5-nock tablets, p/o 50 mg No. 50 per cont.

Compound

One tablet of the drug 5-NOK includes 50 mg of nitroxoline.
Additional substances: lactose monohydrate, calcium hydrogen phosphate, corn starch, colloidal silicon dioxide, talc, povidone K25, magnesium stearate, crospovidone.

Shell composition: povidone K25, acacia gum, sucrose, carmellose sodium, talc, colloidal silicon dioxide, corn starch, titanium dioxide, calcium carbonate, yellow dye.

Contraindications

According to the instructions for the drug, 5-NOK should not be taken:

• Patients with renal failure, if creatinine clearance does not reach 20 ml per minute;
• People with severe renal failure;
• Pregnant women;
• During lactation (if it is necessary to use 5-NOK during this period, the woman should stop breastfeeding);
• Children under 3 years of age (this drug is not prescribed to children due to the “inconvenient” release form and large dosage);
• If you have hypersensitivity to quinolines, nitrocloline or any of the auxiliary components of the medication.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Internet users often ask the question “is this drug an antibiotic or not?” 5-NOK is an antibiotic, chemically a derivative of 8-hydroxyquinoline.

Has a wide range of effects on infectious agents. Selectively inhibits the biosynthesis of bacterial DNA , creates complexes with metal-containing enzymes of the microbial cell.

Effective on:

• gram-positive microorganisms of the genera Staphylococcus, Streptococcus, Enterococcus, Corynebacterium, as well as Bacillus subtilis;
• gram-negative microorganisms of the genera Proteus, Klebsiella, Salmonella, Shigella, Enterobacter, as well as Escherichia coli, Neisseria gonorrhoeae, Haemophilus influenzae;
• other microorganisms - Trichomonas vaginalis, Mycoplasma hominis, Mycobacterium tuberculosis, Ureaplasma urealyticum.

Also effective against a number of fungi (molds, dermatophytes, candida).

Pharmacokinetics

Well absorbed from the intestines. The highest concentration in plasma is achieved approximately 2 hours after ingestion.

Nitroxoline is transformed in the liver. It is excreted mainly in urine in its original form and slightly in bile. There is a high content of conjugated and unconjugated drugs in the urine.

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Gastrointestinal infections, chronic and recurrent infections of the kidneys, caused by gram-positive and gram-negative microorganisms and fungi sensitive to nitroxoline.

Prevention of recurrent infections of the thyroid gland.

Before using this drug, it is necessary to conduct microbiological studies to identify the infectious agent and verify its sensitivity to nitroxoline. However, it must be taken into account that most likely all infections are caused by microorganisms that are sensitive to the drug 5-NOK® - the treatment can be given until the results of the investigation are cleared.

Indications for use of 5-NOK

Acute, chronic and often recurrent urinary tract infections, for which 5-NOK tablets help well, are one of the most common problems among the population. The following are the indications for use (what the medicine is for) 5-NOK:

• epididymitis;
• cystitis;
• pyelonephritis;
• urethritis;
• infected carcinoma or adenoma ;
• prevention of postoperative infectious complications during surgical interventions on the genitourinary tract, as well as during therapeutic and diagnostic procedures;
• prevention of recurrent infections of the genitourinary tract.

Side effects

On the side of the grass tract:

Mild intestinal-scholastic disorders
(
in some cases there may be nausea, bloating, vomiting, loss of appetite), which can be avoided by stagnating the drug within an hour.

On the side of the hepatobiliary system:

decreased activity of transaminases, impaired liver function.

On the side of the immune system:

allergic reactions, such as skin tingling, itching, which quickly disappear after taking the drug; very rarely - allergic reactions with the development of thrombocytopenia.

On the side of the nervous system:

rarely – headache, ataxia, paresthesia, polyneuropathy.

On the side of the thyroid system:

Rarely – changes instead of sechoic acid in blood plasma.

Remnants of nitroxoline are removed with liquid, and when bathed in the preparation, the cuttings turn into an intense yellow color.

Inshe:

tachycardia, cardiac weakness.

Side effects

• Digestive disorders: vomiting or nausea (can be prevented by taking the drug with meals), increased levels of liver transaminases.
• Circulatory disorders: tachycardia .
• Nervous disorders: headache , ataxia, polyneuropathy, paresthesia .
• Allergic reactions: skin rash.
• Other reactions: increased concentration of uric acid in plasma, thrombocytopenia.

Instructions for use of 5-NOK (Method and dosage)

The medicine must be taken before meals.

5-NOK tablets, instructions for use

The usual dosage for adults is 400 mg per day (including for cystitis ), 2 tablets of 5-NOK four times a day. The highest dose is 800 mg per day. The indicated dosages are also applicable for taking 5-NOK for cystitis.

The average dose for pediatric patients over 5 years of age is prescribed at the rate of 200-400 mg per day, divided into 4 doses; and for patients 3-5 years old - at the rate of 200 mg per day, divided into 4 doses.

The average duration of the treatment cycle is 15-30 days; if necessary, treatment is continued in intermittent cycles (15 days per month).

For patients with moderate renal or liver failure, the drug is recommended to be used at 50% of the indicated daily dosage - 1 tablet four times a day.

