If you need to get rid of parasites in an adult or child, doctors suggest the antiprotozoal drug Ornidazole Dazolic with antibacterial properties. It is highly effective in the fight against protozoa and parasites that cause infectious diseases. The medicine is fast-acting due to the achievement of maximum concentration in the blood plasma within the first hour after administration.
The drug "Ornidazole Dazolic" is used to treat parasites and bacteria in humans.
Dazolic release form
According to the instructions, Dazolic is produced in the form of white or almost white round biconvex tablets, film-coated, 10 pieces each. in cellless contour packages in cardboard boxes.
One Dazolic tablet contains 500 mg of ornidazole, microcrystalline cellulose, sodium lauryl sulfate, sodium starch glycolate type A, purified talc, starch, magnesium stearate, povidone and colloidal silicon dioxide.
The film shell contains acetone, titanium dioxide, isopropyl alcohol, Eudragit E-100, polyethylene glycol 6000 and purified water.
general information
"Ornidazole Dazolic" is included in the category of antiprotozoal drugs with antibacterial function. Effective against anaerobic microorganisms and protozoa. It affects parasites that cause infectious diseases such as:
- purulent inflammation (causative agent - fusobacteria, bacteroides);
- giardiasis (giardia);
- trichomoniasis (Trichomonas);
- inflammation in the mouth, colon, upper parts of the respiratory system, vagina (anaerobic cocci);
- clostridiosis (clostridia).
The active formula destroys the structure of the DNA chain, which leads to the death of the parasite. The main component of Ornidazole Dazolica comes from the gastrointestinal tract into the blood and accumulates an hour after administration due to its high bioavailability (90%). The drug enters all tissues through the bloodstream. It is excreted in urine and feces after 12-14 hours.
"Ornidazole Dazolic" is an Indian antiprotozoal drug with antibacterial sensitivity, intended for the treatment of infants and adults from parasitic infestations.
The drug "Ornidazole Dazolic" is available in solid form - tablets, in a package of 10 pieces.
Composition, properties, forms
Dazolic is based on ornidazole with a total concentration of 500 mg. The medicine is produced in the form of round, white tablets with a stripe on one side. The drug is packaged in blister packs of 10 pieces. There can be 1 or 5 such blisters in one package. The main task of Dazolic is the inhibition of protozoa and anaerobic microorganisms by destroying their DNA.
Analogues of Dazolic
Analogs of Dazolic in terms of the active substance are the following drugs:
- Ornisid forte;
- Gairo;
- Orniona;
- Ornidazole;
- Lornizole;
- Ornidazole-Vero;
- Tiberal;
- Quinisol;
- Ornidozole-OBL.
Analogs of Dazolic by mechanism of action and belonging to the same pharmacological group include:
- Metron;
- Atrican 250;
- Metronidazole-LecT;
- Batsimex;
- Metronidazole;
- Klion;
- Metrogil;
- Tinidazole;
- Metrolacare;
- Nitazol;
- Trichobrol;
- Cyptrogyl;
- Trichopolum;
- Flagyl;
- Metronidazole-ESCOM;
- Tinidazole-Acree;
- Tricho-PIN;
- Efloran.
How does it work?
Like many other drugs intended to combat pathogenic microflora, Dazolik belongs to the group of antibiotics (antiprotozoal). In the human body, its active substance - ornidazole - is absorbed into the blood and begins to have a detrimental effect on protozoan parasites. Microorganisms die when treated with Ornidazole Dazolic due to disruption of their DNA structure. The destruction of pathogenic microflora when taking this drug is facilitated by the fact that it inhibits the synthesis of bacterial nucleic membranes.
One of the features of the medicine is its high antibacterial effect. Therefore, “Dazolik” not only cures various kinds of parasitic diseases, but also improves human immunity.
