The drug Pregabalin Canon (25, 50, 75, 100, 150, 200, 300 mg) from the manufacturer

Has restrictions during pregnancy

Prohibited during breastfeeding

Prohibited for children

Has restrictions for older people

Has limitations for liver problems

Has limitations for kidney problems

On pharmacy counters you can find many products that help with epileptic and convulsive attacks. The drug Pregabalin Canon is especially popular. According to the instructions, this remedy is effective for convulsive activity of any etiology, as well as for neurological pain.

Composition and effect of the drug

The main active ingredient of the drug "Pregabalin Canon" is pregabalin. It is an analogue of gamma-aminobutyric acid ((S)-3(Aminomethyl)-5-methylhexanoic acid).

The drug has antiepileptic and anticonvulsant properties, as well as an analgesic effect on the body.

What is this impact based on? How does the drug work? Its anticonvulsant and analgesic effect is explained by the fact that Pregabalin binds with a2-delta protein to calcium channels in the central nervous system and replaces gabapentin, which is similar to gamma-aminobutyric acid.

When taken on an empty stomach, it is absorbed faster. The maximum concentration in the blood after a single dose is reached after 1 hour. If you take the drug simultaneously with food, the time of maximum concentration in the blood decreases, and the time for the onset of the therapeutic effect increases by 2.5 hours. But in general, food intake does not affect the total absorption time of the active substance. Pregabalin does not bind to plasma proteins and penetrates well through the hematoplacental barrier into breast milk.

“Pregabalin” is practically not broken down and is excreted unchanged by the kidneys, so for patients who have problems with the functioning of the main organ of the excretory system and are on hemodialysis, a lower dose of the drug is recommended, and it should be strictly monitored by a doctor.

In case of impaired liver function, the dosage is not reduced, since the drug has no effect on this organ.

What is Pregabalin prescribed for?

Summary of the article:

Surely, when visiting a pharmacy, many have more than once noticed a drug such as Pregabalin on the display window, for which the medicine is prescribed can be found in this article. In a nutshell, the medication is an anticonvulsant, which is extremely necessary for epilepsy or muscle cramps of various etymologies. On the pharmaceutical market, this product is considered one of the most effective of its kind.

Types and composition of the drug

Pregabalin has a powerful antiepileptic effect in a very short period of time, and also actively affects the mental activity of the patient. It is thanks to these qualities that the drug stands out among many alternative remedies.

The main component of the drug is pregabalin. It has another important property - it eliminates pain sensitivity.

You can notice the results from using an antiepileptic drug within a week. By this time, the frequency of seizures decreases markedly.

But it is worth considering that the absorption of the active substance will become much more effective if Pregabalin is taken on an empty stomach.

Auxiliary components of the drug are:

Hydrogenated starch hydrolysate;
Lactose disaccharide;
Magnesium chloride;
Titanium dioxide;
Gelatin;
Dyes.

The release form of Pregabalin is capsules with powder. They are intended for oral administration. On the shelves of pharmacies you can find the following types of medicine:

Pregabalin-Zenitiv;
Pregabalin-Canon;
Pregabalin-Richter.

The above types of medication differ only in the amount of the active component, but the method of use, indications and composition are identical.

Indications and contraindications

It is recommended to use the drug in the following cases:

Neuropathic pain caused by poisoning of the body or metabolic disorders (for example, diabetes mellitus);
Epileptic convulsions;
Fibromyalgia (pain in muscles, tendons and joints).

Often, a specialist prescribes treatment with Pregabalin in combination with other remedies for panic attacks.

There are no restrictions on taking the medication as such. However, doctors do not recommend using this anticonvulsant if:

Individual intolerance to the components of the drug;
Hereditary ailments. In this case, we are talking about those diseases that provoke disturbances in the metabolism and processing of carbohydrates. And all because the drug contains lactose, which is not tolerated by every organism;
Children under 18 years of age. The composition of Pregabalin is not safe and can harm the body that has not yet become stronger.

In addition, the use of the drug should be done with caution if the patient has pathologies of the heart, kidneys or liver. This should also include people who experienced these diseases in the past.

Use of Pregabalin

The instructions for the drug indicate the classic method of taking capsules. However, you should be aware that self-treatment with Pregabalin can lead to negative consequences, since the course of therapy and dosage are often selected individually by the doctor, based on the patient’s condition.

Typically, the anticonvulsant is taken up to 3 times a day, regardless of meals. The daily norm is no more than 600 mg.

The treatment plan depends on the type of disease:

Neuropathic pain. With this pathology, the doctor gradually increases the dose and concentration of the medication every four days until the symptom disappears;
Epilepsy. Dosage adjustments for such illness should be done carefully. For maximum results, it is necessary to increase the amount of medication no more than once a week;
Panic attacks. Treatment for the disorder is prescribed individually on a case-by-case basis. Changing the dosage without the consent of a specialist is prohibited;
Fibromyalgia. Pregabalin is taken no more than twice a day. After three days of therapy, the concentration of the healing agent can be increased.
The duration of the course is prescribed by a specialist based on the improvement or deterioration of the patient’s condition.

