"Rigevidon" belongs to the pharmacological group of oral monophasic contraceptives. It is used to prevent unwanted pregnancy in women of reproductive age. The article will present reviews of Rigevidon. Instructions for use and side effects of the drug are of interest to many.
The drug is produced in tablets. They are covered with an enteric coating. The medicine contains two active substances:
- Levonorgestrel.
- Ethinyl estradiol.
The structure of the drug also includes additional components, which include:
- Starch.
- Silica.
- Lactose.
- Talc.
- Calcium carbonate.
- Croscarmellose.
- Sucrose.
- Corn starch.
- Polyvinylpyrrolidone.
- Ethylene glycol polymer.
- Copolymer of 1-ethenylpyrrolidin-2-one and ethenyl acetate.
The tablets are packaged in blisters of 21 pieces.
Pharmacodynamics and pharmacokinetics
This oral monophasic combined estrogen-progestogen contraceptive drug can have an inhibitory effect on the pituitary production of gonadotropic hormones .
In this case, the contraceptive effect is associated with several mechanisms. The progestin component progestin includes a 19-nortestosterone derivative known as levonorgestrel . This substance is superior in its activity to the corpus luteum hormone progesterone or its synthetic analogue pregnin , which acts at the receptor level without undergoing metabolism .
The estrogenic component ethinyl estradiol leads to a blockade of the release of releasing hormones by the hypothalamus and inhibition of the production of gonadotropic hormones by the pituitary gland. At the same time, the maturation and release of the egg, ready for fertilization, is inhibited.
It has been established that ethinyl estradiol enhances the contraceptive effect of the drug. The increased viscosity of the cervical mucus remains, which makes it difficult for sperm to penetrate.
Also, regular use of the drug leads to normalization of the menstrual cycle and prevents the development of certain gynecological diseases, for example, tumors.
Inside the body, the drug undergoes rapid absorption. The concentration of Rigevidon depends on the dosage of the drug and the duration of use. In this case, the maximum concentration is usually detected after 2 hours, elimination occurs on average within 16 hours. The drug is excreted in metabolites and unchanged through the intestines and kidneys.
Pharmacological properties
The therapeutic effect of "Rigevidon" is due to the active substances included in its structure:
- Levonorgestrel is a structural substitute for the corpus luteum hormone progesterone; its activity is slightly higher. Upon penetration into the body, it cannot be exchanged; it suppresses the release of follitropin and peptide hormone from the hypothalamus, which inhibits the process of ripening and ovulation.
- Ethinyl estradiol is a female estrogen substitute. When entering the body, it increases the viscosity of cervical mucus, which prevents the passage of sperm and improves the contraceptive effect, which is caused by levonorgestrel.
After oral administration of the drug, its active substances are quickly and completely absorbed into the bloodstream from the intestines. They distribute throughout tissues and have a half-life ranging from two to seven hours.
Contraindications
Birth control pills Rigevidon are not prescribed for:
- sensitivity to the drug;
- lactation, pregnancy;
- severe liver diseases;
- congenital hyperbilirubinemia;
- cholecystitis;
- thromboembolism;
- tumor diseases;
- severe forms of arterial hypertension;
- diabetes mellitus and other diseases of the endocrine glands;
- sickle cell anemia ;
- chronic hemolytic anemia;
- hydatidiform mole;
- over 40 years of age;
- migraine;
- otosclerosis.
The drug is also contraindicated for use in cases of bleeding of various origins, idiopathic jaundice, skin itching and herpes in pregnant women.
Rigevidon is prescribed with caution to patients with liver, kidney and gall bladder diseases, epilepsy, depression, ulcerative colitis, uterine fibroids, mastopathy, tuberculosis , diseases of the cardiovascular system, arterial hypertension, renal dysfunction, varicose veins, phlebitis , otosclerosis and multiple sclerosis . Caution is also required when prescribing tablets to adolescent patients.
What restrictions exist?
There are a number of physiological and pathological conditions of a woman’s body that are considered medical prohibitions on taking Rigevidon. These include:
- Severe liver damage with the appearance of its functional failure.
- Hyperbilirubinemia (a lesion characterized by increased bilirubin in the blood).
