Travocort cream is a corticosteroid used in dermatology to relieve inflammatory processes of the surface epithelium caused by several factors - a combination of fungal infections and allergic reactions. The auxiliary substances in the composition increase skin elasticity, prevent loss of tone, and increase local immunity.
Composition, release form, dosage
The drug is produced by the German company Bayer, known throughout the world for the quality of its products. Production facilities are located in several countries.
Travocort is produced in the form of a cream for external application. It has a liquid consistency, spreads well, and is quickly absorbed. Contains a slight specific odor. Packaged in aluminum tubes of 15 g. Sold in cardboard packaging. There are also tubes of 20 and 30 g, but they are practically not found in our country.
It contains 2 active components - isoconazole nitrate in a dose of 10 mg, diflucortolone valerate - 1 mg.
- Isoconazole nitrate is a broad-spectrum antibiotic. It has a pronounced therapeutic effect against dermatophytes, molds, yeast-like fungi, and pathogens of erythrasma. The antifungal component destroys pathogenic microflora and stops the pathological process.
- Diflucortolone valerate enhances the effect of the main component, quickly eliminates the external manifestations of the disease, and stops the allergic reaction. The substance belongs to the group of glucocorticosteroids and is a synthetic hormone.
Additional components of Travocort facilitate the penetration of active components into the deep layers of the epidermis, form consistency, and extend shelf life. In general, the composition is hypoallergenic and suitable for problematic, extremely sensitive skin. The basis is liquid paraffin and Vaseline.
Absorption, distribution, excretion
After application to the skin, Travocort is quickly absorbed, the active components penetrate into the deep layers of the dermis. The maximum concentration of active substances in the human body is observed after an hour. Isoconazole concentrates in places of the pathological process and does not enter into biological processes with epidermal cells and tissues. No more than 1% of isoconazole enters the systemic circulation. Completely excreted from the body after 5 hours with urine and feces.
After absorption, diflucortolone accumulates in the layers of the dermis and is susceptible to chemical processes, as a result of which it turns into a metabolite with an identical mechanism of action. The therapeutic effect lasts 7 hours. About 1% of the substance enters the systemic circulation. It is broken down by the liver and kidneys and is excreted within 11 hours in feces and urine.
Pharmacological characteristics
Pharmacodynamics
The synthetic drug Torvacard inhibits HMG-CoA reductase, limiting the rate of cholesterol synthesis. CS, triglycerides, lipoproteins are found in the circulatory system in a complex.
Depending on their density, they are separated into fractions by ultracentrifugation. The liver incorporates triglycerol and cholesterol into the lowest density lipids (VLDL), where they enter the bloodstream to be sent to peripheral tissues.
High levels of total cholesterol (TC), LDL and apolipoprotein B are a risk factor for atherosclerosis and its complications; a sufficient level of HDL, on the contrary, reduces these indicators.
Experiments on animals revealed that statin reduces the concentration of cholesterol and lipid by inhibiting HMG-CoA reductase and producing cholesterol. The number of “bad” cholesterol receptors, which enhance the absorption of lipoproteins of this type, also increases. Reduces atorvastine and LDL synthesis.
Torvacard helps reduce OC, VLDL, TG, and LDL levels even for patients with non-familial and familial hypercholesterolemia and dyslipidemia, which rarely respond to therapy with alternative medications.
There is evidence of a directly proportional relationship between mortality in pathologies of the heart and blood vessels and the content of LDL and TC, and inversely proportional for HDL.
Torvacard and its metabolites are pharmacologically active in the human body. The main place of their localization is the liver, which performs the function of cholesterol synthesis and LDL clearance. When compared with the systemic content of the drug, the dosage of Torvacard is more actively correlated with a reduction in LDL levels.
The individual dose is selected based on the results of the therapeutic response.
Pharmacokinetics
- Suction. The drug is actively absorbed in the gastrointestinal tract after internal use, reaching its highest concentration within one to two hours. The level of absorption increases with increasing dose of Torvacard. Its bioavailability is at the level of 14%, the level of inhibitory activity towards HMG-CoA reductase is 30%. The indicator of low bioavailability is explained by pre-systemic clearance in the gastrointestinal tract and biotransformation in the liver. The rate of absorption of the medicine is delayed by food, but taking food and medicine separately or together does not affect the drop in levels of “harmful” cholesterol . If you use a statin in the evening, its concentration decreases by 30%, but this result does not affect the reduction in the level of “bad” cholesterol.