Application nuances

It is very important to become familiar with the following features of the drug:

It is not advisable to use the medication throughout pregnancy. Since its composition is not safe and can greatly harm the baby in the womb. Treatment with the drug is permitted only in extreme cases, when the life of the expectant mother is in danger. According to statistics, after taking the drug, most pregnant girls gave birth to children with serious pathologies or suffered miscarriages;
The drug is also prohibited during lactation, since there is no data on the effect of Pregabalin on a newborn. If a young mother urgently needs therapy with this medication, then breastfeeding must be stopped. Replacement with any other analogs is welcome, the composition of which does not negatively affect the born baby, but has the desired therapeutic effect;
Elderly people over 65 years of age should take this drug in a lower dosage, as the drug has a negative effect on kidney function. Treatment should take place exclusively under the supervision of a doctor.

These are the features of Pregabalin, for which the medicine is prescribed is now known.

about the effects of Pregabalin on the body

In this video you will learn how safe Pregabalin is:

Source: https://medic-23.ru/lekarstvennye-preparaty/502-pregabalin-ot-chego-naznachayut.html

Who is the drug prescribed to?

«Pregabalin canon" is prescribed to patients with the following diseases:

Fibromyalgia in adults.
Anxiety disorders in adults.
Pain that is neuropathic in nature.
For epilepsy as part of complex treatment of adult patients, in cases with partial convulsive seizures.

It is worth noting that if you have any of the pathologies listed above, you should not start taking the medicine without consulting a doctor.

Who should not take the medicine

It is necessary to pay attention to those who should not take a drug such as Pregabalin Canon. The instructions highlight the following categories:

Hypersensitivity to the components of the drug.
Children and teenagers under 17 years old. No studies have been conducted in this group.
It is not recommended for pregnant women, as no clinical trials have been conducted.
When breastfeeding. While taking the drug, stop breastfeeding temporarily.
Patients of childbearing potential must use effective contraception during drug treatment.

Prescribe and monitor with caution for the following diseases:

Renal dysfunction.
Heart diseases.
For diabetes mellitus.
History of encephalopathy.
Patients whose age exceeds 65 years.
Genetic diseases in which carbohydrates are poorly absorbed, since the drug contains lactose, which is not tolerated by everyone.

We looked at who is prescribed Pregabalin Canon tablets, what they help with and who should not use them. Next, let's talk about the forms of the medicine and its features.

Indications and restrictions for taking Pregabalin Canon

The medicine is used only in special cases. Indications for its use are:

Treatment of various types of epilepsy (generalized, focal, symptomatic) with or without seizures. In this case, the drug is prescribed as part of combination therapy as an additional antiepileptic drug.
Elimination of neuropathic pain syndrome. It may have central or peripheral localization.

NBS
An anxiety disorder that is not associated with specific objects or situations.
Chronic musculoskeletal pain of a symmetrical nature.

It is strictly forbidden to use the medication if there is an individual intolerance to the active substance or auxiliary components that are part of it, and during lactation (pregabalin passes into breast milk). It is also contraindicated to prescribe it to children and adolescents before reaching adulthood, since there is no data on its effect on the children's body.

In some cases, the medicine is used only in consultation with the attending physician. Among the restrictions are:

severe renal pathologies that negatively affect their functioning;
heart disorders (failure);
diabetes;
presence of encephalopathy;

Encephalopathy concept
dependence on certain medications;
combination with lorazepam, oxycodone, ethyl alcohol;
alcohol abuse;
old age.

The drug may have toxic effects. Therefore, sexually mature women should use reliable methods of contraception during treatment with Pregabalin. Directly during pregnancy, it is used only when the expected benefit is higher than the possible risk to the child.

Forms of release of the drug and dosage

The drug is available in the form of capsules with the following dosage: “Pregabalin Canon” 300, 200, 150, 75, 50 mg.

There is also a drug called Pregabalin Richter. It is also available in capsule form.

Depending on the disease and its neglect, the doctor may prescribe the following dosage of the drug:

The drug "Pregabalin Canon" 300 mg per day is prescribed for fibromyalgia. It is possible to increase the dose to 600 mg per day.
It is recommended to start treatment of neuropathic pain with 150 mg per day. Then, after a few days, the dosage can be gradually increased and increased to 300 mg. This will depend on the results of the treatment. After another week, take 600 mg per day.
Treatment of epilepsy begins with a dosage of 150 mg per day. The drug must be divided into several doses. "Pregabalin Canon" 300 mg instructions recommend starting use no earlier than 7 days, gradually increasing to this dose, and after another 6 days the dosage is increased to 600 mg per day.
For generalized anxiety disorder, treatment begins with a dosage of 150 mg per day and dividing the amount three times. Then after 7 days the dose is increased to 300 mg, but if there is no positive effect of the drug, the dose is increased to 450 mg. After another 7 days, if necessary, the dosage is adjusted to the maximum.
For anxiety attacks, the dosage is selected individually. The doctor must take into account the severity and characteristics of the course of the disease. It is not permissible to change the dosage without consulting a doctor.
If the patient has impaired renal function and is on hemodialysis, treatment is adjusted taking into account creatinine clearance. After undergoing a hemodialysis session, the patient is prescribed an additional dose of the drug.

You can take the drug at any time, regardless of meals. In some cases, doctors recommend taking it before bed to reduce the occurrence of adverse reactions.

I would like to note that it is unacceptable to skip taking Pregabalin Canon. The instructions for use indicate that you should take the missed dose as soon as possible. But you should not take the missed pill if it is time to take the next one.

