Sometimes a sharp deterioration in health - an attack of acute pain - requires taking analgin. It is able to cope with the disorder due to its pharmacological action.
In addition, the medication also has other beneficial effects - antipyretic and anti-inflammatory. Therefore, doctors recommend it in the complex treatment of many diseases, including in pediatric practice - after 10 years, analgin tablets, from 1 year - in rectal suppositories. However, without a doctor’s prescription, analgin in any form of release is not used due to the high risk of complications.
Description of the medication
The medicine "Analgin" is available in different forms. Tablets are very popular. They are easy to take and store in your home medicine cabinet. The drug is also often prescribed to patients in the form of a solution. It is administered intravenously or intramuscularly.
The medicine has a transparent color. It is sealed in ampoules made of fragile glass. After this, the product is placed in a cardboard box with separated cells. In one package you can find 10 such ampoules. On each of them, as well as on the front side of the pack, there is a trade name - “Analgin” (in ampoules). Instructions for use and administration of the medication are included with the package.
Dosages for adults
Recommendations for the safe use of the two drugs in adults should be followed. When you use it for the first time, questions arise: “How to mix Analgin with Diphenhydramine?” adults are administered 0.3 ml of Analgin and 0.2 ml of the second drug at a time. The effect of the complex solution lasts six hours. The answer to the question “How long does it take for an injection of Analgin with Diphenhydramine to work?” given by specialists. If after an injection half an hour later the patient does not feel better, this is a reason to seek medical help. After administering the drugs, the patient must undergo a blood test.
When choosing between an alternative option and the two drugs presented, it is better to give preference to easier drugs.
Action of the medicine
How does the medicine "Analgin" work in ampoules? The instructions for use indicate that it belongs to the category of non-steroidal anti-inflammatory drugs. The product has a pronounced analgesic effect. It also relieves fever and eliminates fever. There is still controversy about the anti-inflammatory effect of the drug. If there is such an effect, it is very insignificant.
The medicine, among other things, can have an antispasmodic effect on the lining of the stomach and intestines. The drug begins to work almost immediately after use. When using tablets, the effect is noticeable within 20-30 minutes. If injections are used, the effect of the medicine begins much faster.
Pharmacological properties
Pharmacodynamics.
Analgesic, antipyretic, antispasmodic (affects the smooth muscles of the urinary and biliary tract) agent of the group of pyrazolone derivatives. The anti-inflammatory effect is weak.
The mechanism of action is due to the inhibition of cyclooxygenase, which leads to a decrease in the synthesis of prostaglandins, which cause the development of pain at the site of inflammation, an increase in temperature and an increase in tissue permeability, as well as a violation of the conduction of painful extra- and proprioceptive impulses, an increase in the threshold of excitation of the thalamic centers of pain sensitivity, and an increase in heat transfer.
Pharmacokinetics.
After administration, metamizole is hydrolyzed to an active metabolite (with intravenous administration, unchanged metamizole is detected in plasma in small quantities). The connection of the active metabolite with proteins is 50–60%. Metabolized in the liver, excreted by the kidneys. Penetrates through the placental barrier and into breast milk.
Clinical characteristics.
What does Analgin in ampoules help with?
Instructions for use of the drug contain information about indications for use. These include the following situations:
- pain of various origins (dental, headache, joint);
- neurological diseases (myalgia);
- fever (often with colds and inflammatory processes);
- inflammation (in complex therapy);
- female periodic ailments accompanied by severe pain;
- white fever (in combination with additional medications);
- condition after surgery, when it is impossible to use other NSAIDs;
- premedication and so on.
The medicine is used only as needed. It is not used for prophylactic purposes. The drug must be prescribed by a specialist in dosage according to an individual regimen. In this case, injections are prescribed in exceptional cases.
Analogues of the product
If the patient has increased susceptibility or intolerance to metamizole sodium, the doctor will select analogues of the drug based on individual needs.
They often resort to the help of other representatives of the NSAID subgroup - for example, based on paracetamol, Eferalgan is produced in solution, suppositories, capsules, or Dynafed, Lecadol, and for children - Panadol.
The active substance ibuprofen is also able to cope with pain and reduce high body temperature. To get rid of these symptoms, you can purchase drugs based on ibuprofen, such as Nurofen, Ibuklin, MIG 200, Motrin, Novigan.
Read the restrictions
The instructions for use of the medicine "Analgin" (in ampoules) inform that it has its contraindications. They need to be studied before starting therapy. Even if the medication is prescribed to you by a specialist, do not be lazy and read the annotation. If one of the contraindications is detected, you must stop using it and consult a doctor for advice.
