The key to the successful functioning of the cells of an entire organism is the continuous supply of nutrients and energy substrates necessary to maintain the functionality of ion pumps and enzyme activity. And when the energy supply to the cell is not enough, disturbances in its functional activity occur, which subsequently results in diseases of various natures. "Trimetazidine" is a drug aimed at restoring and maintaining the body's energy systems in order to ensure its normal functioning. Let's look at how Trimetazidine is used for various pathological conditions, reviews of patients and attending physicians about the medicine. Does it have contraindications and danger of overdose?
"Trimetazidine": instructions for use
By its nature, Trimetazidine is a drug whose main effect is aimed at reducing the susceptibility of biological tissues to a lack of oxygen supply, as well as reducing the myocardial oxygen demand and its resistance to hypoxia.
The main mechanism of action of the drug is aimed at normalizing the content of energy substrates in the cell (adenosine triphosphate) during hypoxia, which determines the maintenance of the functional activity of membrane pumps at the proper level. This in turn maintains the ionic gradient and promotes cell function. Trimetazidine also helps maintain the proper level of cyclic adenosine monophosphate concentration in brain neurons, protecting it from ischemic influences, similar to maintaining energy substrates in liver cells.
Among the pharmacokinetic features, it is necessary to note the almost complete elimination of the drug through the kidneys, which requires a special approach and dose adjustment (downwards) in patients with renal failure.
PREDUCTAL MV
Name:
Olyvia O.
Review:
Can preductal cure “jumping blood pressure”?
Name:
Karina Likhacheva
Review:
after taking the MV-Polish-made preductal, severe diarrhea began and the whole body itched. Nightmare.
Name:
Anatolii Zabolotnev
Review:
There is no reliable data on long-term clinical trials and the effectiveness of this drug either here or abroad... much ado about nothing......
Name:
Anatolii Zabolotnev
Review:
Can preductal cure “jumping blood pressure”?
Name:
Alexey Stepanov
Feedback:
They couldn’t diagnose me for 6 years. At first there was a suspicion of cancer, after 4 years there was a suspicion of AIDS. I no longer recognized people, my speech was slurred, my breathing stopped every night. My arms and legs were twisted, and at the 6th year they told me don’t be afraid, it won’t paralyze you. I cleaned blood, blood vessels were dripping, I underwent intosan, and tomography more than once. I didn’t give up and pestered the doctors, but they slowly hinted at a psychotherapist. I won’t talk about my emotional state. By chance, someone suggested going to a chiropractor in Matroska, Izmail district. Having looked at the spine, he said that I have a hypercritical condition, a stroke, a heart attack can happen at any time. When my parents separated, they left me as a baby with my grandmother. Without supervision, I fell from a 2-meter stove head down, knocking out 3 discs and 1 vertebra. This is a man from God, not everyone can straighten the spine. The case the fact is that there are a lot of chiropractors, but they help, as they say, in the heat of the moment, and when it’s been fused incorrectly for decades and a person is scarred alive, when the bloodstream is pinched, it’s scary. After the appointment, when I arrived home, I fell soundly asleep like an infant. Having opened the ducts, the blood poured into the brain, two hemispheres as if there was a lot of noise and whistling under the compressor. Toxication appeared in the form of blue spots on the elbows. I decided to go to Odessa to tell about it. The neurosurgeon said that I was lucky, and the neurologist began to draw the spine and said that it was impossible to straighten it, because in front of the intestines and behind the back muscles. I stood silently and went home. I took biloba, then cardiomagnyl and now I found out about preductal. The brain greedily absorbs oxygen, I felt better better! Doctors treat the consequences and not the cause... I sincerely wish everyone health!
Name:
Konstantin Khulin
Review:
There is no reliable data on long-term clinical trials and the effectiveness of this drug either here or abroad... much ado about nothing......
Name:
Dima Arnaut
Review:
Is it possible to use Preductal for cataracts and vascular changes in the eyes?
Name:
Tatyana Kulikova
Review:
There is no reliable data on long-term clinical trials and the effectiveness of this drug either here or abroad... much ado about nothing......
Name:
Galina Dmitrijeva
Review:
Can Preductal be used for cataracts and vascular changes in the eyes?
Name:
Galina Romanenko
Review:
Can preductal cure “jumping blood pressure”?
Name:
Alexey Makagonov
Review:
what nonsense, for a preduct to cure something, cancer is likely to whistle on the mountain.
