Arpeflu is an effective new generation drug with antiviral and immunomodulatory effects. The drug perfectly stops the penetration of viruses into the human body, and also activates the work of one’s own defenses.
Arpeflu belongs to the category of low-toxic drugs, which makes it possible to use it in the treatment of children. Arpeflu's instructions for use are included in the kit and confirm that it can be used both in the complex treatment of various diseases of viral origin , and for the purpose of its prevention.
Due to its antiviral properties, the medicine effectively prevents the development of post-flu complications, reduces the frequency of relapses of chronic diseases, and also significantly increases the level of immunity.
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Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Arpeflu is an antiviral drug for systemic use. Contains the active substance umifenovir , which suppresses influenza A and B . The specific effect is associated with the inhibition of the fusion of the viral shell with the cell membranes - thus preventing their penetration into the cells of the body. Also, umifenovir increases interferon . Refers to low-toxic drugs. When using it, there is a reduction in the duration of the disease, a decrease in the severity of influenza , ARVI and the frequency of complications.
Pharmacokinetics
When taken orally, it is quickly and completely absorbed and maximum concentrations in the blood are created after 1.5 hours. Metabolism of the active substance occurs in the liver. It is excreted unchanged by the intestines and a small part by the kidneys. The half-life is 17-20 hours; about 90% of the dose is eliminated within 24 hours.
Operating principle
This is an antiviral drug that acts selectively on viruses type A and B, suppressing them. Arpeflu disrupts the process of connecting the lipid membrane of the virus with the cell membrane by interacting with the hemagglutinin of the virus. As a result, the duration and severity of symptoms of the disease, as well as the incidence of influenza complications, are reduced.
The drug also has an immunomodulatory effect, stimulating the immune system, thereby increasing the body's resistance to viral infections.
Arpeflu, instructions for use (Method and dosage)
Arpeflu tablets are taken before meals with plenty of liquid. Treatment regimens depend on the severity of the disease and are determined by the doctor. The duration of treatment is also adjusted by the doctor depending on the dynamics of the disease and concomitant pathology.
- A single dose for adults and children over 12 years of age is 200 mg.
- For influenza and ARVI - 200 mg 4 times a day. Duration of treatment is up to 5 days.
- For influenza complicated by pneumonia - 200 mg 4 times a day for 5 days, and then once a week, month.
- For recurrent herpetic infection - 200 mg 4 times a day for 7 days, with a transition to taking 200 mg twice a week for a month.
- Preventive administration after contact with patients - 200 mg 1 time per day for 10-14 days.
- During an epidemic - 200 mg 2 times a week for 3 weeks.
Arpeflu for children from 3 to 6 years old is recommended at a dose of 50 mg and 100 mg from 6 to 12 years old. For rotavirus intestinal infection - a single dose in accordance with age is taken 4 times a day for 5 days.
Analogs
The active ingredient Arpeflu - arbidol - also contains the following antiviral drugs for children: Immusstat, Arbivir, Arbidol, Arbimax.
In the treatment of influenza and acute respiratory viral infections, the best analogous drug for antiviral effect can be called Groprinosin, for children, it also exists in the form of syrup.
Acyclovir is perfect for treating herpetic infections, although the active substance is different from that in Arpeflu, but the effect of use is similar.
Arpeflu's analogs
Level 4 ATC code matches:
Vekluri
Remdeform
Areplivir
Coronavirus
Avifavir
Triazavirin
Yodantipyrine
Flavoside
Amizon
Altabor
Hyporamine
Anaferon for children
Anaferon
Amiksin
Arbidol
Ferrovir
Tiloron
Kagocel
Isoprinosine
Allokin-Alpha
Arbidol , Arbidol Maximum , Afludol , Arbivir , Mednat , Immusstat , ORVItol NP , Arbimax .
Composition and release form
The drug is presented on the pharmacological market in the form of film-coated tablets. The dosage of each tablet is from 50 to 100 mg. The tablets are packaged in contour packaging and cardboard packs.
Release form of the drug
The main active component of the drug is umifenovir hydrochloride (arbidol) . Also, the composition of the drug Arpeflu includes other auxiliary components, among which the following can be distinguished:
- magnesium stearate;
- modified starch;
- lactose monohydrate;
- povidone;
- silica;
- talc;
- polyvinyl alcohol.
Important! The drug belongs to the group of inducers of interferon synthesis.