- Distribution. Over 98% of the active substance binds to blood proteins. Experiments on rats showed that the drug can pass into mother's milk.
- Metabolism. The drug is intensively metabolized. About 70% of its inhibitory activity against HMG-CoA reductase is provided by metabolites.
- Excretion. Most of atorvastine and its derivatives are excreted in the bile after processing in the liver. The half-life of statin is up to 14 hours. After consuming a dose, no more than 2% of the drug enters the urine.
- Gender and age characteristics. In healthy mature people, the percentage of statin content is higher than in young people, therefore the degree of reduction in LDL levels is greater in them. In women, the content of Torvacard in the blood is higher, but this factor does not affect the rate of decrease in LDL levels. There are no data on the reaction of children to Torvacard.
- Kidney pathologies. Renal failure does not affect the percentage of statin levels and does not require dose adjustment. Hemodialysis will not increase the clearance of the drug, since atorvastine is tightly bound to proteins.
- Liver diseases. Liver diseases associated with alcohol abuse affect the level of the drug in the blood: its content is noticeably increased.
Therapeutic effects
Quick results and high efficiency are ensured thanks to the combined action of Travocort. The drug has anti-inflammatory, antibacterial, antifungal, and antiallergic properties. The main components enhance each other's action and accelerate regeneration processes.
Isoconazole is a powerful systemic antibiotic that destroys the cell membranes of pathological microorganisms. The main advantage of the component is its selective action - it does not affect the vital activity of beneficial bacteria.
The antibiotic is effective against:
- dermatophytes;
- yeast-like, yeast, mold fungi;
- micrococci;
- staphylococci;
- streptococci;
- trichomonas;
- corynebacteria.
Diflucortolone stops allergic and inflammatory processes. Thanks to this component, itching, burning, irritation, redness and swelling disappear. The local hormone is much stronger than betamethasone, and practically does not enter the systemic circulation, which reduces the likelihood of side effects.
The therapeutic effect occurs within a few minutes after using the cream. Over the course of a day, the affected area decreases, tissue swelling, redness, and itching disappear. The duration of therapy depends on the complexity of the symptoms, but not more than 2 weeks.
Reviews from doctors and patients
In modern dermatology, Travocort cream is often used. Reviews from doctors about it are positive, since the drug really quickly copes with its main task, while rarely causing side effects.
Patients also respond well to this product. Positive changes can be noticed after 1 – 2 days. Itching, burning and other unpleasant sensations disappear almost immediately. Longer therapy will be required to eliminate spots and other skin lesions. The cream is quickly absorbed, does not leave an unpleasant odor, is light and easy to use.
The disadvantages include its high cost, which not everyone can afford. On the other hand, healthy, beautiful skin costs so much money.
Indications
Travocort cream is indicated for dermatological diseases complicated by fungal infection with the presence of an inflammatory process in the presence of obvious signs of allergy. The drug is prescribed for various dermatoses caused by fungal, bacterial pathogenic microflora.
- Mycoses of the skin on different parts of the body, including the face, head, genitals;
- Candidomycosis of any localization;
- Tinea versicolor;
- Erythrasma.
The drug is prescribed for dermatitis of various origins, complicated by a secondary infection.
Instructions for use
The combined drug Travocort is characterized by rapid effectiveness, the maximum course of therapy is 2 weeks. An improvement in the condition of the skin is observed after 1 day of use.
General rules
It is recommended to apply the product in a thin layer to the affected areas, slightly covering the area of healthy skin. Distribute with circular massage movements without intense rubbing. First, you should clean the epidermis of dirt and secretions using soap and water and a cotton swab soaked in hydrogen peroxide.
It is recommended to carry out the treatment procedure twice a day. After the disappearance of severe symptoms - swelling, redness, cracks, peeling, itching - switch to a single application before bedtime. This usually happens after 3 days.
Special instructions when using Travocort cream:
- In case of deep cracks or severe damage to the skin, it is recommended to soak gauze with cream and fix the eczema in place with a plaster or bandage.
- Throughout the course of therapy, direct sunlight should be avoided on the treated areas of the body.
- Do not apply the product to the skin around the eyes and should not be applied to open wounds. In case of contact with the mucous membrane of the eye, rinse immediately with water.
