Pyrogenal is a drug in demand in modern pharmaceutical practice, the main action of which is aimed at providing a high-quality immunomodulatory effect. If we talk about why the medicine Pyrogenal is prescribed to children and adults, we can highlight the following indications for use:
- Chronic liver pathologies.
- Severe burns localized in different parts of the body.
- Prostatitis, urethritis (chronic form).
- All kinds of venereal pathologies.
- Inflammatory lesions of the uterine appendages.
- Adhesive disease of the peritoneum.
- Strictures of the urethra and ureters.
Composition and release form
Injection Pyrogenal is available in ampoules in the form of a sterile solution for parenteral administration. Each package contains ten ampoules of 1 ml of the drug.
The active ingredient of Pyrogenal is bacterial-type lipopolysaccharide in doses of 10, 25, 50 or 100 mcg in one milliliter of sterile solution. The preparation contains an additional ingredient, such as a phosphate buffer solution with a neutral acidity index, which acts as a preservative. The injection solution is sold in ampoules, 10 pieces in a pack. For ease of opening the vessels, an ampoule scarifier is included in the package.
An alternative form of drug release is rectal suppositories. The dosage of the active ingredient in suppositories is 50, 100, 150 or 200 mcg. An increased concentration of the active component implies its gradual release and prolonged modeling of the immune response. The sales package contains 3 suppositories.
Contraindications
All dosage forms
- Acute febrile diseases;
- Pregnancy;
- Hypersensitivity to the components of Pyrogenal.
Solution for injection (optional)
- Chronic diseases in the stage of decompensation and exacerbation, except for diseases that are an indication for the use of Pyrogenal;
- Blood diseases;
- Lactation period.
For chronic diseases of the cardiovascular system, kidneys, and diabetes, Pyrogenal is prescribed under the supervision of a doctor.
If there is anamnestic evidence of febrile convulsions or in case of convulsive readiness, the use of the drug is possible against the background of anticonvulsant treatment.
pharmachologic effect
Pyrogenal is a broad-spectrum immunomodulator, therefore it is used to treat many diseases, including viral and bacterial origin. The drug has the following therapeutic effects:
- anti-inflammatory;
- desensitizing;
- adjuvant;
- immunomodulatory;
- pyrogenic;
- fibrinolytic;
- regenerating.
The bacterial polysaccharide, which acts as an active substance, is isolated from the group of gram-negative bacteria. Therefore, its mechanism of action is comparable to vaccination.
The principle of action of the drug is to increase the activity of the hypothalamic-pituitary-adrenal system. The production of glucocorticosteroid hormones, which have powerful anti-inflammatory and antiallergic effects, increases.
The drug also affects the reticuloendothelial and phagocytic systems, in particular macrophages, resulting in increased synthesis of oxygen radicals, interleukins, interferons and cell necrosis factor. Thanks to this, cellular immunity is activated. Bacterial polysaccharide directly affects the central nervous system, accelerating the restoration of damaged cells and tissues.
Equally important is that Pyrogenal can influence the rate of collagen synthesis by fibrocytes. This property of the drug prevents the formation of coarse scar tissue in burns. The fibrinolytic effect of Pyrogenal allows it to be used to prevent adhesions in the abdominal cavity. The drug has a hemostatic effect, accelerates wound healing, and also improves microcirculation in internal organs.
In addition, inhibition of the collagen production process and an increase in the enzymatic properties of hyaluronidase contribute to fibrinolysis, resorption of the inflammatory focus and improvement of microcirculation. Pyrogenal increases the absorption and permeability of capillary walls and blood-brain barrier tissues, which has a positive effect on the speed of metabolic processes. The drug also facilitates the penetration of other drugs into tissues and potentiates their effects. Pyrogenal is often prescribed as a background drug during a course of chemotherapy, since it increases its effectiveness.
