Rating of the TOP 5 best drugs for the liver: use, contraindications, reviews from doctors

Essentiale Forte N/Essentiale N

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Hofitol

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Ursofalk

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The liver is one of the most important glands of the human body. It is responsible for cleansing, normalizing digestion, affects metabolism, synthesizes proteins and bile, which are very important for the normal functioning of all organs. Due to such intense work, the liver suffers more often than other organs. If you overeat a little, drink too much alcohol, or undergo a complex course of treatment, all the negativity will settle on the liver, causing pain and disruption of its functioning. To prevent this and help the liver work stably, you need to periodically take a course of medications to improve its health.

The effects of alcohol on the body

The main component of any alcoholic drink is ethanol (ethyl alcohol). Even small doses of this substance poison the body, creating additional stress on the main filter of the human body - the liver.

Excessive or regular consumption of alcohol leads to the destruction of liver hepatocytes. Over time, tissues undergo pathological changes (fibrosis), even irreversible (cirrhosis).

Long-term abuse of alcoholic beverages is fraught with the occurrence of the following pathologies:

• enlarged liver (hepatomegaly);
• fatty hepatosis, alcoholic hepatitis;
• tissue fibrosis and cirrhosis;
• liver failure;
• hepatocellular carcinoma (cancer).

These diseases develop over a long period of time, so it is necessary to identify symptoms of liver damage by alcohol as early as possible.

Heptral

Heptral is a hepatoprotector that is a derivative of amino acids. This medicine, unlike other hepatoprotectors, can only be purchased with a prescription from your doctor. By the way, in the Russian Federation a group analog of this medication is produced called Heptor. But this substitute, as practice shows, is less effective.

So, the active component of Heptral is a substance called ademetionine. The component has hepatoprotective, anti-inflammatory, neuroprotective, detoxification, antifibrosing, and antidepressant effects.

Heptral:

1. Delays the development of fibrosis and cirrhosis of the liver.
2. Replenishes SAM deficiency in the liver.
3. Stabilizes the production of proteins, phospholipids and other components necessary for normal liver function.
4. Enhances bile production.
5. Stabilizes the activity of liver enzymes.
6. Eliminates skin manifestations of hepatobiliary disorders.
7. Improves mood and fights asthenovegetative syndrome.
8. Protects hepatocytes from destruction.
9. Accelerates regenerative processes in liver cells.
10. Fights acute and chronic inflammatory processes in the cells of the liver, gallbladder and bile ducts.

Indications for the use of Heptral may be angiocholitis, intrahepatic cholestasis, fatty hepatosis, cirrhosis, intoxication, liver failure, hepatic encephalopathy, depressive syndrome, non-calculous cholecystitis. Heptral is also used as part of the complex treatment of infectious diseases, including HIV, hepatitis, and AIDS.

Dosage – 2-4 tablets per day. When using a lyophilisate, you must first mix it with a solvent, the daily dose is 1-2 ampoules. It is recommended to use Heptral for no longer than 20 days.

The price of tablets (20 pieces of 400 mg each) is 1700-1850 rubles, and the lyophilisate costs about 1800-1900 rubles for 5 ampoules.

What are the signs that your liver is damaged by drinking alcohol?

The cause of the development of liver pathologies is severe intoxication that occurs under the influence of alcohol consumption.

The state of alcohol poisoning occurs:

• acute, when a large amount of ethanol enters the body in a short period of time;
• chronic, when alcohol remains in the blood for a long time without having time to be released into the external environment.

In acute intoxication, the degree of intoxication and the amount drunk play an important role, since severe forms of alcohol poisoning can cause irreversible processes in the organs and require urgent medical intervention.

Chronic alcohol intoxication is manifested by the following symptoms:

• periodic or constant pain in the right side (the area under the ribs);
• weight loss, loss of appetite, taste distortion;
• yellowness of the skin and cornea of ​​the eye;
• swelling;
• signs of food poisoning: nausea, vomiting, diarrhea;
• speech and memory disorders, hallucinations, neuroses and psychoses.

Complex hepatoprotector - Remaxol, infusion solution

What should be done first to alleviate the condition of intoxication?

First aid for a person suffering from alcohol intoxication can be provided at home. To alleviate the condition, it is important to remove toxins and poisons from the body as quickly as possible, protect liver cells and restore the balance of microelements.

Adsorbents (Activated carbon, Polysorb, Enterosgel, etc.) are best suited for cleansing the body. It makes sense to give them only if there is no severe vomiting.

Otherwise, the person is first given the drug Cerucal, which suppresses the urge to vomit. In order to enhance and speed up the work of adsorbents, those suffering from alcohol poisoning are advised to drink plenty of fluids.

Hepatoprotectors (Essentiale Forte, Essliver, Phosphogliv, etc.) help protect hepatocytes from the destructive effects of alcohol. The earlier you start taking medications, the lower the risk of developing severe liver pathologies.

The balance of microelements is restored with the help of complex vitamin supplements. You can take vitamins only after the adsorbents have cleansed the body, otherwise all useful substances will be removed along with decay products.

