At what pressure and how to take Raunatin tablets correctly?

Medicine information

The drug Raunatin belongs to the group of alkaloids. It is characterized by a minimal range of contraindications and a huge number of useful properties, thanks to which it is successfully used in the medical field to combat various pathologies.

Release form

On the modern pharmaceutical market, the medicine for blood pressure Raunatin is presented in the form of tablets with a greenish tint, convenient for dosing and use. The drug is sold in a cardboard box containing from 5 to 10 blisters (10 tablets each).

Packaging of Raunatin tablets

Composition of tablets

The main active components of the drug Raunatin are alkaloids, extracts of the rhizome of emetic rauwolfia and snake rauwolfia in a dosage of 2 mg.

Tablets include auxiliary elements such as talc, aerosil, titanium dioxide, starch, stearic acid.

Price and terms of sale

The price of Raunatin tablets varies from 90 to 160 rubles (depending on the number of capsules in the package). You can purchase medicine in pharmacy chains absolutely freely. A doctor's prescription is not required for this.

Storage conditions

It is recommended to store the drug in a place protected from moisture and direct sunlight. The optimal storage temperature is about +20 C. The maximum shelf life of the tablets is 3 years from the date of production.

General information about the drug

Raunatin is a herbal preparation. Belongs to the group “rauwolfia alkaloids and other antihypertensive drugs of plant origin.” The international nonproprietary name is ceftibuten.

Forms and cost

It is available in tablet form and is a weakly active antihypertensive combination drug. Each tablet is film-coated and light green in color. The dosage of the active substance is 2 mg. The drug is sold in cardboard packages of 50 or 100 tablets.

The cost of packaging varies between 90-160 rubles. This allows us to classify the drug as one of the inexpensive but effective remedies for arterial hypertension. The cost of the drug differs depending on the number of tablets in the package (Table 1). The drug is available without a prescription, which also makes it popular among patients.

Table 1 – Cost of Raunatin

Compound

One tablet contains 2 mg of the active substance – raunatin. Additional components include:

1. Potato starch.
2. Talc.
3. Beeswax.
4. Pigmented titanium dioxide.
5. Gelatin.
6. Cross-povidone.
7. Stearic acid.
8. Cerulesum.
9. Calcium stearate and others.

This composition allows the drug to act gently on the body without causing side effects when used correctly.

Pharmacokinetics and pharmacodynamics

Raunatine is obtained from the roots of rauwolfia, isolating a group of alkaloids, including ajmaline, reserpine and serpentine. When converted to dry matter, their total content is at least 90%.

The drug has a pronounced hypotensive effect and has an antiarrhythmic effect. A slight calming effect is also noted.

Rauwolfia alkaloids

The hypotensive effect occurs due to a decrease in the content of norepinephrine, dopamine, and serotonin in the central nervous system, in particular in the structures of the hypothalamus.

By disrupting the processes of mediator deposition in the vesicles of the presynaptic membrane of peripheral adrenergic nerve endings, the vascular wall, and the adrenal medulla, Raunatin blocks adrenergic transmission, which causes a decrease in blood pressure.

The drug actively affects the functioning of the kidneys, in particular, it increases their glomerular filtration, and, accordingly, blood flow in the organs.

Raunatin is well tolerated by patients, and the therapeutic effect develops slowly, but is persistent. After taking the tablet, the active substance is absorbed through the gastrointestinal tract and enters the blood. This process proceeds quite slowly, which reduces the likelihood of side effects.

About 60% of the drug is excreted in feces, and 8% in urine through the kidneys. The half-life ranges from 45 to 168 hours.

Pharmacodynamic characteristics

Blood pressure tablets Raunatin have a pronounced hypotensive effect. The therapeutic effect is due to the ability of the drug to reduce the concentration of the hormone norepinephrine, serotonin and dopamine.

Raunatin lowers blood pressure smoothly and gradually, which is considered an advantage of the drug, as well as its ability to activate glomerular filtration processes localized in the renal canals, increasing blood flow in the renal apparatus.

The tablets stabilize the psycho-emotional state of the user, have a moderate sedative effect, relieve anxiety and tension, stabilize the heart rhythm, eliminating manifestations of arrhythmia.

The drug has a cumulative effect, so therapeutic results become noticeable after 1.5-2 weeks of treatment. Blood pressure levels are fully stabilized after a 2-3 month course of Raunatin tablets.

Raunatin has a cumulative effect, so you should complete the full course of treatment with the drug

What does Raunatin help with?

