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Manufacturers: Moscow Pharmaceutical Factory (Russia)
Active ingredients
- Sulodexide
Disease class
- Not indicated. See instructions
Clinical and pharmacological group
- Not indicated. See instructions
Pharmacological action
- Not indicated. See instructions
Pharmacological group
- Anticoagulants
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
An anticoagulant drug that has antithrombotic, fibrinolytic and angioprotective effects. Sulodexide is an extract of the mucous membrane of the small intestine of animals, which contains a heparin-like fraction and dermatan sulfate. Suppresses blood coagulation factors Xa and Pa, reduces the concentration of fibrinogen in the blood. Increases the concentration of plasminogen. The angioprotective effect is associated with restoration of the integrity of endothelial cells.
The drug, by reducing the concentration of triglycerides and reducing blood viscosity, normalizes rheological properties. In large doses, an anticoagulant effect occurs if the drug is administered intravenously.
Pharmacokinetics
When administered intravenously, it is quickly distributed throughout tissues and organs. About 90% of the active substance is absorbed in the endothelium. Cmax when administered intravenously is achieved within 5-15 minutes. The difference from heparins is that the active substance is not desulfated, so its antithrombotic activity is not reduced and is not eliminated from the body so quickly. It is metabolized in the liver and excreted by the kidneys—about 50% within 24 hours.
Angioflux: capsules and solution
In this medical article you can familiarize yourself with the drug Angioflux. The instructions for use will explain in what cases you can take 600 LE injections or 250 LE tablets, what the medicine helps with, what are the indications for use, contraindications and side effects. The annotation presents the forms of release of the drug and its composition.
In the article, doctors and consumers can only leave real reviews about Angioflux, from which you can find out whether the medicine helped in the treatment of thrombosis in adults and children, for which it is still prescribed. The instructions list analogues of Angioflux, prices of the drug in pharmacies, as well as its use during pregnancy.
The instructions for use classify the medicine Angioflux as a direct-acting anticoagulant.
Release form and composition
Angioflux is produced in the following dosage forms:
- capsules: soft gelatin, oval, brick-red; contents – a suspension of white or white-gray color, pink or pinkish-cream shade is possible (10 or 25 pieces in contour strip packs, 5 or 2 packs in a cardboard pack, respectively);
- solution for intravenous and intramuscular administration: transparent, from light yellow to yellow (2 ml in dark glass ampoules, 5 ampoules in a strip pack, 2 packs in a cardboard pack).
Active substance – sulodexide:
- 1 capsule – 250 lipoprotein lipase units (LE);
- 1 ampoule with solution – 600 LE.
pharmachologic effect
The anticoagulant drug Angioflux has angioprotective, fibrinolytic and antithrombotic effects. The mechanism of action of the drug is associated with the interaction of both fractions, the antithrombotic effect is due to the suppression of blood coagulation factor IIa, activated by Xa, increased production of prostacyclin, and a decrease in the content of fibrinogen in the blood.
Profibrinolytic properties are caused by an increase in the content of tissue plasminogen activator in the vessels and a decrease in the concentration of tissue plasminogen activator inhibitor.
Angioprotective properties are provided by restoring the functional and structural integrity of the vascular endothelium, as well as restoring the density of the negative charge of the pores of the vascular membrane. Under the influence of the drug, the rheological properties of plasma are normalized by reducing the content of triglycerides, as the lipolytic enzyme is stimulated.
The effectiveness of treatment for diabetic nephropathy is determined by its ability to reduce the thickness of the basement membrane and the production of extracellular matrix by reducing the proliferation of mesangium cells.
In large doses, when administered intravenously, an anticoagulant effect may occur.
Angioflux injections
The instructions for use indicate that Angioflux solution is used IV (bolus or drip) or IM, 2 ml (1 ampoule) per day.
For intravenous drip administration, the drug is pre-diluted in 150-200 ml of 0.9% sodium chloride solution.
