Veins and blood vessels are an important link in the chain of our health. In the literal sense, veins, vessels and capillaries are the most important highways along which the energy of life flows. Any disturbances in these structures: varicose veins, blockage, stretching and a number of other problems can significantly reduce the quality of life and, in some cases, lead to serious consequences and the development of serious diseases. Therefore, it is important to monitor your health constantly and always.
In the article we will consider the drug “Detralex” as a means of treating and preventing diseases of the veins and blood vessels. Let's talk about what makes it special, what its composition is, how to take it correctly and when a positive effect is achieved.
Compound
Detralex contains 500 mg of micronized flavonoid fraction (Purified micronized flavonoid fraction), in which diosmin is 90% (450 mg), hesperidin is 10% (50 mg).
Auxiliary components: gelatin, magnesium stearate, MCC, sodium carboxymethyl starch, talc, purified water. Composition of p/o: macrogol 6000, sodium lauryl sulfate, premix for p/o orange-pink color (magnesium stearate, glycerol , hypromellose, iron dyes - yellow and red oxides, titanium dioxide).
Pharmacodynamics and pharmacokinetics
It has an angioprotective and venotonic effect, reduces venostasis , venous distensibility and capillary permeability, increases the tone of the venous walls, improves microcirculation and lymphatic drainage. Increases the ability of capillaries to maintain the integrity of the walls under mechanical stress.
The use of the drug Detralex helps to reduce the interaction of leukocytes and endothelium , as well as the adhesion of leukocytes in post-capillary venules, which reduces the severity of the damaging effect of inflammatory mediators on the valve leaflets of the veins and venous walls .
T½ - 11 o'clock. Excretion of active components is carried out mainly through the intestines. About 14% of the dose taken is excreted by the kidneys.
Indications for use of Detralex
When are vein pills prescribed?
Indications for the use of Detralex are organic and functional venolymphatic insufficiency of the lower extremities , which is manifested by swelling and pain, a feeling of heaviness in the legs, trophic disorders, and convulsions.
When is the drug used as a pill for hemorrhoids?
The use of the drug Detralex is indicated for the symptomatic treatment of acute hemorrhoidal attack.
Additionally
For both varicose veins and hemorrhoids the drug is used as a symptomatic remedy and often as part of complex therapy.
To reduce the severity of symptoms of venous insufficiency, a venotonic ointment or gel can be prescribed along with tablets.
In the treatment of hemorrhoids Relief , Proctosan , Nigepan , etc.) and ointments ( Ichthyol , Hepatrombin , Bezornil , etc.) can be used to relieve pain and inflammation, improve vascular tone, reduce thrombosis and stop bleeding
Signs of varicose veins
The initial signs of varicose veins are considered to be the appearance of small vessels on the surface of the skin. They appear in small groups on the thighs.
This is especially noticeable with cellulite. By the way, cellulite is directly related to varicose veins.
Fatty tissue altered by cellulite impedes the outflow of blood from the lower extremities and increases the risk of developing varicose veins. Doctors call blood vessels that appear on the skin telangiectasias.
These spider veins are formed by small vessels, which can be a simple cosmetic defect, or can serve as a sign of the onset of varicose veins.
To find out if you are at risk of varicose veins, MirSovetov recommends consulting with your doctor. The doctor will also advise the method by which spider veins should be treated. Another sign of varicose veins can be swelling of the legs. However, legs can also swell due to other diseases (kidney disease, heart disease, etc.), so you first need to rule out these
. And finally, the most unpleasant and indicative symptom of varicose veins is pain in the legs. The pain usually appears in the afternoon, after heavy physical activity. The calf muscles hurt, the pain is nagging and not very strong.
So, if you have these symptoms: spider veins, swelling, pain in the legs, you should consult a doctor.
Side effects
Side effects of Detralex are extremely rare. Most often the body reacts to treatment with dyspeptic disorders (nausea, diarrhea, etc.), sometimes neurovegetative disorders (malaise, headache, dizziness, etc.) and disorders of the subcutaneous tissue and skin (urticaria, skin rashes) , itching).