- Gilbert's syndrome (pigment disease, which is characterized by a moderate intermittent increase in free bilirubin in the blood as a result of disruption of intracellular transport in hepatocytes to the site of its connection with glucuronic acid, as well as a decrease in the degree of hyperbilirubinemia under the influence of phenobarbital and an autosomal recessive type of inheritance).
- Rotor syndrome (a rare pathological process that is congenital in nature and is characterized by moderate yellowing of the skin).
- Dubin-Johnson syndrome (enzymopathic jaundice, a rare pigmentary hepatosis, which is characterized by impaired excretion of conjugated bilirubin from hepatocytes into the bile capillaries).
- Cholecystitis (inflammatory damage to the gallbladder).
- Unstable angina (a period of coronary heart disease that threatens the occurrence of myocardial infarction).
- Brain stroke (a pathological process that develops after a sudden disruption of blood microcirculation in nerve cells, which leads to their death).
- Myocardial infarction (one of the clinical forms of ischemic heart damage, which occurs with the appearance of ischemic necrosis of a portion of the heart muscles).
- Thromboembolism (acute blockage of the vascular bed with a thrombus that has broken off from the site of formation on the wall of the heart or blood vessel and entered the bloodstream).
- Severe arterial hypertension (a disease in which there is persistent high blood pressure).
- Endocrine pathology (a disease in which the normal functioning of the endocrine glands is disrupted).
- Diabetes mellitus (a group of endocrine lesions that are associated with impaired glucose absorption and occurs as a result of an absolute or relative deficiency of the hormone insulin).
- The woman is over forty years old.
- Hyperlipidemia (a pathological process characterized by the accumulation of cholesterol in the blood).
- Anemia (hematological diseases, the common point of which is a decrease in hemoglobin in the blood, usually with a joint decrease in red blood cells).
- Breast-feeding.
- Otosclerosis (a lesion characterized by a decrease in hemoglobin in the blood, more often with a combined decrease in the number of red blood cells).
- Hydatidiform mole (pathological damage to the ovum, which is characterized by the transformation of the villi of the outer embryonic membrane into cysts).
- Pregnancy.
- Migraine (a neurological disorder, the most common and characteristic symptom of which is episodic or constant severe pain in the head).
- Idiopathic jaundice (the result of diseases of the liver and other organs, which manifest themselves in the coloring of the skin, as well as the mucous membranes and sclera in a yellow color).
- Skin itching.
- Herpes (a viral infection with a characteristic rash of grouped blisters on the epidermis and mucous cavities).
- Individual intolerance to any of the substances of the drug.
What other contraindications and side effects does Rigevidon have?
Side effects of Rigevidon
Usually this drug is well tolerated by patients, but sometimes side effects of Rigevidon occur, which develop transiently and disappear spontaneously. For example, nausea, vomiting, headaches, weight gain and changes in libido , mood, acyclic bleeding, conjunctivitis , vision problems, and so on.
In rare cases, long-term use of the drug causes chloasma, hearing loss, jaundice, generalized itching , convulsions, frequency of epileptic seizures, hypertriglyceridemia , hyperglycemia , increased blood pressure, thrombosis or venous thromboembolism, skin rashes, changes in vaginal secretion, high fatigue, vaginal candidiasis , etc. .
Indications for use
for adults
Rigevidon can be used as a contraceptive for premenstrual syndrome, functional disorders of the menstrual cycle, including painful periods.
for children
Rigevidone can be taken in adolescence as prescribed by a doctor (the drug should be taken with caution if regular ovulatory cycles are not observed).
for pregnant women and during lactation
Rigevidon is contraindicated in pregnant and lactating women. Also, the drug should not be taken if idiopathic jaundice, severe skin itching, or herpes were observed during a previous pregnancy.
Rigevidon tablets, instructions for use (Method and dosage)
Instructions for use of Rigevidon recommend taking the tablets orally, whole, with water.
When hormonal contraception was not used during the previous menstrual cycle, it should be started on the 1st day of menstruation. Then you need to take one tablet every day for 21 days, preferably at a certain time of day.
After this, a break of 7 days is taken, during which menstrual-like bleeding occurs. For the next 21 days, the tablets are taken from a new package, that is, already on the 8th day, regardless of whether the bleeding has stopped or not.