If a person is unconscious, has an irregular heartbeat or breathing, or is vomiting profusely with blood, then he needs hospitalization and self-medication can be dangerous.

Essentiale

Essentiale is one of the most effective and best-selling hepatoprotectors. There are two types of hepatoprotector available in pharmacies - Essentiale N and Essentiale Forte N. They differ in the form of release. The first is available in the form of a solution for intravenous administration, and the second in the form of capsules for oral administration.

The main active ingredient is a mixture of essential phospholipids from soybeans. This component stops inflammatory processes in liver cells, removes toxins and alcohol breakdown products from the body, normalizes bile flow and synthesis, and has a positive effect on carbohydrate, lipid and protein metabolism.

According to the instructions for use, the indications for use of Essentiale N and Essentiale Forte N are:

1. Hepatitis.
2. Fatty steatosis.
3. Cirrhosis, fibrosis.
4. Noncalculous cholecystitis.
5. Chronic alcoholism.
6. Liver failure.
7. Increased levels of low-density lipoproteins (bad cholesterol) in the blood, atherosclerosis.
8. Radiation sickness.
9. Autoimmune diseases, including psoriasis.

Essentiale Forte N should be taken during or after meals. Patients under the age of 12 years are recommended to drink 1-2 capsules 2-3 times a day. Essentiale N is administered intravenously. Daily dosage – 1-2 ampoules. Before administration, the contents of the ampoules are mixed with the patient's blood. It is recommended to use these hepatoprotectors for 1-3 months. If the course is preventive, then 4-5 weeks will be enough.

The price of 5 ampoules of the solution is about 1200-1300 rubles, and a package of 90 capsules costs about 1300-1450 rubles.

Main principles of restoration of liver structures

Subject to complete abstinence from alcoholic beverages, the liver structures can be restored, which occurs in 3 stages:

1. Hepatocyte regeneration.
2. Production of new cells.
3. Active tissue replication.

If a person, despite problems with the liver, continues to drink alcohol, then the tissues begin to replace functional connective tissue - fibrosis, which subsequently turns into cirrhosis (tissue death), which cannot be treated.

Watch a video about liver restoration:

Drug neutralization

The process consists of three stages, the role of which is to transform, neutralize and eliminate chemicals that enter the body. During the action, enzyme elements take part, forming equally dangerous substances that also need to be removed.

If a person drinks alcohol and then drinks ibuprofen, the toxic metabolism increases a thousand times. Poor nutrition, constant consumption of alcohol, and taking medications, such as bromhexine, in large quantities lead to the inability of the neutralization system. The result is the accumulation of fat cells, inflammation, disruption of bile outflow, and cell death.

Medicines that relieve intoxication

Drug therapy of the liver after damage by ethanol plays an important role. Medicines are divided into 4 groups according to their action: protective, regenerating, cleansing and activating.

Phospholipids

Phospholipids have a protective effect on hepatocytes. These drugs contain useful components that stimulate enzyme metabolism and improve the composition of bile. To obtain results, it is recommended to carry out a course of treatment lasting at least six months.

The most popular phospholipid drugs are:

• Gepagard;
• Phosphogliv;
• Essliver Forte;
• Essentiale N (Essentiale Forte).

Amino acids

Amino acids, in particular Ademethionine and Ornithine, are actively involved in the restoration of the liver gland, activating cell regeneration and accelerating the growth of healthy functional tissue. The best results are observed when the drugs are administered intravenously for at least 3 months.

Among the effective amino acids for the liver are:

• Heptral;
• Heptor;
• Hepa-Merz.

Medicines with milk thistle

The substance Silymarin, extracted from milk thistle, has choleretic and antispasmodic effects, which has a beneficial effect on the processes of restoration of damaged hepatocytes. Contraindications to taking such medications are: endometriosis, oncology and hormonal disorders associated with increased estrogen levels.

For the treatment of alcohol intoxication the following is used:

• Karsil Forte;
• Silimar;
• Gepabene;
• Legalon 70.

Artichoke preparations

Artichoke extract contains a large amount of inulin, carotene, iron and other beneficial substances. Pharmaceutical products based on cymarin, the main active ingredient, have a significant choleretic and hepatoprotective effect. Contraindications to the use of artichoke-based herbal remedies are: cholelithiasis, acute hepatitis and severe cholestasis.

In pharmacies you can buy:

• Chophytol;
• Cynarix;
• Artichoke extract.

Medicines of animal origin

Medicines of animal origin are made from extracts from the liver of cattle or pigs. Drugs of this type are contraindicated for children, pregnant and lactating women, as well as people suffering from acute forms of hepatitis. Treatment should be carried out strictly as prescribed by a doctor and under his supervision.

There are two products that have proven their effectiveness:

• Hepatosan;
• Prohepar.

Bile acids

Bile acids, namely Ursodeoxycholic acid, are used to restore the functions of the liver, gallbladder and biliary tract. The drugs have a powerful choleretic and hypoglycemic effect. Bile acids relieve the symptoms of hepatosis and hepatitis, restore the normal functioning of the gastrointestinal tract. Contraindications are inflammatory processes and cholelithiasis.

Most Popular:

• Ursosan;
• Livodex;
• Ursofalk;
• Urdoxa.