Name:
Vera Grigorievna
Review:
when moving and at rest, there is pressure behind the sternum.
Name:
Vera Grigorievna
Review:
I have sensorineural hearing loss, I constantly have tinnitus and sometimes dizziness, my hearing has also decreased, can I take this medicine?
Name:
Vera Grigorievna
Review:
I was prescribed Cordarone, with a flicker. There is an improvement, but not much, tell me!
Name:
Ilyin Vladimir
Review:
The CF preductal contains many other components that provide a complex effect, incl. reducing the negative impact on the gastrointestinal mucosa. Do not skimp on your health.
Name:
Svetlana Levitskaya
Review:
Lived in Riga. The doctor prescribed Preductal MV 35 mg with the words: You will drink it for the rest of your life. The drug is expensive, but don’t skimp on your health.” He’s right. The drug saturates the heart muscle with oxygen and improves blood circulation. I tried drinking analogues. No comparison. I've been taking the drug for several years now
Name:
Anya Kovalenko
Review:
I read the reviews, but I think it’s a bad joke with my heart, it’s better not to save money.
Name:
Daniel Lee Stevenson
Review:
On the website “drug analogues” the preductal is described as absolutely useless...
Name:
Olga Sergeenkova
Review:
Lived in Riga. The doctor prescribed Preductal MV 35 mg with the words: You will drink it for the rest of your life. The drug is expensive, but don’t skimp on your health.” He’s right. The drug saturates the heart muscle with oxygen and improves blood circulation. I tried drinking analogues. No comparison. I've been taking the drug for several years now
Name:
Vera Kirilova
Review:
Preductal was prescribed to my dad, although it’s a new one, Preductal OD, in capsules. Very pleased with the effect! He began to put more stress on himself, and he says that he gets less tired. Good product, it helps, thank you. Prescribed by a cardiologist in Moscow, we’ve been taking it for almost a year now
Name:
Max Petrov
Review:
Preductal was prescribed to my dad, although it’s a new one, Preductal OD, in capsules. Very pleased with the effect! He began to put more stress on himself, and he says that he gets less tired. Good product, it helps, thank you. Prescribed by a cardiologist in Moscow, we’ve been taking it for almost a year now
Name:
Sergey Mikhailov
Review:
How many people, so many opinions. I think you need to focus on your own well-being. If it helps, you drink it, if it doesn’t, quit and don’t come back to this drug. Reaction to medications is an individual thing.
Name:
Elena Voskoboynikova
Review:
The doctor replaced it with Antisten MV. We found it more effective. Otherwise, you drink and drink, but you feel the same as if you didn’t drink. Moreover, the price is good, this is not the first time I’ve bought it at a pharmacy on sale. Unfortunately, I didn’t particularly notice the result from taking Preductal MB
Name:
Lembit Moist
Review:
Ineffective drug. The American Heart Association did not include it in its recommendations; their European colleagues assigned class IIb recommendations, i.e. application is permissible, but if possible, it is better not to use it. This applies to all trimetazidine-based medicines.
Name:
Vladimir Starkov
Review:
I switched to Antisten MV a long time ago, I buy a combo, 2 packs for the price of one. Absolutely identical in terms of efficiency
Name:
Kado
Review:
My mother (80 years old) was prescribed this drug (tachycardia). The heartbeat did not decrease, but the weakness increased and severe daytime sleepiness appeared!
Name:
Prospector
Review:
I couldn’t get a diagnosis for 6 years. At first there was a suspicion of cancer, after 4 years there was a suspicion of AIDS. I no longer recognized people, my speech was slurred, my breathing stopped every night. My arms and legs were twisted, and at the 6th year they told me don’t be afraid, it won’t paralyze you. I cleaned the blood , dripped blood vessels, underwent intosana, and underwent tomography more than once. I didn’t give up and pestered the doctors, but they slowly hinted at a psychotherapist. I won’t talk about my emotional state. By chance, someone suggested going to a chiropractor in Matroska, Izmail district. Having looked at the spine, he said that I had I am in a hypercritical state, a stroke, a heart attack can happen at any time. When my parents separated, they left me as a baby with my grandmother. Without supervision, I fell from a 2-meter stove head down, knocking out 3 discs and 1 vertebra. This is a man from God, not everyone can straighten the spine. The point is the fact that there are many chiropractors, but they help, as they say, in the heat of the moment, and when the fusion has been wrong for decades and a person is scarred alive, when the bloodstream is pinched, it’s scary. After the appointment, when I arrived home, I fell soundly asleep like an infant. Having opened the ducts, the blood poured into the brain, the two hemispheres seemed to be under the compressor made a lot of noise and whistling. Toxication appeared in the form of blue spots on the elbows. I decided to go to Odessa to tell about it. The neurosurgeon said that I was lucky, and the neurologist began to draw the spine and said that it was impossible to straighten it, because in front of the intestines and behind the back muscles. I stood silently and went home. I took biloba, then cardiomagnyl and now I found out about preductal. The brain greedily absorbs oxygen, I felt better better! Doctors treat the consequences and not the cause... I sincerely wish everyone health!