The transition to these contraceptive pills from another contraceptive is carried out according to the same scheme. You can take the drug as long as you need it.
Taking the drug after an abortion can be started immediately on the day of surgery or the next day. After childbirth, the contraceptive is allowed for use by women who are not breastfeeding. You should start taking it from the first day of menstruation .
When skipping pills, it is important to know how to take Rigevidon in such cases. According to the instructions, the missed pill must be taken within the next 12 hours. If more than 36 hours pass after taking the drug, then contraception will be unreliable, so you need to take care of additional contraceptives .
The use of the drug for medicinal purposes requires individual selection of dosage and therapeutic regimen.
What to remember
According to the instructions for use and reviews of Rigevidon, side effects of the drug are rare, but there are still a number of features regarding its use that are important to pay attention to. These include:
- Before starting to use the drug "Rigevidona", as well as every six months during its use, it is necessary to carry out gynecological and general clinical examinations of the woman.
- The medication should not be used by young women with thromboembolic complications.
- The use of the drug is allowed no earlier than six months after receiving antiviral treatment for concomitant viral hepatitis B or C, provided that laboratory parameters of the functional state of the liver are stabilized.
- The occurrence of sharp pain in the area where the liver is located when taking the medicine may indicate the possible presence of some kind of neoplasm. In this situation, the use of tablets is discontinued until this pathological process is excluded.
- The appearance of regular vaginal bleeding that is not associated with the menstrual cycle is not considered an indication for stopping Rigevidon. In a situation where they recur and do not stop, a gynecological examination is necessary.
- In women who smoke over thirty years of age, the risk of cardiovascular and cerebrovascular pathological processes increases greatly.
According to the instructions, the side effects of Rigevidon in certain cases require stopping the medication. The active components of the drug do not have a direct effect on the functional state of the cerebral cortex, the ability to concentrate, or the speed of psychomotor reactions. If there is renal impairment, the drug should be used with extreme caution.
The active ingredients of the drug "Rigevidona" may interact with drugs from other therapeutic groups, so if they are used simultaneously, you should warn your gynecologist.
In pharmacies, tablets are dispensed only with a prescription from a medical specialist. You cannot use them yourself without appropriate examination and doctor’s prescription.
Interaction
Combination with barbiturates, antiepileptic drugs, for example, Carbamazepine and Phenytoin , as well as sulfonamides, pyrazolone derivatives, can lead to increased metabolism of steroid hormones included in the drug.
The combined use of Rigevidon and certain antimicrobial drugs can reduce the contraceptive effect: Ampicillin, Rifampicin, Chloramphenicol, Neomycin, Polymyxin B , sulfonamides and Tetracycline , as they change the composition of microflora .
This drug can increase the bioavailability and toxicity of tricyclic antidepressants, beta-blockers and Maprotiline , and reduce the effectiveness of Bromocriptine .
Combined use with hypoglycemic drugs and insulin often requires changing their dosage. When taken with the drug Dantrolene, it is possible that its hepatotoxicity may increase, mainly in women over 35 years of age.
Menopause in women age signs symptoms and treatment
The main component inhibits the maturation of follicles, which ensures the contraceptive effect of the drug and therapeutic effect for a number of diseases. After giving birth and breastfeeding, I will return to the drug again. These are herbal preparations that are analogues of synthetic drugs. Proper organization of life, a special diet, psychological assistance, and in some cases drug therapy, create a decent quality of life for a woman experiencing temporary difficulties. Among oral contraceptives, preference is given to drugs that have a fairly small dose of hormones.
Half an hour after taking the drug dose, it reaches maximum serum concentration. During menopause, a lack of sex hormones occurs in the body. Use of the drug during menopause In a woman’s life, a restructuring of the body inevitably occurs, associated with the decline of reproductive function.
The severity of vascular symptoms of sweating is reduced. How should Diana take birth control pills and how do they work? Norkolut for endometrial hyperplasia is used as one of the drugs that allows you to correct the level of hormones, the imbalance of which is considered one of the causes of the onset of hyperplastic processes. Norkolut can cause fluid retention in the body, which weakens the effect of diuretics to lower blood pressure.
special instructions
Before starting to take contraceptive pills, and every six months when using them, it is necessary to undergo a general medical and gynecological examination. It usually includes a cytological analysis, examination of the mammary glands, assessment of blood glucose, cholesterol , liver function, pressure and urine composition.