Rating of the best bile acid drugs for liver treatment

Urdoxa

Hepatoprotector with cholelitic, choleretic, hypocholesterolemic, and immunomodulatory effects. Increases the protection of liver cells from bile acids.

Changes their structure. Improves the production and excretion of bile.

Destroys gallstones and protects the liver from the harmful effects of alcohol. Ursodeoxycholic acid in the drug prevents cholestatic liver diseases.

Produced in the form of milky gelatin capsules. The number of capsules, as well as the duration of administration, depends on the disease and body weight.

Prescribed for biliary cirrhosis at the stage of compensation of the primary type, for biliary reflux gastritis, medium and small cholesterol stones. Intended for oral use.

pros

• Reduces cholesterol production.
• Minimizes bile lithogenicity.
• Destroys cholesterol stones.
• Replaces toxic bile acids with non-toxic ones.
• Improves the secretion of liver cells.
• Improves immunoregulatory processes in the body.
• Copes with bile stagnation.

Minuses

• The drug is not prescribed to children.
• Long-term use will require significant costs.
• Causes side effects - nausea, vomiting, constipation, diarrhea.

Ursodez

An effective hepatoprotective drug with a choleretic effect. Reduces the concentration of cholesterol in the blood and its further absorption in the intestines.

Promotes the formation and secretion of bile. Strengthens pancreatic and gastric secretion.

Has hypoglycemic properties. When administered enterally, it partially or completely dissolves cholesterol stones.

Helps remove organic compounds from gallstones. Has an immunomodulatory effect.

The main active ingredient is ursodeoxycholic acid. The dosage, as well as the duration of treatment, depends on the disease.

To dissolve gallstones, you will need to take Ursodez at the rate of ten milligrams of the active ingredient per kilogram of body weight. The optimal time for use is before bed.

Capsules must not be chewed. It is important to drink a small amount of water.

pros

• Can be taken for a long time - up to 24 months.
• It is very easy to assess the effectiveness of the drug using ultrasound or radiography.
• Effective treatment.
• Has a complex effect.
• Convenient release form.
• Small capsule size.
• Minimal side effects.

Minuses

• Cannot be used for gallstones with high calcium content.
• Not prescribed for acute inflammation of the bile ducts, bladder or intestines.
• May aggravate dysfunction of the kidneys, liver, and pancreas.
• Not suitable for patients weighing less than 34 kg.
• Do not take during pregnancy or breastfeeding.
• Wasteful expense. Long course of treatment.

Urosliv

The hepatoprotector is produced in the form of white gelatin capsules. Packaged in plastic bottles or blisters.

Has a choleretic effect. Prevents the formation of stones.

Displays existing stones. Effectively affects the composition of bile, the functioning of the pancreas and stomach.

Activates the functions of liver cells. Increases the body's protective functions.

Absorbed in the small intestine. The maximum concentration is observed in the blood two hours after administration.

Then binds to plasma proteins. As a result of prolonged use, it is converted into basic bile acid.

Located in blood serum.

pros

• Cholesterol secretion decreases.
• Toxins are removed from the body faster.
• The functioning of the pancreas and stomach improves.
• Lipase activity increases.
• Blood sugar levels drop.
• Convenient packaging.
• It works effectively. The dynamics can be tracked based on the analysis results.
• Affordable price.

Minuses

• It is forbidden to take the drug in case of calcified stones, obstruction of the bile ducts, acute inflammatory processes, hepatic colic, or if you weigh less than 34 kg.
• Causes nausea, vomiting, pain, diarrhea or constipation.
• Capable of calcifying gallstones.
• Exacerbates psoriasis.
• Leads to hair loss from the scalp.

Ursosan

Contains ursodeoxycholic acid. Prescribed in the treatment of diseases of the digestive tract.

The main active ingredient reduces cholesterol synthesis. Due to this, the concentration in the intestines increases.

The drug has a particularly effective effect when the disease is not advanced. Doctors recommend taking the medicine in the evening.

It is enough to take the capsules with plenty of water. In the first days of taking it, you need to monitor the level of liver enzymes.

pros

• The drug replaces harmful bile acids (with toxins) with non-toxic UDCA.
• Stimulates the body's protective functions.
• Improves the secretory properties of liver cells.
• Ursosan quickly breaks down and is eliminated from the body.
• Painlessly dissolves stones.
• Relieves the condition of gastritis.
• Wide spectrum of action.
• Safe composition.
• Eliminates colic in the right hypochondrium.
• Reduces cholesterol levels.
• Helps against jaundice in newborns.

Minuses

• Not prescribed if the diameter of the stones exceeds 15 mm.
• It may not help with primary type biliary cirrhosis of the liver, even with prolonged use - from 6 to 24 months.
• There are contraindications. Do not take for acute inflammation of the gallbladder and gallstones, colic, or obstruction.
• Causes side effects.
• Prescribe with caution for hepatitis and cirrhosis of the liver.
• As a standard, the drug is allowed to be given to children from 5 years of age. But the age threshold can be changed by the doctor’s decision.
• Exceeding the dosage specified in the instructions causes distress. You need to stop the drug and consult a doctor. It is necessary to restore the water-salt balance in the body.