Reviews about Arpeflu
ARVI and influenza are a common group of infectious diseases. They often have a severe course and unfavorable outcomes. One of the reasons for this is reduced immunity . of endogenous interferon and immunomodulators , is relevant . One of these drugs is Arpeflu. It is especially relevant for children, since they have an increased susceptibility to viral infections and an insufficient immune response, which causes a protracted course of the disease. If we compare this drug with amantadine and Remantadine , then their spectrum of action is narrow - they act only on the influenza A virus and side effects are possible when taking them.
This drug has a direct effect on influenza A and B . The use of Arpeflu is also effective for herpes and rotavirus infections . The presence of interferon-inducing, immunomodulatory and antioxidant activity ensures high efficiency in the treatment and prevention of viral diseases, prevents complications and exacerbations of concomitant chronic pathology. The drug is well tolerated and is compatible with antibiotics if there is a need to take them. All these points are reflected in the reviews.
- “... I think it helps. My husband got sick, his temperature was 39. He only took the antiviral drugs Arpeflu and Nimesil. In three days I got myself back on my feet and went to work.”
- “... I was prescribed it for an exacerbation of chronic purulent bronchitis along with antibiotics, I tolerated it well. I recovered faster than usual.”
It is most advisable to use the drug for preventive measures before the rise in the incidence of influenza and ARVI in the fall. Its high effectiveness lasts for 2-3 months. According to observations, after the preventive course, the number of children who fell ill with ARVI was 1.4 times less. A sign of effectiveness is also a reduction in the incidence of acute respiratory viral infections in adults with chronic respiratory diseases.
Contraindications and side effects
Contraindications
Contraindications include:
- Individual intolerance to umifenovir (arbidol) or any other excipient.
- Under three years of age.
- The presence of lactase deficiency, galactosemia or hereditary glucose-galactose malabsorption syndrome, because the drug contains lactose.
Use with extreme caution in cases of impaired liver and kidney function.
Side effects
The drug is low-toxic and has virtually no side effects. If individual intolerance to Arpeflu occurs, allergic manifestations are possible (itching, rashes, urticaria, angioedema), which usually disappear as a result of discontinuation of the drug. Very rarely, manifestations from the digestive system (heaviness in the abdomen, heartburn) are possible.
Arpeflu price, where to buy
You can buy Arpeflu in many pharmacies. The cost of 30 tablets of the drug 50 mg is 150 - 200 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Arpeflu tablets p.p.o.
50 mg 30 pcs. SOOO "Lekpharm" 266 rub. order
Pharmacy Dialogue
- Arpeflu tablets 50 mg No. 30 Lekfarm LLC
RUB 287 order
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PaniPharmacy
- Arpeflu table.
p/o 100 mg No. 10 + Arpeflu tablet. p/o 50 mg No. 10 PROMOTION 104 UAH. order - Arpeflu capsule Arpeflu film-coated tablets 100 mg No. 10 Belarus, Lekpharm
114 UAH order
- Arpeflu capsule Arpeflu film-coated tablets 50 mg No. 10 Belarus, Lekpharm
55 UAH order
- Arpeflu table. 50 mg No. 10 Promotion 1+1 Ukraine, Lekpharm
55 UAH order
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Reviews
Below you can read some reviews and comments about the use of the drug Arpeflu.
- Natalya regularly uses Arpeflu to prevent colds in the autumn-winter period for her family. She notes the low cost and good effect of the drug, as well as the absence of adverse reactions when taken. Recommends this inexpensive and reliable antiviral drug to everyone.
- Anna noted that Arpeflu helps her in the treatment of ARVI in a fairly short time, and there are no adverse reactions. And the plus is that the drug is inexpensive.
- Vasilina purchased the drug Arpeflu at the pharmacy for her daughter, having learned that it is also used for bronchitis. Her daughter suffers from chronic bronchitis and has a hard time suffering from colds, which are complicated already on the second day by attacks of suffocation. Arpeflu helped, and a week later the girl was able to go to school (before that, recovery took about 3 weeks). The only drawback of this drug is the need for frequent use.
- Tatyana takes Arpeflu herself and gives it to her 4-year-old daughter at the first sign of a cold; the drug turned out to be more effective than Anaferon for children, which is more expensive. Previously, my daughter was sick at least once a month in the autumn. At the moment, the child gets sick less often and recovers much faster.
- Julia advises everyone to take Arpeflu, as it helped her daughter recover from herpes sore throat in a fairly short time without the use of antibiotics prescribed by the doctor. She began taking it from the very first day of her illness, already on the third day her condition improved significantly, and on the fourth day she noted her daughter’s complete recovery.
