Dermovate cream and ointment - application features, effectiveness, reviews

Compound

Dermovate merhem ointment contains 50 mg of lobetasol , the active substance.
Additional Ingredients:

• 500 mg - sorbitan sesquioleate;
• 5 g - propylene glycol;
• up to 100 g - white soft paraffin.

Dermovate cream contains 50 mg of clobetasol , the active substance.

Additional Ingredients:

• 11 g - glyceryl monostearate;
• 1.5 g - arlacel 165;
• 8.4 g - cetostearyl alcohol;
• 1.25 g - beeswax substitute 6621;
• 47.5 g – propylene glycol;
• 50 mg - sodium citrate;
• 75 mg - chlorocresol;
• 50 mg - citric acid monohydrate;
• up to 100 g - purified water.

general description

Dermovate ointment has a white tint and a soft translucent consistency. The main ingredient of this drug is clobetasol propionate. Also included are additional ingredients:

• Sorbitan sesquioleate;
• Glyceryl monostearate;
• Sodium citrate;
• Propylene glycol;
• Arlatzel;
• Chlorocresol;
• Cetostearyl alcohol;
• Water;
• Lemon acid;
• Light colored paraffin.

The drug is sold in pharmacies only upon presentation of a medical prescription. It is produced in 25-gram aluminum tubes, packed in cardboard boxes. The ointment should be kept in a room where the air temperature does not exceed 30 degrees. If stored properly, it will be good for 2 years. The average price of Dermovate is 440-450 rubles.

Pharmacological characteristics

Glucocorticosteroids for external use prevent the accumulation of certain leukocytes, reduce the release of inflammatory exudate and lymphokines, and also stop the circulation of cells that can absorb some particles, crush them and make infiltration less intense.

GCS has antipruritic, anti-inflammatory, antiexudative and antiallergic properties.

Pharmacodynamics and pharmacokinetics

The drug Dermovate belongs to the group of glucocorticosteroids and is used for external (local) use. Application of ointment or cream prevents the marginal position of neutrophils in the vascular bed, reduces the production and inflammatory effusion of lymphokines , prevents the migration of macrophages granulation and infiltration processes , thereby providing anti-inflammatory, antiexudative, antiallergic and antipruritic effects of a local nature.

The average Cmax of clobetasol is observed in plasma 13 hours after the first application of 30 g of the drug in the form of an ointment to healthy skin (or after 8 hours with repeated application) and is equal to 0.63 ng/ml.

The average Cmax of clobetasol when reapplying 30 g of the drug in cream form after 10 hours is slightly higher than when applying an ointment.

After a single application of 25 g of ointment after 3 hours in patients suffering from eczema and psoriasis the average Cmax of the drug in plasma is, respectively, 4.6 ng/ml and 2.3 ng/ml.

The metabolism of the active substance of the drug Dermovate has not been fully studied.

Release form

The drug is available in the form of ointment and cream. It differs in auxiliary components, consistency, absorption rate, and duration of the therapeutic effect.

• The cream has a light consistency, is quickly absorbed, the therapeutic effect occurs quickly, lasting about 4 hours. The product has a specific smell that disappears after a few minutes.
• The ointment is quite thick, but spreads well. It is absorbed more slowly, the therapeutic effect after one application lasts about 8 hours.

Dermovate is packaged in aluminum tubes of 25 g. The product is used sparingly, one tube is enough for the entire course of therapy for 14 days.

Indications for use

• various forms of eczema;
• psoriasis;
• discoid form of lupus erythematosus;
• lichen planus;
• pathologies of the skin that are resistant to treatment using less active external glucocorticosteroid drugs.

Dermovate in the form of an ointment is recommended for use for skin diseases that are accompanied by dryness, thickening and hyperkeratosis, since the ointment base helps retain moisture in the skin.

Dermovate in the form of a cream is recommended for use in the opposite cases, in pathological processes with severe inflammation, which are accompanied by weeping.