Name:
Svetlana Shadrina
Review:
I’ve been drinking for two weeks, my blood pressure drops below normal, tachycardia and poor sleep.
Name:
Vasily Repin
Review:
The cost of the preproduct is 659 rubles. Trimetazidine is written under this name on the box. Its cost is 35 rubles!!! Moreover, both drugs were produced in Russia. BEFORE YOU PURCHASE WHAT THE DOCTOR PRESCRIBED (obviously he knows only expensive drugs:(()), ASK FOR DOMESTIC PRODUCTS AND DON’T FEED THE LORDERS!!!
Directions for use and doses
Let's look at the method of using the drug Trimetazidine. The instructions say that for adults the daily dose is 70 mg. This corresponds to taking two tablets: one taken in the morning, the second in the evening.
You need to drink a sufficient amount of still water. For patients suffering from renal failure, the dose of the drug is reduced to 35 mg per day.
Contraindications
Some groups of people are prohibited from using the drug Trimetazidine. The instructions contain the following list of contraindications for the use of the drug:
- severe renal and liver failure;
- progressive pregnancy;
- period of breastfeeding (lactation);
- lactase deficiency;
- individual lactose intolerance;
- glucose/galactose malabsorption syndrome;
- patient age under 18 years;
- hypersensitivity of the body to the active ingredients of the drug.
Side effects
They are rarely observed when taking the drug, since its main effect is aimed at maintaining the body’s energy supply. However, from the gastrointestinal tract, dyspepsia, nausea and vomiting, and stool disorders may be observed.
On the part of the central nervous system, the most typical undesirable manifestations are: headache and dizziness, the occurrence of extrapyramidal symptoms in the form of tremor, akinetic states, impaired posture maintenance reflexes, etc. The appearance of orthostatic hypokinesia and hyperemia of the skin of the head and face is extremely rare (analysis of reports of side effects of the drug "Trimetazidine", patient reviews, clinical observations confirm this fact).
Riboxin for pressure
- 1 Active ingredient and release form 1.1 Does Riboxin increase or decrease blood pressure?
- 3.1 Additional information about taking the drug
Have you been struggling with HYPERTENSION for many years without success?
Head of the Institute: “You will be amazed at how easy it is to cure hypertension by taking it every day...
The drug "Riboxin" in combination with other drugs effectively fights diseases of various etymologies. For medical reasons, it can be prescribed as an independent remedy. What is the likelihood of side effects when taking Riboxin in combination, does this drug affect blood pressure and how long do you need to take the pills for the effect to appear?
Active substance and release form
"Riboxin" is produced in several dosage forms. This allows you to choose the most effective method of administration for a particular patient. Tablets (0.2 mg inosine) come in regular and film coatings, usually orange, round, convex, yellowish or white inside. Packaged in blisters of 10 pieces or 50 pieces. into plastic containers. The capsules are oblong, hard, and orange in color. If you open it, you will find white powder inside. The body of the capsule is gelatinous. The dosage and packaging method are similar to tablets. The doctor may also prescribe a 2% solution for injection. Sold in cardboard boxes, each containing 10 ampoules of 5 and 10 ml. The liquid inside the ampoule is transparent and colorless. 10 ml contains 20.02 mg of inosine, the main active ingredient.
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Does Riboxin increase or decrease blood pressure?