Ursofalk

Has a choleretic effect. Destroys cholesterol stones.

Prevents the proliferation of connective tissue after damage to liver cells. Contains ursodeoxycholic acid.

The substance forms mixed type micelles. Protects membranes from damage.

Increases the content of bile acids. Which, in turn, promotes the dissolution of cholesterol gallstones.

Strengthens the secretion of the pancreas and stomach. It also has an immunological effect.

Regulates the number of immune cells. It stops fibrosis in cases of primary biliary cirrhosis, cystic fibrosis, and also in cases of alcoholic liver damage.

Reduces the likelihood of varicose veins in the esophagus. As a result of research, the effectiveness of Ursofalk in delaying the development of tumor tissues has been proven.

Therefore, it is prescribed in combination with other drugs for the treatment of colon cancer. Produced in the form of suspension and capsules.

pros

• There are no age restrictions.
• Reduces bilirubin. It is even prescribed to newborns.
• Can be used in combination with other drugs and herbal decoctions.
• Dissolves gallstones.
• Eliminates bending of the gallbladder.
• Has a choleretic effect.
• Eliminates allergic reactions.
• Can be used during pregnancy. Prescribed for hypatosis.
• Relieves nausea and itching.

Minuses

• High price.
• It does not work on all types of gallstones.
• Long course of treatment.
• After taking it, abdominal pain and upset stool appear.
• After withdrawal, the entire effect may disappear.

What should you know when taking the medications described?

Only a doctor can assess the real condition of the liver and develop a treatment strategy. Self-administration of medications is not always safe and does not guarantee results.

An important condition for recovery after drinking alcohol is complete abstinence from alcohol. Even small doses of ethanol nullify any therapy. In addition, some pharmaceutical products are incompatible with alcohol and can cause unpredictable reactions in the body.

During the recovery course, it is recommended to adhere to the following rules:

• give up not only alcoholic beverages, but also smoking;
• adhere to the principles of proper nutrition, exclude fatty, smoked, rich foods, etc. from the menu;
• keep your body weight under control, try to normalize your BMI (body mass index);
• strictly follow the instructions for use of medications and doctor’s recommendations, observe dosages;
• do not interrupt the prescribed course of treatment, even if you feel better.

The occurrence of an allergic reaction or side effects is a reason to consult a doctor for advice.

When are hepatoprotectors needed?

In Russia there is a huge selection of hepatoprotectors, and these drugs are used very often. Moreover, the cost of the course of treatment costs patients large amounts of money, and many do not feel the result. Disputes about the need and advisability of such therapy have been going on for a long time; in our country, a doctor can prescribe hepatroprotectors in the following cases:

• Viral hepatitis (see symptoms of chronic hepatitis) - they are prescribed if antiviral drugs do not help or for some reason antiviral treatment is not possible. In this case, hepatoprotectors can be used to prevent liver cirrhosis in complex treatment.
• Alcoholic hepatitis, threatened by cirrhosis of the liver - in this case, you should avoid alcohol, these drugs do not have a significant effect. If alcohol intake continues, whether the patient uses hepatoprotectors or not is not important. No, even the best medications for the liver will help if a person continues to drink alcohol.
• Fatty liver disease (non-alcoholic) - in obese patients or those with type 2 diabetes, fat cells also form in the liver, which leads to its destruction (see symptoms of fatty liver disease). In this case, hepatoprotectors are needed to accelerate the effect only with an integrated approach to therapy - a diet that promotes weight loss, increased physical activity, antidiabetic drugs, lowering cholesterol (see how to reduce cholesterol without drugs).
• Drug-induced hepatitis (toxic), primary biliary cirrhosis - certain hepatoprotectors are prescribed in complex therapy.

It should be understood that it is impossible to restore the liver with medications alone; you should follow a diet, limit alcohol intake, quit smoking, and also treat concomitant diseases, since the patient often has impaired functions of other organs involved in digestion - the gallbladder, pancreas.

Why are hepatoprotectors as a class of drugs available only in Russia and the CIS countries?

The class of drugs “hepatoprotectors” exists only in Russia and the CIS countries; most of them are not registered in Europe, North America, or Australia. They are not included in the list of tablets for the treatment of liver diseases due to the fact that their therapeutic effectiveness has not been proven and clinical significance has not been confirmed.

Very rarely, some of them are used in the USA and Europe for narrow indications, used as dietary supplements (that is, their use does not guarantee effect). The French company Sanofi, one of the manufacturers of Essentiale, sends 99% of its production to Russia and the CIS countries, since no one in the world needs this drug.

It is worth noting that the pharmaceutical market in the 21st century is a very profitable business, in which competition is as fierce as in any sector of the market economy. And today it is very difficult to determine how effective a particular drug is, since research (very expensive) is funded by interested parties.

Diet with choleretic products

A special diet, including low-fat, fortified and choleretic foods, can significantly speed up the process of liver recovery. A balanced diet solves several problems that arise due to alcohol abuse:

• reduces the load on the gastrointestinal tract;
• cleanses the body of waste and toxins;
• helps normalize microflora.

