – 80 mg (in the form of film-coated granules);
- auxiliary components: sugar spheres 710–850 microns in size (sucrose, corn starch, starch hydrolysis products, dyes), hypromellose;
- composition of the film shell of the granules: ethylcellulose, tributylacetyl citrate, talc;
- composition for dusting granules: talc, magnesium stearate;
- capsule body composition: titanium dioxide (E171), gelatin;
- capsule cap composition: gelatin, titanium dioxide (E171), red iron oxide (E172);
- ink composition: shellac, simethicone, propylene glycol, titanium dioxide, ammonium hydroxide.
special instructions
It has been established that Preductal MV is not designed to relieve attacks of angina, therefore it is not recommended for use for the treatment of unstable angina, as well as myocardial infarction at the initial stage or in the first days of hospitalization.
The fact is that Preductal MB often causes or intensifies symptoms of parkinsonism, for example, tremor , akinesia and increased tone. For this reason, regular monitoring of patients is required. If the treatment is in doubt, then an appropriate examination by a neurologist is necessary.
If movement disorders appear, for example: symptoms of parkinsonism, restless legs syndrome, tremors, instability and unsteadiness of gait, you must immediately stop taking the pills. Such cases occur quite rarely and usually the symptoms disappear after discontinuation of the drug.
dizziness and drowsiness may occur . Therefore, during the treatment period, you should drive vehicles and perform work that requires quick reactions with the utmost caution.
What to choose: Preductal MV or Preductal OD?
Preductal MV or Preductal OD are drugs used to eliminate ischemia as part of complex therapy. They have both the same properties and some differences.
Preductal MV or Preductal OD are drugs used to eliminate ischemia as part of complex therapy.
Analogues of Preductal
Level 4 ATX code matches:
Vazonat
Phosphaden
Hawthorn fruit
Meldonium
Angiosil Retard
Ranexa
Lily of the valley tincture
Neocardil
Rimecore
Triductane
ATF-Long
Hawthorn tincture
Triductan MV
Trimectal MV
Trimectal
Neoton
Predisin
Trimetazidine
Tivortin Aspartate
Metamax
The drug Preductal and its analogues ATP-long, Triductan, Kratal and Trimetazidine can only be sold with a prescription. Similar drugs are prescribed by a doctor, and you can choose a substitute only with a responsible approach. The price of analogues may differ depending on the country and city, so it is better to find out the price of a specific medicine at the pharmacy.
Features of use and prescription of the drug
The duration of therapy is regulated by a doctor, the drug is taken 2-3 times a day (domestic analogues of the drug), when taken with food. The original French-made drug should be used 2 times a day - morning and evening.
Some patients look for reviews about Preductal in various online communities before using the medicine. But it should be remembered that the drug is prescribed in each case purely individually. The cardiologist selects the dosage for the patient, allowing him to reduce the frequency of nitroglycerin intake and control blood pressure.
And reviews about Preductal can be found diametrically opposite: some are very satisfied, while others do not notice the positive effect at all and are negative. Therefore, you should only rely on the advice of an experienced specialist with appropriate education.
In general, Preductal has proven its clinical effectiveness both in monotherapy and in combination with other drugs. A wide range of actions and good results during use make Preductal one of the most popular drugs for the treatment and prevention of cardiovascular diseases.
Before starting a preventive course of using Preductal, the patient should definitely consult with his doctor, who will determine the duration of use and dosage of the drug.
Reviews about Preductal
Numerous reviews of Preductal MB indicate that it should be taken with extreme caution. However, some users think differently, although they don’t even know exactly why the pills are prescribed by doctors.
Sometimes some specialists in the field of cardiology also show distrust of Preductal Mr. Therefore, reviews from cardiologists are varied. The fact is that the effect of Preductal has not been fully studied and more than one forum contains discussions on this topic. According to some experts, its effectiveness is equal to dietary supplements. Doctors prescribe a drug to improve the condition of the myocardium, constantly monitoring the patient’s condition, and if a positive result does not occur, they make an adequate replacement.