What kind of drug is this?
Arpeflu is classified as an effective new generation antiviral immunomodulatory agent that has a dual effect. The main ingredients suppress the development of viruses in the body, while at the same time the drug stimulates the restoration of its own defenses.
Arpeflu helps the body produce its own interferon, which significantly increases immunity. Thereby:
- the patient’s recovery occurs much faster;
- the risk of complications is reduced;
- symptoms of acute respiratory viral infections, acute respiratory infections, and influenza are much easier to tolerate by the body.
The drug is officially recognized as low-toxic, which allows it to be used for children.
The gastrointestinal tract absorbs the drug well, the maximum concentration of the substance in the blood is observed after 1.2-1.5 hours.
Arpeflu is metabolized by the liver, excretion occurs naturally, mainly through the intestines, a certain amount is excreted through the kidneys.
In a day, the body will leave 90% of the substance from the dose taken; half-life occurs 17-21 hours after consumption.
Overdose
Over the entire period of presence on the pharmaceutical market, there has been no negative information regarding overdose. But you should not take a double dose if you miss a dose.
If an increased dose of the drug enters the child’s body, standard measures are taken:
- gastric lavage with a weak solution of potassium permanganate;
- artificially induce vomiting.
Consulting with a specialist in such a situation will not hurt; you should not ignore visiting a doctor.
The drug Arpeflu is stored for no more than 2 years from the date of release out of the reach of children. The optimal storage temperature is 15-25 degrees Celsius at normal humidity, without direct sunlight.
There are no special recommendations for interactions with other drugs. The exception is ethyl alcohol.
Arpeflu tablets 100 mg No. 20 in Nur-Sultan
Instructions for medical use of the drug
Arpeflu
Trade name Arpeflu
International nonproprietary name Umifenovir
Dosage form Film-coated tablets, 50 mg and 100 mg.
Composition One tablet contains the active substance - umifenovir hydrochloride 50 mg or 100 mg, excipients: povidone (K 17), microcrystalline cellulose, modified corn starch (Starch 1500), colloidal anhydrous silicon dioxide, magnesium stearate, lactose monohydrate, opadry II white ( polyvinyl alcohol, titanium dioxide (E 171), polyethylene glycol, talc).
Description Film-coated tablets, white, with a biconvex surface.
Pharmacotherapeutic group Anti-infective drugs for systemic use. Antiviral drugs for systemic use. Direct acting antiviral drugs. Other antiviral drugs. Umifenovir. ATX code J05AX13
Pharmacological properties Pharmacokinetics Umifenovir hydrochloride is rapidly absorbed and distributed to organs and tissues. The maximum concentration in blood plasma when taken at a dose of 50 mg is achieved after 1.2 hours, at a dose of 100 mg - after 1.5 hours. Metabolized in the liver. The half-life is 17-21 hours. About 40% is excreted unchanged, mainly with bile (38.9%) and in small amounts by the kidneys (0.12%). During the first day, 90% of the administered dose is eliminated. Pharmacodynamics Umifenovir hydrochloride is an antiviral agent and also has a moderate immunomodulatory effect. Specifically suppresses influenza viruses type A and B, as well as other viruses - causative agents of acute respiratory viral infections (ARVI) (coronavirus (Сoronavirus)), associated with severe acute respiratory syndrome (SARS), rhinovirus (Rhinovirus), adenovirus (Adenovirus), respiratory - syncytial virus (Pneumovirus) and parainfluenza virus (Paramyxovirus). According to the mechanism of antiviral action, it belongs to fusion inhibitors, interacts with the hemagglutinin of the virus and prevents the fusion of the lipid membrane of the virus and cell membranes. It has interferon-inducing activity, stimulates humoral and cellular immune responses, the phagocytic function of macrophages, and increases the body's resistance to viral infections. Reduces the incidence of complications associated with viral infection, as well as exacerbations of chronic bacterial diseases. Therapeutic effectiveness for viral infections is manifested in a decrease in the severity of general intoxication and clinical phenomena, and a reduction in the duration of the disease. Refers to low-toxic drugs. Does not have any negative effects on the human body when administered orally in recommended doses.