When choosing products, preference should be given to:

• all types of cabbage (white cabbage, cauliflower, broccoli, Brussels sprouts);
• salad and greens (arugula, watercress, parsley, basil, spinach);
• onions (red and white);
• vegetables (pumpkin, carrots, artichoke, beets, etc.);
• fruits and berries;
• avocado;
• vegetable oils;
• mineral waters.

Meals during the diet should be fractional and divided into small portions.

List of popular hepatoprotectors for 2021

The list of hepatoprotectors with proven effectiveness for 2021 is not that long. First of all, it is ursodeoxycholic acid, as well as amino acids. However, the effect of amino acids in most cases manifests itself only with injections, and ursodeoxycholic acid is used for liver diseases to treat only certain manifestations and cannot be considered as a universal drug.

List of inexpensive and effective hepatoprotectors:

Classification of liver drugs by type of active substances:

Application of vegetable oils and mineral waters

Some vegetable oils have a protective effect on hepatocytes and promote better bile flow. These properties make it possible to use them as an additional means of combating the effects of alcohol intoxication in the body.

Among the vegetable oils that are most beneficial for the liver are:

• pumpkin;
• sesame;
• olive;
• corn.

Proper use of oil as a medicine involves taking 1 tablespoon of the product in the morning on an empty stomach.

Mineral water is an additional means of supporting the body during the recovery period of the liver gland. Drinking plenty of fluids throughout the day is recommended after drinking alcohol, even in small quantities.

You should choose water with a magnesium sulfate composition. If a person does not have chronic diseases and does not suffer from increased gas formation, then drinking carbonated mineral water is acceptable.

Classification of drugs

Liver medications fall into three categories:

• gastroprotectors that restore the organ at the cellular level, protect the liver from harmful influences and remove toxins;
• choleretic, stimulating the liquefaction and outflow of bile;
• cholelitholytics, which break down cholesterol and can dissolve gallstones.

Monastic syrup for liver restoration

Monastic syrup can be used as an additional remedy in the treatment of damaged liver. This product is made on the basis of medicinal plants: ginseng, arrow-leaved horny weed, hawthorn, ginkgo biloba and elderberry.

It is recommended to take 2 dessert spoons of syrup 2 times a day 20 minutes before meals. The result will be most noticeable if weekly cleansing enemas are added to the treatment.

The full course of getting rid of toxins using Monastic syrup is 1 month. If necessary, treatment can be repeated after six months. Contraindications are allergies or individual intolerance to the components.

Allohol

Allohol is a drug with a choleretic effect. In its therapeutic effect, it is somewhat different from the above-mentioned hepatoprotectors. Allochol contains four active ingredients, namely stinging nettle extract, dry bile extract, activated carbon and garlic extract.

The drug affects the secretory activity of the liver. Under the influence of drug components, the activity of liver enzymes stabilizes and even the level of bilirubin in the blood decreases, due to which, after completing the course, it is possible to stop the jaundice syndrome.

Also Allohol:

• Stimulates the production of bile and stabilizes its physical and chemical composition. There is evidence that Allochol reduces the density of bile and even slightly reduces its lithogenicity index, thereby preventing the development of cholelithiasis.
• Fights inflammatory processes in the bile ducts, liver and gallbladder cells.
• Normalizes the activity of the gastrointestinal tract. The tablets improve the process of absorption of fats and other nutrients, reduce the severity of rotting and fermentation processes in the intestines, and eliminate flatulence.
• Removes toxins from the body. Activated carbon binds toxic substances and accelerates excretion from the body.

The abstract mentions that the indications for use of the drug are non-calculous cholecystitis, biliary dyskinesia, atonic constipation, chronic hepatitis, cholangitis. You can also take Allochol for congestion in the biliary tract and for the prevention of hepatobiliary disorders.

It is recommended to take the choleretic medication immediately after meals. The manufacturer recommends taking 1-2 tablets 3-4 times a day. Duration of therapeutic

events – from 2 to 4 weeks.

In pharmacies, the cost of a package of Allohol (50 tablets) does not exceed 70 rubles.

Homeopathic remedies

Despite the fact that the effectiveness of homeopathy has not been confirmed in modern clinical and laboratory studies, single-component herbal preparations have the mildest effect. It is almost impossible to cause harm to health with such drugs, but it is possible to increase the impact of pharmaceutical drugs.

Homeopathic remedies for liver restoration include:

• Galstena;
• Hepel;
• Gepar Compositum.

How do medications affect the liver?

Some medications can cause not only serious illness, but also death. You can often encounter dysfunctions of the organ, resulting in drug toxicity.

In practice, it has been proven that improper and long-term use of drugs not only has a detrimental effect on the liver, but also causes a number of diseases. The results of recent studies indicate that every third person has an important organ that is not healthy.

Dietary supplement for the liver

Dietary supplements that can have a beneficial effect on the restoration process of hepatocytes contain vitamins, minerals and lecithin. As an independent remedy, dietary supplements are ineffective, but in combination with medications they can quickly achieve improvements in the condition.