In extremely rare cases, angioedema .
Medicine "Detralex": side effects
This drug is usually well tolerated by patients even after long-term use. However, if used incorrectly or due to the individual characteristics of the body, side effects can sometimes still occur in patients drinking Detralex. Most often this is nausea and vomiting. The patient may also feel pain in the epigastric region. Sometimes patients taking this medicine also develop diarrhea.
In some cases, the drug "Detralex" also produces side effects on the nervous system. This usually manifests itself in the form of dizziness. In addition, the patient's general health may deteriorate.
Most often, when taking Detralex, the side effects are not too obvious. If nausea or, for example, headache occurs, doctors do not even usually recommend stopping the course of treatment started with this medication. After some time, all unpleasant symptoms usually disappear. Only if you are allergic to any of its components.
Detralex does not cause any side effects on the heart during the course. It can have a negative effect mainly only on the gastrointestinal tract and nervous system. This drug does not affect other organs in any way.
Detralex tablets: instructions for use
Instructions for use of Detralex for varicose veins
For venolymphatic insufficiency, the recommended dose is 2 tablets. 500 g per day. The tablets are taken with meals, one in the daytime, the second in the evening.
The medicine is prescribed only to adult patients. To enhance the effect, the doctor may also recommend using external therapy - ointment or gel.
The duration of treatment with Detralex for varicose veins , as well as the need for repeated courses, is determined by the doctor.
Detralex for hemorrhoids. How long to take pills for hemorrhoids?
The description attached to the drug on how to take Detralex for hemorrhoids states that in the acute stage of the disease (during an acute hemorrhoidal attack ) it is necessary to take 6 tablets per day. during the first 4 days of treatment and 4 tablets/day. in the next 3 days. Take the medicine with meals, dividing the daily dose into 2-3 doses.
Treatment of chronic hemorrhoids involves taking 4 tablets daily. They are taken with meals, 2 at each dose. After 7 days, you can reduce the dose by half and reduce the frequency of applications to 1 r./day.
How long to take the medicine depends on the degree of advanced disease and the effectiveness of therapy. On average, doctors for chronic hemorrhoids recommend taking pills in courses lasting 2-3 months. In case of an acute attack, treatment is carried out in short courses lasting 7 days.
If symptoms persist longer than this time, the patient should be examined by a proctologist.
Reviews of Detralex for hemorrhoids are mostly good. The main disadvantage of the drug, according to consumers, is its high price. However, given that Detralex is a drug with proven effectiveness (patients often notice an improvement in the situation after 2-3 days of taking the tablets), many people still prefer it over cheaper analogues.
Terms of sale
Detralex is available without a prescription.
Storage conditions
Detralex is included in group B (category of potent drugs), so tablets and sachets must be stored out of the reach of children. The maximum temperature is +30 degrees Celsius. During storage, avoid exposure to direct sunlight. In summer, it is advisable to keep the drug in the refrigerator.
Best before date
The drug in tablets must be consumed orally within 4 years from the date of manufacture, in the form of a suspension - 3 years.
Manufacturer
Detralex is produced by the French pharmaceutical (Servier Industry Laboratory), located at 905 route de Saran, 45520 Gidy, France (905 route de Saran, 45520 Gidy, France).
In the Russian Federation, the drug is produced under a French license. The organization is located at: Paveletskaya Square, 2/3, Moscow, 115054.
Detralex tablets and suspension are highly effective drugs against varicose veins and hemorrhoids. Prescribed as an independent remedy and in complex therapy. It has a minimum of adverse reactions, has a small number of contraindications, and quickly restores the structure of blood vessels.
special instructions
The use of tablets during an acute hemorrhoidal attack cannot replace specific therapy and creates obstacles to the treatment of other proctological diseases .
If after a short time there is no rapid decrease in the severity of symptoms, the patient should be examined by a proctologist, and the doctor should reconsider the therapy.