How to use Dazolic
According to the instructions, Dazolic is taken orally after meals. The dosage of the drug depends on the disease and the age of the patient, namely:
- Trichomoniasis - Dazolic tablets are taken 500 mg twice a day for a course of at least 5 days. For children, treatment with the drug lasts no more than five days. The dose is calculated based on the ratio: 25 mg of Dazolic per kg of child’s weight;
- Intestinal amebiasis – 1.5 g of the drug once a day (adults and children whose body weight exceeds 35 kg), 2 g once a day (with a body weight exceeding 60 kg), 40 mg per kg per day (children with weighing less than 35 kg);
- Extraintestinal amebiasis - 0.5 g in the morning and evening for 5-10 days (adults and children over 12 years of age). A single dose for children under 1 year of age is 0.125 g, 1-6 years - 0.25 g, 7-12 years - 0.375 g;
- Giardiasis - 1.5 g per day (adults and children whose body weight exceeds 35 kg) and 40 mg per kg of body weight per day (children weighing less than 35 kg).
When preventing infections caused by drug-sensitive anaerobic bacteria, Dazolic tablets are taken 0.5-1 g per day before surgery and 0.5-2 g per day after surgery for three to five days.
Indications for use
The drug is prescribed for:
- giardiasis;
- trichomoniasis;
- amebiasis;
- to prevent infections that can be caused by anaerobic bacteria, it is often prescribed for sanitation before operations of the pelvic and colon organs.
Only a doctor can prescribe the drug. He will select the appropriate dosage, taking into account the patient’s characteristics and the presence of contraindications.
Side effects of Dazolic
According to reviews, Dazolic can cause side effects from many body systems, namely:
- Drowsiness, tremors, headache, incoordination, dizziness, muscle rigidity, temporary loss of consciousness, convulsions, distortion of taste, fatigue and sensory or mixed peripheral neuropathy (central nervous system and peripheral nervous system);
- Nausea and increased activity of liver enzymes (digestive system).
Also, according to reviews, Dazolic in case of overdose can cause allergic reactions, depression and neuritis of peripheral nerves.
Reviews
The effectiveness of Dazolic is confirmed by numerous positive reviews. Patients note the rapid action of the medication and the ability to eliminate pathogenic bacteria as much as possible. Normalization of the condition is revealed during re-examination after a course of therapy.
Some patients report symptoms of drowsiness when taking the pills, but this effect is not considered a side effect. If you have had experience using Dazolic, please share the information with site visitors.
Overdose
Patients, of course, should not take too much Ornidazole Dazolic, like any other medicine. An overdose can lead, for example, to nephritis of the peripheral nerves. If a patient drinks too much of this medicine, he will most likely experience the following symptoms:
- depression;
- convulsions;
- gastrointestinal disorder.
Treatment of an overdose of Dazolic is symptomatic. For seizures, the patient, among other things, may be prescribed the drug "Diazepam".
Are there any contraindications?
According to the instructions for Ornidazole Dazolic, this medicine cannot be used to treat infections or prevent people with liver problems. Also, the drug is not prescribed for:
- if the patient is allergic to any of its components;
- children under 3 years old;
- women during lactation.
Doctors do not prescribe medicine for some patients suffering from nervous diseases:
- epilepsy;
- multiple sclerosis.
During pregnancy, you can drink the product, but only on the recommendation of a doctor and under his supervision. Experts also prescribe Dazolic with caution to people who have problems with alcohol.
Instructions:
Clinical and pharmacological group
07.001 (Antiprotozoal drug with antibacterial activity)
Release form, composition and packaging
White or almost white, film-coated tablets, round, biconvex, scored on one side.
| 1 tab. | |
| ornidazole | 500 mg |
Excipients: sodium starch glycolate (type A), starch, colloidal silicon dioxide, magnesium stearate, sodium lauryl sulfate, polyvinylpyrrolidone K90 (povidone), purified talc, microcrystalline cellulose.
Shell composition: Eudragit E-100, titanium dioxide, polyethylene glycol 6000, isopropyl alcohol, acetone, purified water.
10 pieces. — strips (1) — cardboard packs.
pharmachologic effect
Antiprotozoal drug, a derivative of 5-nitroimidazole. The mechanism of action is the biochemical reduction of the 5-nitro group of ornidazole by intracellular transport proteins of anaerobic bacteria and protozoa. The reduced 5-nitro group of ornidazole interacts with DNA in microbial cells, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria.