Increasing the dosage on your own, without consulting a doctor, can be dangerous to your health.

Pregabalin canon instructions for use reviews

Pregabalin Canon: instructions for use and reviews

Latin name: Pregabalin Canon

ATX code: N03AX16

Active ingredient: pregabalin (Pregabalin)

Manufacturer: Kanonpharma production, CJSC (Russia)

Update of description and photo: 07/08/2019

Pregabalin Canon is an antiepileptic drug with anticonvulsant activity.

Release form and composition

The drug is available in the form of capsules: gelatin, with a solid structure, Pregabalin Canon 25 mg – No. 3, blue, Pregabalin Canon 50 mg – No. 3, yellow, Pregabalin Canon 75 mg – No. 2, dark yellow, Pregabalin Canon 100 mg – No. 1, blue, Pregabalin Canon 150 mg – No. 1, white body, yellow cap, Pregabalin Canon 200 mg – No. 0, white, Pregabalin Canon 300 mg – No. 0, yellow; the contents of the capsules are a powdery mass of almost white color with inclusions in the form of small compressed pieces or a compressed mass of almost white color, crumbling when pressed (in blister packs: 7 pcs., in a cardboard pack 2, 4, 6 or 8 packs; 10 each or 14 pcs., in a cardboard pack 1-4 packs; 15 pcs., in a cardboard pack 2 packs; 56 pcs. in a can, in a cardboard pack 1 can. Each pack also contains instructions for the use of Pregabalin Canon).

Composition of 1 capsule:

active ingredient: pregabalin – 25, 50, 75, 100, 150, 200 or 300 mg;
auxiliary components: mannitol, pregelatinized corn starch, magnesium stearate, talc;
capsule body and cap: gelatin, titanium dioxide.

In addition, the capsule shell contains:

dosage 25 mg: indigotine dye;
dosage 50 and 300 mg: quinoline yellow dye, sunset yellow dye;
dosage 75 mg: iron oxide yellow dye;
dosage 100 mg: proprietary blue V dye;
dosage 150 mg: cap – quinoline yellow dye, sunset yellow dye.

Pharmacodynamics

Pregabalin Canon is an antiepileptic drug with anticonvulsant activity. Its active ingredient, pregabalin, is an analogue of GABA (gamma-aminobutyric acid).

The mechanism of action of the drug is due to the ability of pregabalin to bind to alpha2-delta protein, which is an additional subunit of voltage-gated calcium channels (N, P or O type calcium channels) in the central nervous system, which leads to irreversible replacement of [3H]-gabapentin.

Presumably, this binding may contribute to the anticonvulsant and analgesic effects of Pregabalin Canon.

Pharmacokinetics

When taken orally before meals, pregabalin is rapidly absorbed from the gastrointestinal tract (GIT). Its maximum concentration (Cmax) in the blood plasma is achieved after 1 hour both with a single dose and with regular use of Pregabalin Canon. The bioavailability of pregabalin is at least 90% and does not depend on the dose taken.

With repeated dosing, steady-state concentrations of pregabalin are achieved within 24–48 hours. Simultaneous food intake reduces the rate of absorption, increasing the time to reach maximum plasma concentration by approximately 2.5 times and reducing Cmax by 25–30%.

It should be noted that food intake does not have a clinically significant effect on the overall absorption of pregabalin.

Pregabalin does not bind to plasma proteins.

The apparent volume of distribution is approximately 0.56 l/kg.

Pregabalin is almost not metabolized. 0.9% of the dose taken is metabolized to form an N-methylated compound, which is the main metabolite that is excreted by the kidneys. There were no signs of racemization of the S-enantiomer of pregabalin into the R-enantiomer.

It is excreted through the kidneys mainly unchanged. The half-life averages 6.3 hours. Plasma and renal clearance of pregabalin are directly proportional to creatinine clearance.

In the range of therapeutic doses, the pharmacokinetics of pregabalin is linear; it does not change with repeated use of the drug. Therefore, there is no need for regular monitoring of pregabalin concentration levels.

The gender of the patient does not have a clinically significant effect on the concentration of pregabalin in plasma.

If renal function is impaired, a dose reduction is required. During hemodialysis, pregabalin is intensively removed from the plasma; after a hemodialysis session lasting 4 hours, its plasma concentration decreases by approximately 50%. Therefore, after hemodialysis it is necessary to take an additional dose of Pregabalin Canon.

When liver function is impaired, the pharmacokinetics of pregabalin does not change significantly.

In patients over 65 years of age with impaired renal function, a dose reduction of Pregabalin Canon may be required.

The pharmacokinetic parameters of pregabalin at steady state in patients with epilepsy on antiepileptic therapy are similar to those in patients with chronic pain syndromes or healthy volunteers.

Indications for use

epilepsy - as an additional therapy in patients with partial convulsive seizures, which are accompanied or not accompanied by secondary generalization;
neuropathic pain;
generalized anxiety disorder;
fibromyalgia.

Contraindications

breast-feeding;
age under 18 years;
individual intolerance to the components of the drug.

Pregabalin Canon should be prescribed with caution in case of impaired renal function, heart failure, diabetes mellitus, a history of encephalopathy, concomitant therapy with lorazepam, oxycodone, ethanol-containing oral medications, a history of drug dependence, and in patients over 65 years of age.