During therapy with Pyrogenal, a temporary decrease in the level of leukocytes is observed, the normal content of which in the blood is restored after a short time.
After administration into the body, 10% of the drug binds to plasma proteins, 85% is adsorbed on the surface of white blood cells and 5% on the surface of red blood cells. Metabolites of Pyrogenal are excreted by the kidneys. The bacterial polysaccharide does not accumulate in the liver.
Use of the drug in gynecology
In gynecological practice, Pyrogenal is used quite widely. As a rule, it is prescribed in cases of diagnosis in patients:
- secondary infertility;
- any sexually transmitted disease, for example, syphilis, gonorrhea, trichomoniasis, etc.;
- inflammatory processes of the uterine appendages;
- human papillomavirus infection
Also, this drug is successfully used to open hidden sexually transmitted infections using pyrotherapy (artificially raising the temperature).
In the treatment of sexually transmitted diseases, the active substance Pyrogenal consistently begins to fight each new wave of the disease pathogen. It effectively suppresses in full the causative agent of trichomoniasis - Trichomonas, as well as Giardia precisely at the cellular microlevel, thereby quite effectively promoting various regenerative processes that arise and occur in the affected tissues.
In addition, it significantly helps other chemical drugs penetrate the source of infectious inflammation as quickly as possible to completely destroy harmful microorganisms.
Why are Pyrogenal injections prescribed?
Indications for the use of the injection form of the drug are as follows:
- diseases of the hepatobiliary system with a chronic course;
- narrowing of the urinary canal and ureters;
- chronic inflammation of the prostate gland;
- inflammation of the urinary canal with a chronic course;
- inflammation of the fallopian tubes and ovaries;
- male and female infertility;
- adhesions inside the abdomen;
- extensive burns;
- sexually transmitted diseases;
- bruises and concussions;
- spine and spinal cord injuries;
- active tuberculosis;
- inflammation of the choroid of the eyeball;
- inflammation of the iris;
- eye infections of herpes viral etiology;
- cataract;
- psoriasis;
- eczema;
- pyrotherapy.
Pyrogenal is used as part of complex therapy only as prescribed by the treating doctor. Self-medication can be harmful to health.
The drug can also be prescribed to women and men for diagnostic purposes, when it is necessary to cause activation of a sluggish infectious disease of the genitourinary system.
Contraindications
Treatment with Pyrogenal has a number of limitations, namely:
- a history of individual intolerance to the drug or its individual components;
- severe pathology of the cardiovascular system;
- liver dysfunction;
- severe renal failure;
- chronic autoimmune diseases;
- gestation period;
- lactation.
Indications for use
All dosage forms
- Chronic liver diseases;
- Burn disease;
- Strictures of the ureters and urethra;
- Adhesive disease of the abdominal cavity;
- Chronic prostatitis and urethritis;
- Venereal diseases;
- Secondary infertility;
- Diseases of the uterine appendages of inflammatory etiology.
Suppositories (optional)
- Human papillomavirus infection;
- Incomplete recovery after acute viral and bacterial diseases (immunorehabilitation and immunoprophylaxis).
Solution for injection (optional)
- Traumatic injuries of the peripheral and central nervous system;
- Herpes virus infection of the eyes;
- Tuberculosis in a sluggish form in the resorption phase;
- Chronic skin diseases, including psoriasis;
- Iridocyclitis;
- Cloudiness of the cornea;
- Uveitis;
- The need for pyrotherapy (as a pyrogenic drug).
Instructions for the use of Pyrogenal injections
Pyrogenal in ampoules is intended only for intramuscular injections. It is better to inject the drug into large muscles, such as the gluteal or quadriceps femoris, since they have a well-developed vascular network.
Injections of the drug should only be performed by a nurse, and the first injection of Pyrogenal is given in the manipulation room of a medical institution. This is necessary to monitor the patient’s reaction to the drug. In case of allergies, the treatment room has all the necessary medications to relieve intolerance reactions.