Today, the following complexes for the liver are presented on the dietary supplement market:

• Dipana;
• Coopers NEO;
• Hepatrin;
• Gepar-Phyto.

Liv 52

Liv52 is an Indian medicine for the liver. The hepatoprotector is classified as a dietary supplement. Liv52 is a multicomponent medication. Its active ingredients are prickly capers, western cassia, common chicory, arjuna, Gali tamarix, and common yarrow.

The Indian dietary supplement has antitoxic, hepatoprotective, choleretic, anti-inflammatory, antianorectic, antioxidant and immunomodulatory effects.

Liv52:

• Normalizes the concentration of triglycerides, HDL, LDL.
• Has a membrane-stabilizing effect.
• Stimulates the production of phospholipids and proteins.
• Reduces the level of alkaline phosphatase and bilirubin.
• Improves colloidal parameters of bile, prevents the formation of gallstones, stimulates gallbladder peristalsis.
• Delays the development of liver fibrosis.
• Increases appetite.
• Fights pain in the abdominal region and hypochondrium, digestive disorders, bitterness in the mouth.
• Eliminates jaundice syndrome, improves the condition of the skin.

Basically, Liv52 is prescribed for fatty hepatosis, toxic and viral hepatitis, cirrhosis of the liver, anorexia, ADHD, non-calculous cholecystitis. It is also useful to take a hepatoprotector during the rehabilitation period after surgery. It is allowed to take it to prevent toxic changes in the liver.

It is better to take Liv 52 tablets before meals. Dosage – 2 tablets/2 times a day. The course lasts 1-2 months. For prevention purposes, it is enough to use the hepatoprotector for 30-40 days; the course can be repeated every 3-4 months.

Packaging price – 400-450 rubles.

Traditional medicine recipes

Traditional medicine is a good help in combating the consequences of alcohol intoxication. They can be used at home in combination with drug therapy.

An important condition for using traditional recipes is timely contacting a doctor for qualified medical care.

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Traditional medicine recipes for protecting, cleansing and restoring the liver:

1. Take 1/2 cup of milk thistle infusion daily before meals.
2. Introducing freshly squeezed grapefruit juice into the diet. You should drink 1 liter of it during the day, 2 times a week.
3. For breakfast, eat low-fat cottage cheese every day with the addition of fruits and berries.

There are special folk recipes for the prevention of liver diseases after alcohol abuse:

1. Avoid fatty, smoked and sweet foods for 2-3 days.
2. For several days after drinking alcohol, drink freshly squeezed vegetable and fruit juices daily.
3. Take a decoction of rowan or hawthorn every day.

Rating of the best drugs for the liver of animal origin

Allohol

The drug contains both plant and animal components. The effectiveness of treating pathological conditions of the hepatobiliary system has been proven.

The composition includes crushed nettle leaves, garlic powder, dry bile, activated carbon. The components regulate metabolic processes in the intestinal wall.

Suppresses the development of helminths. Vitamins of group A, D, E, K promote absorption.

Has a detoxifying effect. Stimulates the emulsification of lipids in the gastrointestinal tract.

Speeds up metabolism. Removes them from the body.

Helps reduce flatulence and the growth of pathogenic microorganisms. The duration of treatment, as well as the dosage, depends on the disease.

pros

• Improves the secretory function of liver cells.
• Stimulates the synthesis of bile acids.
• Accelerates the movement of bile along the biliary tract.
• Eliminates atonic constipation.
• Prevents infection.
• Reduces inflammation.
• The film coating of the drug protects the properties of Allochol.
• Can be combined with other medications.

Minuses

• There are contraindications.
• May cause side effects such as diarrhea. Clinical cases of allergic reactions are also known.
• Exceeding the prescribed amount of the drug leads to an overdose.
• Do not take simultaneously with Cholestyramine, aluminum hydroxide and Cholestipol.

Progepar

The drug was created to protect liver tissue. It also helps restore damaged functional and structural elements of the organ.

Normalizes hepatic blood flow. Increases urination.

Improves liver function. Prescribed for chronic hepatitis, hepatocardial syndrome, liver cirrhosis, toxic hepatitis, toxicosis of pregnancy, kwashiorkor and other disorders.

There are several forms of release. Dragees are suitable for oral use.

It is also produced in the form of a solution for intravenous and intramuscular injections.

pros

• Fast action.
• Effectively restores the liver.
• Created on a biological basis.
• Helps with viral hepatitis.
• Helps with exhaustion of the body.

Minuses

• Causes side effects in the form of redness, vomiting, headache, fever.
• There are contraindications.
• High cost even for one course of treatment.

Hepatamine

The liver bioregulator improves its functions. Restores after a course of treatment, poisoning or under the influence of other negative factors.

Available in tablet form. There are 40 pieces in one package.

Prescribed for the prevention and treatment of polyetiological diseases and other liver damage. Eliminates the consequences of toxic, infectious, metabolic, involutional and other influences.

The drug relieves chronic and acute liver failure. Has hepatotropic properties.

The composition includes nucleoproteins and proteins from cattle. Strengthens reparative processes in liver cells.

Restores their work. The functional-corrective and hepatoprotective effect of the drug has been clinically confirmed.