It is recommended to begin treatment with parenteral administration of the drug for 15-20 days, after which they switch to taking capsules for 30-40 days.
Pills
In the form of capsules, Angioflux should be taken orally in between meals - 1 piece. 2 times a day for 30-40 days.
The full course of treatment is recommended to be carried out 2 times a year.
The dose of the drug and duration of treatment can be adjusted by the doctor depending on the results of the clinical diagnostic examination of the patient.
Side effects
- nausea, vomiting;
- hematoma at the injection site;
- pain, burning;
- stomach pain;
- skin rash.
Children, pregnancy and breastfeeding
In the first trimester, medication should not be prescribed. In the second and third trimesters, the drug can be prescribed only as a last resort, if the benefit to the expectant mother outweighs the potential risk to the development of the fetus.
special instructions
Angioflux does not affect the speed of psychophysical reactions and the ability to concentrate.
If concomitant use of antiplatelet agents or anticoagulants is necessary, blood coagulation parameters should be periodically monitored.
Drug interactions
When using the drug Angioflux, its possible interaction with other groups of drugs should be taken into account.
Due to the risk of developing undesirable side reactions, this drug is not recommended to be taken simultaneously with drugs from the group of direct and indirect anticoagulants, as well as with antiplatelet agents.
Analogs of the drug Angioflux
Analogues are determined by structure:
- Wessel Due F;
- Sulodexide.
Anticoagulants have a similar effect:
- Sodium citrate;
- Fragmin;
- Venolife;
- Medical leech;
- Dolonite;
- Eliquis;
- Arixtra;
- Detragel;
- Dolobene;
- Pradaxa;
- Heparoid;
- Antithrombin 3 human;
- Flenox Neo;
- Gepalpan;
- Heparidex;
- Enixum;
- Klivarin;
- Wessel Due F;
- Heparin;
- Bystrum Sprint;
- Nigepan;
- Viatromb;
- Emeran;
- Thrombophobe;
- Troparin;
- Venabos;
- Trombless;
- Essaven;
- Phenilin;
- Warfarin;
- Warfarex;
- Angiox;
- Ellon gel;
- Marewan;
- Fluxum;
- Nadroparin calcium;
- Seprotin;
- Clexane;
- Fraxiparine;
- Lyoton;
- Xarelto;
- Hemapaxan;
- Thrombogel;
- Dry grape leaf extract;
- Pelentan;
- Acenocoumarol;
- Troxevasin Neo;
- Sinkumar;
- Enoxaparin;
- Anfiber;
- Angioflux;
- Skinlight;
- Hepatrombin;
- Piyawit;
- Calciparin.
Vacation conditions and price
The average cost of Angioflux (capsules No. 50) in Moscow is 2510 rubles, 10 ampoules can be bought for 1720 rubles. Dispensed by prescription.
The drug should be stored at a temperature of no more than 30 degrees in a place inaccessible to children. Shelf life – 3 years.
Source: https://instrukciya-po-primeneniyu.ru/angioflyuks.html
Reviews about Angioflux
Most often there are reviews and discussions of taking this drug during pregnancy. One of the physiological features of the female body during this period is an increase in blood clotting. High levels of estrogen will provoke thrombosis, so constant monitoring of d-dimer levels is necessary as a marker of fibrin formation. In case of positive tests for fibrin formation markers, antithrombotic therapy is immediately prescribed.
They especially monitor the state of hemostasis and pay attention to this indicator after IVF, since d-dimer after embryo transfer can increase sharply and affect implantation and pregnancy. According to patient reviews, it is mandatory to study the state of hemostasis already at the IVF planning stage, and if this indicator is higher than the norm for planning, then Angioflux was prescribed to everyone.
- “... The doctor prescribed me Angioflux tablets for a month in preparation for IVF.”
- “... I take two capsules a day, prescribed before IVF.”