- During therapy, you should refrain from alcoholic beverages, which may increase the occurrence of side effects.
- To speed up the healing process, you should take a bath or shower daily. Change bedding and sleeping linen every 3 days.
- Manufacturers do not recommend using the cream for children under 18 years of age, due to the lack of reliable data on the effect on the growing body. However, in pediatrics the drug is prescribed after 2 years, therapy is carried out under the supervision of a specialist.
- The cream should not be used by pregnant women in the first trimester or while breastfeeding. In the second and third trimester, it is prescribed in case of urgent need, under the supervision of specialists. The maximum course is no more than 10 days. If it is necessary to use the product during breastfeeding, the child is temporarily transferred to artificial nutrition.
- The drug should not be used on the face for more than 5 days. It is recommended to apply once a day before bedtime.
If you follow the instructions, Travocort cream quickly copes with bacterial and fungal infections, stops allergies, and promotes tissue restoration.
Travocort for lichen
The cream is prescribed for complex forms of lichen, with large areas of inflammation, cracks, and itching.
Pre-cleanse the skin and dry it with a napkin. Travocort is applied in a thin layer, twice a day until the skin condition normalizes. After the disappearance of severe symptoms - after 1-2 weeks, they switch to an antifungal drug without a hormone. Travocort should not be used for lichen if there are no deep cracks, inflammation, or severe itching. In this case, use a local antibiotic without a glucocorticosteroid.
Travocort for balanoposthitis
The cream is part of complex therapy and is used together with antibiotics in tablet form. The product is applied twice a day for 5 days to the head of the genital organ. The drug quickly stops an allergic reaction, relieves irritation, relieves itching, and stops the restoration of pathogenic microflora. If necessary, after 5 days, treatment with a local antibiotic is continued, but without the hormone.
Groin fungus
Travocort is used for pronounced inflammatory processes and large areas of damage. The skin in the groin area is first cleaned with warm water and soap and dried with a napkin or towel. Apply the cream in a thin layer twice a day until inflammation, itching, and peeling disappear. The maximum allowed use of the medication is 2 weeks. If necessary, continue treatment with an antibiotic without a hormone. To speed up recovery, it is recommended to carry out water procedures daily and change underwear every day.
special instructions
After applying Travocort, susceptibility to ultraviolet radiation increases, so you should avoid exposing the treated areas to direct sunlight. But this is not the only limitation when using Travocort.
During treatment:
- Do not apply to the skin near the eyes, and if it gets on the conjunctiva, rinse immediately with running water. If the recommendation is not followed, glaucoma may develop. If you already have a history of this disease, you must notify your doctor.
- When using the cream, you will have to give up alcohol - the likelihood of side effects increases.
- Not prescribed to children under 2 years of age.
No interaction is observed when used together with other drugs. Travocort does not reduce the speed of reactions and does not impair coordination.
No effect on fertility was detected. Reproductive toxicity has been established in animal studies, therefore the drug is not prescribed in the 1st trimester of pregnancy. During lactation it is not recommended to apply to the mammary glands. When using, compare the possible risk to the baby with the benefit to the mother. It is still not clear whether diflucortolone valerate - isoconazole nitrate is excreted in breast milk, so lactation is interrupted during use.
Use of Travocort and Travogen
The drugs are produced by one company and are intended for the complete treatment of fungal infections. Travogen differs from Travocort only in the absence of a hormonal substance. It has pronounced antifungal and anti-inflammatory properties, accelerates tissue regeneration.
Trovocort is used for complicated dermatitis of various etymologies, with pronounced painful symptoms. The product quickly eliminates the external manifestations of the pathological process. However, the skin does not always have time to recover in 2 weeks. Typically, treatment for a fungal infection lasts about a month. Consequently, Travocort is used for the first 14 days, then they switch to Travogen until complete recovery.
Additional Information
It is worth noting that the drug Travocort alone is not always enough for a complete cure. The cream certainly helps to destroy pathological fungal microflora, but in the presence of a combined infection, additional use of antibiotics and other medications is sometimes necessary.
You should also follow a healthy diet during treatment. It is extremely important to maintain hygiene - change clothes, towels, bed linen, etc. every day, and then wash everything at high temperature with appropriate cleaning products - this will help prevent re-infection and speed up the recovery process.
Side effects
In most cases, Travocort is well tolerated and does not cause side effects. The exception is the presence of individual intolerance to the components, which manifests itself in increased allergic symptoms.