During pregnancy, the use of the drug is possible only in cases where the benefit of therapy for the mother is much higher than the possible risk to the fetus.

Pregabalin Canon, instructions for use: method and dosage

Pregabalin Canon capsules are taken orally, regardless of food intake, swallowed whole (the integrity of the shell must not be damaged) and washed down with a sufficient amount of water.

The doctor determines the dose and duration of treatment taking into account the nature of the disease and the individual characteristics of the patient.

The prescribed daily dose of Pregabalin Canon should always be divided into 2-3 doses.

neuropathic pain: initial dose – 150 mg per day. With good tolerability and positive dynamics of therapy, after 3–7 days the dose, if necessary, can be increased to 300 mg, and after another 7 days - to a maximum daily dose of 600 mg;
epilepsy: initial dose – 150 mg per day. Taking into account the tolerability of Pregabalin Canon and the degree of effectiveness of treatment, after 7 days the initial daily dose can be increased to 300 mg, and after another 7 days - to 600 mg;
fibromyalgia: initial dose - 150 mg per day for 3-7 days, then, taking into account individual tolerance and the achieved effect, an increase in the dose of Pregabalin Canon to 300 mg is indicated. In the absence of positive dynamics, the dose is increased to 450 mg, then, if necessary, after 7 days - to 600 mg;
generalized anxiety disorder: 150 mg per day for 7 days, then, depending on tolerability and effect achieved, the dose can be increased to 300 mg. If the desired effect is absent, the dose is increased to 450 mg, after 7 days, if necessary, to 600 mg.

Treatment with Pregabalin Canon should not be stopped abruptly; if necessary, discontinuation of the drug should be done by gradually reducing the dose over at least 7 days.

If liver function is impaired, no dose adjustment is required.

If renal function is impaired, the dose should be prescribed taking into account CC (creatinine clearance), which is determined by calculation using serum creatinine.

So, to calculate the QC, it is necessary to multiply the patient’s body weight in kilograms by the difference, in which the minuend is 140, and the subtracted is his age in years. The result obtained is divided by 72 and multiplied by the individual serum creatinine.

For women, the result obtained is additionally multiplied by a factor of 0.85.

Recommended daily dosage of Pregabalin Canon for the treatment of patients with impaired renal function, taking into account CC:

CC more than 60 ml/min: initial dose – 150 mg, maximum dose – 600 mg, frequency of administration – 2-3 times a day;
CC from 30 to 60 ml/min: initial dose – 75 mg, maximum dose – 300 mg, frequency of administration – 2-3 times a day;
CC from 15 to 30 ml/min: initial dose – 25–50 mg, maximum dose – 150 mg, frequency of administration – 1–2 times a day;
CC less than 15 ml/min: initial dose – 25 mg, maximum dose – 75 mg, frequency of administration – 1 time per day.

The dose for patients on hemodialysis is selected individually, taking into account CC, and immediately after the end of the hemodialysis session, the patient is additionally prescribed from 25 to 100 mg of pregabalin.

For patients over 65 years of age with CC above 60 ml/min, no dosage adjustment is required.

If you accidentally miss the next dose of Pregabalin Canon, the missed dose can be taken if the time for the next dose has not yet arrived, and this would not correspond to taking two doses at the same time.

Side effects

During clinical trials and post-marketing surveillance, the following adverse reactions from systems and organs were recorded (classified by frequency of occurrence as follows: very often - ≥ 1/10 prescriptions; often - from ≥ 1/100 to

Education: First Moscow State Medical University named after I.M. Sechenov, specialty “General Medicine”.

Information about the drug is generalized, provided for informational purposes and does not replace official instructions. Self-medication is dangerous to health!

A person taking antidepressants will, in most cases, become depressed again. If a person has coped with depression on his own, he has every chance to forget about this condition forever.

Human blood “runs” through the vessels under enormous pressure and, if their integrity is violated, it can shoot at a distance of up to 10 meters.

Tooth decay is the most common infectious disease in the world, which even the flu cannot compete with.

According to WHO research, talking on a mobile phone for half an hour every day increases the likelihood of developing a brain tumor by 40%.

Over the course of a lifetime, the average person produces no less than two large pools of saliva.

The liver is the heaviest organ in our body. Its average weight is 1.5 kg.

When lovers kiss, each of them loses 6.4 calories per minute, but at the same time they exchange almost 300 types of different bacteria.

Source: https://u-druzey.ru/pregabalin-kanon-instrukcija-po-primeneniju-otzyvy/

What is the difference between the drug "Pregabalin Richter"

The drug "Pregabalin Canon" or "Pregabalin Richter" the difference is insignificant. The instructions are almost the same. They have the same indications and contraindications. Also, the dosage for the treatment of diseases is the same. The active ingredient is pregabalin. But each of these drugs has its own small feature:

The drug "Pregabalin Canon" is produced by a Russian manufacturer, which is its full owner. The medicine is available in the form of capsules from 14 to 56 pieces. in the package, depending on the amount of active ingredient. It can be from 50 mg to 300 mg.
The drug "Pregabalin Richter" is an analogue and is produced by a Russian company, but has a representative office in Hungary. Medicine in the form of capsules, 14 pcs. on 1 sheet. Pack contains 4 sheets. The amount of the main active ingredient ranges from 75 mg to 300 mg.