For people prone to allergies, experts recommend conducting a sensitivity test. To do this, one drop of solutions of Pyrogenal, 0.9 percent Sodium chloride and Histamine is applied to the skin of the inner surface of the forearm in a row every few centimeters, after which the skin is shallowly scratched with a scarifier. After 15 minutes, the reaction is assessed: if itching, burning or hyperemia appears in the place where Pyrogenal was applied, then it is considered that the patient is allergic to this medicine. In this case, the use of the drug is prohibited.
For patients who have no contraindications to treatment with Pyrogenal, the drug is prescribed at a dose of 2.5 mcg, which is increased by 2.5-5 mcg with each injection. The maximum permissible dose of the drug is 100 mcg.
Pyrogenal injections are given once every two days, preferably at the same time. The drug is diluted with physiological sodium chloride solution in a 1:1 ratio.
The duration of treatment is from 3 to 4 weeks. But, depending on the type of nosology, the treating doctor can adjust the duration of treatment with the drug. Some patients may need a second course of therapy, which can be done after 8-12 weeks. In severe cases of the disease, injections of Pyrogenal are combined with the use of this drug in the form of rectal suppositories.
When carrying out pyrotherapy, higher doses of Pyrogenal are used. Treatment begins with 10-20 mcg, gradually increasing the dose to 150 mcg. Injections are performed once every two to three days for one month.
Doctors' opinions on the most effective methods of treating warts and papillomas
The chief physician of Moscow City Hospital No. 62 describes his vision on this matter. Anatoly Nakhimovich Makhson Medical practice: more than 40 years.
“I have been treating people’s papillomas and warts for many years. I’m telling you as a doctor, papillomas along with HPV and warts can really lead to serious consequences if they are not dealt with.
The human papillomavirus is present in everyone on whose body there are papillomas, moles, warts and other pigmented formations. According to rough estimates, 80-85% of the planet's population has it. By themselves they are not dangerous. The problem is that an ordinary papilloma can become melanoma at any time.
These are incurable malignant tumors that kill a person in just a few months and from which there is no salvation.
Unfortunately, in Russia and the CIS countries, pharmaceutical corporations sell expensive medications that only relieve symptoms, thereby hooking people on one drug or another. That is why in these countries there is such a high percentage of cancer diseases and so many people suffer from “non-working” drugs.
The only drug that I want to recommend, and it is also officially recommended by WHO for the treatment of papillomas and warts, is Papinol. This drug is the only remedy that has an effect not only on external factors (that is, it removes papillomas), but also acts on the virus itself. At the moment, the manufacturer has managed not only to create a highly effective product, but also to make it accessible to everyone. In addition, within the framework of the federal program, every resident of the Russian Federation and the CIS can receive it for 149 rubles.”
To find out more, read this article.
Provocation by Pyrogenal
Often, various sexually transmitted pathologies develop in the human body without pronounced and noticeable symptoms (for example, the same gonorrhea). Therefore, a person who is a carrier of diseases of this type, without realizing it, infects his sexual partner (or several).
With the help of Pyrogenal, provocation is carried out, i.e. transferring the disease from a latent form to an obvious one, which makes it possible to detect developing but invisible sexually transmitted infections in men and women. This approach allows for high-quality diagnosis of the disease, as well as rational monitoring of the effectiveness of the prescribed therapeutic intervention.
The drug is administered intramuscularly upon provocation (together with other vaccines against sexually transmitted diseases). The dosage in each case is determined individually (usually 20 mcg for men and women). Two injections may also be prescribed before testing for an STI. If you believe the reviews, then the use of Pyrogenal is one of the most effective ways to provoke hidden sexually transmitted pathologies.
You can find out how many injections of Pyrogenal you need to make to provoke and trigger an exacerbation of sexually transmitted pathology from a doctor, who will first study all the available facts. With the help of the drug, the work of the human immune system is artificially restarted, and the active life activity of pathogens of venereal disease is also enhanced.