Doctors recommend taking Raunatin for high blood pressure, users who have the following clinical indications:

• Diseases of a cardiac nature;
• Arterial hypertension;
• Rapid heartbeat (tachycardia);
• Hypertonic disease;
• Thyrotoxicosis, accompanied by increased blood pressure, rapid pulse and heart rhythm disturbances;
• Diseases of the gastrointestinal tract of an infectious or parasitic nature.

In most cases, tablets are prescribed to patients with diagnosed hypertension to reduce blood pressure, improve blood supply to the kidneys, and strengthen the cardiovascular and central nervous systems.

When use is contraindicated

Raunatin for high blood pressure is strictly prohibited for use by patients with the following clinical contraindications:

• Bronchial asthma;
• Nephrosclerosis;
• Ulcerative lesions of the gastrointestinal tract;
• Individual intolerance and excessive sensitivity to the components included in the tablets;
• Hypotonic disease (low blood pressure);
• Severe form of depression;
• Aortic defects;
• Violation of coronary circulation processes;
• Biliary dyskinesia;
• Myocardial pathologies;
• Colitis;
• Parkinson's disease;
• Cerebral atherosclerosis;
• Pheochromocytoma;
• Severe heart failure;
• Epileptic syndrome;
• Bradycardia (slow heart rate).

Despite the fact that the drug is good for blood pressure, using the tablets to treat minor patients, women expecting the birth of a baby or breastfeeding is strictly contraindicated!

The drug should be taken strictly as prescribed by the doctor

Features of application

Taking Raunatin should be supervised by a doctor. Before surgical interventions, Raunatin should not be used for several days. Do not continue treatment with the drug before an electropulse therapy session.

Raunatin is contraindicated for pregnant and lactating women, as alkaloids pass into breast milk and cross the placenta.

Reviews about Raunatin are such that the substances included in the drug interfere with the patient’s ability to react quickly during the first time of treatment. Therefore, it is worth abandoning dangerous activities and driving a vehicle.

Instructions for use for hypertension

Instructions for use of Raunatin recommend taking the tablets immediately after meals. The optimal dose and treatment regimen are determined by a qualified specialist on an individual basis. Dosage for blood pressure in hypertensive patients is calculated as follows:

• On the first day of therapy - 1 tablet of the drug before going to bed;
• On the second day - 2 tablets, which should be taken with a temporary break of 12 hours;
• On the third day, the dose is increased to 3 tablets of Raunatin.

Gradually, the dosage of the drug increases to 5-6 tablets throughout the day, which are taken at equal time intervals, preferably at the same hours. After 2 weeks of the therapeutic course, the daily dose of Raunatin also begins to be smoothly and gradually reduced.

The average duration of treatment is determined individually. In most cases, doctors recommend drinking Raunatin for high blood pressure for 3-4 weeks.

For preventive purposes, the drug is taken in a dosage of 1 tablet throughout the day.

Special instructions and recommendations

Despite the natural composition and a slight range of restrictions, the drug can only be taken as prescribed by a doctor. The specialist also determines the optimal dosage, dosage regimen and duration of the therapeutic course with Raunatin for a particular patient.

If surgery is planned, the pills should be stopped a few days before the date of the intended operation.

In patients with diagnosed coronary artery disease, the medication can provoke angina attacks. In such situations, it is necessary to consult a doctor about temporarily stopping treatment or adjusting the daily dosage of Raunatin.

Since the drug is characterized by the presence of sedative and sedative properties, at the beginning of therapy it is recommended to refrain from driving a car and other activities that require quick reactions and extreme concentration. If there is no effect on cognitive functions, you can return to your usual lifestyle.

Raunatin can cause a decrease in concentration, so it is better not to drive during treatment with the drug

Raunatin

Raunatin is an antihypertensive drug of plant origin based on rauwolfia alkaloids. In addition to the “profile” antihypertensive. It also has an antiarrhythmic effect. Unlike reserpine (another drug obtained from Rauwolfia serpentine), raunatin exhibits a sedative effect to a much lesser extent. At the same time, the antihypertensive effect of both drugs is comparable in strength, and raunatin is superior to reserpine in terms of tolerability. The main indication for the use of raunatin is arterial hypertension (we are talking here primarily about the I and II stages of this disease). The drug has not found wide use in psychiatric practice, due to its insufficiently expressed neuroleptic activity, but it can still be used for a number of neurotic conditions. The antihypertensive effect of raunatin develops somewhat more slowly than that of reserpine. This drug is a combination of alkaloids from rauwolfia roots, among which reserpine, ajmaline and serpentine are of greatest therapeutic importance. Raunatin alkaloids differ from each other in the rate and degree of absorption in the gastrointestinal tract. Metabolism of the drug occurs mainly in the liver. Raunatin is excreted in the form of metabolites through the kidneys along with urine.