I would like to note that the difference between Pregabalin Canon and Pregabalin Richter is also the price. So, a Russian-made drug is cheaper than a Hungarian-made drug.

General information

Pregabalin-based drugs are widely used throughout the world for long-term treatment of epilepsy; drugs based on it are produced in different countries. Pregabalin Canon is produced by domestic pharmaceutical companies.

Drug group, INN, application

This medicine belongs to a large drug group - antiepileptic drugs. They help with various types of epilepsy to relieve attacks and treat pathology in general.

The international nonproprietary name is the name of the active component that is part of the drug and determines its effect on the body. The INN of Pregabalin is the same as the trade name. Only it still has the prefix Canon, which means the manufacturing company.

The drug is used to relieve convulsive and epileptic seizures. It is also used to treat neurological diseases.

Release form, cost

The medicine is produced in the form of oblong gelatin capsules, inside of which there is a white powder. The color of the capsule depends on the content of the active substance in it (blue, yellow, blue or white). Capsules are packed in plastic blisters of 7, 10, 14 or 15 pieces. The most common cardboard boxes are those containing 14, 30 or 56 capsules.

The cost of the drug depends on the content of the active component and the number of capsules in the package. The drug is available with a prescription. It is often not available in the most famous pharmacies in Russian cities. Average prices for the drug (in the Avicenna Pharma pharmacy chain, Moscow):

Drug, content of active substance, number of capsules	Cost in rubles per package
Pregabalin canon 75 mg No. 14	260
Pregabalin 150 mg No. 14	309-340
Pregabalin 300 mg No. 14	400-503
Pregabalin 300 mg No. 56	1600-1779

The drug at this pharmacy can be ordered in advance by phone or on the website. The medicine is available in other cities. For example, in St. Petersburg at the City-Pharm pharmacy Pregabalin 300 mg (56 capsules) can be purchased at a price of 1,820 rubles.

Possible adverse reactions

If the drug is taken incorrectly or its dosage is not observed, the following adverse reactions may occur:

Drowsiness.
Dizziness.
Confusion.
Impaired movement coordination.
Loss of sharpness of vision.

After prolonged use or sudden use, the instructions for use indicate what adverse reactions may occur:

Blood and lymph system: thrombocytopenia, leukopenia.
Heart diseases: chronic heart failure, tachycardia, sinus arrhythmia.
Nervous system: drowsiness, involuntary trembling of the limbs, dizziness, impaired attention and coordination, lack of taste, memory loss, stupor, fainting, memory impairment, decreased reflexes, convulsions, burning sensation on the skin, psychomotor agitation.
Psyche: confusion, feelings of euphoria, depression, decreased libido, depressed or excited mood, hallucinations, panic attacks, aggression or apathy.
Vascular manifestations: surges in blood pressure, cold extremities, hot flashes.
Visual organs: blurred vision, pain in the eyes, dryness, swelling or tearing of the eyes, narrowing of the field of vision, increased brightness of perception, loss of peripheral vision.
Musculoskeletal manifestations: spasms, pain in the limbs, swelling of the joints, muscle stiffness, muscle twitching.
Digestive organs: flatulence, bloating, vomiting, constipation, nausea, diarrhea, exacerbation of pancreatitis, dry mouth.
Respiratory organs: nasal congestion, snoring, cough, nosebleeds, shortness of breath, dry mucous membranes, pulmonary edema.
Reproductive and genitourinary organs: urinary incontinence, renal failure, erectile and sexual dysfunction, breast pain, amenorrhea.
Metabolism: increase or, conversely, decrease in body weight, anorexia, increased appetite
Skin: rash, urticaria, increased sweating, itching, swelling.
Immune system: allergic reactions, angioedema, hypersensitivity.
Encephalopathy may develop.

It is also possible to feel drunk, fall, pain, chills, fatigue, thirst. The most common side effect is confusion, anxiety and restlessness, and drowsiness.

If adverse events caused by an overdose occur, it is necessary to perform gastric lavage. Symptomatic therapy and, if necessary, hemodialysis are carried out.

It is worth noting that with prolonged use of the drug Pregabalin Canon, dependence may develop. This drug can be classified as a narcotic.

Therefore, before taking a drug such as Pregabalin Canon, instructions for use, reviews should be carefully studied and considered. When prescribing, the doctor must take into account all the factors of the current disease and the general condition of the patient’s body.

Instructions for use of the drug Pregabalin Canon and its analogues

General information

Drug group, INN, application

This medicine belongs to a large drug group - antiepileptic drugs. They help with various types of epilepsy to relieve attacks and treat pathology in general.

The drug is used to relieve convulsive and epileptic seizures. It is also used to treat neurological diseases.

Release form, cost

Drug, content of active substance, number of capsules Cost in rubles per package

Pregabalin canon 75 mg No. 14	260
Pregabalin 150 mg No. 14	309-340
Pregabalin 300 mg No. 14	400-503
Pregabalin 300 mg No. 56	1600-1779

Composition and pharmacological properties

The drug contains an active substance – pregabalin. 1 capsule may contain 25, 50, 75, 100, 150, 200 or 300 mg.

There are also additional components - corn starch, mannitol, talc, gelatin, magnesium stearate, titanium dioxide.

They are approximately the same for all capsules, only their concentration and the presence of one or another dye (yellow, blue iron oxide) differ.