The drug helps normalize cardiac function, increases metabolism, reduces heart rate, and copes well with hypoxia. After treatment, deviations from the isoline of cardiogram segments decrease, blood circulates stably in the heart vessels. Metabolism increases in the absence of adenosine triphosphate. Inosine is involved in glucose metabolism, affecting tissue repair if blood circulation is reduced. The course of treatment combats tissue hypoxia and activates myocardial metabolism. "Riboxin" is quickly absorbed. It is processed in the liver and excreted by the kidneys in the urine.
Indications for use
- Complex therapy of cardiac ischemia (pre-infarction conditions, angina pectoris).
- Cardiomyopathies of various origins.
- Rheumatic heart disease, congenital or acquired.
- Atherosclerosis, heart rhythm disturbance.
- Urocoproporphyria (congenital changes in metabolism).
- Liver diseases: cirrhosis, fatty degeneration, hepatitis.
- Liver intoxication due to professional activities, alcoholism or drug overdose.
- Stomach ulcer.
- Rehabilitation course after radiation for cancer.
- Keeping athletes in good shape during long-term training.
Directions for use and doses
The dose of medication and duration of therapy are determined by the doctor.
The tablets are taken before meals with a sufficient amount of water. At the initial stages, the patient takes 0.6–0.8 g of the drug per day or 1 tablet 3 times a day. The daily dose is increased to 2.4 g in the absence of negative consequences of taking it, the dose is divided into 3 times a day, 2 tablets. The duration of the course is determined by the attending physician for each case individually, and can range from 4 weeks to 3 months. In addition to tablets, a 2% injection solution may be prescribed. The drug is administered in a stream or drip (40–60 drops per minute). If the doctor prescribes a jet injection of the drug, the procedure should not be carried out quickly. On the first day, 10 mg is administered, and if there is no negative reaction, the dose is increased to 20 mg. The duration of treatment is 1.5–2 weeks. Before administration, the drug is diluted with glucose or saline.
Additional information about taking the drug
Due to its ability to improve metabolism and stimulate biochemical processes, Riboxin was actively used by bodybuilders in the second half of the last century. With his help, they gained weight, became stronger and more resilient. Modern athletes have abandoned Riboxin in its pure form. It is contained in nutritional supplements for strength athletes. The drug is administered in a jet manner during operations to provide a pharmacological barrier to the kidneys, and is also indicated for high blood pressure in cases of acute arrhythmias, since due to the general beneficial effects, the symptoms of hypertension are reduced. You need to understand that Riboxin will not reduce blood pressure, however, due to its effect on the general condition of the body, the tonometer readings improve. If your blood pressure is low, additional consultation with a specialist is necessary before taking it.
The medicine is contraindicated in pregnant women.
"Riboxin" is contraindicated in patients under 18 years of age, pregnant women and nursing mothers, with allergies or intolerance to the components of the drug. It is forbidden to take it if there is salt deposition, with increased levels of uric acid in the blood, or with a syndrome of impairment of all renal functions. Film-coated tablets should not be taken by people with lactose intolerance.
Taking the drug is rarely accompanied by unwanted complications. Side effects occur in a small number of patients. Before use, you must familiarize yourself with the list of possible body reactions to the drug. "Riboxin" causes:
- redness, skin irritation, urticaria;
- weakness;
- increases heart rate;
- aggravates gout;
- manifestation of hyperuricemia;
- lowers blood pressure levels.
Compatibility
The simultaneous use of Riboxin and vitamin B6 neutralizes the therapeutic effects of both drugs.
“Riboxin” enhances the effect of cardiac glycosides and prevents arrhythmia, therefore it is often prescribed in combination with them. Prolongs the therapeutic effect and exposure time of anticoagulants such as heparin. "Riboxin" is not compatible with ethanol and acids, pyridoxine hydrochloride. As a result of the interaction of these substances with Riboxin, non-removable chemical compounds are formed. This rule especially applies to injections. To avoid unwanted interactions, when carrying out intravenous injections and diffusions, do not mix with other medications, except for the previously specified solvents. The effect of Riboxin on the body is reduced if taken in combination with immunosuppressants. Cannot be combined with Furosemide, Spironolactone, Nifedipine, Nitroglycerin. Combination with vitamin B6 negatively affects the healing properties of both drugs.
"Riboxin" is not on the list of drugs used to provide first aid for malfunctions of the heart muscle. To avoid the manifestation of gout or hyperuricemia, the doctor periodically monitors urea in general tests. The drug is discontinued at the first signs of hyperemia. Riboxin should not be combined with alcohol. Does not affect driving and does not distort concentration.