- “... I had a successful protocol on Angioflux, I took it before and after IVF.”
- “... I think the drug is effective. I saw it in the protocol after taking d-dimer.”
- “... They discovered the Leiden mutation, and the hematologist immediately prescribed Angioflux, this in addition to heparins!”
- “... I have the Leiden mutation - hence all the problems with conception, miscarriages and failure to carry a pregnancy to term. This medicine was prescribed.”
- “... I drank throughout my pregnancy, at first I was prescribed 2 capsules a day, and when heparins were added, 1 capsule. There were no side effects."
- “... Before the protocol, I drank it for a month, in the protocol they gave injections until the 25th week.”
- “...I have a blood clot after childbirth. I’ve been injecting Fraxiparin for two months, now I’m taking Angioflux.”
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** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use the drug Angioflux, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.
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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Angioflux is provided for informational purposes and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!
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Angioflux: instructions for use of capsules and solution
Latin name: angioflux ATC code: B01AB11 Active ingredient: sulodexide Manufacturer: Mitim, Italy Dispensed from the pharmacy: By prescription Storage conditions: up to 30 degrees Shelf life: 3 years.
Angioflux can be used if there is an increased risk of thrombosis in people with high blood viscosity.
Indications for use
These include:
- Risk of thrombotic blood clots
- Ischemic disease of the lower extremities
- History of nephropathy and retinopathy
- Macroangiopathy due to diabetes.
Composition and release forms
1 capsule contains 250 LE of the active ingredient, and the injection solution consists of 300 LE per 1 ml.
Capsules and injection solution, 2 ml per package. Ampoules 5 pieces in a pack.
Medicinal properties
Angioflux is an anticoagulant and has fibrinolytic, anticoagulant and antithrombotic pharmacological properties. Sulodexide is a concentrated extract of the small intestinal mucosa of cattle.
The substance contains heparin-like elements and dermatan in sulfate form. Ultimately, after use, suppression of coagulation factors occurs, and fibrinogen content decreases, in parallel, plasminogen concentrations increase.
The drug is also capable of restoring endothelial cell structures.
Angioflux lowers levels of bad cholesterol in the body, improves the rheological properties of blood, and in large dosages acts as an anticoagulant. A more pronounced effect on the body occurs with intravenous injections.
After parenteral administration, the substance quickly disperses throughout the body, and 90% of the administered dosage enters the endothelium. The peak concentration of the substance in the blood is observed after 10 minutes.
The drug is completely eliminated from the body, without prior metabolization in the liver, through the kidneys in two days.
Directions for use and doses
The average cost of the medicine is 1,423 rubles per package.
The duration of therapy and dosage are selected individually for the patient. You can administer the medicine intramuscularly or intravenously at 600 units, up to two weeks inclusive.
Next, capsules are used after a two-week period of use, 250 units 2 times a day, for a month and a half.
It is advisable to carry out therapy 2 times a year and at the same time monitor blood clotting indicators.
During pregnancy and breastfeeding
Angioflux is not prescribed to pregnant and nursing mothers, as it is contraindicated.
Contraindications and precautions
Angioflux should not be prescribed in the following cases:
- In case of severe sensitivity and intolerance to the substance or any of the components in its composition
- With a pronounced tendency to hemorrhage
- During pregnancy and breastfeeding
- With reduced blood clotting rates.
Cross-drug interactions
Antiplatelet agents and other blood thinning substances cannot be prescribed in parallel, since the anticoagulant effect is potentiated, which can provoke the appearance of severe hemorrhages.
Side effects and overdose
These include:
- Painful sensations in the stomach
- Pain and burning sensation
- Skin rashes
- Vomiting and nausea
- Bruises and hemorrhages at injection sites.
Typically, an overdose of antiflux manifests itself in the form of severe bleeding. If this happens, you just need to stop the drug.
Heparin
Sintez OJSC, Russia
The average cost of the medicine is 27 rubles per package.