Interestingly, many patients who suffer from coronary heart disease and angina report that they feel significant improvement when treated with this drug. They also note a reduction in the number of attacks, which is what the medicine helps best with.
Thus, it becomes clear that Preductal Mr cannot be the only and main treatment, but it can significantly improve a person’s well-being. Such drugs help normalize metabolism and the functioning of the heart muscle, so they are also considered “vitamins for the heart.” Even if they do not restore heart health, they significantly improve the functioning of the body, preventing the development of any malfunctions and disorders.
Preductal tablets: what the medicine helps with and when it is prescribed
From the instructions for the medication it follows that the drug “Preductal” has an extensive list of conditions in which it can alleviate a person’s well-being:
- complex therapy of ischemic heart disease;
- prevention of frequent attacks of angina pectoris;
- elimination of manifestations of cochleo-vestibular disorders - precisely the ischemic nature of their occurrence;
- mitigation of symptoms of dizziness, tinnitus;
- various hearing impairments;
- chorioretinal pathologies.
Despite all the positive aspects of taking the medication, self-medication is not permissible - only a specialist should recommend monotherapy or complex treatment with the drug.
Preductal price, where to buy
The price of Preductal MV in pharmacies is 680-750 rubles.
The price of Preductal tablets depends on the content of the active substance.
You can buy medicine in Kharkov at a cost of 195 UAH.
You can buy Preductal in Moscow in almost any pharmacy with a prescription.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Preductal OD capsules extended action 80 mg 30 pcs. Pharmstandard-Leksredstva OJSC/LLC SERVIER RUS
765 rub. order - Preductal OD capsules extended action 80 mg 60 pcs. Pharmstandard-Leksredstva OJSC/LLC SERVIER RUS
1310 rub. order
Pharmacy Dialogue
- Preductal OD extended release capsules 80 mg No. 30FS.-Leksredstva
RUB 833 order
- Preductal OD (caps.prolon.high.80mg No.60)FS.-Leksredstva
RUB 1,391 order
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Pharmacy24
- Preductal MR 35 mg N60 tablets Lab.Serv e Industries, France/Anfarm Pidp.Pharmac.
AT, Poland/TOV Serdiks, Russia 176 UAH.order
PaniPharmacy
- Preductal MR tablets Preductal MR film-coated tablets 35 mg No. 60 France, Servier Industrie
199 UAH order
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Description and Instructions
Preductal is a drug designed to prevent hypoxia, that is, lack of oxygen in tissues.
The effect of this medicine on the metabolic processes occurring in the heart muscle is especially pronounced. But, Preductal also improves the condition of the retina, hearing, and functions of the vestibular apparatus. The active ingredient of this drug is trimetazidine. This component slows down the oxidation of fatty acids, changing the vector of biochemical processes to preferential breakdown of glucose, the main source of energy in cells.
During treatment with Preductal, there are no sharp fluctuations in blood pressure, the patient’s heart gradually begins to tolerate physical activity better, angina attacks occur less frequently, tinnitus goes away, and so on.
Preductal is produced in tablets with different dosages and different release patterns of the active component. The instructions for the drug describe its standard dosages for various lesions.
In principle, Preductal is low-toxic. It should not be taken if you have individual hypersensitivity. During pregnancy, breastfeeding, in the presence of severe damage to the liver or kidneys, as well as children and adolescents - that is, patients under eighteen years of age - it is not recommended to prescribe Preductal due to the fact that sufficient clinical studies of its possible effects have not been conducted for these groups of patients.
The drug Preductal is presented as round, biconvex, red, film-coated tablets. It is white at the break. The active element of the drug is trimetazidine dihydrochloride. 1 tablet of Preductal contains 20 mg of the substance.
Excipients:
- colloidal silicon dioxide;
- povidone;
- titanium dioxide;
- macrogol-6000;
- hypromellose;
- calcium hydrogen phosphate dihydrate;
- magnesium stearate;
- red dye iron oxide;
- glycerol