Indications for use - influenza A and B, acute respiratory viral infections (ARVI) - as part of complex therapy of chronic bronchitis, pneumonia and recurrent herpetic infections - prevention of influenza and ARVI during the epidemic season - prevention of postoperative infectious complications - as part of complex therapy of acute intestinal infections infections of rotavirus etiology in children over 6 years of age
Directions for use and dosage: Orally, 30 minutes before meals or 2 hours after meals. Single dose: children from 6 to 12 years old - 100 mg, over 12 years old and adults - 200 mg (2 tablets of 100 mg or 4 tablets of 50 mg). For nonspecific prophylaxis In direct contact with patients with influenza and other acute respiratory viral infections: - children from 6 to 12 years old - 100 mg once a day, over 12 years old and adults - 200 mg once a day for 10- 14 days. During an epidemic of influenza and other acute respiratory viral infections: - children from 6 to 12 years old - 100 mg, over 12 years old and adults - 200 mg twice a week for 3 weeks. For the treatment of influenza and other acute respiratory viral infections without complications: - children from 6 to 12 years old - 100 mg, over 12 years old and adults - 200 mg 4 times a day (every 6 hours) for 5 days. In the complex treatment of chronic bronchitis, pneumonia, herpes infection: - children from 6 to 12 years old - 100 mg, over 12 years old and adults - 200 mg 4 times a day (every 6 hours) for 5-7 days, then a single dose 2 times a week for 4 weeks. Complex therapy of acute intestinal infections of rotavirus etiology in children over 6 years of age: - children from 6 to 12 years old - 100 mg, over 12 years old - 200 mg 4 times a day (every 6 hours) for 5 days. Prevention of postoperative infectious complications: - children from 6 to 12 years old - 100 mg, over 12 years old and adults - 200 mg once 2 days before surgery, then in the same dose once on days 2 and 5 after surgery.
Side effects Rarely - allergic reactions (rash, anaphylactic reaction) - heartburn, nausea, vomiting, diarrhea
Contraindications - hypersensitivity to any component of the drug - children under 6 years of age - pregnancy and lactation - hereditary lactose intolerance, lactose intolerance, malabsorption of glucose, galactose
Drug interactions When prescribed with other drugs, no negative effects were noted.
Special instructions It is necessary to follow the regimen and duration of taking the drug recommended in the instructions. If you miss taking one dose of the drug, the missed dose should be taken as early as possible and continue taking the drug according to the started regimen. Pregnancy and lactation Due to the lack of necessary clinical experience, it is not recommended to take Arpeflu during pregnancy, unless the possible benefit to the mother outweighs the potential risk to the fetus. Due to the lack of necessary clinical experience, it is not recommended to take Arpeflu during breastfeeding. Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms It does not exhibit central neurotropic activity and can be used by people of various professions, incl. requiring increased attention and coordination of movements (transport drivers, operators, etc.).
Overdose Not noted.
Release form and packaging 10 or 20 tablets in a blister pack made of polyvinyl chloride film and aluminum foil. One, two or three blister packs of 10 tablets, together with instructions for medical use in the state and Russian languages, are placed in a cardboard pack. One contour blister pack of 20 tablets with a dosage of 50 mg, together with instructions for medical use in the state and Russian languages, is placed in a cardboard pack.
Storage conditions Store at a temperature not exceeding 25 ºС. Keep out of the reach of children!
Do not use after the expiration date.
Conditions for dispensing from pharmacies Without a prescription
, Republic of Belarus
Registration certificate holder of Lekpharm JLLC, Republic of Belarus...
Main indications for use
The medicine is used both for the treatment and prevention of various viral diseases in adults and children.
What is the drug taken for?
The main indications for the use of this pharmacological product:
- Influenza caused by group A or B viruses.
- ARVI, ARZ.
- Pneumonia.
- Chronic bronchitis during exacerbation.
- Treatment of various complications arising from diseases of infectious origin.
- Acute intestinal infections.
- Increased activity of the herpes virus.
- Rotavirus infection in children.
Also, these tablets are considered one of the most effective means for preventing the occurrence of postoperative complications of an infectious nature, as well as improving the immune status of adult and pediatric patients.
Doctors recommend using the drug in complex therapy for children over 3 years old.
This is interesting! How to take Anvimax: instructions for using powder
Contraindications
The effect of the drug on the body is safe, but not everyone can take it. The tablets will not have the desired effect if your child has:
- Increased sensitivity of the body to arbidol.
- He was less than 3 years old.
- Lactose intolerance.
It is worth closely monitoring the baby’s reaction for the first few days after starting to take the drug. In case of any reactions that are not typical for a child, do not hesitate, immediately seek help from doctors.
Arpeflu should be suspended until examined by a specialist.