Contraindications

• skin cancer;
• acne vulgaris;
• nodular prurigo Hyde;
• genital and perianal itching;
• perioral dermatitis;
• widespread pustular and plaque psoriasis;
• breastfeeding period ;
• children under 1 year of age;
• fungal, viral and bacterial pathologies of the skin (including chicken pox, herpes simplex, actinomycosis, skin tuberculosis );
• hypersensitivity to the constituent ingredients of the drug Dermovate.

Side effects

When using the drug Dermovate topically, hypersensitivity was very rarely observed.

Among the local manifestations of hypersensitivity, the following were noted: rash, erythema, itching, local burning sensation of the skin, urticaria and contact dermatitis of allergic etiology, which occur at the sites of application of the drug and are similar to those symptoms for the treatment of which the drug was prescribed.

If hypersensitivity symptoms occur, therapy with Dermovate should be discontinued.

On the part of the endocrine system, symptoms of hypercortisolism , which manifest themselves when using a large amount of ointment or cream, as well as when applying the drug to large areas of the skin, and are a consequence of significant systemic absorption of the drug. These manifestations are most likely in patients of childhood and infancy, as well as when using a sealed bandage after applying the drug. It is worth remembering that in infants, the use of a diaper can act as an airtight bandage.

When adult patients use doses of the drug not exceeding 50 g per week, inhibition of pituitary or adrenal function is temporary, with the return of normal parameters of these organs after discontinuation of a short course of therapy using local glucocorticoids .

Rarely, when Dermovate was prescribed, dilation of the superficial vessels of the circulatory system was noted, especially with intensive rubbing of the drug into the folds of the skin or the use of occlusive dressings.

atrophy and atrophic streaks were rarely observed in the skin and subcutaneous tissues . Very rarely, there was an exacerbation of the main symptoms of the disease, changes in pigmentation, thinning of the skin, hypertrichosis and the development of psoriasis in the pustular form . These manifestations also most often occur when the drug is rubbed into skin folds or when occlusive dressings are used.

Local hormonal therapy

Hormonal ointments contain glucocorticosteroids, which have a strong effect on the endocrine system, reducing the production of hormones. The patient feels the effect of using such products immediately after application. Due to this property, steroid drugs are prescribed at the peak of exacerbation of the disease.

Hormonal ointments should not be used for more than one week, otherwise it can cause serious disruptions in the functioning of the body:

• development of urolithiasis;
• the appearance of addiction to the product;
• skin pigmentation;
• atrophic changes in the dermis;
• hormone imbalance.

https://www.youtube.com/watch?v=dQGDb_u4Rxg

Instructions for use (Method and dosage)

The instructions for Dermovate recommend applying a thin layer of cream or ointment to the affected areas of the skin, once or twice a day, depending on the severity of the lesion.

Dermovate cream is more suitable for pathologies with severe inflammation and weeping , while the instructions for use recommend using Dermovate ointment for diseases accompanied by dry skin.

The course of therapy with Dermovate is determined individually based on the diagnosed disease and its severity, but should not exceed 4 weeks, without further assessment of the advisability of its continuation.

In case of exacerbation of previously treated skin diseases, repeated short courses of therapy with Dermovate may be prescribed.

If necessary, if the external manifestations of the disease do not completely disappear, after completing the course of treatment with Dermovate, they switch to the use of less aggressive external agents from the group of glucocorticosteroids.

In particularly severe cases of skin lesions, especially in the presence of hyperkeratosis, the anti-inflammatory effect of Dermovate ointment and cream can be enhanced by using plastic film as a dressing at night. An occlusive dressing is applied to the affected area for a greater positive effect, if achieved, further progress in treatment can be maintained without applying an occlusive dressing.

The maximum recommended weekly dose of ointment or cream is 50 g per week.

