All about Curantil: instructions for use, indications and analogues

Description and composition

25 mg tablets are round, coated, their color can vary from yellow to yellow-green.

They contain dipyridamole as an active substance. It contains 25 mg in 1 tablet.

In addition to this, the medication includes the following auxiliary components:

• Aerosil;
• milk sugar;
• corn starch;
• E 572;
• talc;
• gelatin.

The shell is formed by the following substances:

• sucrose;
• calcium carbonate;
• titanium white;
• propylene glycol 6000;
• E 504;
• talc;
• polyvidone;
• palm wax;
• glucose;
• quinoline yellow.

The package contains 100 tablets.

Also on sale you can find Curantil tablets No. 25 mg, 120 pieces per pack. They are covered with a yellow film shell, round, flat-cylindrical in shape.

They contain dipyridamole as an active ingredient, 25 mg per tablet.

They contain almost the same auxiliary components as the composition of the Curantil 25 No. 100 dragee, but instead of talc they contain sodium carboxymethyl starch (type A).

They also differ in the composition of the shell; it is formed by the following substances:

• talc;
• propylene glycol 6000;
• emulsion simethicone;
• hypromellose;
• titanium white;
• quinoline yellow dye.

Tablets Curantil No. 75 have a flat-cylindrical, round shape. Each of them is covered with a yellow film shell on top. 1 tablet contains 75 mg of dipyridamole. The package contains 20 tablets.

The composition of the shell and excipients is the same as that of Curantil No. 25 tablets, which come in 120 pieces. packaged.

pharmachologic effect

The active substance dilates blood vessels, stops platelet aggregation, and normalizes microcirculation.

Vasodilation is associated with suppression of adenosine uptake by blood and endothelial cells. After taking the medication orally, the adenosine content in the blood increases and its vasodilatory effect increases, platelet adhesiveness is inhibited, and the tendency to form blood clots decreases.

In addition, the active substance inhibits the enzyme phosphodiesterase, which is also responsible for platelet adhesion.

Dipyridamole also stimulates the production of interferon, resulting in increased nonspecific resistance of the body to infections of viral etiology.

After a single oral dose of 150 mg, the highest plasma concentration is observed after an hour. The active substance is almost completely bound to blood proteins and deposited in the heart and red blood cells. Passing through the liver, it undergoes metabolism. The half-life may vary from 20 to 30 minutes. The drug is excreted in the form of metabolites through the intestines.

Use when planning pregnancy: arguments for

The main active component of this drug is dipyridamole , a substance that can improve the conditions of microcirculation of blood in the tissues of the body due to a direct effect on the aggregation (sedimentation and accumulation) of platelets.

Accordingly, under the influence of this medicine, tissue metabolic processes in any organs and tissues are improved, including the uterus, ovaries, endocrine glands, and, in addition, tissue circulation is restored in all organs of the female body.

The clinical effects of the drug, despite the skeptical opinion of patients, with a sufficiently long course of treatment (taken for at least 2-3 months) ensure the restoration of blood circulation in the vessels of the brain and heart, which becomes the prevention of pregnancy toxicosis and complications of the circulatory system.

Stroganina parasites

The drug Curantil has another unique property - it affects the activity of the immune system.

Firstly

, the drug destroys circulating immune complexes present in the blood, the action of which could cause spontaneous termination of a previous pregnancy.

Secondly , it normalizes the production and activity of complement, which is used to increase the effectiveness of therapy prescribed for the treatment of infections, including sexually transmitted infections and TORCH infections, which may complicate the course of pregnancy in the future.

Indications

Indications for prescribing Curantil are as follows:

• ischemic type of cerebral circulation disorder (the drug is prescribed for both treatment and prevention);
• encephalopathy;
• microcirculation disorders of various origins (in combination with other medications);
• prevention of venous and arterial thrombosis and treatment of their complications;
• prevention of coronary heart disease, especially if the patient does not tolerate aspirin-based drugs;
• prevention of thromboembolism after surgery performed for heart valve replacement.

Tablets in dosages of 25 mg will be prescribed for the treatment and prevention of viral infections.

How to understand the term “immunomodulator”?

It's simple. This means that it restores immunity – the body’s ability to fight various viral infections. This happens because Curantil promotes the stimulation of interferon synthesis. Interferon is a blood protein that has antiviral and antitumor properties. Under the influence of this medication, interferon is not only released, but its activity also increases. This causes the human body to become immune to viral infections.

Contraindications

Curantil tablets should not be prescribed if the following pathologies are observed:

• low pressure;
• unstable angina;
• decompensated heart failure;
• collapse;
• acute myocardial infarction;
• liver failure;
• severe heart rhythm disturbances;
• uncontrolled high blood pressure;
• pathologies that are accompanied by a high probability of bleeding, for example, stomach and duodenal ulcers;
• hypersensitivity to the composition of the drug;
• hemorrhagic diathesis;
• chronic lung pathologies accompanied by obstruction;
• chronic renal failure;
• subvalvular aortic stenosis;
• widespread stenosing atherosclerosis of the arteries of the heart.

Curantil tablets should be prescribed with caution during lactation, only when the benefit to the woman outweighs the potential risk to the baby.

Also, the drug is not recommended for use in patients under 12 years of age, since it has not been studied how it will affect the growing body.

What is an antiplatelet agent?

In simple terms, an “antiplatelet agent” is a substance that prevents the clumping of cells, in this case, blood cells in blood vessels, from which blood clots form. Thrombi - blood clots - are dangerous because they clog a vessel, resulting in a number of health problems, and sometimes life-threatening (myocardial infarction, stroke, thrombophlebitis).