Side effects of Pyrogenal
When using Pyrogenal, various side effects may occur. The most common side effect is fever, which often lasts for a month after treatment with this drug.
Important!
During treatment with this medicine, patients may experience an increase in body temperature of up to 37.5 degrees. Along with this, other characteristic symptoms arise: slight chills, increased fatigue, and a feeling of weakness. This unpleasant and uncomfortable condition can last for several hours, and in some cases, the whole day.
In this case, the doctor can also administer the same dose of Pyrogenal the next day, monitoring the patient’s reaction. If an increase in temperature and corresponding symptoms are observed again, then this, oddly enough, is a good sign. The dosage is not reduced until the body stops giving such a reaction. Once this happens, the doctor may decide to increase the dosage.
In exceptional cases, after the administration of Pyrogenal, some patients experience severe chills, an increase in body temperature up to 39 degrees, pain in the head and lumbar region. Such a reaction to the use of the medicine may last for several hours. Then there is a gradual decrease in temperature, weakening of pain, which after a day completely disappears. If there is such a strong reaction to the drug the next day, doctors will necessarily reduce the dosage.
If the injection site is inflamed, it should be examined by a doctor. Pyrogenal cannot cause such a reaction.
Side effects and overdose
An increase in body temperature during Pyrogenal therapy is considered normal and indicates an immune response. In this case, hyperthermia is observed for three to eight hours and does not exceed 37.5 °C. The dose of the drug that caused hyperthermia is repeated one to three more times, after which it is gradually increased.
Some patients may develop more pronounced pyrogenic reactions: chills, body temperature above 38.0 °C, cephalalgia, lower back pain, which go away on their own after six to eight hours. In this situation, the dose of the drug is reduced.
During the use of Pyrogenal, not a single case of overdose was registered.
Combination of medicine with alcohol
Experts note the effective use of this drug in relieving long-term alcoholic binges, as well as hangovers. The positive result of such practices is up to 97-98%.
The drug is prescribed to a patient suffering from alcohol dependence according to the following scheme: 50-75-100-125-150 mcg per day. As a result, the patient’s temperature naturally rises to 39%, and then decreases independently without the use of antipyretics. In this way, a person’s pathological craving for drinking alcoholic beverages is significantly reduced, especially during the first days of treatment.
special instructions
Pyrogenal should not be used in patients with concomitant severe pathologies of the cardiovascular system, kidneys and liver. For diseases of moderate severity, the drug is prescribed under close medical monitoring.
In addition, treatment with the drug in persons over 60 years of age requires special attention and observation. The initial dose of the drug for elderly patients is slightly reduced.
For patients who have previously experienced seizures when the temperature rises, Pyrogenal is used in combination with anticonvulsants.
Interaction
Pyrogenal is combined with all medications used in the treatment of diseases that are included in the list of indications for this drug. But, nevertheless, before prescribing an immunomodulator, you need to consult with your doctor.
The manufacturer warns about the following drug interactions:
- Pyrogenal increases the effectiveness of drugs used for chemotherapy;
- immunomodulator enhances the effect of antibacterial and antiviral drugs;
- non-hormonal anti-inflammatory drugs (Nurofen, Paracetamol, Nimesil and others) reduce the effect of Pyrogenal;
- the drug reduces the toxicity of ethanol on the body and also reduces cravings for alcohol, which made it possible to use it in the treatment of alcoholism and withdrawal symptoms.
Use during pregnancy and lactation
Clinical studies that would determine the effect of Pyrogenal on the course of pregnancy and fetal development have not been conducted. Therefore, the drug should not be prescribed to pregnant women.
Also, given the risk of the drug passing into breast milk, it is not used during lactation.
Purpose for children
The drug can be used in childhood, but in children under 5 years of age smaller dosages are used.
be careful
The presence of papillomas, warts, condylomas, moles and spines on the body is the first sign of malignant melanoma!