How to use the product correctly

For psoriasis, the use of Dermovate ointment is not uncommon. The product can quickly cope with the existing problem, but do not forget about the rules of use and basic precautions. It will be very good if a person uses the specified ointment, guided by the following recommendations:

• Apply only to clean, dry skin;
• Wash your hands before each application of medicinal ointment;
• when using this product and other creams, observe the time interval before applying each;
• do not apply the product to healthy areas of the skin;
• avoid contact of the medication with the mucous membranes of the nose and eyes;
• do not use after the expiration date;
• Complete the prescribed course of treatment completely, regardless of the effectiveness of the results.

The ointment should be used extremely carefully. Before purchasing a product, you should pay attention to the conditions in which it was stored and check for quality certificates. If discomfort occurs during treatment of psoriasis with this drug, a person should notify the doctor about this effect.

Dermovate should be kept away from sunlight and children. This medication must be used daily.

Overdose

Due to the fact that the dosage forms of the drug Dermovate are used exclusively topically, the likelihood of developing symptoms of acute overdose is minimal.

In cases of chronic overdose, due to prolonged use of the drug or the use of large doses, the development of hypercortisolism syndrome , which is an indication for reducing the dose of Dermovate or discontinuing therapy using local corticosteroids. Cancellation of therapy should be carried out under the constant supervision of the attending physician, due to the risk of possible development of adrenal insufficiency.

For liver dysfunction

In patients with liver dysfunction, in the case of systemic absorption of the active substance Dermovate (when applied to large areas of skin over a long period of time), its metabolism and elimination rate slow down somewhat, which can significantly increase the risk of developing systemic toxicity. Therefore, in patients of this category, the drug is used in small quantities for a limited period of time, while paying special attention to achieving the required clinical effect.

special instructions

Therapy using drugs from the group of glucocorticosteroids is not recommended for a long period of time, especially when prescribing this group of drugs for the treatment of patients of young childhood, due to the possible suppression of the function of the adrenal cortex.

The use of Dermovate drugs in childhood requires mandatory monitoring of the patient's condition by the attending physician, at least once every 7 days.

As a result of long-term treatment with glucocorticosteroids, atrophic changes in the skin may appear, most often more pronounced on the skin of the face.

If it is necessary to apply ointment or cream to the eyelids, it is necessary to protect the mucous membrane of the eyes from contact with the drug, as this can lead to the development of glaucoma.

Therapy of psoriasis with the use of Dermovate may be accompanied by relapses of the underlying disease, the development of a generalized pustular form of pathology, increased tolerance to the drug, systemic and local toxic reactions occurring due to violations of the barrier functions of the skin, and therefore, constant monitoring of the patient’s condition is necessary .

If signs of a secondary infection joining the underlying disease are detected , appropriate antibacterial treatment is prescribed .

For any symptoms indicating generalization of infection , therapy should be discontinued and adequate treatment using antibacterial drugs should be prescribed.

It should be remembered that when using an occlusive dressing, moist, warm conditions are created that contribute to the development of bacterial infection , and therefore it is necessary to thoroughly clean the affected areas of the skin before applying the next dressing.

It is not recommended to dilute the drug Dermovate in the form of a cream.

What is more important – the health of the unborn child or the young mother?

Psoriasis or eczema is not at all a reason to deprive yourself of the joy of motherhood. Such women are likely to give birth to a completely healthy baby. But how to properly use Dermovate ointment - a hormonal substance, so as not to harm the fetus? At present, there is no final confirmation or refutation of treatment with the drug during pregnancy. But animal studies have shown an intrauterine effect on the fetus.

Therefore, is it worth considering such an active drug on yourself? The same applies to the lactation period and the prescription of treatment for a baby up to one year old. It is best to spot Dermovate on Cloveit or Powercourt. And then, only after consultation with a specialist. This applies especially to young mothers who are trying to cure diaper rash.

Additional Information

Avoid getting the ointment on the mucous membrane of the eyes - this can cause glaucoma. After each use, try to wash your hands, avoiding washing off the ointment in places where it is needed. Insist on frequent consultation with a specialist and do not experiment on yourself. Self-medication is much more difficult than preventing an exacerbation. Be sure to read the internal instructions for the drug - this information is for informational purposes only and does not bear responsibility for your health.