Heparin is used to treat various pathological conditions associated with increased blood viscosity. This substance is produced in the form of injection solutions, ointments and gels for external use.
This anticoagulant is much cheaper and more effective; it has also been used in medical practice for a long time, as it has repeatedly proven its effectiveness. Heparin sodium can treat varicose veins when applied topically.
Heparin gels are good for removing bruises.
Pros:
Minuses:
- If used improperly it will cause harm
- There are contraindications.
Download instructions for use
The drug "Angioflux" Download instructions "Angioflux" 52 kb
Source: https://lekhar.ru/lekarstva/preparaty-dlya-krovi/angiofljuks-instrukcija-po-primeneniju/
Angioflux injections - instructions for use, price, analogues
Direct acting anticoagulant. Application: thrombus formation, ischemia, macroangiopathy. Price from 1825 rub.
Analogs: Heparin, Clexane, Wessel Due F.
What kind of drug
Angioflux injections are a drug that belongs to the pharmaceutical group of drugs that normalize the blood coagulation system and prevent the formation of blood clots in blood vessels.
The product in the form of a solution can be administered intramuscularly or as a bolus, due to which it begins to affect the problem area 15 minutes after administration.
Composition and active substance
In 1 milliliter of solution there are 300 LE of the active component sulodexide.
Additional substances are sodium chloride and water for injection. The product is available in a cardboard pack of 10 ampoules.
Pharmacodynamics and pharmacokinetics
The active component of the drug, sulodexide, is able to eliminate the blood clotting factors Xa and Pa, and also reduces the level of fibrogen in the blood and increases the concentration of plasminogen. And its anti-protective effect on blood vessels is primarily associated with the restoration of the integrity of blood vessels.
In the case of intravenous administration, the drug is evenly distributed throughout the body in a matter of minutes. 90% of the active component of Angioflux is absorbed by the endothelial part.
The maximum concentration of the drug in the blood is achieved after 5-15 minutes when administered intravenously. The main difference from the heparin group is that the active substance is not desulfated.
Thanks to this, its antithrombitic effects are not reduced and are not removed from the body for a long time. The drug is metabolized in liver cells - about 50% within 24 hours.
Directions for use and dosage
The instructions for use of Angioflux state that it is used only for internal and intramuscular administration. The daily dose should not exceed 1 ampoule (2ml).
In the case of intravenous administration, before the injection, pre-dilute in 1500-200 milliliters of 0.9% sodium chloride solution. The duration of the therapeutic course does not exceed 20 days.
After this, the patient is prescribed oral administration of the drug in capsule form.
In childhood, during pregnancy and pregnancy
The product is strictly forbidden to use during the 1st trimester of pregnancy. In the future, Angioflux injections are used only in case of emergency. During lactation, the drug is not recommended for use.
Angioflux – for venous diseases
Diseases of the cardiovascular system are considered one of the most common problems; such pathologies are common among people who exhibit changes in the veins (blood clots, cholesterol plaques).
All these ailments are caused by an incorrect lifestyle, frequent exposure to the wrong position, and an unbalanced diet.
If problems with the veins occur, you should immediately consult a doctor, otherwise you may lose your ability to work.
One of the effective drugs in such cases is Angioflux, which should be taken only as prescribed by a doctor.
The drug has virtually no contraindications or side effects; in some cases, dosage adjustments are provided.
Release form, composition
Angioflux is available in capsules and ampoules, 1 capsule contains 250 lipoprotein lipase units (LU) of sulodexide, 1 ml of solution contains 300 LU of sulodexide.
Sulodexide is an extract of the mucous membrane of the small intestine of animals, which includes substances such as dermatan sulfate and heparin-like fraction. The capsules also contain glyceryl caprylocaprate, sodium lauryl sulfate, colloidal silicon dioxide.