Prescribed depending on the complexity of the disease. The standard course of treatment is from 10 to 14 days.

Repeat therapy may be required after 3 or 6 months.

pros

• Has a complex effect.
• Restores liver function after chronic and acute diseases, a course of antibiotics and other harmful factors.
• Removes weakness, increases performance and appetite.
• Reduces the intensity of pain.
• Normalizes bilirubin levels.

Minuses

• Do not take if you are hypersensitive to the drug, during pregnancy or breastfeeding.
• May cause an allergic reaction.

Hepatosan

It has a detoxifying and hepatoprotective effect. It has an effect at two stages - in the intestines and during metabolism.

The drug is able to absorb harmful components from the intestines and restore liver cells. The composition includes essential phospholipids, amino acids, vitamins, cytochromes, microelements, mesenchymal enzymes.

"Hepatosan" prevents the absorption of toxins and metabolic products from the large intestine. Also strengthens the walls of liver cells.

Prescribed for the treatment of liver cirrhosis, poisoning with mushrooms, alcohol or medications, chronic and acute forms of liver failure, cholelithiasis. Capsules are intended for oral use.

Doctors recommend drinking them with plenty of water. The best time to take it is half an hour before meals.

The dosage and duration of treatment depends on the complexity and type of disease.

pros

• Supports the liver, pancreas, and gastrointestinal tract.
• Quick effect.
• Easy to take.
• Can be combined with other drugs, for example, Enterosan.
• Available in almost all pharmacies.

Minuses

• There are side effects.
• You can take the drug during pregnancy only under the supervision of a doctor.
• Causes allergies.

Sirepar

The hepatoprotective drug has detoxification properties. Restores liver parenchyma, changes the synthesis of methionine and choline.

Prevents fat filtration. Contains vitamin B12.

The component ensures normal maturation of red blood cells and also promotes better hematopoiesis. It also contains amino acids, fatty acids, and carbohydrates.

Available in the form of an injection solution. Suitable for intravenous and intramuscular slow administration.

You need to mix the drug with blood or sodium chloride (0.9%). Before treatment, it is important to check the body's reaction to possible hypersensitivity.

It is enough to inject no more than 0.2 milliliters of the drug intramuscularly, and then observe the reaction for half an hour. Children from one year to fourteen years will need from 1 to 3 milliliters of the drug per day.

The course of treatment ranges from 2 to 6 weeks. Adults can use from 2 to 8 milliliters.

pros

• Can be combined with other drugs to treat the liver.
• Prescribed to children from one year of age.
• The kit includes detailed instructions.
• It has a complex effect.
• Helps protect the liver during chemotherapy.

Minuses

• After administration, the temperature may rise.
• Causes an allergic reaction. It may appear a few days after the start of treatment.
• There are contraindications.
• The drug has not been imported into the Russian Federation since 2004. Therefore, you can only find it abroad.

Vitamin complexes

Complexes of vitamins and microelements can reduce the destructive effects of ethyl alcohol on liver cells.

Such complexes must include:

• vitamin C;
• B vitamins;
• vitamin E;
• calcium and magnesium;
• retinol (vitamin A).

Pharmacy complexes are suitable for use during the course of liver restoration:

• Supradin,
• Undevit,
• Complivit,
• Vitrum.

What it is?

Hepatoprotectors are a group of diverse drugs that, in domestic practice, prevent the destruction of cell membranes and stimulate the regeneration of hepatocytes, thereby having a positive effect on liver function. They increase the liver's resistance to pathological influences, enhance its detoxification function by increasing the activity of enzyme systems (including cytochrome P450 and other microsomal enzymes), and also help restore its functions in case of various damages (including toxic ones).

At the same time, the proven clinical effectiveness of the use of hepatoprotectors for various conditions is contradictory.

Drawing conclusions

Many patients consider herbal remedies and nutritional supplements to be completely safe and sometimes take them without the knowledge of the doctor and without restrictions. This is a big mistake. During treatment, you should tell your doctor about all dietary supplements, herbs and medications you are taking, as they may be hepatotoxic and interact with other medications you are taking.

All medicinal plants have a complex composition and contain, although minimal doses, toxic (poisonous) substances. For example, many Chinese herbs have hepatotoxic properties, leading to acute liver failure. Moreover, control over such herbal products (food additives) even in the USA, where the safety of drugs and products is strictly controlled, is not carried out to the proper extent. What can we say about Russia? Therefore, the use of any herbal remedies should be treated with caution, keeping in mind their possible hepatotoxicity.

Therefore, for 2021, hepatoprotectors are considered drugs with proven effectiveness (to varying degrees):

1. Ursodeoxycholic acid
2. Amino acid preparations (ornithine aspartate, ademetionine)
3. Silymarin preparations are hepatoprotectors with supposed but unproven effectiveness, used for certain conditions
4. Essential phospholipids - the effectiveness of their use in capsules remains controversial; intravenous administration is more preferable

Cattle liver hydrolysates should not be used due to the potential danger to the human body. Other herbal remedies cannot yet be recommended for widespread use in chronic liver diseases, since their effectiveness has not been properly proven.