Mechanism of action of Pregabalin

This substance is able to bind to an additional subunit in calcium channels, which leads to pain relief and a decrease in the frequency of seizures. This effect is observed after just a few days of using the medicine. Another property of the drug is anxiolytic (anti-anxiety).

Pharmacokinetic features:

absorbed in the digestive tract;
absorption occurs faster on an empty stomach; when eating it slows down;
the largest amount of the substance in the blood is observed 60 minutes after ingestion;
bioavailability (about 90%) does not depend on the dose taken;
if you drink the drug repeatedly, then the equilibrium concentration is observed after a day or two;
the active substance has practically no ability to be metabolized;
excreted unchanged in the urine;
half-life lasts about 6 hours.

People with impaired renal function and those on hemodialysis need to reduce the dosage of the drug. The same applies to older people.

Analogs

Often, to replace such a drug, structural analogues are selected - drugs based on pregabalin. They have the same mechanism of action, indications for use, contraindications and side effects. The most popular of them:

Algerica. An effective, but quite expensive product from Croatia.
Lyrics. A German drug, which is produced in the form of capsules for internal use, containing from 25 to 300 mg of the active ingredient. The medicine is very expensive (compared to its Russian counterpart), but is of high quality.
Pregabio. Antiepileptic drug based on pregabalin. The manufacturer is a well-known pharmaceutical company. Excellent value for money.

Such drugs differ only in the manufacturer, on whom the quality of the drug depends.

Indications and restrictions for taking Pregabalin Canon

The medicine is used only in special cases. Indications for its use are:

Treatment of various types of epilepsy (generalized, focal, symptomatic) with or without seizures. In this case, the drug is prescribed as part of combination therapy as an additional antiepileptic drug.
Elimination of neuropathic pain syndrome. It may have central or peripheral localization.
NBS
An anxiety disorder that is not associated with specific objects or situations.
Chronic musculoskeletal pain of a symmetrical nature.

In some cases, the medicine is used only in consultation with the attending physician. Among the restrictions are:

severe renal pathologies that negatively affect their functioning;
heart disorders (failure);
diabetes;
presence of encephalopathy; Concept of encephalopathy
dependence on certain medications;
combination with lorazepam, oxycodone, ethyl alcohol;
alcohol abuse;
old age.

Instructions for use

According to the instructions for use, Pregabalin Canon is recommended to be used according to the following rules:

Take capsules orally, preferably on an empty stomach. In this case, they are swallowed whole, washed down with liquid.
Take the daily dose in several doses (2 or 3).
The dosage depends on the nature of the pathology and the characteristics of the patient. It is determined by the attending physician. As a rule, treatment begins with 150 mg per day, which is divided into 2 or 3 times. Then it is doubled (up to 300 mg). If there is a need, you can increase the daily dose to the maximum (no more than 600 mg).
Dosages for neuropathic pain
Do not exceed the recommended daily dose, which is 600 mg.
If it is necessary to discontinue the medication, you should gradually reduce the dose over the course of a week until you completely stop taking it.
For patients with renal diseases, as well as those on hemodialysis, dose selection takes into account creatinine clearance.

Elderly people also require a dose reduction because their kidney function decreases with age. Patients with renal pathologies do not need dose adjustment.

Pharmacological interaction

Pregabalin can provoke the development of negative reactions when combined with certain medications:

If it is taken simultaneously with drugs that depress the nervous system (sedatives, hypnotics, antidepressants and others), then respiratory function may be depressed and a coma may occur.
Results of Pregabalin therapy
Simultaneous use with opium-based painkillers causes a negative effect on the digestive tract, which is manifested by constipation and intestinal obstruction.
The substance enhances the toxic effect of ethyl alcohol and lorazepam.
When interacting with oxycodone, the impairment of mental and motor activity that this substance can provoke increases.

Other medications do not have a significant effect on pregabalin because this component undergoes minimal metabolism, does not bind to blood proteins, and does not inhibit the metabolism of other substances.

Article on the topic: Instructions for use of Dobrokam and reviews of the drug

Features of use

When using the medication, some special instructions must be taken into account. Among them:

Patients with diabetes mellitus who take capsules with pregabalin require a reduction in the doses of hypoglycemic drugs (if weight gain is observed).
Elderly people should take the medicine with caution. They often experience falls and injuries due to adverse reactions (drowsiness, dizziness).
Patients may develop convulsions and petit mal seizures during treatment with the drug.
Some side effects (for example, visual disturbances) go away on their own without stopping the medication.
In case of angioedema reactions (swelling of the face, upper respiratory tract), the drug should be discontinued.

Most antiepileptic drugs, when taken continuously, can provoke negative thoughts about suicide and depression in the patient. Therefore, such people should be under the constant supervision of a psychiatrist.

