How to take Slabilen drops - instructions and reviews

Pharmacological properties

Pharmacodynamics

As a local laxative, sodium picosulfate, after bacterial breakdown in the large intestine, has a stimulating effect on the colon mucosa, increasing peristalsis, and promoting the accumulation of water and electrolytes in the large intestine. This leads to stimulation of the act of defecation. Reducing evacuation time and softening stool. The effect occurs 10-12 hours after administration.

Sodium picosulfate, being a laxative acting at the level of the colon, stimulates the natural process of evacuation of contents from the lower parts of the gastrointestinal tract. Therefore, sodium picosulfate does not affect the digestion or absorption of high-calorie foods or essential nutrients in the small intestine. The use of the drug is not accompanied by tenesmus and spasms. During a course of treatment, it stimulates the growth and metabolic activity of normal intestinal microflora.

Pharmacokinetics

After oral administration, it is not absorbed from the gastrointestinal tract and does not undergo hepatic-intestinal circulation.

Analogs

Drugs with similar effects are:

1. Enterolax is a laxative in tablets that softens the consistency of stool and promotes its movement through the intestines.
2. Guttalax - improves the peristalsis of the large intestine, retains water, normalizes the process of defecation.
3. Laxigal is not absorbed into the intestinal mucosa and acts only in its cavity. Blocks the absorption of water and electrolytes through the intestinal walls, stimulates their excretion along with feces.
4. Eucarbon is a herbal remedy with a laxative effect. It contains senna leaves, vegetable charcoal, rhubarb root extract and other natural ingredients.
5. Dulcolax - comes in the form of tablets for oral administration and suppositories for rectal administration. Prescribed for constipation, for bowel movements before operations, instrumental studies.
6. Slabilax is a laxative that can be given to children from birth. It is used not only for constipation, but also to improve the bowel movement process.
7. Softovak - prescribed for constipation, to soften stool in proctological and gastroenterological diseases.
8. Regulax - has a gentle effect on the intestinal mucosa, providing a therapeutic effect after 7-8 hours. Contains plant components.

Cheap analogues are: Bisacodyl, castor oil, Senade. The cost of funds is from 20 to 80 rubles.

Use during pregnancy and breastfeeding

There are no reliable and well-controlled studies of sodium picosulfate in pregnant women. However, long-term experience with use has not revealed a negative effect of sodium picosulfate on pregnancy. The use of sodium picosulfate in the first trimester of pregnancy is contraindicated. In the second and third trimesters of pregnancy (as with the use of other laxatives), the use of the drug is possible only as prescribed by a doctor.

The active metabolite and its glucuronides are not excreted in breast milk. Thus, the drug can be used during breastfeeding.

Price

The medicine can be purchased at pharmacies. Approximate prices in Moscow are presented in the table:

Directions for use and doses

Inside. Adults and children over 10 years of age: 10-20 drops (5-10 mg) per day. The maximum daily dose for adults and children over 10 years of age is 20 drops (10 mg). Children 4-10 years old: 5-10 drops (2.5-5 mg) per day. The maximum daily dose for children from 4 to 10 years is 10 drops (5 mg).

It is recommended to start taking it with the minimum recommended dose. In order to achieve regular bowel movements, the dose may be increased to the maximum recommended. It is not recommended to exceed the maximum recommended daily dose.

The recommended dose for children under 4 years of age is 0.25 mg/kg body weight per day. This corresponds to 1 drop of the drug (0.5 mg sodium picosulfate) per 2 kg of body weight per day.

To obtain a laxative effect in the morning, you should take the drug the night before. The drug does not have to be dissolved in liquid.

Contraindications

Laxatives are not recommended for use if the following indications exist:

• lactase deficiency, lactose intolerance, malabsorption of glucose and galactose;
• abdominal pain of unknown origin;
• peritonitis, inflammatory processes of the abdominal organs, other diseases of the gastrointestinal tract;
• severe dehydration;
• open bleeding from the stomach, intestines, uterus;
• intestinal obstruction;
• strangulated hernia, cystitis, metrorrhagia;
• with spastic constipation;
• if you are allergic to the components of the drug.

The medicine Slabilen should be taken with caution during pregnancy, under the supervision of a doctor. In the first trimester, the drug is prescribed in situations where the expected benefit of treatment outweighs the potential harm to the mother and child. Laxative Laxative is not recommended for use during breastfeeding. During treatment, the child should stop drinking milk. The product in tablet form is strictly contraindicated for children under 10 years of age, and drops for children under 4 years of age.

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Side effect

With short-term use of the drug, side effects are rare.

Possible side effects are classified according to frequency of occurrence as follows: very often (≥1/10), often (≥1/100 and <1/10), infrequently (≥1/1000 and <1/100), rarely (≥1/100). 10,000 and <1/1000), very rare (<1/10,000), frequency unknown (currently there are no data on the prevalence of adverse reactions).

With long-term use of the drug in significantly increased doses, the following disorders are possible:

From the skin and subcutaneous tissues

Frequency unknown: skin rash, urticaria, itching.

Metabolism and nutrition

Frequency unknown: increased excretion of potassium, sodium and other electrolytes, possible development of dehydration.

