Instructions for use of the drug Sorbifer Durules - composition, indications, side effects and analogues

Iron is one of the constituent elements of human blood. It promotes the production of hemoglobin in the blood, which, in turn, saturates the tissues with oxygen. This element is also necessary for metabolic processes in the body and to maintain the immune system. Pregnant women especially need it. Iron is necessary for normal fetal development. You can compensate for its deficiency with the help of products, but this is not always possible, so medications are prescribed. One of these is Sorbifer. Side effects, indications, and features of administration will be discussed below.

What is Sorbifer Durules

Sorbifer is a drug that replenishes iron deficiency in the body, Durules is a special technology for creating a medicine that prevents the active substances from being released in the stomach under the influence of digestive juice. Instead, iron ions are gradually activated in the intestine through peristalsis. This mechanism prevents irritation of the mucous membrane of the digestive system and prevents a sharp jump in iron levels in the body.

Providing assistance in case of overdose

In case of overdose, the following steps must be taken:

• Drink enough liquid to induce vomiting. You can use milk.
• Rinse the stomach with Desferoxamine solution 2 g/l.
• “Desferoxamine” 5 g + 50-100 ml of water enter the stomach and leave.
• An adult can drink Sorbitol.
• It is necessary to take an x-ray of the stomach after lavage to identify the remaining tablets.
• In severe cases, maintenance therapy and intravenous Desferoxamine are prescribed.
• For less severe intoxication, Desferoxamine is administered intramuscularly.

The patient must be under constant supervision. It is necessary to monitor serum iron levels.

pharmachologic effect

The drug has an antianemic effect; its active substances increase the level of hemoglobin in the blood. This complex iron-containing protein is part of the blood and is responsible for the transport of oxygen and carbon dioxide. The generation of hemoglobin is enhanced due to the fact that ferrous sulfate is included in metabolic processes and directly affects the synthesis of heme, the structural part of hemoglobin. Ascorbic acid promotes the penetration of ferrous sulfate from the intestinal lumen into the bloodstream.

What are Sorbifer Durules tablets for?

The drug is used to treat exclusively iron deficiency anemia - it is ineffective for anemia caused by other reasons. Recommended after heavy bleeding to quickly replenish blood loss. This is especially true for uterine, nasal and gastrointestinal effusions. The product is used to compensate for iron deficiency caused by any factors: previous diseases, intensive growth during the transition period, regular donation, poor nutrition, etc.

Sorbifer can be prescribed for preventive purposes to pregnant women, mothers during breastfeeding, blood donors and other conditions characterized by low levels of iron in the body. It is often recommended for athletes to prevent hidden deficiency associated with the inevitable loss of iron during intense training.

Indications

Indications for prescribing the drug Sorbifer Durules are:

• prevention and treatment of anemia (anemia);
• replenishment of iron after severe injuries, illnesses, during active teenage growth, pregnancy, blood donation;
• persistent diarrhea;
• poor, unhealthy diet.

The most appropriate use of the drug is if the low hemoglobin is caused by a lack of iron. To prescribe the correct medications for treatment, you first need to do a blood test. If it is not iron deficiency anemia, Sorbifer Durules will not be effective.

Instructions for use

How to take Sorbifer Durules correctly is determined by your attending physician. The usual therapeutic dose is 1 tablet 2 times a day. In case of side effects, the dosage can be reduced to one dose per day. In severe cases of anemia, 3-4 tablets per day are prescribed. The treatment course continues until the iron deficiency is completely eliminated (this usually takes about two months). After normalization of indicators, it is recommended to continue taking the drug to create a reserve of the substance in the body. For prevention, a maintenance dose is prescribed - 1 tablet per day.

Before or after meals

The summary on how to take Sorbifer Durules states that it is effective when taken 40-45 minutes before meals or 2 hours after meals. People suffering from diseases of the gastrointestinal tract should not take the drug on an empty stomach to avoid possible damaging effects on the gastric mucosa. The tablet is coated and must not be broken or chewed before taking it. The drug should be taken with plenty of liquid - at least half a glass.

Features of application

When carrying a child, a woman should be especially careful when taking any medications. Therefore, it is necessary to familiarize yourself with the features of taking Sorbifer.

• Before treatment, it is necessary to establish the level of iron in the blood serum and the ability of iron to combine in the blood serum using a laboratory method.
• Ineffective in the treatment of other types of anemia.
• When treated with the drug, feces turn dark.
• When taking the drug orally, diseases of the gastrointestinal tract may worsen.
• During a course of treatment, it is necessary to monitor hemoglobin and serum iron levels in the blood.
• For urolithiasis, ascorbic acid intake per day should not exceed 1 g.
• In case of increased blood clotting, high doses of the drug should not be used.
• Long-term course use requires monitoring of the following indicators: blood pressure, kidney function, pancreas function.