Side effects and symptoms of pregabalin overdose

Tolerability of the drug depends on the individual characteristics of the person. Most often he experiences the following side effects:

inhibition of hematopoiesis (leukopenia, thrombocytopenia, anemia);
nasopharyngitis;
cardiac disorders (attacks of tachycardia, heart block, failure);
flushed face;
cold hands or feet;
surges in blood pressure (decrease or increase);
drowsiness;
dizziness and headache;
impaired coordination and balance;
problems with memory and attention;
sedation;
hand trembling;
depression, aggressiveness, anxiety, panic attacks;
twitching of eyelids;
numbness of body parts;
ataxia;
lethargic state;
cognitive disorders;
seizures;
problems with speech activity;
memory losses;
weakening of reflexes;
disturbance of taste sensations;
stupor;
fainting;
psychomotor agitation;
euphoric state;
confusion;
hallucinations;
decreased or increased sexual desire;
depression or elation;
vision problems (deterioration, tearing or dry eyes, keratitis, loss of vision);
deterioration of digestive function (flatulence, bloating, heartburn, diarrhea, constipation, nausea and vomiting);
pancreatitis;
ascites;
swelling of the throat and tongue;
nasal congestion, rhinitis;
development of cough;
dyspnea;
swelling of the lung;
muscle spasms, pain in the back and joints;
weight loss or gain;
urinary retention or incontinence;
menstrual irregularities in women, decreased potency in men;
allergic reactions on the skin (redness, itching, burning, rash, urticaria, erythema);
angioedema;
generalized or peripheral edema;
increase in body temperature.

In some cases, dependence on the medication may occur. However, after stopping its use (especially with long-term therapy), withdrawal syndrome may occur. The following signs are typical for this condition:

headache;
sleep problems;
flu symptoms;
attacks of nausea and vomiting;
depression;
development of seizures;
increased sweating;
anxiety.

When taking too high a dose of medication, mood disorders, drowsiness, confusion, anxiety and restlessness are observed. In case of overdose, the patient is given gastric lavage, sorbents are given and, if necessary, hemodialysis is used.

Doctors

Khoroshun P., neurologist: “Pregabalin is definitely a good remedy. Many people consider it an anticonvulsant, but I insist that it is more of an analgesic. That’s why I use it to eliminate neurological pain. My patients are happy. For epilepsy I prescribe completely different medications. This, in my opinion, is rather weak.”

Patients

Anna, 35 years old: “I was diagnosed with trigeminal neuropathy a long time ago. Many means were used. But Pregabalin really helped. At first I took it at 75 mg, and when the pain intensified it reached 300. But it helps. The only problem is that it is often not available in pharmacies.

This medicine is registered, so it can be difficult to get it. I recently ran out of old packaging and needed a new one. I called all the pharmacies in my city. No. Let's go to the region. It's the same story there. I had to go to Moscow. And pharmacies sell the drug by pre-order. I suffered a lot."

Veronica, 32 years old: “A neurologist prescribed Pregabalin to me after I complained of anxiety. He said he would help. I took the medicine for about a month. Everything seems to have passed, the panic attacks have decreased. But terrible side effects arose - hand tremors, muscle spasms, headaches, weakness. I had to stop taking the drug, which is a pity. He helped me."

Pregabalin is an antiepileptic and analgesic drug that is widely used in medical practice. This remedy is used if there are appropriate indications. It can only be purchased with a special doctor's prescription.

Source: https://med-anketa.ru/instrukciya-po-primeneniyu-preparata-pregabalin-kanon-i-ego-analogi/

Features of use

Some features of the use of the drug "Pregabalin Canon" should be noted:

In diabetics, dosage adjustment is necessary in case of weight gain.
Elderly people need to be careful, especially since symptoms such as drowsiness, dizziness, and confusion were often observed when taking the drug.
Seizures or epileptic seizures are possible while taking the drug, as well as when it is discontinued. Therefore, it is not advisable to discontinue other anticonvulsants and antiepileptic drugs.
The occurrence of drowsiness may increase when taking antispastic drugs together.
Problems with the visual organs are temporary. They may appear and then disappear both while taking the drug and after its withdrawal.
If problems arise in the functioning of the kidneys, they will go away after stopping the drug.
Elderly people may develop chronic heart failure while taking the drug. This drug should be used with caution in this category of people. After its cancellation, such phenomena were not recorded.
If angioedema develops, you should stop taking the pills.
It is possible to develop a “withdrawal syndrome” after stopping its use. Therefore, it is necessary to discontinue the medicine gradually, over the course of a week, gradually reducing the dosage.
Cases of addiction development have been recorded. In such situations, medical supervision is necessary.
The drug "Pregabalin Canon " can cause suicidal thoughts and behavior, therefore, when taking it, constant monitoring is necessary in case of detection of depressive states, suicidal thoughts and behavior.
You should refrain from driving vehicles and machinery, as well as from performing work that requires great concentration. The drug may cause drowsiness, dizziness and other side effects described earlier.
You should strictly not drink any alcoholic beverages while taking Pregabalin Canon.

special instructions

The most common symptoms associated with the use of the drug are dizziness and drowsiness. Adverse events are usually mild or moderate. Depending on the subjective tolerability of Pregabalin Canon, side effects requiring discontinuation of treatment include: severe dizziness or drowsiness, confusion, ataxia, asthenia, blurred vision, impaired attention and/or coordination, peripheral edema.

Taking Pregabalin Canon in some cases causes drug dependence, which, when discontinued after long-term or short-term therapy, can be manifested by the following undesirable effects: headache, sweating, dizziness, nausea, insomnia, diarrhea, flu-like syndrome, depression, convulsions and anxiety. The dependence of the frequency and severity of manifestations of pregabalin withdrawal syndrome on the duration of treatment or dose has not been established.

It should be borne in mind that if body weight increases in patients with diabetes mellitus during drug therapy, it may be necessary to consider adjusting the doses of hypoglycemic agents.

