pharmachologic effect
Hematopoiesis stimulator . Iron occupies the central part of the hemoglobin and is responsible for stimulating hematopoiesis. Elimination of hematopoiesis disorders is carried out by replenishing the lack of iron in the body due to the active substance of the drug.
Ascorbic acid allows you to increase the digestibility of Fe sulfate up to 4 times during the digestion process. Mucoproteosis improves the tolerability of the active component.
Pharmacological properties
Tardiferon is a hematopoiesis stimulator. Iron atoms are located in the central part of the hemoglobin molecule and are responsible for stimulating hematopoiesis. Hematopoiesis disorders are eliminated by replenishing iron reserves in the body due to the intake of ferrous sulfate, which is the active component of the drug.
Ascorbic acid, also part of Tardiferon, increases the digestibility of ferrous sulfate by approximately 4 times during its absorption in the gastrointestinal tract. Mucoproteosis improves the tolerability of the active substance of the drug.
Pharmacodynamics and pharmacokinetics
Tardiferon tablets are characterized by a prolonged effect. Mucoproteosis increases the bioavailability of ferrous ions, which ensures its gradual release in the small intestine. The maximum concentration of iron is found in the blood plasma approximately 7 hours after oral administration. The level of this substance is maintained at a consistently high level for 24 hours. Bioavailability is 5–35%.
The rate and degree of absorption of ferrous sulfate is directly determined by the presence of the body's own iron reserves. Excess iron accumulates in tissues in the form of ferritin, and is also excreted through the kidneys, intestines and during sweating.
Pharmacodynamics and pharmacokinetics
Tablets of this drug have a prolonged effect. Mucoproteosis increases the bioavailability of ferrous ions and its gradual release in the small intestine. The maximum concentration after consumption of Fe 2+ is recorded in plasma after 7 hours. The iron content in the blood is maintained at a constantly high level for a long time (within 24 hours). Bioavailability ranges from 5% to 35%.
The absorption of the active substance directly depends on the own iron reserves of each individual organism. Iron is stored in the form of ferritin. Excretion occurs in urine, sweat and feces.
Contraindications
- anemia not associated with iron deficiency (thalassemia, hemolytic and aplastic anemia, megaloblastic anemia associated with isolated vitamin B12 deficiency);
- violation of the mechanisms of iron utilization (sideroachrestic anemia, anemia caused by lead poisoning);
- increased iron content in the body (hemochromatosis, hemosiderosis);
- acute bleeding from the gastrointestinal tract;
- intestinal obstruction, esophageal stenosis, obstructive changes in the gastrointestinal tract;
- invertase/isomaltase deficiency syndrome, galactose and glucose malabsorption syndrome, fructose intolerance;
- children under 6 years of age;
- hypersensitivity to individual components of the drug.
Carefully:
- renal failure;
- liver failure;
- peptic ulcer of the stomach and duodenum;
- inflammatory bowel diseases;
- alcoholism.
Instructions for Tardiferon (Method and dosage)
The tablets are taken orally during or immediately after meals with liquid. The instructions for use of Tardiferon indicate that the effectiveness of the medication is significantly reduced when the tablet is broken and chewed. Admission is allowed for children from 6 years old, dose is 1 tablet per day. Children over 10 years old and adults - 1-2 tablets. The drug is prescribed to pregnant women, starting from 4 months, 1 tablet daily.
The course of treatment must be continued until the iron deficiency is corrected (blood counts usually return to normal after 3-6 months).
Tardyferon Retard is taken 1 tablet twice a day.
Release form and composition
Dosage form – sugar-coated tablets, prolonged action: biconvex, from white to light beige in color, with a smooth smooth surface (10 pcs. in blisters, 3 blisters in a cardboard pack).
Active ingredient: iron sulfate x 11/2 H2O – 256.3 mg in 1 tablet, which corresponds to 80 mg of iron.
Auxiliary components: magnesium trisilicate, potato starch, mucoproteose (anhydrous), magnesium stearate, talc, triethyl citrate, methacrylic acid and methacrylate copolymer (Eudragit S), hydrogenated castor oil, povidone, ascorbic acid.
Shell composition: rice starch, carnauba wax, titanium dioxide, sucrose, talc, methyl methacrylate, dimethylaminoethyl methacrylate and butyl methacrylate copolymer (Eudragit E).
