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Manufacturers: Chengdu Sino-Strong Pharmaceutical Co. Ltd
Active ingredients
- Diosmin
Disease class
- Varicose veins
- Haemorrhoids
- Venous insufficiency (chronic) (peripheral)
- Other and unspecified circulatory system disorders
Clinical and pharmacological group
- Not indicated. See instructions
Pharmacological action
- Venotonic
- Angioprotective
- Venoprotective
Pharmacological group
- Angioprotectors and microcirculation correctors
Diosmin release form
- VAZOKET 600 (VASOKET 600). WHIMER PHARMA GMBH, Germany. 1 tablet contains: diosmin - 600 mg. Table 600 mg, No. 30.
- PHLEBODIA 600 (PHLEBODIA 600). "LABORATORIE INNOTECH INTERNATIONAL", France. 1 tablet contains: diosmin - 600 mg. Table 600 mg, No. 15, No. 30.
- DETRALEX. "SERVIER", France. 1 tablet contains: 500 mg. purified micronized flavonoid fraction: 450 mg diosmin (90%) and 50 mg. flavonoids in the form of hesperidip (10%). Table p/o, No. 30, No. 60.
- NORMOVEN. "KIEV VITAMIN PLANT", Kyiv, Ukraine. 1 tablet contains: flavonoid fraction 500 mg, including diosmin 450 mg, hesperidin 50 mg. Table p/o contour cells up., No. 10, No. 30.
Pharmacological effect
- In the postoperative period, it increases vascular resistance; with orthostatic hypertension, it increases systolic and diastolic pressure. Has a vasoconstrictor effect,
- ensures normal fluid circulation,
- Has an anti-inflammatory effect - prevents the formation of prostaglandins and thromboxane synthesis,
- Increases capillary resistance and reduces capillary permeability,
- Reduces the adhesion of leukocytes to the venous walls,
- eliminates congestion in the lymphatic system,
- Used to prevent bleeding when using intrauterine devices,
- Improves blood supply to skin tissues in natural conditions,
- Improves the diffusion of oxygen in the skin,
- Reduces the migration of leukocytes into paravenous tissues,
- Prevents and stops the formation of free radicals in the blood.
Absorbed into the blood two hours after administration, reaching maximum concentration.
It is detected in plasma after five hours. The maximum of metabolites occurs at 9 hours of accumulation in the body and lasts for 96 hours. The absorption of components is high.
It accumulates slightly - in the kidneys, liver and lungs. The greatest accumulation occurs in the lower extremities (saphenous veins) and the areas of the vena cava. The half-life of the drug is eleven hours.
Excretion of active substances in urine is 79% and 21% in feces. When taking the drug as a course, a pronounced decrease in general clinical indicators is observed.
pharmachologic effect
Detralex has venotonic and angioprotective properties. The drug reduces the distensibility of veins and venous stagnation, reduces capillary permeability and increases their resistance. The results of clinical studies confirm the pharmacological activity of the drug in relation to indicators of venous hemodynamics.
A statistically significant dose-dependent effect of the drug Detralex was demonstrated for the following venous plethysmographic parameters: venous capacity, venous distensibility, venous emptying time.
The optimal dose-effect ratio is observed when taken at a dose of 1000 mg per day.
Detralex increases venous tone: using venous occlusion plethysmography, a decrease in the time of venous emptying was shown. In patients with signs of severe microcirculation disorders, after treatment with Detralex there is a (statistically significant, compared to placebo) increase in capillary resistance, assessed by angiostereometry.
The therapeutic effectiveness of the drug Detralex has been proven in the treatment of chronic diseases of the veins of the lower extremities, as well as in the treatment of hemorrhoids.
How to take Diosmin
Diosmin tablets are taken orally with meals.
For varicose veins and venous insufficiency, usually take 2 tablets per day: preferably at lunchtime and in the evening. The course of treatment ranges from 1 to 4 months, depending on the specific disease, and in particularly severe cases (for example, in the presence of trophic ulcers) it is extended to 6 months. After 2-3 months, the treatment course can be repeated.
How to take Diosmin?
For hemorrhoids, tablets are taken according to the following scheme:
- for 4 days – 3 tablets 2 times a day;
- over the next 3 days, 2 tablets twice a day;
- then 1 tablet 1 time per day can be taken for 1-2 months.
If the symptoms of hemorrhoids do not disappear with short-term treatment, you should consult your doctor about the advisability of further use of this drug.
The attending physician may prescribe other dosages and frequency of use of Diosmin depending on the clinical picture of the disease in your particular case.