Due to the fact that treatment may be accompanied by drowsiness and dizziness, confusion or loss of consciousness, impaired cognitive functions, which increase the risk of falls and accidental injuries, it is recommended to exercise caution until the patient evaluates the possible individual effects of Pregabalin Canon.

There is insufficient information about the possibility of discontinuing other anticonvulsants when seizures are suppressed with pregabalin and the advisability of monotherapy with this drug.

When prescribing Pregabalin Canon for the treatment of central neuropathic pain caused by spinal cord lesions, one should take into account the existing risk of increased incidence of adverse events from the central nervous system, including those caused by the summation of the effects of simultaneously taken drugs and pregabalin.

Violations of the organ of vision in most cases are transient and go away on their own.

Renal failure that occurs during pregabalin therapy is reversible; after discontinuation of the drug, renal function is restored.

It should be taken into account that when using Pregabalin Canon in elderly patients suffering from impaired cardiac function and receiving the drug for neuropathy, the risk of developing chronic heart failure increases.

If combination therapy with opioid analgesics is necessary, simultaneous preventive measures are recommended to prevent constipation and intestinal obstruction, especially in elderly patients.

If symptoms of angioedema develop (facial edema, perioral edema or edema of the tissues of the upper respiratory tract), Pregabalin Canon should be discontinued immediately.

When prescribing the drug, the doctor must inform the patient about the possible development of dependence during treatment with pregabalin. Careful medical monitoring of patients with a history of drug dependence is required.

During therapy with Pregabalin Canon, the risk of suicidal thoughts or behavior increases. In this regard, patients need careful monitoring by loved ones for the onset and worsening of depression, including suicidal thoughts or behavior.

Impact on the ability to drive vehicles and complex mechanisms

When treated with Pregabalin Canon, patients are advised to refrain from performing potentially hazardous activities, including driving vehicles and mechanisms that require increased concentration and high speed of psychomotor reactions, for a period until the individual effect of the drug on the development of side effects from the nervous system becomes clear. and the organ of vision.

Interaction with other drugs

Since the drug does not reduce or suppress the rate of chemical reactions in the body, it does not affect the metabolism of other drugs, and therefore does not interact with them.

However, attention should be paid to the combined use of certain medications.

Drugs that depress the central nervous system, together with Pregabalin Canon, can cause breathing problems, even leading to coma.
Opioid analgesics in combination with Pregabalin Canon have a negative effect on the functioning of the gastrointestinal tract. May cause constipation and intestinal obstruction.
The simultaneous use of Oxycodone, Lorazepam and Ethanol with Pregabalin can significantly enhance the effect of ethyl alcohol and Lorazepam. This manifests itself in impaired consciousness and motor functions. No effect on breathing was detected.
Oral contraceptives, when taken together with Pregabalin, did not change their effect on the body.

Studies have shown that the drug “Pregabalin canon ” does not have any interaction at the level of absorption, distribution and excretion with the following drugs:

"Valproic acid."
"Phenytoin."
"Carbamazepine".
"Lamotrigine."
"Lorazepam."
"Gabapentin."
"Oxycodone."
"Ethanol."

And also: Insulin, diuretics, Phenobarbital, Topiramate, Tiagabine and oral hypoglycemic drugs.

Next, let’s look at the reviews about the drug “Pregabalin Canon”.

Doctors' reviews about the drug

The drug has been used for a long time and is well known to doctors. You can hear different reviews from doctors about the drug Pregabalin. So many people note a positive effect in the treatment of epilepsy. A good effect is achieved when relieving neuropathic pain. Positive results for sleep disorders and anxiety conditions. In this case, the dosage is strictly controlled by the doctor.

Another category of doctors treats the drug with caution. Since this medicine is used to treat drug addicted patients. It is believed that such a medicine should be prescribed as a last resort, in case of very severe pain, in very small doses. The course of treatment should also be short so as not to cause addiction.

The task of each doctor is to determine the advisability of prescribing this drug and to monitor patients who use it. It is also necessary to warn those who are prescribed this medicine about all possible adverse reactions and the effect of drug withdrawal.

When prescribing a medication such as Pregabalin, it is important for a doctor to know patient reviews and tolerability of the drug’s components in order to exclude possible negative side effects.

It is worth noting that the drug “Pregabalin Canon” is sold in pharmacies only with a doctor’s prescription.

What are patient reviews about the drug “Pregabalin”? We will consider further.

Reviews of Pregabalin Canon

Doctors

Khoroshun P., neurologist: “Pregabalin is definitely a good remedy. Many people consider it an anticonvulsant, but I insist that it is more of an analgesic. That’s why I use it to eliminate neurological pain. My patients are happy. For epilepsy I prescribe completely different medications. This, in my opinion, is rather weak.”

Patients

Anna, 35 years old: “I was diagnosed with trigeminal neuropathy a long time ago. Many means were used. But Pregabalin really helped. At first I took it at 75 mg, and when the pain intensified it reached 300. But it helps. The only problem is that it is often not available in pharmacies.
This medicine is registered, so it can be difficult to get it. I recently ran out of old packaging and needed a new one. I called all the pharmacies in my city. No. Let's go to the region. It's the same story there. I had to go to Moscow. And pharmacies sell the drug by pre-order. I suffered a lot."