If a woman has been diagnosed with increased cell aggregation, the doctor will take measures that, in a future pregnancy, will prevent complications from internal organs. Most likely, the doctor will prescribe Curantil, which in this situation will also help the fetus. The drug will relax the walls of small blood vessels, improve blood circulation and eliminate blockage of the blood vessels of the placenta, thereby providing the baby with full access to oxygen and nutrients. It happens that increased blood clotting can cause temporary infertility, so Curantil is prescribed to improve blood circulation in the pelvic organs.

Treatment regimens

The treatment regimen is selected by the doctor personally depending on the clinical picture of the pathology and the patient’s individual response to therapy:
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The pills or tablets should be taken whole on an empty stomach with a small amount of water. The duration of the course of therapy is determined by doctors individually.

Reviews

In most cases, patients' opinions about the drug are positive. There are even forums where they discuss to whom and under what circumstances doctors prescribed Curantil. These are mainly women who either took the course during pregnancy, or those who were just prescribed it, and they are interested in what effect the medicine gives. Some women are unhappy that gynecologists prescribe the drug for prevention, but none of them had fetal hypoxia.

Many people write in reviews about the instructions for use of “Curantyl 75”, noting that it is very detailed. It even states that you should not take the tablets with tea and coffee and explains why.

Side effects

During therapy, the following undesirable effects may occur:

• increased or decreased heart rate, drop in blood pressure, flushing of the face, redness, subclavian steal phenomenon (when prescribed in daily dosages of at least 225 mg;
• nausea, vomiting, loose stools, epigastric pain (these reactions disappear with long-term use of the medication);
• decreased platelet levels, changes in their function, blood loss, increased bleeding during or after surgery;
• headaches, vertigo, noise and congestion in the ears;
• allergies, which can manifest as nettle fever or skin rashes;
• weakness;
• runny nose;
• joint inflammation and muscle pain.

When using the drug in therapeutic dosages, undesirable effects are usually mild and disappear quickly.

Price of Kurantila

The cost of the medicine in the pharmacy is overpriced, so the purchase will be cheaper if you order the medicine online. There you can also find reviews about the treatment completed with Curantil. Here are approximate prices in pharmacies:

Compatibility with other drugs

When Curantil is prescribed in parallel with anticoagulants or aspirin, there is an increase in the antithrombotic effect of the latter and, therefore, the likelihood of developing hemorrhagic complications.

When taken together with drugs that lower blood pressure, an enhanced antihypertensive effect may be observed.

When Curantil is prescribed together with cholinesterase blockers, a weakening of the anticholinergic effect may be observed.

When used in parallel, xanthine derivatives weaken the vasodilatory effect of Curantil.

Overdose

If therapeutic doses are exceeded, the following symptoms of overdose may occur:

• drop in blood pressure;
• angina pectoris;
• cardiopalmus;
• tides;
• vertigo;
• impotence.

The victim is prescribed gastric lavage, induction of vomiting, and administration of enterosorbents. To eliminate the vasoconstrictor effect of the medication, aminophylline is prescribed, which is administered intravenously at a rate of 50-100 mg per minute. If signs of angina do not go away, nitroglycerin is given under the tongue.

special instructions

In case of an overdose of "Curantyl 75", blood pressure sharply decreases, tachycardia occurs, and severe weakness appears. It is necessary to rinse the stomach, induce artificial vomiting and drink absorbents (hydrolytic lignin, activated carbon).

To avoid disruption of the normal functioning of the stomach, the drug is washed down with milk.

To normalize intracardiac blood flow in the event of circulatory disturbances in the myocardium, Amminophylline is prescribed.

When driving vehicles, you should be careful. If there is a sharp decrease in pressure, it is better not to drive.

Analogs

Instead of Curantyl, you can take the following medications:

1. Dipyridamole is a complete analogue of Curantil. The medicine is produced by domestic and foreign companies. It comes in tablets and suspension for oral administration. The drug in a suitable dosage form can be used in children over 12 years of age. It can be used by women expecting a baby and breastfeeding.
2. Sanomil-Sanovel is a Turkish medicine that is a complete analogue of Curantil. It is produced in tablets, which, according to indications, can be prescribed to pregnant women. The medicine is prohibited for persons under 18 years of age and patients supporting breastfeeding.
3. Dipyridamole-FPO is a complete analogue of the drug Curantil. This is a domestic medicine, which is produced in tablets, approved for patients over 12 years of age, including pregnant women. During therapy you need to stop breastfeeding.
4. Agrenox is a combination medication that is a partial analogue of Curantil. It is produced in capsules with modified release of active ingredients. They can be prescribed to pregnant women with caution. The medicine is contraindicated for persons under 18 years of age while breastfeeding.

What can replace the drug?

The question of what could replace chimes for coronavirus is asked by those who have excessive sensitivity specifically to this drug. As for generics, there are drugs with a similar composition, but sold under different names.

Among them is Dipyridamole, which costs from 365 rubles. per pack and Dipyridamole-FPO, available in pharmacies for 388 rubles. There are other generics - Apo-Dipyridamole, Vero-Dipyridamole and Dipyridamole-Ferein.

If there is intolerance to the active substance dipyridamole, then specialists may prescribe a drug with a different composition, but from the same group of vasodilating agents. Among them there are many medicines that cost much less.

Group analogues:

1. Magnesium sulfate. Its price starts from 13 rubles. There is also Magnesium Sulfate Bufus - from 51 rubles.
2. Dibazol. The cost of the drug is from 28 rubles. There is also Dibazol UBF costing from 30 rubles.
3. Pentoxifylline. The drug costs about 50 rubles.

The category of popular analogues of Curantil also includes Aspirin Cardio and Clopidogrel. There are many drugs that can replace it. But to prescribe another drug, it is better to consult your doctor.

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