Precautions while using diosminagesperidin
It should be borne in mind that in case of exacerbation of hemorrhoids, the use of diosmin (it should be short-term) does not replace the specific treatment of other anal disorders. A proctological examination and a revision of treatment tactics are necessary if the symptoms of hemorrhoids do not disappear after short-term therapy.
During treatment, it is recommended to avoid prolonged exposure to the sun, reduce body weight, take walks, and in some cases wear special stockings to improve blood circulation, because. The maximum effect of therapy for venous circulation disorders is achieved when combined with a certain lifestyle.
Mode of application
Taken orally. The dosage regimen is prescribed depending on the indications. Therapy of peripheral venous insufficiency: 2 tablets per day (recommended to take 1 tablet at noon and 1 tablet in the evening). Therapy of acute hemorrhoids: 6 tablets per day (recommended to take 3 tablets at noon and 3 tablets in the evening ). 4 days after the start of the course, the dose is reduced to 4 tablets per day (2 doses of 2 tablets), this dose is taken for 3 days. The general course for acute hemorrhoids is 7 days. For acute hemorrhoids, Diosmin is prescribed only in complex therapy regimens; diosmin monotherapy may be ineffective. In case of acute hemorrhoids, long courses of taking diosmin are not prescribed; if short-term therapy is not effective enough, re-diagnosis is prescribed. The dosage regimen and its duration may vary individually for each patient.
Indications for use
Detralex is indicated for the treatment of symptoms of chronic venous diseases (elimination and relief of symptoms).
- Treatment of symptoms of venous-lymphatic insufficiency: pain;
- spasms of the lower extremities;
- feeling of heaviness and fullness in the legs;
- "tired" legs.
- swelling of the lower extremities;
Operating principle
The drug Diosmin works on affected venous vessels, including in the area of the spinal column. As a result of completing a course of treatment with this drug, congestion in the veins decreases, the tone of the vascular wall is normalized, and the increased distensibility of blood vessels decreases (smooth muscle fibers contract). Diosmin also helps restore microcirculation in smaller vessels and capillaries, preventing their fragility and microtrauma.
The second, quite important effect of this medication is its participation in restoring physiological and healthy gas exchange and metabolism. The drug also reduces inflammatory processes in blood vessels, accelerates the removal of harmful free radicals from veins and capillaries, and to some extent improves the outflow of lymph through their vessels.
Diosmin, Detralex, Phlebodia, Venarus: their analogues on iHerb
If you are concerned about the health of your veins, then you have probably heard about drugs called: Detralex, Phlebodia 600, Venarus, Diosmin 600, Diosmin 500. These are over-the-counter pharmaceutical drugs that separately contain diosmin or the aforementioned “micronized purified flavonoid fraction.”
Do these complexes have more profitable analogues ? Yes, various comprehensive vein health supplements, including diosmin with hesperidin, can be purchased on the iHerb website.
Natural Balance, Diosmin, Vein Health Support, 60 Tablets
Buy at a discount
One tablet contains 500 mg of diosmin.
Garden of Life, Extraordinary Beauty, Lovely Legs, 30 Vegan Caplets
Buy at a discount
Lovely Legs formula contains 95% diosmin in a citrus bioflavonoid complex with hesperidin. This is one of the effective formulas widely prescribed by doctors in Europe for decades. The clinical effectiveness of this complex is supported by extensive clinical studies in humans.
Lovely Legs improves the health and tone of small veins and capillaries, supporting healthy circulation, essential for healthy and beautiful legs.
The complex also promotes lymph flow and drainage, which supports the body's natural detoxification system.
ZOI Research, Vein Support, 250 Vegetarian Capsules
Buy at a discount
Zoi Research is a unique drug that contains diosmin and a patented complex of herbal ingredients, such as horse chestnut and centella asiatica, combined with natural plant components for better absorption.
Horse chestnut seeds contain a mixture of saponins, which improves blood circulation, strengthens capillaries and prevents the formation of spider veins.
Centella asiatica (Gotu Kola) is known in Ayurvedic traditional medicine as a health tonic. Research shows that gotu kola can improve blood circulation and help with venous insufficiency in the lower extremities.
Country Life, VaricoVein, Men & Women, 60 Vegetarian Capsules
Buy Now Discount
This product was manufactured in an NSF registered Good Manufacturing Practices (GMP) facility.
The complex contains vitamin C (in the form of ascorbic acid), diosmin, orange fruit extract, grape seed extract.
Flora, SirkuVein, 60 Vegetarian Capsules
Buy at a discount
CircuVein Complex - a complete analogue of Detralex, Venarus . It also contains diosmin and hesperidin in the ratio of 450 mg and 50 mg. Total 500 mg of flavonoids. This ratio and amount of diosmin to hesperidin has demonstrated the ability to reduce the symptoms of varicose veins, as well as reduce swelling of the legs and ankles.