Overdose
The following symptoms have been reported in cases of overdose:
- diarrhea;
- vomit;
- epigastric pain;
- constipation
In case of overdose: first of all, immediately induce vomiting and rinse the stomach. Next, it is recommended to drink milk or a raw egg to bind excess iron ions and subsequently remove them from the body. If a blood test shows a significant excess of ferritin , Desferal must be prescribed.
Drug interactions
The following drugs reduce iron absorption:
- pancrelipase, pancreatin;
- preparations containing bicarbonates, oxalates, phosphates, carbonates;
- antacids containing magnesium, calcium, aluminum salts;
- etidronic acid;
- calcium preparations;
- agents that reduce gastric acidity (for example, cimetidine).
There is a mutual decrease in absorption with the combined use of D-penicillamine, tetracyclines, egg yolk and tea.
When combined with the above drugs or food products, Tardiferon should be taken 1 hour before or 2 hours after their use.
In high doses, iron supplementation reduces zinc absorption.
Ascorbic acid increases iron absorption.
Ethanol enhances iron absorption and increases the risk of toxic complications.
Other iron preparations (including those for parenteral use) should not be prescribed simultaneously with Tardiferon, since an overdose of iron is possible.
Analogs
Level 4 ATC code matches:
Ferrogradumet
Hemofer
Sorbifer Durules
Medicines with similar effects:
- Hemophere prolongatum;
- Sorbifer Durules;
- Ferrogradumet, Gyno-Tardiferon .
Use of the drug Tardiferon
Inside, with a glass of water, before meals. Adults and children over 7 years of age: for the prevention of iron deficiency anemia, 1 tablet per day before meals. Treatment of iron deficiency anemia: children - 1 tablet per day (morning), adults - 1-2 tablets per day (morning and evening). The duration of treatment depends on the severity of the anemia. To replenish the iron depot in the body, treatment with Tardiferon should be continued for another 1–3 months after normalization of hemoglobin levels in the blood - 1 tablet per day (in the morning).
Reviews about Tardiferon
An analysis of medical communities and forums showed that the drug is considered effective, restoring hemoglobin levels to normal after the first course of use. Reviews of Tardiferon on forums do not report any side effects. Even with alarmingly low hemoglobin levels before starting the drug, significant improvements were noticed by all community participants.
Many women leave reviews during pregnancy, since low hemoglobin is practically the most common problem among women during pregnancy. Many reports indicate that if anemia occurs, then a special diet is practically useless without taking special iron supplements. Tardiferon was well tolerated by all forum participants who signed up.
Instructions for use of Tardiferon: method and dosage
Tardiferon tablets should be taken orally before or during meals: swallow whole and wash down with water.
For medicinal purposes, adults and children over 10 years old are prescribed 1 tablet 1-2 times a day, children 6-10 years old - 1 tablet 1 time a day.
For preventive purposes, pregnant women are prescribed the drug 1 tablet once a day or every other day during the second and third trimesters of pregnancy (starting from the 4th month of pregnancy).
The duration of treatment is determined individually. The drug is taken until it is possible to correct anemia and restore the iron reserve in the body.
For iron deficiency anemia, the duration of treatment is 3–6 months, depending on the degree of iron deficiency. In some cases, if anemia cannot be controlled, the duration of taking the drug may be increased.