From the gastrointestinal tract

Very common: diarrhea. Common: dyspeptic symptoms, abdominal cramps and pain, flatulence. Uncommon: vomiting, nausea. Frequency unknown: pain in the stomach and anus, increased intestinal motility, which disappears when the dose of the drug is reduced.

From the immune system

Frequency unknown: allergic reactions, angioedema, allergic dermatitis.

From the nervous system

Uncommon: dizziness. Frequency unknown: headache, fatigue, drowsiness, convulsions, fainting. Dizziness and fainting may be associated with a vasovagal reaction (such as cramping abdominal pain or straining during bowel movements).

What is Slabilen?

Slabilen is an irritant laxative based on sodium picosulfate. It acts directly on the large intestine and promotes the rapid removal of feces. It has a quick effect, has a small number of side reactions and contraindications.

Available in pharmacies without a prescription in the form of tablets and drops with different concentrations of the active substance and additional components. The drops are a transparent, slightly viscous, colorless or slightly colored substance. The drug is available in pharmacies without a prescription, costs about 170 rubles, shelf life is 3 years at room temperature. Manufacturers: Lance-Pharm and Veropharm, Russia.

Overdose

Symptoms: When taking high doses, the following are possible: diarrhea, dehydration, decreased blood pressure, water and electrolyte imbalance, hypokalemia, convulsions.

In addition, there are reports of cases of ischemia of the muscles of the large intestine associated with taking the drug Slabilen®, significantly exceeding those recommended for the usual treatment of constipation.

Slabilen®, like other laxatives, in chronic overdose can lead to chronic diarrhea, abdominal pain, hypokalemia, secondary hyperaldosteronism, and urolithiasis. Renal tubular damage, metabolic alkalosis, and muscle weakness associated with hypokalemia may develop due to chronic laxative abuse.

Treatment: To reduce the absorption of the drug after oral administration, you can induce vomiting or perform gastric lavage. Fluid replacement and correction of electrolyte balance may be required, as well as antispasmodics.

Weak in old age

Slabilen is an effective laxative that rarely causes side effects and can be used in old age. Before treatment, it is necessary to take into account the features of using the product, study the instructions for use and consult a doctor. Medicines based on sodium picosulfate can be addictive and, with prolonged use, lead to intestinal atony. This is a serious pathology, as a result of which the muscles lose tone and bowel movements are disrupted.

To avoid unpleasant consequences, Slabilen and its analogues are recommended to be taken only in extreme cases. In case of unexpressed disruption of the digestive tract associated with age-related changes, it is better to treat them with safer means. To do this, you need to eat right, include vegetables and fruits in your diet, avoid eating fatty, fried and heavy foods, and drink as much fluid as possible.

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special instructions

It is not recommended to use the drug continuously for more than 10 days without consulting a doctor. Children should take the drug only as prescribed by a doctor. Long-term use of high doses of the drug can lead to fluid loss, electrolyte imbalance, and hypokalemia.

Dizziness and fainting have occurred in patients taking sodium picosulfate. The analysis showed that these cases are associated with syncope during defecation (or syncope caused by straining to defecate), or with a vasovagal reaction to abdominal pain, which may be due to constipation, and is not necessarily related to the drug.

1 ml of the drug contains 0.375 g of sorbitol.

The drug has no taste, so it can be added to food.

Composition, release form

Slabilen drops are a colorless solution with a viscous consistency. Its laxative property is associated with sodium picosulfate, the main component. Additionally, the drops contain the following substances:

• purified water;
• hydrochloric acid solution;
• sorbitol;
• sodium methyl parahydroxybenzoate.

The viscous solution is poured into dark glass bottles in a volume of 15, 30 ml. 1 ml of solution equals 15 drops. The manufacturer produces Slabilen in the form of tablets with the same active ingredient, as well as others.

Impact on the ability to drive vehicles and machinery

No special clinical studies have been conducted on the effect of the drug on the ability to drive a car or use machinery. However, patients should be advised that they may experience dizziness and/or fainting due to a vasovagal reaction (i.e. during bowel spasm). If patients experience intestinal spasms, they should refrain from performing potentially hazardous activities that require increased concentration and speed of psychomotor reactions (driving vehicles, working with moving mechanisms, working as a dispatcher, operator).

Causes of constipation

Constipation

called a violation of the intestines, expressed in a delay in bowel movement for more than two days.

Causes

The occurrence of this problem is quite varied. One of the common ones is unhealthy diet and stomach diseases. A passive lifestyle, sedentary work, frequent stress, body fatigue, and intestinal surgery can also cause problems with stool.

Women and the elderly most often suffer from this disease. For the former, it is usually caused by frequent dieting and pregnancy. And in older people, the cause is bed rest.

Constipation can be a side effect of various medications. As a rule, in this case it is prescribed in the instructions for taking the medications.

It is called "travelers' disease"

. After all, during long-term trips, the diet changes, which negatively affects the functioning of the intestines, slowing down its work.

The disease can be recognized by certain signs and symptoms.

Drug interactions

The treatment regimen should be drawn up by the attending physician, who takes into account the effect of the laxative on the action of other drugs. According to the instructions for use, Slabilen has the following drug interactions:

• there is a risk of increasing the patient’s sensitivity to cardiac glycosides;
• broad-spectrum antibiotics have a negative effect on the effectiveness of sodium picosulfate;
• diuretics, glucocorticosteroids increases the risk of developing electrolyte disturbances.