Cases of overdose

In case of overdose, side effects may increase. Uncontrollable vomiting, dyspeptic pain and spasms develop. The patient develops general weakness, drowsiness, possible depressive disorders, and increased irritability. In this case, you must stop taking the drug and consult a doctor, especially under a medical policy it is completely free.

Against the background of an overdose, the development of irreversible changes in the body is unlikely.

If the patient accidentally took a large number of tablets, it is necessary to urgently induce vomiting and refer the patient to a medical facility. Treatment for overdose is prescribed depending on the symptoms that appear.

Interaction

When nitroxoline with tetracyclines , the summation of their effects is revealed, and with Levorin and Nystatin - potentiation of the action.

When used together with antacids containing magnesium , the absorption of nitroxoline slows down.

Nitroxoline weakens the therapeutic effect of nalidixic acid.

To prevent a neurotoxic effect, it is prohibited to combine nitroxoline with nitrofurans.

The drug should not be used together with medications that include hydroxyquinolines.

Interactions with other medicinal drugs and other types of interactions

When nitroxoline is combined with drugs of the tetracycline group, the effects of the skin drug are avoided, and with nostatin and levorine there is a potentiation of the effect.

With one-hour stagnation with antacid agents, which replace magnesium, the soaking of nitroxoline is satisfied.

To avoid the negative neurotropic effect, you cannot combine nitroxoline with nitrofurans.

Nitroxoline reduces the effectiveness of nalidixic acid.

Nitroxoline should not be combined with drugs that replace hydroxyquinolines or their derivatives.

Analogs

Level 4 ATX code matches:
Monural

Nitroxoline

Zyvox

Hexamethylenetetramine

Calcex

Kirin

Bacteriophage Klebsiella Pneumonia

Bacteriophage Proteus

Bacteriophage Coli

Bacteriophage Pseudomonas aeruginosa

Bacteriophage Salmonella

Bacteriophage Coliproteus

Bacteriophage Streptococcal

Bacteriophage Klebsiella Polyvalent Purified

Bacteriophage Staphylococcal

Dioxidine

Linezolid

Fosfomycin

Analogs of 5-NOK: Uroxoline, Nitroxoline, 5-Nitrox, Nitroxoline-UBF.

Structural analogues and drugs similar in action

The drug 5-NOK has been successfully used since the 70s of the last century. However, today it is not prescribed so often due to the acquisition of resistance to the active substance by pathogenic microflora. That is why in some cases there is a need to use medications with similar effects. The following medications belong to the same pharmacological group:

In addition to drugs with similar effects, pharmacy chains offer structural analogues of the drug 5-NOK. They have the same active ingredient. Only the auxiliary components may differ. Among the popular synonyms of the described medication are:

1. Nitroxoline
   . It is an antiprotozoal and antibacterial agent. It is used in the treatment of infectious pathologies of the genitourinary system.

2. 5-Nitrox
   . The active ingredient is also nitroxoline. Prescribed to eliminate pathogenic microflora in the genitourinary tract.

3. Noxibiol
   . Effectively affects harmful microorganisms. A course of treatment is required.

The right to choose a substitute for the drug 5-NOK remains with the doctor. Only the attending doctor will be able to calculate all the possible risks from the manifestation of negative effects and select the correct dosage. Self-treatment with antibacterial agents is strictly prohibited.

Price 5-NOK, where to buy

The price of 5-NOK (tablets) No. 50 in Russia is 175-220 rubles. In Ukraine, the average price of the drug is close to 120-130 hryvnia.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

Pharmacy Dialogue

• 5-Nok tablets p/o 50 mg No. 50Lek
  187 rub. order

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Pharmacy24

• 5-nok 50 mg No. 50 tablets Lek pharmaceutical company d.d., Slovenia
  152 UAH order

PaniPharmacy

• 5-NOK tablets 5-NOK tablets 50 mg No. 50 Slovenia, Lek

  179 UAH. order

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Features of good stagnation

The drug should be used with caution in patients with impaired function due to the possibility of cumulation of nitroxoline. It is also necessary to prescribe the drug to patients with cataracts with caution. With repeated and repeated treatment with high doses of halogen-like hydroxyquinoline, the development of peripheral neuritis and neuritis of the visual nerve is described. 5-NOK® is a nitropic quinoline, and no such side effects were observed. However, it is recommended to exercise caution when treating with nitroxoline: patients must be under the close supervision of a doctor. Bathing cannot exceed 4 years without additional medical support.

5-NOK® fragments are stored in lactose and sucrose, patients with rare episodes of fructose intolerance, galactose intolerance, glucose-galactose malabsorption syndrome, lactase deficiency and sucrose-isomaltase deficiency. trace of this drug.

If you have a known intolerance to certain drugs, consult your doctor before taking this medication.

The drug contains orange-yellow barberry S (E 110), which can provoke allergic reactions, including asthma. Patients with hypersensitivity to acetylsalicylic acid are especially welcome.

Suspension during pregnancy or breastfeeding.

The safety and effectiveness of taking the drug during pregnancy or breastfeeding is not established, therefore nitroxoline should not be prescribed during this period.

This is due to the fluidity of the reaction during treatment with vehicles or other mechanisms.

There is no data about the negative impact of the drug on the fluidity of the reaction when administered by vehicles or robots with other mechanisms.