We hasten to warn you that most medications “treat” warts, papillomas, moles, etc. - this is a complete deception of marketers who make hundreds of percentage points on drugs whose effectiveness is zero. They do not cure the disease, but only mask the symptoms.
The pharmacy mafia makes huge money by deceiving sick people.
But what to do? How to treat if there is deception everywhere? Doctor of Medical Sciences Anatoly Makhson conducted his own investigation and found a way out of this situation. In this article, the Doctor also told how to 100% protect yourself from melanoma, for only 149 rubles! Read the article in the official source via the link.
However, Pyrogenal is also sold in the form of suppositories and solution for injection. Most often, suppositories of the drug are prescribed in the presence of active and latent forms of HPV in the patient’s body, as well as in a state of incomplete recovery (against the background of past pathologies of a viral-bacterial nature).
Pyrogenal solution can be prescribed in the presence of mechanical disorders in the central nervous system and peripheral system, in case of herpetic infection of the eyes, in case of tuberculosis (various forms), uveitis and other diseases.
Judging by reviews on forums on the Internet, at the moment there are no direct (more expensive or cheaper) analogues of Pyrogenal, in terms of active substance and effects on the human body, pathogenic microorganisms.
Important!
The most similar drugs are the following: Transfer Factor, Prodiogisan. But the use of these drugs as a replacement for Pyrogenal is not allowed.
Analogs
There are no direct analogues of Pyrogenal that would have an identical composition on the pharmaceutical market.
There are two popular analogues of the drug in terms of therapeutic effects and mechanism of action: Prodiogisan and Transfer Factor.
Prodiogisan is an immunostimulant that activates the production of endogenous interferons. The drug is available in the form of an injection solution.
Transfer Factor belongs to dietary supplements and consists of cow colostrum peptides. According to the manufacturers, this dietary supplement has a pronounced immunostimulating effect, does not cause adverse reactions and has no contraindications.
Pyrogenal: price and sale
This drug is quite widespread and quite well known on the Russian pharmacological market, so buying Pyrogenal will not be difficult at any pharmacy or by ordering online. But due to the fact that the drug has contraindications and can cause adverse reactions, you should not use Pyrogenal on your own. Before taking this product, you should consult your doctor and study the manufacturer's instructions, since the instructions for Pyrogenal are provided for informational purposes only.
In addition, it is not recommended to buy this drug second-hand or from dubious establishments, but rather contact a pharmacy or representatives of the manufacturer. These security measures will help you avoid buying counterfeits. When purchasing the drug Pyrogenal, it is necessary to check the product’s certificate of conformity.
How to use candles
On sale you can find suppositories produced in higher dosages than injections. Suppositories are used only rectally, even for the treatment of gynecological diseases. Vaginal administration is not permitted.
The initial dose of the drug is 50 mcg. Gradually the concentration increases to 200 mcg. The dose is reduced to 100 mcg if the medication is prescribed for preventive purposes after an infectious disease or if the patient is a child or an elderly person. Immunorehabilitation involves the use of 5 to 10 suppositories.
Recommended treatment regimen:
- 50 mcg for 3 days;
- 100 mcg for 3 days;
- 150 mcg for 3 days;
- 200 mcg for 3 days.
You can only light one candle per day. The package contains suppositories for a full course of 12 suppositories. The dosage and regimen for kidney and liver diseases is varied by the attending physician on an individual basis.
Interaction
Pyrogenal is prescribed to enhance the effect of antimicrobial therapy. There is no need to change your eating habits. Taking other immunostimulants will not enhance the effect of any of the medications you are taking.
With other drugs
Pyrogenal is recommended to be prescribed during antibiotic treatment. A modulating agent can enhance the effect of antibacterial treatment and speed up recovery. Also, the lipopolysaccharide in the composition can increase the intensity of chemotherapy.