Raunatin is available in tablet form. The drug should be taken after meals. The regimen for taking raunatin is as follows: on the 1st day at night, take 2 mg in terms of the amount of alkaloids (1 tablet), on the 2nd day - 1 tablet 2 times a day, on the 3rd - 3 tablets, etc. Thus, the total dose taken per day is brought to 4-6 tablets. Upon achieving the desired therapeutic effect, the daily dose taken is reduced to 1-2 tablets. Raunatin is compatible when taken simultaneously or sequentially with other antihypertensive drugs (hydrochlorothiazide, ganglion blockers, hydralazine). Raunatin is only conditionally compatible with some drugs, so their use should be carried out under the supervision of a physician: these are cardiac glycosides, quinidine, guanethidine, beta-blockers (risk of decreased heart rate and decreased conductivity).

Raunatin potentiates the inhibitory effect of ethyl alcohol, antidepressants, and barbiturates on the central nervous system. The drug is not recommended to be combined with sympathomimetics and antiparkinsonian drugs due to the reduced effectiveness of the latter. Diuretics enhance the antihypertensive effect of raunatin. If rauwolfia drugs are abused, an overdose is possible. Its symptoms are hyperhidrosis, general weakness and a pronounced decrease in blood pressure. In especially severe cases, after a short euphoria, lethargy, drowsiness, physical inactivity, depression, parkinsonian symptoms, and loss of consciousness develop. In such situations, gastric lavage, detoxification therapy with activated charcoal, and forced diuresis are indicated. In case of severe hypotension and collapse, the patient should be placed horizontally with his legs elevated. If necessary, intravenous administration of mezatone and rheopolyglucin is carried out with the addition of a 2% solution of norepinephrine hydrotartrate or angiotensinamide. Adrenergic agonists are used with extreme caution due to the risk of developing pulmonary edema. In case of delayed or severe respiratory depression, it is necessary to remove mucus from the respiratory tract, intubate and perform mechanical ventilation. There is no specific antidote for raunatin poisoning. Pharmacotherapy with raunatin should be carried out under the supervision of a physician. In persons suffering from angina pectoris, cardialgia may increase. For planned surgical interventions, the use of raunatin should be interrupted several days before surgery. For emergency surgical interventions in patients taking raunatin, premedication with atropine is indicated. The first positive changes in the patient’s condition appear, as a rule, on the 3-4th day of using the drug.

Side effects from taking the drug

Treatment with Raunatin may cause the following side effects:

• Rhinitis;
• Impaired liver function;
• Depressive states;
• Increased sweating;
• Decreased libido and erectile dysfunction in representatives of the stronger sex;
• Chronic fatigue syndrome;
• Lethargy, apathy, decreased performance, drowsiness during the daytime;
• Dyspeptic disorders;
• Skin itching and allergic rashes such as urticaria;
• Swelling and dryness of the mucous membranes;
• Painful sensations localized under the shoulder blade;
• Manifestations of heart failure.

If you detect at least one of the adverse reactions listed above, you should stop taking the pills and seek advice from a medical specialist! It may be necessary to reduce the daily dose of the drug or select a more suitable analogue.

What to do in case of overdose

The use of Raunatin at high blood pressure in large quantities, uncontrolled and for a long time can lead to an overdose, manifested by the following characteristic symptoms:

• Weakness, lethargy, apathy, decreased performance;
• Fainting conditions;
• A sharp decrease in blood pressure (hypotonic crisis);
• Excessive sweating.

You can help the patient by inducing artificial vomiting and allowing him to take sorbents. A good effect is achieved by diuresis and the use of diuretics, which allow toxic substances to be eliminated through the renal apparatus.

In case of fainting, an emergency call is necessary. Doctors will detoxify the body using IVs and, if necessary, provide artificial ventilation. After stabilization of the patient's condition, symptomatic treatment is prescribed.

An overdose of the drug can cause weakness and sweating

Side effects

Raunatin is well tolerated by patients. Side effects occur in rare cases. Among the undesirable effects observed:

• 

  Angina attack

  Diarrhea.

• Weakness.
• Swelling of the mucous membranes.
• Lethargy.
• Rash on the skin.
• Vomit.
• Painful sensations in the abdominal area.
• Dry mucous membranes.
• Depressive state.
• Drowsiness.