For people with impaired venous circulation, to increase the effectiveness of the drug, it is recommended:
- avoid standing for long periods of time and prolonged exposure to the sun;
- adjust body weight and diet;
- wear compression stockings to improve blood circulation;
- hike.
How to properly store the drug
The shelf life of the drug "Detralex" is 4 years from the date of manufacture. However, this drug will not lose its properties for such a long time, of course, only with proper storage. The box with Detralex should be placed in a place where children cannot find it. This medication should not be stored in the sun. The air humidity in the room should also not be too high. You should put this medicine in the refrigerator only in the summer - during the hottest days. At temperatures up to 30 ° C, it retains its properties simply perfectly.
Detralex analogues: what can replace the drug?
Level 4 ATX code matches:
Rutin
Venosmin
Indovazin
Venoruton
Troxevasin Neo
Troxevasin
Ginkor Gel
Ginkor Fort
Vasocket
Anavenol
Troxerutin
Askorutin
Antistax
Venarus
Drugs similar to Detralex with a similar mechanism of action, but a different composition: Antistax , Ascorutin , Vasoket , Venolek , Venoruton , Rutin , Troxevasin , Troxerutin , Phlebodia 600 , Yuglanex , Phlebofa .
Substitutes based on Hesperidine + Diosmin: Venozol , Venarus .
The medicine and its analogues are used to treat functional and organic venous insufficiency , as well as hemorrhoids (both acute and chronic).
The price of Detralex analogues is from 60 rubles. The cheapest analogues of Detralex are the drugs Rutin and Ascorutin.
In Ukraine, if Detralex is not available in the pharmacy, they may offer to replace it with the drugs Venorin , Venosmin , Juantal , Dioflan , Normoven , Nostalex .
What is better - Detralex or Phlebodia 600?
On forums, the drug is often compared with its analogues. And most often with the drug Phlebodia 600 . The basis of both products is diosmin. Its concentration in Phlebodia is 600 - 600 mg/tab., in Detralex - 450 mg/tab., however, in the latter its effect is enhanced by the presence of hesperidin (50 mg/tab.).
For varicose veins Phlebodia 600 1 tablet per day, Detralex - 2 tablets per day, that is, the daily dose of diosmin in the first case is 600 mg, in the second - 900 mg.
If we compare the pharmaceutical effect of the drugs and the specifics of their use, there are practically no differences.
However, thanks to the use of a unique technology for processing the active substance in its production, Detralex is absorbed into the body faster and more completely than its analogue, while its concentration in the blood plasma reaches a maximum after three to four hours.
Which is better - Detralex or Antistax?
Antistax is a herbal medicine that is used for venous circulation disorders. The capsules are based on a dried extract of red grape leaves with a high content of isoquercetin and quercetin glucuronide - flavonoids that help stabilize cell membranes, normalize vascular permeability, and reduce swelling.
However, if the effectiveness of Detralex was confirmed during clinical experiments, there is currently no of Antistax
Another difference between the drugs is that Detralex can be used during pregnancy, but there is no information regarding the safety and effectiveness of Antistax for pregnant women.
According to experts, Antistax for vascular diseases can be recommended more as a prophylactic agent and as an addition to the main treatment.
Thrombovazim or Detralex - which is better?
Thrombovazim is an enzyme preparation with thrombolytic , cardioprotective and anti-inflammatory activity . Its active ingredient is a complex of proteinases produced by Bacillus subtilis.
The medicine is prescribed as part of complex therapy for chronic venous insufficiency . It is strictly contraindicated for peptic ulcers , pregnancy and breastfeeding.
Considering that the drugs Detralex and Trombovazim have different pharmacological effects, it is not correct to compare them. Especially if you take into account that doctors often recommend taking them in combination.
Which is better - Detralex or Venarus?
Venarus is a Russian analogue of the drug. If we compare which is better - Detralex or Venarus , then we can come to the conclusion that there is no fundamental difference between them.