The medicine is not prescribed to persons with hypersensitivity to metamizole sodium. Also, it should not be administered to patients who have previously experienced an allergic reaction to other non-steroidal anti-inflammatory compounds or Aspirin. It is prohibited to use injections for persons with exacerbation of diseases of the kidneys, liver and hematopoietic system. Anemia of various origins is a contraindication to the use of the drug. The drug is not recommended for lactating women, pregnant women and children under three months of age (with body weight below 5 kilograms).
Particular care should be taken when administering the medicine for bronchitis, urticaria, rhinitis and some diseases of the organs of vision. If you are prone to developing bronchospasm, then you need to have appropriate medications for inhalation with you during therapy.
"Analgin" (ampoules): instructions for use
The price of the medicine will be presented later in the article. You can also read the reviews that the medicine receives. Before this, you need to learn about the method of its use and dosage.
For adult patients and children over 15 years of age, the drug is prescribed 500 milligrams of metamizole sodium once. This amount is in one ampoule (50%) or two (25%). The maximum single dose is 1 gram. The daily volume of medication should not be more than 2 grams.
What else does the instructions for use say about the use of the drug “Analgin” (in ampoules)? For children weighing from 5 to 9 kilograms, the medicine is administered exclusively intramuscularly, while intravenous administration is also acceptable for older patients. The dosage depends on body weight. For every kilogram there should be 5 to 10 milligrams of metamizole sodium. This means that if your child weighs 10 kilograms, he is recommended to take 50-100 mg of the active substance. If you use a 50 percent solution (which happens more often), then you need to take 0.1-0.2 milliliters. The frequency of application should be 2-3 times a day.
Compound
Release form: solution for injection. The main active substance is metamizole sodium.
1 ml of the product contains 500 mg of the active ingredient. An additional substance is water for injection. The transparent liquid has a yellowish tint. Ampoules are available in 1 or 2 ml of medicine. Sold in packs of 10 pieces. Available only by prescription.
How to give an injection?
Despite the fact that instructions for use are included with the drug "Analgin" in ampoules, patients often have questions about the algorithm of actions. First, the consumer must decide on the dosage. After this, you need to prepare everything you need for the injection. At home, the drug is most often administered intramuscularly.
Wash your hands with soap and wipe them with disinfectant gel or an alcohol wipe. Open the ampoule in the marked area. Some containers must first be filed with the supplied sandpaper. Be very careful not to get hurt. After this, unseal the syringe and carefully remove the cap from the needle. Dial the volume of the drug you need. Always remember that the dosage of the solution may vary. Release any excess air from the syringe and proceed to the next step.
Wipe the injection area with an alcohol wipe. This could be the gluteal or femoral muscle. Insert the needle with a sharp movement and gradually empty the syringe. Remember that the instructions (for children and adults) advise administering the medicine “Analgin” (in ampoules) very slowly. If you give a full injection (500 mg), then the syringe should not empty faster than in one minute. Otherwise, there is a high probability of side effects.
Indications for use
Analgin as an injection solution is more often prescribed by doctors than the tablet form. Because metamizole sodium directly enters the bloodstream and does not lose its effectiveness in the gastrointestinal tract, and begins to act much faster.
The injection can be given into a muscle (buttock, thigh) or intravenously. It is very important to remember that analgin has a short period of action, and its help wears off quickly.
The injection helps with:
- High temperature;
- Acute attack of pain;
- Neuralgia;
- Pain with renal colic;
- Migraine;
- Muscle and joint pain;
- Postoperative pain;
- Arthrosis;
- Radiculitis;
- Toothache.
Negative reactions
The instructions for the drug "Analgin" for injections (in ampoules) indicate that it can cause adverse reactions. With very rapid administration, a sharp change in blood pressure and shock are observed, and breathing is impaired. This condition is especially dangerous in children. Therefore, it is important to calculate the correct dose for each child, based on individual characteristics.
Side effects also include allergic reactions. They can take completely different forms: urticaria, rash, itching, bronchospasm, swelling. During treatment with this drug, diseases of the liver, kidneys, and hematopoietic organs may worsen. If an overdose occurs, then there is a high probability of disruption of the digestive process, in which nausea, constipation, and flatulence are observed. Convulsions, fainting and other conditions may develop.