For patients who have suffered viral hepatitis and their liver functions have normalized, the drug is prescribed no earlier than 6 months from the moment of recovery.
If sharp abdominal pain, hepatomegaly and signs of intra-abdominal bleeding , this may indicate a liver tumor. If necessary, the drug is immediately discontinued.
The appearance of intermenstrual bleeding does not require discontinuation of the contraceptive, since it usually stops on its own. When this does not happen, consultation with a gynecologist is necessary.
As is known, women who smoke when taking hormonal contraceptives can develop vascular diseases with serious consequences - myocardial infarction and stroke.
Additional prohibitions
The pharmacological drug is used with extreme caution in the following conditions:
- Tuberculosis (an infectious disease caused by mycobacteria).
- Nonspecific ulcerative colitis (an inflammatory process in which the mucous membrane of the large intestine is diffusely damaged).
- Uterine fibroids (formation and growth of a benign tumor in the myometrium).
- Mastopathy (benign disease of the mammary glands, which is caused by pathological proliferative growths in the tissues of the gland).
- Hypertension (a lesion in which there is a persistent increase in blood pressure).
- Intermittent porphyria (a disease characterized by damage to the nervous system).
- Phlebitis (inflammatory lesion of the venous wall).
- Multiple sclerosis (a chronic disease that affects the myelin sheath of nerve fibers in the brain and spinal cord).
- Epilepsy (a neurological disease that is characterized by the body’s predisposition to the sudden appearance of seizures).
- Chorea minor (a neurological lesion that is caused by erratic muscle spasms and movement disorders).
- Latent tetany (involuntary muscle contractions that can be provoked by diseases that increase the action potential of the frequency of muscle cells or the nerves that innervate them).
Rigevidon's analogs
Level 4 ATC code matches:
Ovidon
Non-Ovlon
Mercilon
Yarina Plus
Yarina
Miniziston 20 fem
Novinet
Microgynon
Janine
Lindineth
Cyclo-Proginova
Regulon
Logest
Midiana
Belara
Femoden
Jess Plus
Jess
Zoely
Main analogues: Yarina, Regulon and Janine.
Rigevidon or Regulon – which is better?
To understand which of these drugs is better, you just need to compare Rigevidon and Regulon. Their main difference lies in the gestagen component - in Regulon it is desogestrel, which also does not have an antiandrogenic effect. Moreover, before taking these pills, it is difficult to understand how suitable they are and how they will be tolerated by patients.
There are many reviews of women taking one of these drugs for a long time. This did not lead to the development of undesirable effects, such as changes in libido or weight gain. Moreover, immediately after discontinuation of these contraceptives, pregnancy occurred almost immediately. Therefore, the selection of such drugs must be carried out taking into account individual characteristics after consultation with a gynecologist.
Reviews and results
I drank it 2 times (with a break). Good, expensive doctors told me that, although he is quite “old,” he is quite good. The feeling I have on it is quite decent (I tried a lot of others - it didn’t work). But 2 months ago my gynecologist prescribed me Qlaira. For comparison: rigevidon is about 100 rubles. for a month, Qlaira - 1000. And now, after 2 months of taking this Qlaira, I realized that there is something better than rigevidon - my stomach used to swell, now there is no swelling at all, I notice that I have lost about 2 kg, which I gained on rigevidon (this is not a problem for me, I’m thin, it’s okay to add a couple of kg).
Guest , https://www.woman.ru/health/medley7/thread/4383567/
I’ve been taking Regivedon for 10 years, I only stopped it during pregnancy and breastfeeding (four years ago), and I also take a break once a year for a couple of months. Now he’s on it again. Apart from the fact that the breasts hurt and enlarged during the withdrawal period (a month and a half), there were no side effects. At the very beginning, when I consulted with a gynecologist, the doctor advised me to “check” my liver once every six months or a year and quit smoking, because it puts a lot of stress on the heart together with OK. And that’s it... Once every three years I get examined - no problems have been identified. But, as I read the comments about “Rigevidon”, my hair stands on end, and everywhere - what am I taking?!!!)))))) It’s possible that everything is individual, but, I think (as an experienced “user” “Rigevidon”))), that the majority of their obesity, health problems associated with an indecent lifestyle for a person, etc., are attributed to “Rigevidon” - it’s easier for them to justify themselves, to justify their own laziness, hence all the “horrors” about side effects.