Active against Trichomonas vaginalis, Giardia lamblia, Entamoeba histolytica, as well as against anaerobic bacteria (Bacteroides spp. /including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus/, Fusobacterium spp., Clostridium spp .). Aerobic microorganisms are not sensitive to ornidazole.
Pharmacokinetics
Suction and distribution
Absorption from the gastrointestinal tract is high. Bioavailability - 90%. Time to reach Cmax is 1-2 hours.
Communication with plasma proteins is less than 15%. Penetrates into most tissues, passes through the blood-brain barrier and the placental barrier. Excreted in breast milk.
Metabolism and excretion
Metabolized in the liver by hydroxylation, oxidation and glucuronidation. T1/2 - 12-14 hours. Excreted in the form of metabolites by the kidneys (60-70%) and with feces (20-25%), about 5% of the dose is excreted unchanged.
Dosage
The tablets are taken orally after meals.
For trichomoniasis, adults are prescribed 1.5 g once or 1 g in combination with intravaginal administration of 500 mg (vaginal tablets) at night. Treatment can be carried out for 5 days, prescribing 500 mg orally 2 times a day (morning and evening), also prescribing 1 vaginal tablet of 500 mg at night. For children, the dose is set at the rate of 25 mg/kg body weight once.
For amoebic dysentery, adults and children with a body weight of more than 35 kg, 1.5 g 1 time / day, with a body weight of more than 60 kg - 2 g / day. For children over 3 years old and weighing less than 35 kg, the daily dose is set at the rate of 40 mg/kg body weight. The course of treatment is 3 days.
For other forms of amebiasis, adults and children over 12 years of age - 500 mg 2 times a day for 5-10 days. Children over 3 years old and weighing less than 35 kg - 25 mg/kg body weight once for 5-10 days.
For giardiasis, adults and children weighing more than 35 kg - 1.5 g 1 time / day, children over 3 years old and weighing less than 35 kg - 40 mg / kg / day. Duration of treatment is 1-2 days.
To prevent infections caused by anaerobic bacteria, prescribe 0.5-1 g before surgery and 0.5 g 2 times a day after surgery for 3-5 days.
Overdose
Symptoms: convulsions, depression, neuritis of peripheral nerves.
Treatment: symptomatic therapy is carried out, for convulsions - diazepam.
Drug interactions
When used together, ornidazole enhances the effect of indirect coumarin anticoagulants and prolongs the muscle relaxant effect of vecuronium bromide.
Compatible with ethanol (does not inhibit acetaldehyde dehydrogenase) unlike other imidazole derivatives (metronidazole).
Use during pregnancy and lactation
The drug is contraindicated for use in the first trimester of pregnancy and during lactation (breastfeeding).
Side effects
From the central nervous system and peripheral nervous system: drowsiness, headache, dizziness, tremor, muscle rigidity, incoordination, convulsions, fatigue, temporary loss of consciousness, sensory or mixed peripheral neuropathy, perversion of taste.
From the digestive system: nausea, increased activity of liver enzymes.
Other: allergic reactions.
Storage conditions and periods
The drug should be stored in a dry place, protected from light and out of reach of children, at a temperature not exceeding 25°C. Shelf life – 3 years.
Indications
- trichomoniasis;
- amebiasis, amoebic dysentery, extraintestinal amebiasis (including amoebic liver abscess);
- giardiasis;
- prevention of infections caused by anaerobic bacteria during operations on the colon and gynecology.
Contraindications
- children under 3 years of age (for this dosage form);
- hypersensitivity to the components of the drug.
The drug should be used with caution in case of diseases of the central nervous system (including epilepsy, multiple sclerosis), liver diseases, alcoholism, pregnancy and lactation.
special instructions
When treating trichomoniasis, both sexual partners should be treated simultaneously.
Impact on the ability to drive vehicles and operate machinery
Because Since ornidazole has a depressant effect on the central nervous system, it should not be used while driving or other work that requires precise coordination of movements.
Use for liver dysfunction
The drug should be used with caution in case of liver diseases.
Conditions for dispensing from pharmacies
The drug is available with a prescription.