• If there is a deficiency of glucose-6-phosphate dehydrogenase, the drug should be used with caution.
• Do not take tablets with alkaline mineral water. This reduces the absorption of the drug.
• Ascorbic acid, which is part of the drug, can affect the following blood parameters: glucose level, bilirubin, lactate dehydrogenase, transaminase activity.

When taking Sorbifer, side effects in women are more likely to occur if they have the following diseases:

• chronic liver and kidney diseases;
• leukemia;
• intestinal diseases;
• inflammatory pathologies of the gastrointestinal tract;
• ulcer of the stomach and duodenum.

Instructions during pregnancy

Almost all women suffer from iron deficiency, the development of anemia and a physiological decrease in hemoglobin levels during pregnancy. To avoid possible complications (for both mother and child), appropriate preventive medications are prescribed. This is especially true during the second and third trimesters. The iron supplement Sorbifer is often used because it quickly increases the level of essential substances.

The recommended dose for preventive purposes during pregnancy is 1 tablet per day. When treating anemia and severe toxicosis, it can be increased to two (depending on the severity of the pathology). The dosage can be increased by the attending physician closer to childbirth (last trimester). While taking Sorbifer, women are advised to avoid dairy products: the calcium they contain makes it difficult for the pregnant woman to absorb iron.

Sorbifer Durules during breastfeeding

During the period from the beginning of pregnancy to the end of breastfeeding, the female body loses approximately 1.4 g of iron, which leads to a serious deficiency of the substance in the body. Sorbifer is effective in replenishing it and is safe for a newborn. Recommended dosage is 2 tablets per day. The course lasts 14-20 days. There is no need to stop breastfeeding during this period.

During lactation, Sorbifer can be taken only on the recommendation of the attending physician, but even in this case, it is advisable to organize the drug intake so that the mother drinks the pill immediately after breastfeeding. You should carefully monitor the baby's condition: if he feels unwell, stop taking Sorbifer immediately, and it is better to show the child to a doctor.

• Vitamin B5 pantothenic acid
• Serum for cucumbers and tomatoes
• Children's menu for every day

Pharmacological properties of Sorbifer

Sorbifer is a combination drug effective for restoring iron levels in various types of anemia. Thanks to the combination of ferrous sulfate and ascorbic acid, an antianemic effect is achieved.

Sorbifer has good reviews as a highly absorbable drug with a gradual release of iron ions, which avoids excess iron in the gastrointestinal tract and blood.

Ferrous sulfate and vitamin C promote hemoglobin production and oxygen transport. Ascorbic acid acts as an antioxidant and collagen, ensuring tissue regeneration.

According to the description, Sorbifer is effective in cases of impaired absorption of iron and its chronic deficiency in the body.

Sorbifer for children

The drug is not suitable for the treatment of children under 12 years of age due to the lack of clinical data on its use (that is, safety for this age has not been established). After 12 years, the drug can be prescribed based on a daily dosage of 3 mg of the drug per 1 kg of the child’s body weight. During the first days of use, you should closely monitor the baby’s condition. If any side effects occur or a general deterioration in your health, you should immediately stop taking the pills. It is advisable to show the child to the doctor.

Side effects

Digestive system: stomach pain, feeling of lack of gastric emptying, narrowing of the esophagus, intestinal obstruction, stool upset, nausea, vomiting, heartburn.

Allergic manifestations: itching, rash, swelling, anaphylaxis. Endocrine disorders - hyperglycemia, glucosuria, diabetes mellitus. Hematopoietic and vascular systems: hypertension, heart attack, increased levels of platelets, leukocytes. Neurology: headache, hyperexcitability, sleep problems.

Side effects usually appear in the first days of taking the drug.

Drug interactions

When Sorbifer is used together with D-penicillamine or tetracycline antibiotics, the absorption of both drugs is equally reduced. The drug reduces the effectiveness of thyroid hormones, enoxacin, methyldopa, levodopa, levofloxacin, clodronate, grepafloxacin. Medicines containing calcium, magnesium or aluminum impair the absorption of iron. The simultaneous use of Sorbifer with Ciprofloxacin, Ofloxacin, Doxycycline, Norfloxacin is unacceptable.

Interaction with other drugs

The drug "Sorbifer" often exhibits side effects during pregnancy if the doctor prescribes several drugs.

Sorbifer should not be used together with the following medications:

• "Moxifloxacin";
• "Ciprofloxacin";
• "Levofloxacin";
• "Norfloxacin";
• "Ofloxacin."

The absorption of these medications is significantly reduced.