Doctor's Best, Vein Support with DiosVein and MenaQ7, 60 Vegetarian Capsules
The most popular complex for maintaining circulatory function, healthy veins and blood vessels. It contains vitamin K, diosmin, and orange extract (containing 90% hesperidin). The presence of vitamin K in the composition makes this complex beneficial for both the legs and the health of the cardiovascular system.
Buy at a discount
Side effects
There were no data on complications during administration; treatment and prevention were well tolerated by the patient. However, in individual cases, allergic rashes may occur in the form of rash, hives or itching (you must stop using), dizziness, and headache.
Disorder and discomfort from the gastrointestinal tract in the form of dyspeptic disorder. These effects are not indicators for drug withdrawal.
The advantages of diosmin are its relatively low cost and rapid accumulation of the main medicinal component, which is important for effective treatment
The disadvantages include its rapid elimination from the body, so it is necessary to monitor timely intake, as well as its lower availability compared to other drugs in this series. But it is most effective in the complex treatment and prevention of cardiovascular diseases.
Mechanism of action
Diosmin increases venous tone and thereby reduces venous capacity, distensibility and stagnation of blood in the veins. This increases venous return and reduces venous hypertensive pressure present in patients suffering from CVI.
Diosmin improves lymphatic drainage by increasing the frequency and intensity of lymphatic contractions, as well as by increasing the total number of functional lymphatic capillaries. In addition, diosmin (together with hesperidin) reduces the diameter of lymphatic capillaries and intralymphatic pressure.
Diosmin was first isolated from plants in 1925 and first introduced as a therapeutic agent in 1969. Clinical evidence suggests that diosmin is a safe, nontoxic, and well-tolerated drug.
In 2021, the American Chronic Venous Disease Task Force recommended the use of diosmin for the treatment of chronic venous disease, either alone or as an adjunct to compression therapy. The German Dermatological Society said diosmin could be used with other drugs to more effectively treat chronic venous diseases.
Chronic venous insufficiency
Chronic venous insufficiency is a condition in which the veins do not return blood from the legs to the heart and causes varicose veins, ankle swelling, and nighttime leg cramps.
A 2012 review of ten studies found that diosmin reduced heaviness, swelling, cramps, and restless legs syndrome (,).
Cardiovascular diseases
Diosmin tablets are highly effective in treating cardiovascular disease by reducing inflammation and improving vein health, circulation and lymphatic flow ( ).
Haemorrhoids
Numerous studies show that diosmin helps treat internal and external hemorrhoids.
In a review of 24 studies, plant flavonoids such as diosmin were found to reduce hemorrhoid-associated itching, bleeding, discharge and other hemorrhoid symptoms ().
In addition, diosmin has been shown to reduce recovery time after hemorrhoidectomy or surgical removal of hemorrhoids (, , ,).
Instructions
For varicose veins and lymphovenous insufficiency, Diosmin is taken 1 time per day. (in the morning before meals). The duration of treatment should be determined by the doctor (individually).
For the treatment of acute hemorrhoids, take 2-3 tablets. (while eating). Reception course – 1 week. If there is a need to continue treatment, the daily amount is reduced to 1 tablet. In this case, the duration of treatment will be 1-2 months.
In case of microcirculation disorders, Diosmin should be taken 1 tablet per day in the morning on an empty stomach. within 1-2 months.
The medicine can be prescribed to pregnant women (except during the 1st trimester). In this case, the possible risk is taken into account, because There is no complete data on the effect of diosmin on the body of pregnant women.
Those taking the medicine should avoid being in the sun for too long. Walking will be useful. You should also control your weight.
It would be good to wear compression garments. It improves blood circulation and enhances the effect of Diosmin treatment. During the period of taking the drug, you should avoid alcoholic beverages.
Contraindications and side effects
Contraindications and side effects
The drug is contraindicated in case of hypersensitivity to its components. There is also an age limit for taking Diosmin - persons under 18 years of age cannot use it.
Among the side effects that may occur when taking the drug, it should be noted allergic reactions in the form of skin rash, itching, as well as digestive disorders: nausea, vomiting, diarrhea, constipation, flatulence. In addition, there is information about side effects such as headaches and dizziness.
If any side effects occur, you should consult your doctor.
Similar drugs:
- Detralex Oral tablets
- Detralex Oral tablets
- Diosmin (DIOSMIN) Oral tablets
** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use Diosmin, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.
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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Diosmin is provided for informational purposes and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!
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How does the medicine work?