The medication may reduce its effect with simultaneous use of anti-inflammatory antipyretics. If possible, you should avoid taking Ibuprofen, Paracetamol, Diclofenac and their analogues.
With alcohol
Often the drug is prescribed as a complex therapy in the treatment of alcohol dependence. Pyrogenal is able to reduce cravings for alcohol and treat hangover syndrome. However, when treating alcoholism, the daily dose should not exceed 100 mcg.
Methods of use in medicine
Pyrotherapy is a universal treatment method. The medication Pyrogenal can be used in pediatrics and taken by adult patients. The medicine is used in venereology, gynecology, urology and other areas to increase the body's resistance to viral and bacterial attacks.
In gynecology
The medicine is often recommended for the treatment of gynecological diseases. The list of contraindications includes only pregnant and lactating women.
Pyrogenal in gynecology is prescribed in the following cases:
- secondary type infertility;
- gonorrhea, syphilis, trichomoniasis and other sexually transmitted diseases;
- inflammatory pathologies of the genitourinary system;
- human papillomavirus (HPV);
- hidden sexually transmitted infections (STDs);
- giardiasis and other diseases caused by trichomonas, chlamydia and gonococci.
The drug is also indicated to enhance the effect of antibiotics in the treatment of ureaplasmosis and chlamydia. Active components help destroy viruses and infections at the cellular level. At the same time, the woman’s temperature will rise slightly to about 37 degrees.
In urology
The use of Pyrogenal in the form of rectal suppositories is advisable in the complex therapy of bacterial chronic prostatitis. This treatment has shown high effectiveness: the intensity of symptoms decreases and overall well-being improves. Pyrogenal directly affects the immune system by enhancing the production of interferon and normalizing hormonal levels.
Before using Pyrogenal injections, carefully read the official instructions for use.
Provocation
Another interesting method of application is provocation. Many sexually transmitted diseases occur in a latent form. After a short course, the infection begins to show symptoms. A patient who was not even aware of the disease may be a carrier.
In this way you can identify:
- hidden sexually transmitted infections;
- clarify the previously made diagnosis.
The medication is also prescribed to monitor the effectiveness of previous treatment. To detect gonorrhea, it is recommended to administer Pyrogenal along with gonovaccine. This way you can confirm the viability of pathogenic microorganisms.
Pregnant and lactating
It is not recommended to use the drug while pregnant. Breastfeeding women should stop breastfeeding until the course is completed.
In old age
For older patients, the drug can be used by reducing the final dose to 100 mcg per day. Additionally, it is recommended to monitor the patient's condition after administration of the drug for 30 minutes.
If kidney function is impaired
The active components are excreted by the kidneys, so if their functions decrease, treatment can be carried out, but under the strict supervision of a doctor. The dosage of the drug is reduced. If renal failure is diagnosed, medication is not prescribed.
For the treatment of children
In pediatric practice, a modulating agent in a reduced dosage can be prescribed even to patients under 5 years of age. For older children, the medication is prescribed in the usual concentration if the bacterial lipopolysaccharide is well tolerated.
General information
The medicine Pyrogenal is prescribed only by a doctor. Independent use is not recommended. It is advisable to have qualified personnel administer intramuscular injections. A family member with medical practice can give injections at home.
Indications for use
Before starting use, it is recommended to carefully read the instructions for use for injections or suppositories. Information on the official insert may vary slightly.
In the list of indications for injections:
- support of immunity during ARVI, severe influenza;
- chronic liver dysfunction;
- urethral diseases;
- gynecological pathologies of internal organs;
- secondary type infertility;
- the presence of adhesions, cysts and other lesions of internal organs;
- damage to abdominal tissue, adhesive disease;
- burns, scars and other damage;
- diseases of the optic nerve, herpes lesions;
- blurred eyes;
- skin lesions, psoriasis;
- carrying out pyrotherapy;
- comprehensive treatment of tuberculosis;
- injuries and other types of damage to the central nervous system;
- sexually transmitted diseases and infections.