The basis of both drugs are the substances diosmin and hesperidin ; the products differ only slightly in the composition of the auxiliary components. The principle of action of Venarus is the same as that of its analogue, and the drug is prescribed for the same thing as Detralex tablets.
Recommendations on how to take both remedies for varicose veins and hemorrhoids are also identical.
The annotations for the drugs are distinguished by the fact that an additional contraindication to the use of Venarus is the lactation period. In addition, the cheaper analogue of Detralex is characterized by lower bioavailability and is somewhat more likely to cause side effects than the drug produced by Les Laboratoires Servier.
Contraindications for use
Both doctors and their patients consider Detralex a fairly mild medicine. As already mentioned, it rarely causes side effects in patients. However, of course, like any other medicine, this drug has various contraindications. These include, first of all, childhood. Doctors do not prescribe this drug to patients under 18 years of age. Perhaps this medicine does not cause any particular harm to the growing body. However, its effect on children, unfortunately, has not been studied.
Also, of course, this drug should not be taken by those people who are allergic to any of its constituent substances.
Another contraindication to the use of Detralex tablets, the side effects of which can actually appear in this case, is the lactation period. Whether the substance penetrates into breast milk and whether it can harm the baby - doctors, unfortunately, do not know about this. Research in this regard has also not been conducted.
Alcohol compatibility
There is no categorical ban on drinking alcohol during treatment with Detralex. The active ingredients of the drug are flavonoids hesperidin and diosmin , which, according to Wikipedia, are plant pigments and powerful natural antioxidants, do not interact with other substances and have no significant side effects.
However, it should be taken into account that, by affecting the cardiovascular system, alcoholic drinks provoke an increase in blood pressure and dilation of blood vessels, and a sharp influx of blood causes an increase in its stagnation in places of accumulation.
Thus, alcohol reduces the effectiveness of therapy and contributes to the progression of the disease.
Interaction
No special studies have been conducted to identify the interaction of Detralex with other drugs. However, to date there are no reports of negative interactions between the drugs and other medications.
Special studies regarding drug and other forms of drug interaction have not been conducted. However, given the extensive experience of post-registration use of Detralex, to date there are no statements about its adverse interaction with other drugs.
Detralex during pregnancy
Despite the fact that studies have not revealed the teratogenic properties of Detralex, it is used with caution during pregnancy.
Due to the lack of information on the ability of diosmin and hesperidin to pass into breast milk during breastfeeding, the use of the drug should be avoided.
The category of effect on the fetus according to the FDA classification has not been determined.
Studies on rats have shown that the drug does not have reproductive toxicity.
Reviews of Detralex during pregnancy allow us to conclude that the drug really helps with problems with veins and hemorrhoids . With the use of tablets, pain in the legs disappears, the legs become less tired and do not swell (and if they swell, then not so much), the development of varicose veins hemorrhoids disappear (or are significantly reduced) .
Main and relative contraindications
Based on the instructions for the drug "Detralex", the list of absolute and relative contraindications includes:
- the period of bearing the baby and its subsequent lactation;
- age category up to 18 years;
- individual hyperreaction to the active and auxiliary components of the Detralex product, from which the tablets can provoke allergic reactions;
- a history of allergic reactions to other angioprotectors.
As a rule, the drug Detralex is well tolerated by patients. No dose adjustment or frequency of administration is required. In some cases, however, the following undesirable effects occurred while taking medications:
- various dyspeptic disorders - nausea, vomiting;
- severe discomfort in the area of intestinal loops;
- diarrhea;
- persistent dizziness;
- intense pain impulses in the head;
- various dermatological rashes;
- exhausting skin itching and burning;
- other allergic conditions.
After stopping taking Detralex, all of the above-described negative effects completely stop. No specialized treatment measures are required.
Reviews of Detralex
On the forums you can find a variety of (and often completely opposite) reviews about Detralex tablets on the forums you can find different ones. But still, most patients respond well to the drug.