In patients with diagnosed angina, increased pain in the heart muscle is observed. In certain cases, liver dysfunction occurs.

To reduce the intensity of side effects, it is recommended to reduce the dosage of the drug by 1-2 days. The course of therapy should be prescribed by the attending physician in accordance with the type of disease, blood pressure levels and the patient’s condition.

The therapeutic effect after taking Raunatin according to the specified regimen is noticeable only after 1-2 weeks. The drug does not have an immediate effect.

The treatment is quite long. When using the medicine at the initial stages of development, the pathology recedes for many years. Thus, the main advantage of the product is its long-lasting effect. The effect after administration is observed for several years.

If the prescribed dosage is exceeded by the doctor or the drugs are used incorrectly, symptoms of overdose may occur. Among them are:

• sweating;
• weakness;
• hypotension.

Concept of hypotension

In certain cases, patients experience:

• drowsiness;
• physical inactivity;
• loss of consciousness;
• signs of parkinsonism;
• coma and depression.

If signs of overdose occur, you must first rinse your stomach and take activated charcoal. In severe cases, forced diuresis is prescribed.

If the patient experiences a significant decrease in blood pressure or collapse, the patient should be placed in bed with his legs elevated. To do this, use a bolster made from a bedspread or blanket.

If necessary, intravenous administration of rheopolyglucin is prescribed. Adrenergic agonists may be prescribed. But they are used with great caution, as they cause pulmonary edema. In cases of sudden depression of respiratory function or respiratory arrest, urgent suction of accumulated mucus and artificial ventilation of the lungs are required.

Drug compatibility

The drug Raunatin has good compatibility with diuretics, calcium antagonists, and ACE inhibitors. At the same time, the effectiveness of the tablets increases, and the patient’s blood pressure decreases somewhat faster.

When combined with adrenergic blockers, quinide, cardiac glycosides, the likelihood of intoxication of the body increases.

It is not recommended to use Raunatin with drugs prescribed for Parkinson's disease, due to the fact that it reduces the effectiveness of the latter.

Substitutes for Raunatin

The following analogues of Raunatin are presented in pharmacy chains:

• Cinepres;
• Adelfan;
• Reserpine;
• Triseride K;
• Bretylate;
• Acenosine;
• Normatens;
• Brinerdine;
• Kristepin;
• Rawolfia extract.

Despite the difference in composition, the drugs listed above have a similar therapeutic effect to Raunatin, which allows them to be used as substitutes.

Raunatin for hypertension is an effective drug that normalizes blood pressure, heartbeat, and improves the general condition of the patient. To obtain the most pronounced positive result and prevent side effects, you should take the tablets in the dosage recommended by the doctor, strictly following all the recommendations of a medical specialist.

Analogs

In cases where it is impossible to use a drug to lower blood pressure due to contraindications, its analogues can be used. Among the products containing the same active substance, the most popular is Rauwolfia dry extract. Belongs to the group of vasodilating agents. Available in powder form. In action it is a complete analogue of Raunatin. Not available for retail sale.

Drugs from other groups include:

• 
  Reserpine SIM_Prep-351. The active components are dihydralazine sulfate and hydrochlorothiazide. Available in the form of tablets for internal use or solution. Has a sedative and hypotensive effect.

• Atenolol. Produced on the basis of atenolol. It is the cheapest drug. The cost of a package is from 12 to 60 rubles, depending on the dosage. Available in tablets. Requires specialist supervision throughout the course of therapy, as it has many contraindications and side effects.
• Amlodipine. The active ingredient is amlodipine. The cost of packaging ranges from 55 to 190 rubles. Refers to antihypertensive drugs. Available in the form of tablets for oral use.
• Normatens. Also prescribed for high blood pressure. The dosage is determined by the attending physician, since the drug has many side effects and can negatively affect the functioning of many organs and systems. Active ingredients: clopamide, reserpine, dihydroergocristine methanesulfonate.
• Enalapril. The maximum cost of packaging the product is 110 rubles. Available in the form of tablets for internal use. The active substance is enalapril meleate.

• 
  Physiotens. A drug based on moxonidine. One of the most expensive means. The price for one package of the product ranges from 225 to 760 rubles. The drug can be taken regardless of meal time. The therapeutic effect is observed after 2 weeks of use.

All medications should be taken only as prescribed by a specialist, as they have many side effects and contraindications. To reduce the risk of their occurrence, it is necessary to follow the rules of administration and dosage.