Injections can be prescribed for any disease if a person cannot cope with a viral and infectious attack on his own. The drug Pyrogenal works especially effectively against bacteria. Suppositories can be prescribed in the same cases.
Additionally in the list of candle readings:
- human papillomavirus;
- bacterial and viral diseases of gynecological or urological nature;
- rehabilitation after a bacterial illness;
- prevention of re-infection.
The drug can also be prescribed at the end of an antibiotic course to boost immunity and prevent incomplete recovery. In this case, the dosage and treatment regimen may not correspond to the instructions and must be adjusted by the attending physician.
Contraindications
The drug can be used even in pediatric practice due to the low likelihood of side effects. This is one of the safest fast-acting immunomodulators. However, before use, it is worth considering that not everyone can tolerate the active ingredients and additional substances.
In the list of contraindications:
- hypersensitivity to the ingredients in the composition;
- diseases of the cardiovascular system in severe form;
- acute renal or liver failure;
- autoimmune lesions;
- period of pregnancy and lactation.
The effect of an immunostimulant on the fetus during pregnancy has not been fully studied, so the use of the drug can be prescribed if there is an urgent need.
Side effects
The medication belongs to a group of drugs with a low incidence of side effects. But reactions of individual intolerance should be taken into account. Also, due to the mechanism of action, body temperature may increase for 2-4 hours.
Possible side effects of suppositories:
- increase in body temperature by 0.5-1 degrees, usually no more than 38 degrees;
- development of influenza condition;
- decreased performance and lethargy.
In rare cases, hypersensitivity may cause nausea. The use of the product during high temperatures can provoke a fever and chills. Anorexia, arthralgia, and myalgia are even less common.
List of side effects of the injection solution:
- temperature increase to 37.6 degrees;
- mild malaise, dizziness and migraine;
- slight chills, fever;
- lower back pain.
The above reactions are a consequence of the action of the drug and disappear on their own within 3-8 hours. However, if you are hypersensitive, you should avoid injection treatment.
If your body temperature has not dropped on its own after 8 hours, you can take an antipyretic. If the patient develops a febrile condition, it is recommended to reduce the dosage.
special instructions
The drug is not prescribed for heart failure, severe liver and kidney diseases. If the functionality of internal organs is reduced, treatment is possible under the strict supervision of a doctor.
During pregnancy, the use of the drug is not recommended. During breastfeeding, it is necessary to stop feeding the baby for the duration of immunomodulatory therapy.
If the patient has a history of febrile seizures, then taking Pyrogenal should be accompanied by anticonvulsant therapy. Otherwise, the medication is not prescribed. The injection should be administered only by medical personnel with subsequent monitoring of the reaction.
Pharmacodynamics and pharmacokinetics
This drug belongs to immunomodulators that have a wide spectrum of action. The compounds included in Pyrogenal affect the hypothalamus, the adrenal cortex, and the pituitary gland. In addition, the drug affects the fibrinolytic as well as the reticuloendothelial system.
LPS increases the level of corticosteroids in the blood, and also affects the functioning of the adrenal cortex, increases resistance and changes the thermoregulatory centers of the hypothalamus, thereby creating a pyrogenic effect that can be controlled.
The drug interacts with the phagocytic system, thus triggering the synthesis of IL-2, as well as IL-1, the secretion of oxygen radicals and IFN (interferon).
Pyrogenal is involved in stimulating the body’s kinin system, prevents the synthesis of collagen by fibroblasts and accelerates the maturation of fibrocytes.
By stimulating hyaluronidosis, as well as reducing the production of collagen fibers, this medicine increases tissue permeability, ultimately improving the fibrinolytic properties of the blood, and increasing the rate of distribution of active compounds in the body.
Information for specialists
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