If you take pills for hemorrhoids , the result becomes noticeable already on the 2-3rd day of treatment. Moreover, the medicine “works” even in advanced cases (including during pregnancy, when almost all drugs are contraindicated, and surgical intervention is simply unacceptable).
If you take pills for varicose veins , the effect develops somewhat more slowly, but the achieved result can significantly improve the quality of life. Analyzing doctors' reviews about Detralex, we can come to the conclusion that the drug is effective, but:
- the result is more noticeable the earlier treatment is started (reviews of Detralex for varicose veins indicate that if you start taking pills when the first signs of the disease appear, you can forget about it (the disease) for many years);
- the effect develops gradually, that is, if the doctor said that the medicine should be taken for 2 months, then it really needs to be taken for the specified amount of time, and to maintain the achieved results, repeat the course 1-2 times a year;
- the approach to treatment must be comprehensive - in order to achieve the desired effect, do not forget about the regimen, diet, adequate physical activity, and the use of other medications.
Side effects from the use of tablets develop extremely rarely, and they do not require special treatment or discontinuation of Detralex. This effect is due to the unique medicinal formula of the drug and a special production technology: the particles of the active components of Detralex are so small that they are very easily absorbed by the body (due to its high bioavailability, the drug is considered more effective than its more inexpensive analogues).
Detralex price: how much does the drug cost in Ukraine, Russia and Belarus?
The drug under the brand name Detralex is produced by only one company, so its cost in pharmacies varies slightly.
The average price of Detralex tablets for hemorrhoids and varicose veins in Ukraine (for 30 tablets 500 mg) is 265 UAH. A pack of 60 tablets can be bought in Kyiv, Zaporozhye, Odessa, Donetsk, Dnepropetrovsk or Lugansk for an average of 440 UAH. The price of Detralex is approximately the same in Kharkov.
The price of Detralex in Moscow and Yekaterinburg also differs slightly. Tablets for varicose veins/hemorrhoids sell for an average of 750 rubles. for package No. 30 and 1450 rubles. per package No. 60. The medicine with the lowest cost can be found at the Ozerka pharmacy.
You can buy Detralex in Minsk from 374.8 thousand rubles (package No. 30).
The drug is available exclusively in tablet form. You won’t be able to find Detralex ointment or lyophilisate.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Detralex tablets p.p.o.
500 mg 60 pcs. LLC Servier Rus 1390 rub. order - Detralex tablets p.p.o. 1000 mg 30 pcs. Servier Rus LLC
1330 rub. order
- Detralex tablets p.p.o. 1000 mg 60 pcs. Servier Rus LLC
RUB 2,340 order
- Detralex tablets p.p.o. 500 mg 30 pcs. Servier Rus LLC
RUR 735 order
- Detralex tablets p.p.o. 1000 mg 18 pcs. Servier Rus LLC
RUR 848 order
Pharmacy Dialogue
- Detralex tablets 1000 mg No. 18 Serdix LLC
RUB 878 order
- Detralex tablets 1000 mg No. 60Servier
RUB 2,459 order
- Detralex tablets 500 mg No. 30Servier
RUR 808 order
- Detralex tablets 500 mg No. 60Servier
RUB 1,469 order
- Detralex tablets 1000 mg No. 30Servier
RUB 1,356 order
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Pharmacy24
- Detralex 500 mg N60 tablets Lab.Serv e Industries, France
271 UAH order
PaniPharmacy
- Detralex tablets Detralex tablets. p/o No. 60 France, Servier Industrie
309 UAH. order
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Price for Detralex
The drug has a component composition that is effective, but at the same time has an appropriate cost. The price of the tablet format of the drug depends on the number of tablets in the package. Price monitoring in Moscow and St. Petersburg revealed the following picture:
- for a package of 30 tablets of 500 mg - 750 rubles;
- per pack of tablets with a concentration of 500 mg 60 pcs. – 1500 rubles;
- 30 tablets with a concentration of 1000 mg – 1700 rubles;
- 60 pcs. 1000 mg – 2800 rub.