Lisa 01 , https://www.woman.ru/health/medley7/thread/4383567/
They prescribed it to me when they discovered a cyst. I took it for 2 months, and I weighed 44-45 kg at 166 height. As side effects: pimples on the cheeks, first on one, then on the other, the skin and hair become greasy. I used to have one or two pimples before my period, and my skin was thin and dry. During the 7-day break between courses of Rigevidon, the face completely clears itself. But my periods are much easier: I used to roll on the floor from wild pain and eat a pack of Pentalgin. Now there are 2 tablets (one in the first day), menstruation is 3 days, not a week and out of the blue, as before. Even in the first days of menstruation, I live calmly: I went to university, ate, walked. but usually she lay like a vegetable and didn’t eat (toxicosis)…
Severus Snape , https://www.woman.ru/health/medley7/thread/4383567/
I’ve been taking it for 6 years, before that I tried Novinet and Lindinet 20, but the side effects didn’t work: nausea and lack of libido. Regividon does not cause any side effects for me personally, the price is very satisfactory. Nothing has changed with the figure. Although I try to still support her, without much effort. Although doctors say that it is too strong for me, I decided to listen to my body.
Guest , https://www.woman.ru/health/medley7/thread/4383567/
Reviews about Rigevidon
Many women of reproductive age take various contraceptive medications. Therefore, you can find reviews about Rigevidon on forums where women actively discuss such products.
Of course, the attitude towards them is completely different. Some believe that birth control pills have only benefits and willingly take them. Others, on the contrary, are afraid of using any hormonal drugs and therefore use other methods of contraception, which are not always effective. There are also reports when users do not know what the pills are for or why they are taking them.
Women who have tested this drug on themselves also express completely different opinions. Some patients report that while taking it they experienced constant nausea, mood swings and gained significant weight. However, many women say that they have been taking Rigevidon 21+7 for several years and during all this time they have not felt any unwanted effects. At the same time, the drug provides them with reliable protection from unwanted pregnancy.
The reviews of doctors who use different drugs in their practice deserve special attention. They once again note that the choice of such funds should not be done independently. If the need for contraception arises, you can always consult a gynecologist to conduct a full examination, determine your hormonal status, discuss pregnancy plans and choose the appropriate method of protection against unwanted conception.
Generics
The following drugs are considered similar in structure and pharmacological action to Rigevidon:
- "Lindynet 20".
- "Tri-regol."
- "Klimonorm".
- "Triquilar."
- "Klayra."
- "Yarina."
- "Logest".
- "Regulon".
- "Janine."
Before replacing the original drug "Rigevidon", you must consult a medical specialist.
Rigevidon price, where to buy
The price of Rigevidon in pharmacies varies between 200-650 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Rigevidon tablets p.p.o.
63 pcs. JSC Gedeon Richter RUB 649 order - Rigevidon 21+7 tablets p.p.o. 28 pcs. JSC Gedeon Richter
RUB 297 order
- Rigevidon tablets p.p.o. 21 pcs. JSC Gedeon Richter
RUB 255 order
- Rigevidon 21+7 tablets p.p.o. 84 pcs. JSC Gedeon Richter
902 rub. order
Pharmacy Dialogue
- Rigevidon (tab. No. 21x3)Gedeon-Richter
RUR 686 order
- Rigevidon (tab. No. 21)Gedeon-Richter
RUB 257 order
- Rigevidon tablets No. 21+7Gedeon-Richter
RUB 315 order
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Pharmacy24
- Rigevidon No. 21 tablets VAT "Gedeon Richter", Ugorshchina
153 UAH. order - Rigevidon No. 63 tablets VAT "Gedeon Richter", Ugorshchina
478 UAH. order
PaniPharmacy
- Rigevidon tablets Rigevidon tablets. p/o No. 21 Hungary, Gedeon Richter
168 UAH order
- Rigevidon tablets Rigevidon tablets. p/o No. 63 Hungary, Gedeon Richter
496 UAH. order
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