It is necessary to maintain an interval of at least 2 hours between taking Sorbifer and the following drugs:

• "Captopril";
• medications containing zinc, calcium, magnesium;
• "Clodronate";
• "Methyldopa";
• "Penicillinamine";
• "Risedronate";
• "Tocopherol";
• thyroid hormones;
• "Pancreatin";
• "Tetracycline";
• glucocorticosteroids;
• "Cimetidine"

Simultaneous use with the drug "Sorbifer" reduces the effect of ascorbic acid:

• oral contraceptives;
• fruit and vegetable juices;
• alkaline mineral water.

The drug "Deferoxamine" together with ascorbic acid increases iron toxicity, especially in the heart muscle.

Side effects

The likelihood of pathological negative reactions increases with increasing dosage, but even in a minimal amount Sorbifer can cause the following side effects:

• nausea and vomiting;
• abdominal pain;
• diarrhea or, conversely, constipation;
• ulcerative lesions or stenosis of the esophagus;
• allergic manifestations (rashes, skin itching);
• nervous system disorders (headaches, weakness, dizziness);
• unpleasant taste in the mouth;
• skin hyperthermia;
• decreased appetite.

Overdose

You need to know the symptoms of a drug overdose:

• nausea;
• vomit;
• abdominal pain;
• diarrhea;
• drowsiness;
• bloody stool;
• tachycardia;

• decreased blood pressure;
• dehydration;
• hyperglycemia.

There is a risk of gastrointestinal perforation.

In severe cases, the health condition may improve for a period of time, but after 6-24 hours the situation worsens again. Convulsions, liver and kidney failure, heart failure, coma are possible.

It is also possible after a few weeks or months to develop cirrhosis of the liver and persistent narrowing of the pylorus of the stomach.

An overdose of vitamin C can lead to hemolytic anemia and severe acidosis.

It is very important to know the symptoms of overdose when taking Sorbifer Durules tablets. Side effects of the drug have similar symptoms; it is important to correctly assess the situation at an early stage. Timely provision of assistance is very important.

Contraindications

The drug cannot be used if the patient has increased sensitivity to any of the components of the drug. Medical contraindications for the drug also include the following body conditions:

• naturally high levels of iron (for example, with hereditary metabolic disorders);
• inability of the body to properly absorb iron (sideroblastic, lead, aplastic, hemolytic anemia);
• heavy bleeding;
• condition after removal of the stomach;
• narrowing of any part of the digestive tract.

Analogs

To compensate for iron deficiency, treatment and prevention of anemia, drugs similar in composition to Sorbifer can be used:

• Fenyuls Zinc is the cheapest possible alternative. Unprofitable for a long course of use due to the small capacity of the package - only 10 capsules.
• Aktiferrin - presented in enteric-coated capsules.
• Tardiferon - has a much lower content of ferrous sulfate (80 mg).
• Ferro-Folgamma has a wider range of both indications and contraindications for use, since the drug, in addition to iron, contains two more active ingredients: cyanocobalamin (vitamin B12) and folic acid.
• Totem - is a solution. Contains additional active substances: gluconates of copper, iron and manganese.
• Actiferrin - comes in the form of oral drops, syrup and capsules. Additionally contains D,L-serine.

What does the drug contain?

"Sorbifer" is produced in the form of biconvex round tablets. Covered with a shell, they have a light yellow color. Z engraving is on one side. They have a peculiar smell. Gray inside.

One tablet contains:

• ferrous sulfate - 320 mg equivalent to 100 mg Fe;
• ascorbic acid - 60 mg.

Auxiliary components of the drug:

• magnesium stearate;
• povidone K-25;
• polyethene powder;
• carbomer 934R.

The shell contains:

• hypromellose;
• titanium dioxide;
• macrogol 6000;
• iron oxide yellow;
• paraffin paraffin

The tablets are packaged in dark glass bottles of 30 or 50 pieces.

Next, we will get acquainted not only with the indications and contraindications for taking the drug “Sorbifer”, we will also pay attention to side effects.

special instructions

The interval between doses of Sorbifer and any other drug should be at least two hours. The tablets are available with a prescription: their independent use is prohibited without a doctor’s prescription and a preliminary determination of the body’s iron-binding activity. While taking the drug, there may be a change in the color of the stool, in some cases even black. This is considered a deviation from the norm and the drug should be stopped.

In case of overdose, you should immediately rinse your stomach, drink a raw egg or milk, and seek medical help. Drinking alcohol during treatment with Sorbifer is unsafe, since under the influence of alcohol the drug loses its effectiveness, its side effects increase, and other pathological processes are possible. As a last resort, you should maintain a twelve-hour break between taking the pill and drinking alcohol.

Price

In Moscow, the drug is available in any pharmacy chain. The cost of Sorbifer varies from 350 to 600 rubles. for a small package, from 440 to 680 rubles. for a large bottle. The product can be purchased in an online store or ordered using an online pharmacy catalog at similar prices: