Bendazole - description of the drug, instructions for use, reviews

Pharmacodynamics and pharmacokinetics

Bendazole has a short-term moderate hypotensive, myotropic effect and is well tolerated by patients. The substance dilates blood vessels in the brain, which allows it to be used for arterial hypertension resulting from sclerosis of the cerebral arteries.

The drug exhibits immunostimulating activity, regulates the ratio of cGMP and cAMP concentrations, activates the formation of antibodies, interferon, and the process of phagocytosis. The substance stimulates the proliferation of mature T- and B-lymphocytes, the release of mutual regulatory factors, and activates the final effector function of cells. In the smooth muscles of blood vessels, the concentration of free calcium decreases, causing them to relax. Interneuronal spinal contacts are also activated.

The hypotensive effect lasts for 2.5 hours. It is recommended to carry out combination therapy with this drug with other drugs.

Peculiarities

This section provides information necessary to study for a certain category of citizens.

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Driving

Has no effect.

Pregnancy

No information provided. However, doctors try not to prescribe this drug to pregnant girls. If taking the drug is still necessary, the girl often visits the doctor.

Sick kidneys

If you have diseased kidneys, then taking the drug is unacceptable.

Sick liver

If you have problems with your liver, your dosage may need to be adjusted.

Dispensing goods from a pharmacy

Sometimes pharmacies ask for a prescription for medicine.

Indications for use

Bendazole is prescribed:

• with spasms of blood vessels, peripheral arteries, with coronospasm;
• during an exacerbation of hypertension, during a hypertensive crisis;
• to eliminate spasm of smooth muscles in internal organs, intestines, pylorus, with gastric ulcer, hepatic and renal colic;
• as part of complex treatment of diseases of the central nervous system, residual effects of poliomyelitis, with peripheral paralysis of the facial nerve, polyneuritis;
• as an immunostimulating agent.

Price

The cost of a medicine is determined based on a number of external factors, which include the markup of the pharmacy, the region of sale, as well as the costs incurred by the company when transporting the goods. Prices will vary significantly across countries. This is due to the exchange rate and currency. You can clearly see the changes using the examples of Ukraine and Russia.

Russia

In Russia, you will have to pay an average of 35 rubles for this medicine.

Ukraine

On average, you will have to pay 17 hryvnia for this medicine.

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Bendazole, instructions for use (Method and dosage)

The medicine is prescribed orally, before or after meals (2 hours apart). From 0.02 to 0.05 g of the drug is taken 2-3 times a day, the duration of treatment is from 3 to 4 weeks.

For the treatment of polyneuritis and other diseases of the nervous system, 5 mg of the drug is prescribed, daily or every other day, for 5-10 days. The course can be taken again after a month or 2 months.

Children under 1 year old are given 1 mg of the drug, from 1 to 3 years old - 2 mg, from 4 to 8 years old - 3 mg, children over 12 years old take 5 mg of the drug per day.

To relieve a hypertensive crisis, 0.03 to 0.04 g of the drug is prescribed intravenously or intramuscularly.

In case of exacerbation of arterial hypertension, if the pressure has increased significantly, intramuscular administration of 20-30 mg of the drug is indicated, 2-3 times during the day. Treatment is carried out from 8 days to 2 weeks.

Side effects

The patient’s body can respond to the treatment provided, which can be expressed in the appearance of conditions such as:

• Skin rash, itching;
• Angioedema;
• With prolonged use of the drug in large dosages, deterioration of ECG readings may be observed;
• When taking the medicine in large dosages, the patient may experience nausea, increased sweating, a feeling of heat, pain in the head, and a feeling of heat.

If these conditions cause significant discomfort to the patient, then the medication should be stopped. If the patient's condition does not stabilize within three days, then you need to go to the hospital.

Overdose

There have been no cases of overdose; however, when taking the drug in large dosages (for tablets), it is necessary to urgently rinse the stomach and carry out symptomatic treatment. If you are not sure that you can do everything correctly, it is better to call a doctor.

Contraindications

This remedy is not recommended for use if you are allergic to certain substances in the medication. With caution, the drug can be prescribed for the treatment of elderly patients.

Pregnancy

It is better to refrain from taking Bendazole during pregnancy. This is due to the fact that the active substance has the ability to penetrate the baby’s body.

If an appointment is still necessary, then the use of this remedy is allowed, however, the girl should regularly visit her doctor.

During breastfeeding, it is better to refrain from taking this drug. This is due to the fact that the active substance has the ability to penetrate the child’s body with the girl’s milk. If there is an urgent need for administration, then the drug is allowed, but the method of natural feeding must be stopped.

Instructions:

Clinical and pharmacological groups

14.009 (Immunostimulating drug) 03.012 (Spasmoanalgesic) 01.048 (Antihypertensive drug) 11.027 (Anspasmolytic) 11.028 (Myotropic antispasmodic)

pharmachologic effect

Antispasmodic agent with myotropic action, benzimidazole derivative. It has an antispasmodic effect on the smooth muscles of blood vessels and internal organs. Lowers blood pressure by reducing cardiac output and dilating peripheral blood vessels. The hypotensive activity of bendazole is very moderate, and the effect is short-lived.

Causes a short-term dilation of cerebral vessels.

Facilitates synaptic transmission in the spinal cord.

Immunostimulating activity is associated with the regulation of the ratio of cGMP and cAMP concentrations in immune cells (increases the cGMP content), which leads to the proliferation of mature sensitized T- and B-lymphocytes, their secretion of mutual regulatory factors, cooperative reaction and activation of the final effector function of cells.

Dosage

Relief of hypertensive crisis - IV or IM 30-40 mg. Exacerbation of arterial hypertension with a significant increase in blood pressure - 20-30 mg intramuscularly 2-3 times a day, course of treatment is 8-14 days.

Orally - 20-50 mg 2-3 times a day for 3-4 weeks.

In the treatment of nervous diseases - for adults at a dose of 5 mg 1 time / day or every other day for 5-10 days, after 3-4 weeks the course of treatment is repeated. In the future, courses are carried out with a break of 1-2 months.

For children, depending on age, the dose is 1-5 mg 1 time / day.

Drug interactions

When used simultaneously with antihypertensive drugs and diuretics, the antihypertensive effect may be enhanced.

Simultaneous administration of bendazole prevents the increase in peripheral vascular resistance caused by beta-blockers.

With simultaneous use, phentolamine enhances the hypotensive effect of bendazole.

Side effects

Possible: allergic reactions.

With long-term use: deterioration of ECG parameters due to a decrease in cardiac output.

When used in high doses: feeling of heat, increased sweating, dizziness, nausea, headache.

Indications

Arterial hypertension, hypertensive crisis.

Spasms of smooth muscles of internal organs (including stomach, intestines).

Residual effects of poliomyelitis, peripheral facial paralysis.

Contraindications

Hypersensitivity to bendazole.

special instructions

Use with caution in elderly patients.

It is not recommended for long-term treatment of arterial hypertension, especially in elderly patients.

Preparations containing BENDAZOL

• DIBAZOL solution for injections (DIBAZOL solution for injections) solution for intravenous and intramuscular administration 10 mg/1 ml: amp. 5 or 10 pcs. • DIBAZOL solution for intravenous and intramuscular administration 10 mg/2 ml: amp. 10 pieces. • DIBAZOL tab. 20 mg: 10, 20, 50 or 80 pcs. • DIBAZOL solution for intravenous and intramuscular administration 10 mg/1 ml: amp. 5 or 10 pcs. • DIBAZOL solution for intravenous and intramuscular administration 50 mg/5 ml: amp. 10 pieces. • ANDIPAL ◊ tab.: 10 pcs. • DIBAZOL solution for injections (DIBAZOL solution for injections) solution for intravenous and intramuscular administration 10 mg/1 ml: amp. 5 or 10 pcs. • CYTOVIR®-3 (CYTOVIR-3) syrup (for children): vial. 50 ml per set with dosing spoon • DIBAZOL solution for intravenous and intramuscular administration 25 mg/5 ml: amp. 5, 10 or 20 pcs. • DIBAZOL solution for intravenous and intramuscular administration 20 mg/2 ml: amp. 5 or 10 pcs. • DIBAZOL-DARNITSA solution for intravenous and intramuscular administration 50 mg/5 ml: amp. 10 pieces. • DIBAZOL solution for injections (DIBAZOL solution for injections) solution for intravenous and intramuscular administration 5 mg/1 ml: amp. 5 or 10 pcs. • ANDIPAL ◊ tab.: 10 pcs. • ANDIPAL ◊ tab.: 10 pcs. • DIBAZOL solution for injection. 25 mg/5 ml: amp. 10 pieces. • ANDIPAL ◊ tab.: 10 pcs. • DIBAZOL solution for injections (DIBAZOL solution for injections) solution for intravenous and intramuscular administration 5 mg/1 ml: amp. 5 or 10 pcs. • ANDIPAL ◊ tab.: 10 pcs. • DIBAZOL solution for intravenous and intramuscular administration 10 mg/2 ml: amp. 10 pieces. • DIBAZOL solution for injections (DIBAZOL solution for injections) solution for intravenous and intramuscular administration 5 mg/1 ml: amp. 5 or 10 pcs. • DIBAZOL tablets 0.02 g (DIBAZOL tablets 0.02) tab. 20 mg: 10 or 20 pcs. • ANDIPAL ◊ tab.: 10 pcs. • DIBAZOL solution for injections (DIBAZOL solution for injections) solution for intravenous and intramuscular administration 5 mg/1 ml: amp. 5 or 10 pcs. • DIBAZOL solution for injection. 10 mg/1 ml: amp. 10 pieces. • DIBAZOL tablets 0.02 g (DIBAZOL tablets 0.02) tab. 20 mg: 10 or 20 pcs. • PAPAZOL ◊ tab. 30 mg+30 mg: 10, 20, 30 or 12000 pcs. • DIBAZOL solution for injections (DIBAZOL solution for injections) solution for intravenous and intramuscular administration 5 mg/1 ml: amp. 5 or 10 pcs. • ANDIPAL ◊ tab.: 10 or 20 pcs. • ANDIPAL ◊ tab.: 10 pcs. • DIBAZOL tablets 0.02 g (DIBAZOL tablets 0.02) tab. 20 mg: 10 or 20 pcs. • DIBAZOL tablets 0.02 g (DIBAZOL tablets 0.02) tab. 20 mg: 10 or 20 pcs. • DIBAZOL solution for intravenous and intramuscular administration 10 mg/1 ml: amp. 5 or 10 pcs. • DIBAZOL tablets 0.02 g (DIBAZOL tablets 0.02) tab. 20 mg: 10 or 20 pcs. • ANDIPAL ◊ tab.: 10 pcs. • DIBAZOL solution for injection. 5 mg/1 ml: amp. 5 pieces. • DIBAZOL tablets 0.02 g (DIBAZOL tablets 0.02) tab. 20 mg: 10 or 20 pcs. • DIBAZOL solution for intravenous and intramuscular administration 5 mg/1 ml: amp. 10 pieces. • DIBAZOL-VIAL solution for intravenous and intramuscular administration 50 mg/5 ml: amp. 10 pieces. • DIBAZOL solution for intravenous and intramuscular administration 10 mg/1 ml: amp. 10 pieces. • DIBAZOL solution for intravenous and intramuscular administration 5 mg/1 ml: amp. 5, 10 or 20 pcs. • ANDIPAL tablets: 10 or 20 pcs. • DIBAZOL solution for injection. 20 mg/2 ml: amp. 10 pieces. • ANDIPAL tablets: 10, 20 or 50 pcs. • PAPAZOL tab. 30 mg+30 mg: 10 pcs. • ANDIPAL ◊ tab.: 10 pcs. • DIBAZOL solution for intravenous and intramuscular administration 10 mg/1 ml: amp. 10 pieces. • DIBAZOL solution for injections (DIBAZOL solution for injections) solution for intravenous and intramuscular administration 5 mg/1 ml: amp. 5 or 10 pcs. • DIBAZOL-UBF (Dibazol-UBF) ◊ tab. 20 mg: 10, 20, 25, 30, 40, 50 or 60 pcs. • DIBAZOL solution for intravenous and intramuscular administration 50 mg/5 ml: amp. 10 pieces. • DIBAZOL solution for injections (DIBAZOL solution for injections) solution for intravenous and intramuscular administration 10 mg/1 ml: amp. 5 or 10 pcs. • DIBAZOL tablets 0.02 g (DIBAZOL tablets 0.02) tab. 20 mg: 10 or 20 pcs. • PAPAZOL tab. 30 mg+30 mg: 10 pcs. • PAPAZOL ◊ tab. 30 mg+30 mg: 10, 20, 3000 or 5000 pcs. • DIBAZOL solution for intravenous and intramuscular administration 50 mg/5 ml: amp. 10 pieces. • DIBAZOL tablets 0.02 g (DIBAZOL tablets 0.02) tab. 20 mg: 10 or 20 pcs. • ANDIPAL ◊ tab.: 10 pcs. • DIBAZOL solution for injections (DIBAZOL solution for injections) solution for intravenous and intramuscular administration 10 mg/1 ml: amp. 5 or 10 pcs. • DIBAZOL tablets 0.02 g (DIBAZOL tablets 0.02) tab. 20 mg: 10 or 20 pcs. • PAPAZOL tab. 30 mg+30 mg: 10, 50 or 10000 pcs. • ANDIPAL ◊ tab.: 10 pcs. • DIBAZOL-VIAL solution for intravenous and intramuscular administration 10 mg/1 ml: amp. 10 pieces. • DIBAZOL solution for intravenous and intramuscular administration 10 mg/1 ml: 1 ml amp. 10 pieces.; 5 ml amp. 10 pcs • DIBAZOL tablets 0.02 g (DIBAZOL tablets 0.02) tab. 20 mg: 10 or 20 pcs. • DIBAZOL solution for injection. 25 mg/5 ml: amp. 5 or 10 pcs. • ANDIPAL ◊ tab.: 10 or 20 pcs. • DIBAZOL solution for injections (DIBAZOL solution for injections) solution for intravenous and intramuscular administration 5 mg/1 ml: amp. 5 or 10 pcs. • DIBAZOL solution for injection. 10 mg/1 ml: amp. 10 pieces. • ANDIPAL ◊ tab.: 10 pcs. • ANDIPAL ◊ tab.: 10 pcs. • DIBAZOL solution for injection. 50 mg/5 ml: amp. 10 pieces. • DIBAZOL solution for injections (DIBAZOL solution for injections) solution for intravenous and intramuscular administration 10 mg/1 ml: amp. 5 or 10 pcs. • ANDIPAL ◊ tab.: 10 or 20 pcs. • DIBAZOL solution for injections (DIBAZOL solution for injections) solution for intravenous and intramuscular administration 10 mg/1 ml: amp. 5 or 10 pcs. • PAPAZOL tab. 30 mg+30 mg: 10 pcs. • CYTOVIR®-3 (CYTOVIR-3) ◊ capsule: 12 pcs. • DIBAZOL tablets 0.02 g (DIBAZOL tablets 0.02) tab. 20 mg: 10 or 20 pcs. • DIBAZOL solution for injection. 10 mg/2 ml: amp. 5 or 10 pcs. • DIBAZOL solution for injection. 50 mg/5 ml: amp. 5 pieces. • DIBAZOL solution for injections (DIBAZOL solution for injections) solution for intravenous and intramuscular administration 10 mg/1 ml: amp. 5 or 10 pcs. • PAPAZOL-UBF tab. 30 mg+30 mg: 10, 20, 25, 30, 40, 50 or 60 pcs. • DIBAZOL solution for injection. 10 mg/2 ml: amp. 10 pieces. • DIBAZOL solution for intravenous and intramuscular administration 25 mg/5 ml: amp. 10 pieces. • DIBAZOL-DARNITSA solution for intravenous and intramuscular administration 10 mg/1 ml: amp. 10 pieces.

Reviews

Patients, as a rule, leave only positive opinions about the drug Bendazole.

This confirms the effectiveness of the drug. People also like the low price of the medicine, the availability of analogues, and the ability to take the medicine during breastfeeding/breastfeeding.

Among the obvious disadvantages, patients note the presence of side effects, as well as contraindications. Patients note that some side effects manifested themselves in acute form. This caused them a lot of problems, which certainly affected their opinion of this medicine.

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** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before you start using Bendazole, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.

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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Bendazole is provided for informational purposes and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!

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Analogs

This medicine has analogues such as: Goliofen, Dibazol-UBF, Dibazol, Dibazol-AKOS, Vinoxin, Oksibral.

Gliophene is one of the medicines that also contains the active substance Bendazole. The medicine is produced in the form of a solution, as well as a suppository. In addition, there is also a tablet form of administration. This remedy has a vasodilating effect.

Dibazol is available in the form of tablets, suppositories, and solutions. The drug has a vasodilating and immunostimulating effect.

Among these analogues there are cheaper drugs, however, only a highly qualified specialist can select them.