Tardiferon price, where to buy
Tardiferon can be purchased at pharmacies. The price of Tardiferon is on average 130 rubles. for 30 tablets and depends on the point of sale.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
LuxPharma* special offer
- Gyno-Tardiferon tablets 80 0.35 mg 30 pcs
1650 rub. order
ZdravCity
- Tardiferon tablets p.p.o. with prolonged release 80 mg 30 pcs. Pierre Fabre Medicine Production
RUB 285 order
Pharmacy Dialogue
- Tardiferon tablets 80 mg No. 30 Pierre Fabre Medicament
RUB 313 order
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Pharmacy24
- Gyno-Tardiferon N30 tablets Pierre Fabre Medicine Production, France
157 UAH.order - Tardiferon 80 mg N30 tablets Pierre Fabre Medicament Production, France
131 UAH order
PaniPharmacy
- Tardiferon tablets Tardiferon tablets. 80 mg No. 30 France, Pierre Fabre Medicament Production
139 UAH. order
- Gyno-tardiferon tablets Gyno-tardiferon tablets. No. 30 France, Pierre Fabre Medicament Production
170 UAH order
- Tardiferon tablet. depot No. 30 Australia, Robafarm
165 UAH order
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Pharmacological properties of the drug Tardiferon
Tardiferon is a complex long-acting drug. Contains ferrous sulfate, the use of which replenishes iron deficiency in the body and stimulates hematopoiesis. The high safety of the drug is due to the presence of mucoproteose in its composition. Mucoproteosis is a natural mucopolysaccharide that protects the mucous membrane of the digestive tract from the irritating (irritating) effects of iron ions, promotes the slow release of iron (within 5-6 hours), which significantly improves the tolerability of the drug. Ascorbic acid, having an antioxidant effect, increases the bioavailability of iron and promotes its absorption. Absorbed in the duodenum and proximal small intestine. The maximum concentration of iron in the blood serum is reached after approximately 7 hours and remains elevated for 24 hours after taking the drug.
Interaction with other drugs
Reduce iron absorption:
- antacid drugs containing salts AL3+, Ca 2+, Md 2+, calcium preparations, etidronic acid, drugs that reduce the acidity of gastric juice (including cimetidine);
- medicines containing carbonates, bicarbonates, phosphates, oxalates);
- pancreatin, pancreolipase.
Mutually reduce absorption when used together:
- tetracyclines, D-penicillamine, tea, egg yolk.
If it is necessary to combine it with the drugs or foods listed above, iron supplements should be taken 1 hour before or 2 hours after their use.
Increases absorption:
- ascorbic acid, ethanol (including increases the risk of toxic complications).
Iron supplementation in large doses reduces the absorption of zinc.
It should not be prescribed together with other iron preparations, including those for parenteral use, to avoid overdose.
Composition and release form
For 1 tablet 80 mg:
- Active components: iron sulfate (II) sesquihydrate - 256.30 mg (in terms of iron 80 mg);
- Excipients: ascorbic acid 30.00 mg, mucoproteose (anhydrous) - 80.00 mg, potato starch - 2.00 mg, methacrylic acid and methyl methacrylate copolymer (Eudragit S) - 20.84 mg, triethyl citrate - 2.08 mg, povidone - 17.00 mg, talc - 22.00 mg, magnesium stearate - 2.00 mg, hydrogenated castor oil - 6.50 mg, magnesium trisilicate - up to 495.00 mg;
- Shell: talc - 8.00 mg, titanium dioxide - 9.10 mg, rice starch - 7.00 mg, carnauba wax ~ 0.21 mg, Eudragit E (methyl methacrylate, dimethylaminoethyl methacrylate and butyl methacrylate copolymer) - 1.25 mg, sucrose - up to 650.00 mg.
Tablets of 10 pieces in a blister made of PVC/PVDC and aluminum foil. 3 blisters along with instructions for use are placed in a cardboard pack.
special instructions
During the period of taking the drug, it is necessary to take into account that coffee, milk, vegetables, and cereals reduce the absorption of iron.
During the period of taking the drug, a dark coloration of the stool may be observed, which is due to the excretion of unabsorbed iron and has no clinical significance, as well as a false-positive benzidine test.
Due to the presence of sucrose in the drug, its use is contraindicated in persons with fructose intolerance, glucose and galactose malabsorption syndrome, or invertase/isomaltase deficiency syndrome (rare metabolic disorders).
Directions for use and doses
It is advisable to take the drug with water, before or during meals. Use for medicinal purposes: children over 6 years old - 1 tablet/day, children over 10 years old and adults - 1-2 tablets/day.
Use for preventive purposes: pregnant women - 1 tablet/day or every other day during the last two trimesters of pregnancy (or starting from the 4th month).
Adult patients should take the drug for a period that ensures correction of anemia and restoration of iron reserves in the body. The dose for women is 600 mg, for men - 1200 mg.
For iron deficiency anemia, the duration of use is from 3 to 6 months, depending on the degree of depletion of the iron reserve: if necessary, in the absence of adequate control of anemia, it is necessary to increase the duration of use of the drug.