Overdose
Symptoms:
hypothermia, marked decrease in blood pressure, palpitations, shortness of breath, tinnitus, nausea, vomiting, gastralgia, weakness, oliguria, anuria, drowsiness, delirium, impaired consciousness, tachycardia, convulsive syndrome; the development of acute agranulocytosis, hemorrhagic syndrome, acute renal and liver failure, paralysis of the respiratory muscles is possible.
Treatment.
Induction of vomiting, gastric lavage, administration of saline laxatives, activated charcoal. Carrying out forced diuresis, hemodialysis, blood alkalization, symptomatic therapy aimed at supporting vital functions. When a convulsive syndrome develops, intravenous diazepam and fast-acting barbiturates are administered.
Special situations
What other information does the instructions for use tell the consumer about injections of Analgin (in ampoules)? For adult women during pregnancy, the drug is not prescribed in the first and last trimesters. At this time, the medicine can be dangerous both for the patient herself and for her baby. Injections can be administered under the strict supervision of a doctor only during the period from the 4th to the 6th months of pregnancy.
The medicine "Analgin" is often used to prepare a lytic mixture. At the same time, it is mixed with an antihistamine (usually Diphenhydramine or Tavegil) and an antispasmodic (No-shpa, Papaverine). All ingredients should be selected according to the age and/or body weight of the patient. The medicine is administered intramuscularly and produces a pronounced antispasmodic, antipyretic and anti-allergic effect.
additional information
In elderly people, as well as in patients with reduced kidney function, the drug is used in lower dosages, since the metabolites of the main substance are eliminated more slowly in them than in young patients, as well as in those whose kidneys function normally.
If hepatic or renal function is reduced, high doses should be avoided. Without dosage reduction, only short-term use of this drug is possible.
Patients taking this medication long-term should have blood tests to monitor their white blood cell count.
Opinions about the drug
You already know what the instructions say about the medicine “Analgin” in ampoules. The price of the drug is very attractive and affordable. Most consumers report this. One package of medication will cost you on average about 130 rubles. In this case, do not forget to purchase syringes of the appropriate volume.
Consumers say that the administered product begins to act instantly. The instructions for use promise a noticeable effect only 20 minutes after use. Most consumers say that the effect is detected after 5-10 minutes. The duration of the drug is determined individually and ranges from 4 to 8 hours.
Many users report that after intramuscular injections they are left with lumps at the injection site. Doctors say that such consequences usually go away on their own and do not require additional therapy. The medicine is often prescribed in combination with other drugs. Before such use, be sure to read the composition and study the interaction. If you are taking other medications, but at the same time you were prescribed the drug "Analgin" by injection, then you should definitely inform your doctor. Your doctor may need to adjust your medication regimen so that it does not react in your body. After all, some medications can often reduce or increase the effectiveness of others.
Expiration dates and storage conditions
In order for any pharmaceutical drug to be as effective as possible, including analgin, it is necessary to comply with the storage conditions of the medication.
For example, if a package of tablets can simply be placed on a shelf in a closet, away from direct sunlight, while the room temperature should not exceed 22–25 degrees, then an injection solution in ampoules requires special storage - preferably on the bottom shelf in the refrigerator . Immediately before use, take out the required amount of the drug and heat it to human body temperature. Do not store an open ampoule of medicine - the solution is administered immediately.
An additional requirement is that the drug is not available to children. All forms of antipyretic can cause significant damage to the child’s body, so it is recommended to hide it from children in an inaccessible place.
Compliance with the expiration dates of analgin is another important requirement. On average, it is 3–5 years from the date of release of the medicine. The use of metamizole after the date printed on the end of the package is unacceptable due to its high toxicity.
A short summary...
The medicine "Analgin" in ampoules has been used for quite some time. This is a well-known and affordable drug. It is available from pharmacies without a prescription. Despite this fact and all the positive reviews, you should not use the product yourself. This is especially true for intravenous and intramuscular administration. After all, you cannot predict the reaction to a particular medicine. Be sure to consult a doctor if necessary. The doctor will select the most suitable regimen and dose of the drug for you. Good health to you, don’t get sick!
Side effects
If the dosage of any medication is not observed, an overdose occurs, causing serious consequences. Violations are associated with convulsions and death of the patient. The dose calculation should be entrusted to an ambulance paramedic or a qualified doctor.
Main adverse reactions:
- Nausea, vomiting.
- Heart rhythm disturbances.
- Excessive sweating.
- Diarrhea, stool retention.
- Changes in blood parameters (for example, decreased hemoglobin).
The most difficult health situations were resolved in favor of recovery, pain relief, fever with the help of two drugs. Despite the strong effect, you need to take precautions, take into account contraindications, and also know the risk of adverse reactions.