To prevent negative consequences, a test must be performed before active use. The cream is applied in a small amount to the skin on the elbow or under the knee. Observe the condition of the epidermis for half an hour. The appearance of any negative changes is grounds for refusing Travocort therapy.
Since the active substances enter the general bloodstream in minimal quantities, the development of side effects is minimized. However, with prolonged use of the product - more than 4 weeks, the condition of the skin worsens, and relapses of fungal infection or allergies are possible.
- Spider veins;
- Atrophy;
- Excessive dryness;
- Perioral dermatitis;
- Excessive hair growth;
- Striae, stretch marks;
- Acne;
- Change in color of the epidermis;
- Kidney, liver failure;
- Sleep disturbance;
- Irritability;
- Decreased ability to work;
- Headache;
- Nausea;
- Dizziness.
Systemic side effects disappear on their own within a few days after discontinuation of the drug. Changes in the skin require symptomatic therapy.
Side effects and overdose
Usually the drug is easily tolerated, even when applied to sensitive skin. But at the site of application, burning, rashes in the form of vesicles and papules may occur. Infrequently, redness and peeling occur due to dryness. With a negative effect on the subcutaneous tissue, stretch marks are formed.
Due to the hormonal component, if the recommendations for use are not followed, the following may appear: atrophy of the epithelium in a limited area, folliculitis, increased hair growth, perioral dermatitis, acne, changes in pigmentation. Systemic effects may develop, as indicated by digestive disorders such as nausea, diarrhea, or dizziness.
During pregnancy or lactation, the drug is prescribed with caution, especially if it is necessary to apply to large areas. Immunosuppression (decreased immunity) and disruption of the adrenal cortex (hypofunction) may occur.
Symptoms of overdose are similar to the side effects from Travocort. Negative reactions occur only due to increased absorption when applied to large areas of the skin or accidentally taken orally. Treatment is symptomatic.
Read more Salvisar ointment - instructions for use and analogues
Contraindications
A direct contraindication to the use of Travocort cream is the presence of individual intolerance to the components. Side effects develop after the first use. In this case, therapy should be stopped immediately. Other contraindications are associated with the presence of pathological processes and various diseases:
- open wounds;
- rosacea;
- acne;
- syphilis, skin tuberculosis;
- viral infections;
- reaction after the vaccine;
- perioral dermatitis;
- children under 2 years of age;
- pregnancy in the first trimester;
- lactation.
The hormonal drug should not be used in case of severe renal or liver failure.
Reviews about Torvacard
Reviews about the drug Torvacard are mixed, but conclusions about its ineffectiveness and severe side effects are premature. Everyone who has been helped by the drug, as a rule, does not share their successes. Those who have individual intolerance or have chosen the wrong dosage complain.
Sometimes, consumers confuse their bad habits with the side effects of atorvastatin. If a patient has an alcohol addiction, he is unlikely to advertise it, and he will definitely complain about pain in the liver after taking pills.
Anton, Rostov. I am an insulin-dependent diabetic and hypertensive (2nd degree). I have been taking Tovacard for five years – 20 mg in the evening. My cholesterol is normal, I get tested regularly. The state of health is also good. I’m glad that after 4 years there was no addiction – my dosage was never adjusted.
Julia, Ekaterinburg. During a comprehensive examination, I was diagnosed with elevated total cholesterol - 7.5 mmol/l. To reduce the level, the doctor suggested Tovacard. Statins are not the cheapest drugs, but I was prescribed only one tablet (10 mg) per day. A month later, cholesterol was already 5.7 mmol/l and I no longer needed to take Torvacard tablets. The doctor advised me to continue following the low cholesterol diet that he recommended to me at the beginning of the course.
In this video, immunologist, Ph.D., talks about modern methods of lowering cholesterol. I.D. Lozhkin is Deputy Director for Science at Apifarm.
Analogues of Travocort
There is no identical drug on the domestic pharmaceutical market. There are many products with a similar mechanism of action. The drugs include an antifungal component, a hormone from the group of glucocorticosteroids.
- Akriderm;
- Belosalik;
- Diprosalik;
- Candiderm;
- Elokom;
- Rederm.
The drugs have similar indications and contraindications. The main factor that buyers pay attention to is price. The cost of analogues is from 200 rubles. However, the issue of replacing one drug with another should be discussed by a specialist.