Reviews from people

We have selected some reviews from people who have used various hepatoprotectors:

1. Maria. I used to have serious problems with the liver, so for prevention I take a course of hepatoprotectors once a year. I’m not sure whether they help me or not, but I haven’t felt any deterioration in my health for 5 years now. When I was a teenager, I was treated with Essentiale - the drug helped a lot, and as a form of prevention I prefer something homeopathic or milk thistle decoctions.
2. Anton. I have had epilepsy since I was 21. As soon as anticonvulsant therapy was selected, the neurologist prescribed Karsil. I didn’t believe I would need it because I was taking handfuls of PEP and didn’t want to add more medication to it. But after 3 years, liver tests worsened, and I had to cleanse my liver. Since then I have been taking hepatoprotectors twice a year and following diet No. 5.
3. Egor. I underwent a two-week liver cleanse with Heptral as a preventive measure, since I often drink red wine, eat fatty meats and other “healthy” foods. There were no obvious changes in my health, but my health had never bothered me before. The only big advantage of taking the hepatoprotector that I noted was the improvement in intestinal perilstatics.
4. Veronica. She was registered with her illness and regularly donated blood. The drug Phosphogliv was prescribed to me by my attending physician. I can’t say that it somehow protected my liver and improved my condition. It happened that I did not take hepatoprotectors for years, and sometimes I drank it regularly. I didn't notice any difference. Each time I used them I felt sick and, interestingly, I got a runny nose. When the diagnosis was finally removed and the main treatment stopped, the liver tests returned to normal. This was not associated with hepatoprotectors. As soon as I stopped taking the medications, everything returned to normal. I consider these drugs to be a common money grab.
5. Alexei. When I underwent a medical examination at the enterprise, doctors strongly recommended treating my liver, as there was a possibility of developing cirrhosis. I spent three weeks in the hospital, was given a course of heptral, and after discharge I continued treatment with the hepatoprotector on my own. Two months of therapy cost me 12 thousand rubles, but my health improved. The latest examination showed a significant improvement in the condition of the organ.

Ornithine aspartate - Hepa-Merz

Positive opinion - Ornithine helps reduce high levels of ammonia, is used for disorders of brain function associated with impaired liver function, as well as for fatty degeneration and toxic hepatitis. This medicine is practically not used for prevention.

The effectiveness of Hepa-Merz was proven in a randomized multicenter study in patients with liver cirrhosis with elevated levels of ammonia in the blood. It is prescribed for various types of hepatitis, non-alcoholic steatohepatitis, especially for hepatic encephalopathy and cirrhosis of the liver.

Negative opinion - in the case of alcoholic liver damage, it has practically no effect, so supporting and protecting the liver with this remedy is ineffective. A noticeable effect is observed only in hepatic coma. It is advisable to use the drug for the purpose of short-term recovery from this state.

Dietary supplements or homeopathic medicines

List of drugs:

1. Galstena with active plant components - milk thistle, medicinal dandelion and celandine. The drug also contains phosphorus and sodium sulfate. Prescribed for the treatment of liver pathologies occurring in acute and chronic forms, in case of impaired functioning of the gallbladder, chronic pancreatitis.

The medicine is taken after meals or 1 hour before meals. Children under one year old are prescribed ½ tablet 3 times a day, children 1-12 years old - ½ tablet (or 5 drops of the drug), children over 12 years old and adults - 1 tablet. In severe forms of the disease, the frequency of taking the drug is increased to 8 times a day.

1. Hepel. The medicine contains spotted milk thistle, components of the quinn tree, celandine, nutmeg, phosphorus and colocynth. It has anti-inflammatory, analgesic, choleretic and antidiarrheal properties. Prescribed to patients suffering from bloating, appetite disorders, eczema, acne on the body, as well as toxic and inflammatory liver diseases. Hepel is taken three times a day, one tablet. In severe forms of pathology, patients are administered 1 ampoule of the drug intramuscularly.

Hepatoprotectors with amino acids: Heptral, Heptor (Ademethionine)

Positive opinion - amino acids, for example, ademetionine, take part in the synthesis of biologically active substances and phospholipids, and have regenerating and detoxifying properties. By the end of 1 week of use, Heptral also exhibits a pronounced antidepressant effect, breaks down fats and promotes their removal from the liver. These medications are used for fatty liver hepatosis (fatty degeneration), chronic hepatitis, toxic hepatitis, withdrawal syndrome, and depression.

Analysis of clinical studies conducted indicates the clinical effectiveness of ademetionine and indicates a pronounced hepatoprotective effectiveness in alcohol and drug-induced liver damage, cholestatic liver diseases (primary biliary cirrhosis), and chronic viral hepatitis. It has choleretic and cholekinetic effects, antioxidant, neuroprotective and antifibrosing properties.

Negative opinion - Heptral is a registered drug in Russia, Germany and Italy. It is also a veterinary drug in Australia (for dogs and other animals). In all other countries, the drug is positioned as a dietary supplement, since research results have shown dubious results.

Most doctors still claim the effectiveness of this drug, but only if it is infused intravenously, since it is poorly absorbed when taken orally.