The drug Diosmin is considered a prominent representative of angioprotective agents. Its action is explained by the activity of the main component – diosmin. This natural substance belongs to the group of bioflavonoids and has a multifaceted effect on the body, but most importantly, it has a venotonic effect. In addition, the active component of the drug stimulates blood microcirculation, prevents thrombus formation and controls lymphatic outflow, thereby eliminating stagnation of venous blood.
However, that's not all. The drug Diosmin improves metabolic processes in the vascular walls, thereby improving their elasticity (reducing extensibility and reducing fragility). And given that Diosmin has a slight vasoconstrictor effect, under its influence the pressure in the vascular walls increases and blood flow increases, which is another factor that prevents blood stagnation.
Description of the active substance DiosminDiosmin.
Formula: C28H32O15, chemical name: 7-hydroxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one. Pharmacological group: organotropic agents/cardiovascular agents/angioprotectors and microcirculation correctors/bioflavonoid. Pharmacological action: angioprotective, venotonic, venoprotective.
Pharmacological properties
Diosmin increases venous tone (the vasoconstrictor effect on veins is dose-dependent), reduces the volume of venous stasis and venous stagnation. Increases capillary resistance (the effect also depends on the dose), reduces their permeability, improves microcirculation. Has angioprotective properties. Increases vascular resistance, as well as diastolic and systolic pressure in the postoperative period with orthostatic hypertension. Diosmin also improves lymphatic drainage. There is evidence that the drug is effective in preventing bleeding that can occur as a result of phlebectomy and when using an intrauterine device. It is quickly absorbed in the gastrointestinal tract after oral administration from the second hour. After 5 hours, the maximum concentration of diosmin in plasma is reached. It accumulates in the area of the saphenous veins of the lower extremities, vena cava, less in the liver, kidneys and lungs, in small quantities in other tissues and organs. Selective accumulation of diosmin and/or its metabolites becomes maximum at 9 o'clock and continues over the next 4 days. Does not penetrate the hematoplacental barrier. Excreted in urine - 79%, feces - 11%, bile - 2.4%.
Indications
Varicose veins; exacerbation of hemorrhoids; lymphovenous chronic insufficiency of the lower extremities; microcirculation disturbance.
Method of administration of diosmin and dose
Diosmin is taken orally. For venous insufficiency - 600 mg before meals in the morning for 2 months; in case of severe lymphovenous chronic insufficiency (pain, swelling, cramps), therapy is continued for 3–4 months; if there are ulcers and trophic changes, the course lasts up to six months or more; the course of treatment is repeated after 2–3 months. In case of exacerbation of hemorrhoids - 1200-1800 mg per day, taken with meals for 1 week, then, if necessary, therapy can be continued - 600 mg once a day with food for 1-2 months. When treating chronic lymphovenous insufficiency in the 2nd and 3rd trimesters of pregnancy, the drug should be stopped 2–3 weeks before birth. If one or more doses are missed, the drug should be taken further in the usual dosage according to the treatment regimen. It must be remembered that during exacerbation of hemorrhoids, taking diosmin does not replace specific therapy for other anal disorders. A review of treatment tactics and a proctological examination are necessary if the symptoms of hemorrhoids do not go away after short-term treatment with diosmin. During therapy, it is necessary to avoid prolonged exposure to the sun, take walks, reduce body weight, and also wear special stockings that improve blood circulation, because the maximum effect of treatment for venous circulation disorders is possible when combined with a certain lifestyle.
What is diosmin?
Diosmin is a natural bioflavonoid that is taken in the form of a dietary supplement to improve the health and strengthening of vascular walls. It can be obtained from certain plant sources or can be isolated by extracting another flavonoid, hesperidin, found in citrus peels.
Diosmin is a phlebotonic, a class of therapeutic agents used to prevent and treat venous diseases such as chronic venous insufficiency (CVI), varicose veins, spider veins, lymphedema, stasis dermatitis and venous ulcers. Diosmin is also used for hemorrhoidal diseases, both acute and chronic.
As a flavonoid, diosmin also has anti-inflammatory, free radical and antimutagenic properties.
Extensive clinical trials have shown that diosmin has a positive effect on all stages of venous disease and significantly improves quality of life.
In addition, diosmin is believed to stimulate blood circulation, protect liver health, and reduce swelling after surgery. It is also used to improve cardiac function in adults who have undergone coronary artery bypass surgery, pelvic congestion in men and women caused by varicose veins, and varicoceles in men.
Diosmin is used for the following diseases:
- Phlebeurysm
- Trophic venous ulcers (defects of the skin and mucous membranes caused by poor blood circulation)
- Lymphedema (swelling in the arms or legs caused by damage to the lymphatic system)
- High blood pressure
- Bleeding Gums
- Premenstrual syndrome
- Ulcerative colitis