Similar drugs
There are a number of drugs in modern pharmaceuticals that are similar in their action to Riboxin. Absolute analogues are “Ribonosine” and “Inosine”. “Cytoflavin” has a similar composition, and, in addition to the main effect, has a beneficial effect on brain neurons, activating their work. Mildronate syrup is used for children. This remedy provides energy hemostasis to the entire body.
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Since these products contain the same active ingredient, there is practically no difference between them. Minor differences include:
- Release form. Trimetazidine is available in the form of tablets and capsules; Preductal has only one dosage form.
- Price. The price of Trimetazidine is much lower and is about 130 rubles per pack of 60 capsules. Preductal will cost 1,400 rubles.
Both medications are equally effective and do their job perfectly. Their advantage is that they are coated with a special substance that allows the drug to be slowly released and distributed evenly. This allows you to increase the effect of the drug for a longer time.
Since the cost of Trimetazidine is significantly lower, it is recommended to make a choice in its favor. The efficiency will be the same, and money will be saved. After the first unpleasant symptoms appear, you should immediately consult a doctor. The sooner he can make a diagnosis, the faster he can get better.
Available in the form of round tablets coated with a pink film. Ten tablets in a contour package, one package in a cardboard pack.
There are no data on cases of drug overdose.
There are no data on drug interactions.
The drug can only be purchased with a prescription.
The drug must be stored at a temperature not exceeding 25 degrees in a dry place protected from light.
The drug can be stored for three years.
"Trimetazidine": reviews of the drug
Almost all reviews about the drug "Trimetazidine" are positive. Both from patients who underwent the course of treatment themselves, and from doctors who noted the effectiveness of the product. This is due to the effectiveness of the drug Trimetazidine against hypoxic conditions of the brain and ischemic damage to the heart muscle. The price of a medicine of this level is more than affordable and is about 100-120 rubles.
Reviews from patients who received this drug as antianginal and anti-ischemic therapy contain information about improved well-being, improved flow and clarity of thoughts. The threshold of physical activity at which angina attacks occur is reduced, the level of physical activity and quality of life increase when prescribing Trimetazidine. Analogues of this drug are represented by the drugs “Preductal”, “Tricard”, “Trimet”, “Kardazin-Zdorovye”.
Analogs
If, after starting a course of using the medication, there is no positive dynamics, or the patient complains of side effects, the doctor replaces the medication. Popular analogues of Trimetazidine are the following drugs:
- Antisthene. Pink coated tablets. They are prescribed for angina pectoris, vestibular disorders, and cardiac ischemia. You are supposed to drink 1 tablet. 2 times a day - morning and evening.
- Predisin. The drug is intended for oral use for ischemia. According to the instructions, the doctor prescribes 1 tablet. in the morning and in the evening.
- Precard. The recommended dosage of the drug is 40–60 mg per day, dosage frequency 2–3 times per day for 2 weeks.
- Trimet. An antihypoxic agent, which according to the instructions should be taken 1 tablet. 2–3 times a day.
- Trimectal. The drug is approved for patients over 18 years of age with angina, hypoxia, and cardiac ischemia. According to the instructions, you are supposed to drink 1 tablet. in the morning and before bed.
- Triducard. Modified-release tablets recommended for use in stable angina. Daily dose – 2 tablets. in 2 doses.
- Rimekor. This medication is prescribed less frequently because the instructions for use contain a comprehensive list of side effects. Daily dose – 1 tablet. twice a day.
- Trimitard MV. This medicine in tablet form normalizes the energy metabolism of cells and suppresses the severity of ischemic symptoms. Daily doses and course of treatment are described in the instructions.
Which is better – Preductal or Trimetazidine
Both medications restore vascular capacity, prevent hypoxic processes in tissues, and normalize blood circulation. Their principle of action in the body is identical, the only difference is the price. The medicine Preductal is much more expensive. Doctors say that this medication is more effective than Trimetazidine tablets.
Dosage form
The drug Trimetazidine is available in two dosage forms - tablets and capsules for oral use. The tablets are round in shape with a pink shell. Capsules, as well as tablets, have a pink enteric coating. The active component of the drug is trimetazidine hydrochloride at a dose of 20 mg in each capsule or tablet. The drug is packaged in blisters of 10 pieces. The package with the drug may contain 3, 6 or 10 blisters, and instructions for use are also included.