The capsule shell contains the following auxiliary components: red iron oxide dye, glycerol, sodium ethyl parahydroxybenzoate, sodium propyl parahydroxybenzoate, gelatin.
The oval-shaped capsules are red in color, packaged in 10 or 25 pcs in blister packs, in a cardboard pack of 2.5 packs.
The solution is transparent, 2 ml ampoules, 5 ampoules in a cell package, 2 pcs in a cardboard box.
Drug interactions
Angioflux enters into drug interactions very rarely; when taken simultaneously with antiplatelet agents or anticoagulants, it is necessary to periodically monitor blood clotting parameters. You should not take angioflux and heparin at the same time, as the effect of heparin is enhanced.
The attending physician should be informed about all diseases and other medications taken.
Side effects
Taking the medicine may be accompanied by the following side effects:
- allergic reactions;
- abdominal pain;
- nausea.
If allergic reactions occur, immediate consultation with your doctor is required; in such cases, replacing the drug or adjusting the dosage is indicated.
During pregnancy
The medication should be discontinued in the first trimester of pregnancy; in the 2nd and 3rd trimesters, use is allowed only if the benefit to the woman’s health outweighs the likely risk to the fetus.
Storage conditions and periods
| Storage conditions | It should be stored in a dry place, it is important to take into account the level of humidity, the place should be protected from children. |
| Storage temperature | The temperature should not exceed 30 degrees and be at least 5 degrees. |
| Best before date | Is 3 years |
Price
The cost of Angioflux in Russia for 50 capsules is 2,500 rubles, 10 ampoules of the solution can be purchased for 1,700 rubles.
A package in Ukraine of 50 capsules is sold for 1200 UAH, 10 ampoules of solution - for 890 UAH.
Analogs
Analogues of Angioflux based on the active substance are sulodexide and Wessel Due f.
Reviews
There are not very many reviews about the drug Angioflux on the Internet; there is practically no information on the forums. In existing reports, people write about the effectiveness of the drug for pain in the legs, burning in the feet - pathologies that often accompany diabetes.
Patients note improved blood circulation and a positive effect on damaged nerves. The effect is observed within a week after the start of treatment, the condition of the venous system begins to noticeably improve.
Most patients indicated the absence of any side effects after the injections; there were practically no marks from the injections or they quickly disappeared. Against the general background, there is also an improvement in health; patients report that their legs get less tired, they can move more without additional effort, and there is no pain.
At the same time, people warn that during therapy they should not overload themselves.
Patients who completed the course of treatment emphasized that they were able to achieve the desired effect (reducing blood clotting, improving the condition of the venous system), they did not need to take other medications, with the exception of general strengthening ones.
Patients with increased blood clotting speak with caution about angioflux; in any case, the therapy process is under the supervision of a doctor.
Most sick patients were required to undergo a coagulogram to detect blood clotting; a conclusion about the effectiveness of therapy had to be made based on the data obtained.
After treatment, 85% of people did not need additional therapy over the next 6 months, 98% of patients had no problems with the cardiovascular system, pain in the legs disappeared, blood pressure normalized, and overall positive dynamics were noted.
Doctors say that angioflex is a necessary medication for diabetes; it allows you to get rid of such negative consequences of the disease as heart rhythm disturbances, attention and memory disorders. Experts write that self-medication is strictly contraindicated; therapy requires doctor’s supervision.
Conclusion
- Angioflux is prescribed for vein pathologies associated with increased blood clotting; the action of the active components is aimed at restoring arteries, blood vessels, and cell membranes.
- The drug is available in capsules and solution, the cost is quite high, there are very few analogues.
- The medicine is not recommended for use in the first trimester of pregnancy and has a limited range of contraindications and side effects.
- Angioflex practically does not enter into drug interactions; patients with open wounds and patients who have undergone surgery should be careful.
Source: https://upheart.org/lechenie/tabletki/angioflyuks-pri-zabolevaniyakh-ven.html