Dermovate, like any medication, has indications and contraindications. What is important is not even the effect of the drug on the body, but the attitude towards your health itself. Timely consultation with a specialist, the correct dosage and monitoring of your condition will help you live a full life, even with diseases such as psoriasis or eczema on your hands.

Cost of the drug

The price of the drug is 450 - 500 rubles. It is partially higher than its domestically produced counterparts. It can be bought at every pharmacy, but despite its availability, you should be especially careful when using medications.

Analogs

Level 4 ATX code matches:
Powercourt

Triacort

Locacorten

Laticort

Afloderm

Fluorocort

Lorinden

Analogues of Dermovate cream or ointment may be prescribed when switching to a less aggressive therapy, or due to any reasons why this drug is not suitable for treating a particular patient.

You may be offered the following analogues of Dermovate for topical use:

• Afloderm;
• Lokoid;
• Laticort;
• Triacort;
• Fluorocort , etc.

Substitutes

There are several analogues of Dermovate, sold cheaper, but with similar properties:

1. Laticort;
2. Powercourt;
3. Cloveit;
4. Delors;
5. Carizon;
6. Klobeskin.

Laticort

Powercourt

Cloveit

Delors

Carizon

Klobeskin

Reviews of Dermovate

Reviews of Dermovate ointment, used to treat various skin diseases, including psoriasis, indicate the high effectiveness of therapy, rapid relief and subsequent complete disappearance of external manifestations. Dermovate cream also receives positive reviews.

On user forums there are mentions that in case of relapses of psoriasis or eczema , the previously effective remedy Dermovate did not have the same therapeutic effect when used again.

It is worth noting that with frequent use of a cream or ointment, especially in large quantities, the body may develop resistance to this drug. In this regard, it is recommended to use the drug only as indicated and in minimally effective doses, especially for the treatment of pediatric patients.

Is the ointment hormonal?

Containing active ingredients belonging to the class of corticosteroids, Dermovate ointment is hormonal . The hormone used is also present in the body . Corticosteroids are produced by the adrenal glands. The active substance effectively affects metabolic processes involving proteins and carbohydrates. Therefore, the ointment is used to treat skin diseases .

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On the one hand, the presence of hormones in the medicine gives a longer lasting result in a short period of use . Helps to speed up recovery, eliminate clinical signs and the source of the disease.

But long-term use of hormonal treatment may have the opposite effect . The wounds do not heal ; small hemorrhages are visible under the skin. The hair at the site of the lesion either accelerates its growth, or the area quickly becomes bald . Often spots on the skin. Therefore, the use of the product occurs under the supervision of a doctor.

Dermovate price, where to buy

Dermovate cream, depending on the region, can be purchased in Russian pharmacies at a price of 300 to 500 rubles.

The price of Dermovate ointment fluctuates around the same range.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Dermovate ointment 0.05% 25gGlaxoSmithKline Pharmaceuticals SA
  RUR 541 order
• Dermovate cream 0.05% 25gGlaxoSmithKline Pharmaceuticals SA

  516 RUR order

Pharmacy Dialogue

• Dermovate ointment (tube 25g)GlaxoSmithKline

  612 rub. order

• Dermovate cream (tube 25g)GlaxoSmithKline

  590 rub. order

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Pharmacy24

• Dermovate 0.05% 25 g cream GlaxoSmith Klein Pharmaceuticals S.A., Poland
  128 UAH order
• Dermovate 0.05% 25 g ointment GlaxoSmith Klein Pharmaceuticals S.A., Poland

  135 UAH order

PaniPharmacy

• Dermovate ointment Dermovate ointment 0.05% 25g Poland, GlaxoSmithKline Pharmaceuticals

  136 UAH order

• Dermovate cream Dermovate cream 0.05% 25g Poland, GlaxoSmithKline Pharmaceuticals

  142 UAH order

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